EIF3B eukaryotic translation initiation factor 3, subunit B [Homo sapiens (human)]
| Gene Symbol | EIF3B |
| Entrez Gene ID | 8662 |
| Full Name | eukaryotic translation initiation factor 3, subunit B |
| Synonyms | EIF3-ETA, EIF3-P110, EIF3-P116, EIF3S9, MGC104664, MGC131875, PRT1 |
| Gene Type | protein-coding |
| Organism | Homo sapiens (human) |
| Genome |
7 7p22.3 |
| Summary | |
| Disorder | MIM: 603917 |
| mRNA | NM_003751, 83367073 |
| Protein | NP_003742, 33239445 |
| Product | eukaryotic translation initiation factor 3 subunit B |
| RefSeq Status | VALIDATED |
| mRNA | NM_001037283, 83367071 |
| Protein | NP_001032360, 83367072 |
| Product | eukaryotic translation initiation factor 3 subunit B |
| RefSeq Status | VALIDATED |
| hsa03013 | RNA transport |
WikiPathways
| WP107 | Translation Factors |
| WP49 | IL-2 Signaling Pathway |
Reactome
| REACT_2159 | Eukaryotic Translation Initiation |
| REACT_1797 | Formation of a pool of free 40S subunits |
| REACT_1258 | Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S |
| REACT_1014 | Translation |
| REACT_931 | Ribosomal scanning and start codon recognition |
| REACT_17015 | Metabolism of proteins |
| REACT_1979 | Translation initiation complex formation |
| REACT_79 | L13a-mediated translational silencing of Ceruloplasmin expression |
| REACT_2085 | GTP hydrolysis and joining of the 60S ribosomal subunit |
| REACT_71 | Gene Expression |
| REACT_2099 | Cap-dependent Translation Initiation |
| REACT_1079 | Formation of the ternary complex, and subsequently, the 43S complex |
| Homo sapiens (human) | EIF3B | NP_001032360.1 |
| Canis lupus familiaris (dog) | EIF3B | XP_536894.2 |
| Bos taurus (cattle) | EIF3B | NP_001095826.1 |
| Mus musculus (house mouse) | Eif3b | NP_598677.1 |
| Rattus norvegicus (Norway rat) | Eif3b | NP_001026810.1 |
| Danio rerio (zebrafish) | eif3b | XP_001335480.2 |
| Drosophila melanogaster (fruit fly) | eIF3-S9 | NP_611228.1 |
| Caenorhabditis elegans | eif-3.B | NP_001022469.1 |
| Arabidopsis thaliana (thale cress) | TIF3B1 | NP_001031954.1 |
| Arabidopsis thaliana (thale cress) | EIF3B-2 | NP_568477.1 |
| ID | Name | Evidence |
| GO:0006412 | translation | TAS |
| GO:0006413 | translational initiation | IC |
| GO:0006413 | translational initiation | IDA |
| GO:0006446 | regulation of translational initiation | IDA |
| GO:0010467 | gene expression | TAS |
| GO:0044267 | cellular protein metabolic process | TAS |
Component
| ID | Name | Evidence |
| GO:0005737 | cytoplasm | IEA |
| GO:0005829 | cytosol | EXP |
| GO:0005829 | cytosol | TAS |
| GO:0005852 | eukaryotic translation initiation factor 3 complex | IDA |
Function
| ID | Name | Evidence |
| GO:0000166 | nucleotide binding | IEA |
| GO:0003723 | RNA binding | IEA |
| GO:0003743 | translation initiation factor activity | IC |
| GO:0003743 | translation initiation factor activity | IDA |
| GO:0003743 | translation initiation factor activity | IDA |
| GO:0005515 | protein binding | IPI |
| GO:0032947 | protein complex scaffold | TAS |
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