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TNFRSF10B tumor necrosis factor receptor superfamily, member 10b [Homo sapiens (human)]


Clone ID RefSeq Accession Definition Vector Stock Status *Turnaround time Price Order
OHu15833 NM_147187 Homo sapiens tumor necrosis factor receptor superfamily, member 10b (TNFRSF10B), transcript variant 2, mRNA. pcDNA3.1+-DYK On-demand 7-9 $219.00
OHu22693 NM_003842 Homo sapiens tumor necrosis factor receptor superfamily, member 10b (TNFRSF10B), transcript variant 1, mRNA. pcDNA3.1+-DYK On-demand 7-9 $219.00
OHu42191 XM_006716409 PREDICTED: Homo sapiens tumor necrosis factor receptor superfamily, member 10b (TNFRSF10B), transcript variant X1, mRNA. pcDNA3.1+-DYK On-demand 7-9 $219.00
OHu15833C NM_147187 Homo sapiens tumor necrosis factor receptor superfamily, member 10b (TNFRSF10B), transcript variant 2, mRNA. Customized vector On-demand 7-9 $269.00
OHu22693C NM_003842 Homo sapiens tumor necrosis factor receptor superfamily, member 10b (TNFRSF10B), transcript variant 1, mRNA. Customized vector On-demand 7-9 $269.00
OHu42191C XM_006716409 PREDICTED: Homo sapiens tumor necrosis factor receptor superfamily, member 10b (TNFRSF10B), transcript variant X1, mRNA. Customized vector On-demand 7-9 $269.00

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Gene Symbol TNFRSF10B
Entrez Gene ID 8795
Full Name tumor necrosis factor receptor superfamily, member 10b
Synonyms CD262, DR5, KILLER, KILLER/DR5, TRAIL-R2, TRAILR2, TRICK2, TRICK2A, TRICK2B, TRICKB, ZTNFR9
General protein information
Preferred Names
tumor necrosis factor receptor superfamily member 10B
Names
tumor necrosis factor receptor superfamily member 10B
Fas-like protein
death receptor 5
cytotoxic TRAIL receptor-2
apoptosis inducing receptor TRAIL-R2
apoptosis inducing protein TRICK2A/2B
TNF-related apoptosis-inducing ligand receptor 2
death domain containing receptor for TRAIL/Apo-2L
tumor necrosis factor receptor-like protein ZTNFR9
p53-regulated DNA damage-inducible cell death receptor(killer)
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

8

8p22-p21

Summary The protein encoded by this gene is a member of the TNF-receptor superfamily, and contains an intracellular death domain. This receptor can be activated by tumor necrosis factor-related apoptosis inducing ligand (TNFSF10/TRAIL/APO-2L), and transduces an apoptosis signal. Studies with FADD-deficient mice suggested that FADD, a death domain containing adaptor protein, is required for the apoptosis mediated by this protein. Two transcript variants encoding different isoforms and one non-coding transcript have been found for this gene. [provided by RefSeq, Mar 2009].
Disorder

MIM: 603612

Squamous cell carcinoma, head and neck, 275355 (3)

mRNA Protein Product Sequence Price Select
NM_003842, 224494018 NP_003833, 224494019 tumor necrosis factor receptor superfamily member 10B isoform 1 precursor ORF Sequence $550.00
NM_147187, 224494025 NP_671716, 224494026 tumor necrosis factor receptor superfamily member 10B isoform 2 precursor ORF Sequence $400.00
XM_006716409, 578815520 XP_006716472, 578815521 tumor necrosis factor receptor superfamily member 10B isoform X1 ORF Sequence $550.00
KEGG
hsa04115p53 signaling pathway
hsa04650Natural killer cell mediated cytotoxicity
hsa04060Cytokine-cytokine receptor interaction
hsa04210Apoptosis
hsa05162Measles
hsa05164Influenza A
WikiPathways
WP254Apoptosis
WP707DNA damage response
WP1772Apoptosis Modulation and Signaling
Pathway Interaction Database
p53downstreampathwayDirect p53 effectors
trail_pathwayTRAIL signaling pathway
Reactome
REACT_402TRAIL signaling
REACT_1503Caspase-8 activation
REACT_1059Extrinsic Pathway for Apoptosis
REACT_832Dimerization of procaspase-8
REACT_578Apoptosis
REACT_1619Death Receptor Signalling
REACT_164011Regulation by c-FLIP
Homo sapiens (human)TNFRSF10BNP_003833.4
Pan troglodytes (chimpanzee)TNFRSF10BXP_001158074.1
Macaca mulatta (Rhesus monkey)LOC716650XP_001107490.2
Gallus gallus (chicken)TNFRSF10BNP_989446.2
Xenopus (Silurana) tropicalis (western clawed frog)tnfrsf10bNP_001004894.1
Process
IDNameEvidence
GO:0006915apoptotic processNAS
GO:0006915apoptotic processTAS
GO:0006919activation of cysteine-type endopeptidase activity involved in apoptotic processTAS
GO:0007166cell surface receptor signaling pathwayTAS
GO:0007250activation of NF-kappaB-inducing kinase activityNAS
GO:0008625extrinsic apoptotic signaling pathway via death domain receptorsNAS
GO:0034976response to endoplasmic reticulum stressIDA
GO:0042981regulation of apoptotic processNAS
GO:0043123positive regulation of I-kappaB kinase/NF-kappaB signalingIEP
GO:0070059intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stressIMP
GO:0071260cellular response to mechanical stimulusIEP
GO:0097190apoptotic signaling pathwayTAS
GO:2001239regulation of extrinsic apoptotic signaling pathway in absence of ligandTAS
Component
IDNameEvidence
GO:0005886plasma membraneTAS
GO:0016021integral component of membraneIC
Function
IDNameEvidence
GO:0004872receptor activityNAS
GO:0005515protein bindingIPI
GO:0045569TRAIL bindingNAS
GeneCards TNFRSF10B
UniProt O14763, Q7Z2I8
Vega OTTHUMG00000097826
MIM 603612
Ensembl ENSG00000120889
HGNC 11905
HPRD 04680

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Interactant

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