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ABCB11 ATP-binding cassette, sub-family B (MDR/TAP), member 11 [Homo sapiens (human)]

RefSeq Accession Definition Service Stock Status Price *Turnaround time Order
NM_003742 Homo sapiens ATP-binding cassette, sub-family B (MDR/TAP), member 11 (ABCB11), mRNA. GenEZ ORF Cloning In-stock $1198.00 $1149.00 16

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Gene Symbol ABCB11
Entrez Gene ID 8647
Full Name ATP-binding cassette, sub-family B (MDR/TAP), member 11
Synonyms ABC16, BRIC2, BSEP, PFIC-2, PFIC2, PGY4, SPGP
Gene Type protein-coding
Organism Homo sapiens (human)



Summary The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. The protein encoded by this gene is the major canalicular bile salt export pump in man. Mutations in this gene cause a form of progressive familial intrahepatic cholestases which are a group of inherited disorders with severe cholestatic liver disease from early infancy. [provided by RefSeq, Jul 2008].

MIM: 603201

Cholestasis, progressive familial intrahepatic 2, 601847 (3);

mRNA Protein Product Sequence Price Select
NM_003742, 21536377 NP_003733, 21536378 bile salt export pump ORF Sequence $999.00
hsa02010ABC transporters
hsa04976Bile secretion
WP2289Drug Induction of Bile Acid Pathway
WP299Nuclear receptors in lipid metabolism and toxicity
REACT_11041Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol
REACT_11040Bile acid and bile salt metabolism
REACT_11054Synthesis of bile acids and bile salts
REACT_11042Recycling of bile acids and salts
REACT_22258Metabolism of lipids and lipoproteins
Homo sapiens (human)ABCB11NP_003733.2
Pan troglodytes (chimpanzee)ABCB11XP_526100.2
Macaca mulatta (Rhesus monkey)ABCB11XP_001097771.2
Canis lupus familiaris (dog)ABCB11NP_001137404.1
Bos taurus (cattle)ABCB11NP_001179632.1
Mus musculus (house mouse)Abcb11NP_066302.2
Gallus gallus (chicken)ABCB11XP_003641685.1
Danio rerio (zebrafish)abcb11bXP_003199513.1
GeneCards ABCB11
UniProt O95342
MIM 603201
Ensembl ENSG00000073734
HPRD 04436

GeneRIFs: Gene References Into Functions What's a GeneRIF?

General protein information

Preferred Names
bile salt export pump
bile salt export pump
sister p-glycoprotein
ABC member 16, MDR/TAP subfamily
ATP-binding cassette sub-family B member 11
progressive familial intrahepatic cholestasis 2


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