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SQSTM1 sequestosome 1 [Homo sapiens (human)]

RefSeq Accession Definition Service Stock Status Price *Turnaround time Order
NM_001142298 Homo sapiens sequestosome 1 (SQSTM1), transcript variant 2, mRNA. GenEZ ORF Cloning On-demand $549.00 14
NM_001142299 Homo sapiens sequestosome 1 (SQSTM1), transcript variant 3, mRNA. GenEZ ORF Cloning On-demand $549.00 14
NM_003900 Homo sapiens sequestosome 1 (SQSTM1), transcript variant 1, mRNA. GenEZ ORF Cloning On-demand $699.00 18

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Gene Symbol SQSTM1
Entrez Gene ID 8878
Full Name sequestosome 1
Synonyms A170, OSIL, PDB3, ZIP3, p60, p62, p62B
Gene Type protein-coding
Organism Homo sapiens (human)



Summary This gene encodes a multifunctional protein that binds ubiquitin and regulates activation of the nuclear factor kappa-B (NF-kB) signaling pathway. The protein functions as a scaffolding/adaptor protein in concert with TNF receptor-associated factor 6 to mediate activation of NF-kB in response to upstream signals. Alternatively spliced transcript variants encoding either the same or different isoforms have been identified for this gene. Mutations in this gene result in sporadic and familial Paget disease of bone. [provided by RefSeq, Mar 2009].

MIM: 601530

Paget disease of bone, 602080 (3)

mRNA Protein Product Sequence Price Select
NM_001142298, 214830437 NP_001135770, 214830438 sequestosome-1 isoform 2 ORF Sequence $400.00
NM_001142299, 214830450 NP_001135771, 214830451 sequestosome-1 isoform 2 ORF Sequence $400.00
NM_003900, 188497651 NP_003891, 4505571 sequestosome-1 isoform 1 ORF Sequence $550.00
hsa04380Osteoclast differentiation
Pathway Interaction Database
il1pathwayIL1-mediated signaling events
tnfpathwayTNF receptor signaling pathway
trkrpathwayNeurotrophic factor-mediated Trk receptor signaling
p75ntrpathwayp75(NTR)-mediated signaling
WP2018RANKL/RANK Signaling Pathway
WP615Senescence and Autophagy
REACT_75790Cytokine Signaling in Immune system
REACT_13415p75NTR recruits signalling complexes
REACT_13643NRIF signals cell death from the nucleus
REACT_22442Interleukin-1 signaling
REACT_111102Signal Transduction
REACT_13696NF-kB is activated and signals survival
REACT_11061Signalling by NGF
REACT_13776p75 NTR receptor-mediated signalling
REACT_13537p75NTR signals via NF-kB
REACT_6900Immune System
REACT_13720Cell death signalling via NRAGE, NRIF and NADE
REACT_22232Signaling by Interleukins
Homo sapiens (human)SQSTM1NP_003891.1
Pan troglodytes (chimpanzee)SQSTM1XP_001153075.1
Macaca mulatta (Rhesus monkey)SQSTM1XP_001102347.1
Bos taurus (cattle)SQSTM1NP_788814.1
Mus musculus (house mouse)Sqstm1NP_035148.1
Rattus norvegicus (Norway rat)Sqstm1NP_787037.2
Gallus gallus (chicken)SQSTM1XP_001233249.2
Danio rerio (zebrafish)sqstm1NP_998338.1
Drosophila melanogaster (fruit fly)ref(2)PNP_001014491.1
GeneCards SQSTM1
PDB 2K0B, 1Q02, 2KNV, 2JY8, 2JY7
UniProt Q13501
MIM 601530
Ensembl ENSG00000161011
HGNC 11280
HPRD 03319

GeneRIFs: Gene References Into Functions What's a GeneRIF?

General protein information

Preferred Names
EBI3-associated protein p60
oxidative stress induced like
ubiquitin-binding protein p62
EBI3-associated protein of 60 kDa
phosphotyrosine independent ligand for the Lck SH2 domain p62
phosphotyrosine-independent ligand for the Lck SH2 domain of 62 kDa


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