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SQSTM1 sequestosome 1 [Homo sapiens (human)]


RefSeq Accession Definition Service Stock Status Price *Turnaround time Order
NM_001142298 Homo sapiens sequestosome 1 (SQSTM1), transcript variant 2, mRNA. GenEZ ORF Cloning On-demand $549.00 14
NM_001142299 Homo sapiens sequestosome 1 (SQSTM1), transcript variant 3, mRNA. GenEZ ORF Cloning On-demand $549.00 14
NM_003900 Homo sapiens sequestosome 1 (SQSTM1), transcript variant 1, mRNA. GenEZ ORF Cloning On-demand $699.00 18

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Gene Symbol SQSTM1
Entrez Gene ID 8878
Full Name sequestosome 1
Synonyms A170, OSIL, PDB3, ZIP3, p60, p62, p62B
General protein information
Preferred Names
sequestosome-1
Names
sequestosome-1
EBIAP
EBI3-associated protein p60
oxidative stress induced like
ubiquitin-binding protein p62
EBI3-associated protein of 60 kDa
phosphotyrosine independent ligand for the Lck SH2 domain p62
phosphotyrosine-independent ligand for the Lck SH2 domain of 62 kDa
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

5

5q35

Summary This gene encodes a multifunctional protein that binds ubiquitin and regulates activation of the nuclear factor kappa-B (NF-kB) signaling pathway. The protein functions as a scaffolding/adaptor protein in concert with TNF receptor-associated factor 6 to mediate activation of NF-kB in response to upstream signals. Alternatively spliced transcript variants encoding either the same or different isoforms have been identified for this gene. Mutations in this gene result in sporadic and familial Paget disease of bone. [provided by RefSeq, Mar 2009].
Disorder

MIM: 601530

Paget disease of bone, 602080 (3)

mRNA Protein Product Sequence Price Select
NM_001142298, 214830437 NP_001135770, 214830438 sequestosome-1 isoform 2 ORF Sequence $400.00
NM_001142299, 214830450 NP_001135771, 214830451 sequestosome-1 isoform 2 ORF Sequence $400.00
NM_003900, 188497651 NP_003891, 4505571 sequestosome-1 isoform 1 ORF Sequence $550.00
KEGG
hsa04380Osteoclast differentiation
WikiPathways
WP615Senescence and Autophagy
WP2380BDNF signaling pathway
WP2018RANKL/RANK Signaling Pathway
Pathway Interaction Database
il1pathwayIL1-mediated signaling events
trkrpathwayNeurotrophic factor-mediated Trk receptor signaling
tnfpathwayTNF receptor signaling pathway
p75ntrpathwayp75(NTR)-mediated signaling
Reactome
REACT_6900Immune System
REACT_13720Cell death signalling via NRAGE, NRIF and NADE
REACT_11061Signalling by NGF
REACT_13776p75 NTR receptor-mediated signalling
REACT_13643NRIF signals cell death from the nucleus
REACT_13537p75NTR signals via NF-kB
REACT_13415p75NTR recruits signalling complexes
REACT_13696NF-kB is activated and signals survival
REACT_22232Signaling by Interleukins
REACT_22442Interleukin-1 signaling
REACT_75790Cytokine Signaling in Immune system
REACT_111102Signal Transduction
Homo sapiens (human)SQSTM1NP_003891.1
Pan troglodytes (chimpanzee)SQSTM1XP_001153075.1
Macaca mulatta (Rhesus monkey)SQSTM1XP_001102347.1
Bos taurus (cattle)SQSTM1NP_788814.1
Mus musculus (house mouse)Sqstm1NP_035148.1
Rattus norvegicus (Norway rat)Sqstm1NP_787037.2
Gallus gallus (chicken)SQSTM1XP_001233249.2
Danio rerio (zebrafish)sqstm1NP_998338.1
Xenopus (Silurana) tropicalis (western clawed frog)sqstm1NP_001007894.1
Process
IDNameEvidence
GO:0001934positive regulation of protein phosphorylationIEA
GO:0002376immune system processIEA
GO:0006468protein phosphorylationNAS
GO:0006511ubiquitin-dependent protein catabolic processTAS
GO:0006914autophagyIMP
GO:0006914autophagyTAS
GO:0006950response to stressTAS
GO:0008104protein localizationTAS
GO:0016197endosomal transportTAS
GO:0016236macroautophagyISS
GO:0016239positive regulation of macroautophagyIMP
GO:0030154cell differentiationIEA
GO:0035556intracellular signal transductionTAS
GO:0043065positive regulation of apoptotic processTAS
GO:0043066negative regulation of apoptotic processTAS
GO:0043122regulation of I-kappaB kinase/NF-kappaB signalingIMP
GO:0045944positive regulation of transcription from RNA polymerase II promoterTAS
GO:0046578regulation of Ras protein signal transductionNAS
GO:0048011neurotrophin TRK receptor signaling pathwayTAS
GO:0051291protein heterooligomerizationIEA
GO:0097190apoptotic signaling pathwayTAS
Component
IDNameEvidence
GO:0000407pre-autophagosomal structureIEA
GO:0000932cytoplasmic mRNA processing bodyIDA
GO:0005654nucleoplasmTAS
GO:0005737cytoplasmIDA
GO:0005764lysosomeIEA
GO:0005770late endosomeIEA
GO:0005776autophagic vacuoleIDA
GO:0005783endoplasmic reticulumIEA
GO:0005829cytosolTAS
GO:0016234inclusion bodyIDA
GO:0016235aggresomeIEA
GO:0016605PML bodyIDA
GO:0031410cytoplasmic vesicleIEA
GO:0070062extracellular vesicular exosomeIDA
Function
IDNameEvidence
GO:0004674protein serine/threonine kinase activityNAS
GO:0005080protein kinase C bindingIPI
GO:0005515protein bindingIPI
GO:0008270zinc ion bindingIEA
GO:0019901protein kinase bindingIDA
GO:0030971receptor tyrosine kinase bindingTAS
GO:0042169SH2 domain bindingIDA
GO:0042802identical protein bindingIPI
GO:0042803protein homodimerization activityIEA
GO:0043130ubiquitin bindingIDA
GO:0070530K63-linked polyubiquitin bindingIEA
GeneCards SQSTM1
UniProt Q13501
Vega OTTHUMG00000150643
MIM 601530
Ensembl ENSG00000161011
HGNC 11280
HPRD 03319

GeneRIFs: Gene References Into Functions What's a GeneRIF?

What is the normal function of the SQSTM1 gene?

The SQSTM1 gene provides instructions for making a protein called p62. This protein plays an important role in bone remodeling, a normal process in which old bone is broken down and new bone is created to replace it. The p62 protein helps regulate this process through its role in a chemical signaling pathway that promotes the formation of osteoclasts. Osteoclasts are specialized cells that break down bone tissue during bone remodeling.

Studies suggest that p62 may have other functions in addition to its role in bone remodeling. It may be involved in recycling worn-out cell parts and unneeded proteins (autophagy), the self-destruction of cells (apoptosis), and the body's immune responses and inflammatory reactions.

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