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Sequence in raw or FASTA format:

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SYNGAP1 synaptic Ras GTPase activating protein 1 [Homo sapiens (human)]


Clone ID RefSeq Accession Definition Vector Stock Status *Turnaround time Price Order
OHu18330 NM_006772 Homo sapiens synaptic Ras GTPase activating protein 1 (SYNGAP1), mRNA. pcDNA3.1+-DYK On-demand 25 $1699.00
OHu18330C NM_006772 Homo sapiens synaptic Ras GTPase activating protein 1 (SYNGAP1), mRNA. Customized vector On-demand 25 $1699.00

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Gene Symbol SYNGAP1
Entrez Gene ID 8831
Full Name synaptic Ras GTPase activating protein 1
Synonyms MRD5, RASA1, RASA5, SYNGAP
General protein information
Preferred Names
ras GTPase-activating protein SynGAP
Names
ras GTPase-activating protein SynGAP
neuronal RasGAP
synaptic Ras GTPase-activating protein 1
synaptic Ras GTPase activating protein, 135kDa
synaptic Ras GTPase activating protein 1 homolog
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

6

6p21.3

Summary The protein encoded by this gene is a major component of the postsynaptic density (PSD), a group of proteins found associated with NMDA receptors at synapses. The encoded protein is phosphorylated by calmodulin-dependent protein kinase II and dephosphorylated by NMDA receptor activation. Defects in this gene are a cause of mental retardation autosomal dominant type 5 (MRD5). [provided by RefSeq, Dec 2009].
Disorder

MIM: 603384

Mental retardation, autosomal dominant 5, 612621 (3)

mRNA Protein Product Sequence Price Select
NM_006772, 194248067 NP_006763, 194248068 ras/Rap GTPase-activating protein SynGAP ORF Sequence $1500.00
KEGG
hsa04014Ras signaling pathway
Homo sapiens (human)SYNGAP1NP_006763.2
Pan troglodytes (chimpanzee)SYNGAP1XP_003311264.1
Macaca mulatta (Rhesus monkey)SYNGAP1XP_001109824.1
Canis lupus familiaris (dog)SYNGAP1XP_005627810.1
Bos taurus (cattle)SYNGAP1NP_001192395.1
Mus musculus (house mouse)Syngap1NP_001268420.1
Rattus norvegicus (Norway rat)Syngap1NP_851606.3
Danio rerio (zebrafish)LOC100151149XP_001919204.4
Danio rerio (zebrafish)si:dkeyp-24a7.8XP_005159373.1
Xenopus (Silurana) tropicalis (western clawed frog)syngap1NP_001128288.1
Process
IDNameEvidence
GO:0007265Ras protein signal transductionIEA
GO:0007389pattern specification processIEA
GO:0008542visual learningIEA
GO:0016358dendrite developmentIEA
GO:0032320positive regulation of Ras GTPase activityIBA
GO:0032851positive regulation of Rab GTPase activityIEA
GO:0043113receptor clusteringIEA
GO:0043408regulation of MAPK cascadeIEA
GO:0043524negative regulation of neuron apoptotic processIEA
GO:0046580negative regulation of Ras protein signal transductionIBA
GO:0046580negative regulation of Ras protein signal transductionISS
GO:0048167regulation of synaptic plasticityISS
GO:0048169regulation of long-term neuronal synaptic plasticityIEA
GO:0050771negative regulation of axonogenesisIEA
GO:0050803regulation of synapse structure and activityIEA
Component
IDNameEvidence
GO:0005737cytoplasmIBA
GO:0031235intrinsic component of the cytoplasmic side of the plasma membraneIBA
GO:0043198dendritic shaftIEA
Function
IDNameEvidence
GO:0005097Rab GTPase activator activityIEA
GO:0005099Ras GTPase activator activityIBA
GO:0017124SH3 domain bindingIEA
GeneCards SYNGAP1
UniProt Q96PV0
Vega OTTHUMG00000031096
MIM 603384
Ensembl ENSG00000197283
HGNC 11497
HPRD 16018

Related articles in PubMed

GeneRIFs: Gene References Into Functions What's a GeneRIF?

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