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ABCB11 ATP-binding cassette, sub-family B (MDR/TAP), member 11 [Homo sapiens (human)]


Clone ID RefSeq Accession Definition Vector Stock Status *Turnaround time Price Order
OHu25383 NM_003742 Homo sapiens ATP-binding cassette, sub-family B (MDR/TAP), member 11 (ABCB11), mRNA. pcDNA3.1+-DYK In-stock 16 $1149.00
OHu36716 XM_006712817 PREDICTED: Homo sapiens ATP-binding cassette, sub-family B (MDR/TAP), member 11 (ABCB11), transcript variant X1, mRNA. pcDNA3.1+-DYK On-demand 25 $1699.00
OHu36716 XM_006712818 PREDICTED: Homo sapiens ATP-binding cassette, sub-family B (MDR/TAP), member 11 (ABCB11), transcript variant X2, mRNA. pcDNA3.1+-DYK On-demand 25 $1699.00
OHu25383C NM_003742 Homo sapiens ATP-binding cassette, sub-family B (MDR/TAP), member 11 (ABCB11), mRNA. Customized vector In-stock 16 $1149.00
OHu36716C XM_006712817 PREDICTED: Homo sapiens ATP-binding cassette, sub-family B (MDR/TAP), member 11 (ABCB11), transcript variant X1, mRNA. Customized vector On-demand 25 $1699.00
OHu36716C XM_006712818 PREDICTED: Homo sapiens ATP-binding cassette, sub-family B (MDR/TAP), member 11 (ABCB11), transcript variant X2, mRNA. Customized vector On-demand 25 $1699.00

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Gene Symbol ABCB11
Entrez Gene ID 8647
Full Name ATP-binding cassette, sub-family B (MDR/TAP), member 11
Synonyms ABC16, BRIC2, BSEP, PFIC-2, PFIC2, PGY4, SPGP
General protein information
Preferred Names
bile salt export pump
Names
bile salt export pump
sister p-glycoprotein
ABC member 16, MDR/TAP subfamily
ATP-binding cassette sub-family B member 11
progressive familial intrahepatic cholestasis 2
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

2

2q24

Summary The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. The protein encoded by this gene is the major canalicular bile salt export pump in man. Mutations in this gene cause a form of progressive familial intrahepatic cholestases which are a group of inherited disorders with severe cholestatic liver disease from early infancy. [provided by RefSeq, Jul 2008].
Disorder

MIM: 603201

Cholestasis, progressive familial intrahepatic 2, 601847 (3);

mRNA Protein Product Sequence Price Select
NM_003742, 21536377 NP_003733, 21536378 bile salt export pump ORF Sequence $999.00
XM_006712817, 578805072 XP_006712880, 578805073 bile salt export pump isoform X1 ORF Sequence $1500.00
XM_006712818, 578805074 XP_006712881, 578805075 bile salt export pump isoform X2 ORF Sequence $1500.00
KEGG
hsa02010ABC transporters
hsa04976Bile secretion
WikiPathways
WP299Nuclear receptors in lipid metabolism and toxicity
WP2289Drug Induction of Bile Acid Pathway
Reactome
REACT_11040Bile acid and bile salt metabolism
REACT_11054Synthesis of bile acids and bile salts
REACT_11041Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol
REACT_11042Recycling of bile acids and salts
REACT_22258Metabolism of lipids and lipoproteins
REACT_111217Metabolism
Homo sapiens (human)ABCB11NP_003733.2
Pan troglodytes (chimpanzee)ABCB11XP_526100.2
Macaca mulatta (Rhesus monkey)ABCB11XP_001097771.2
Canis lupus familiaris (dog)ABCB11NP_001137404.1
Bos taurus (cattle)ABCB11NP_001179632.1
Mus musculus (house mouse)Abcb11NP_066302.2
Rattus norvegicus (Norway rat)Abcb11NP_113948.1
Gallus gallus (chicken)ABCB11XP_004942815.1
Danio rerio (zebrafish)abcb11bXP_003199513.2
Xenopus (Silurana) tropicalis (western clawed frog)LOC100489579XP_004917764.1
Process
IDNameEvidence
GO:0006200ATP catabolic processIEA
GO:0006699bile acid biosynthetic processTAS
GO:0006810transportTAS
GO:0008206bile acid metabolic processTAS
GO:0015721bile acid and bile salt transportTAS
GO:0015722canalicular bile acid transportIBA
GO:0035725sodium ion transmembrane transportTAS
GO:0044281small molecule metabolic processTAS
GO:0055085transmembrane transportIBA
Component
IDNameEvidence
GO:0005886plasma membraneTAS
GO:0005887integral component of plasma membraneTAS
GO:0016020membraneTAS
GO:0016021integral component of membraneIBA
GO:0045177apical part of cellIEA
GO:0046581intercellular canaliculusIEA
GO:0070062extracellular vesicular exosomeIDA
Function
IDNameEvidence
GO:0005215transporter activityTAS
GO:0005524ATP bindingIEA
GO:0008554sodium-exporting ATPase activity, phosphorylative mechanismTAS
GO:0015126canalicular bile acid transmembrane transporter activityIBA
GO:0015432bile acid-exporting ATPase activityTAS
GO:0042626ATPase activity, coupled to transmembrane movement of substancesIBA
GeneCards ABCB11
UniProt O95342
Vega OTTHUMG00000154039
MIM 603201
Ensembl ENSG00000073734
HGNC 42
HPRD 04436

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Interactant

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