Sequence in raw or FASTA format:
CCNA1 cyclin A1 [
Homo sapiens (human)]
Gene Symbol CCNA1
Entrez Gene ID
Full Name cyclin A1
General protein information
Gene Type protein-coding
Homo sapiens (human)
Chromosome:13 Map Location:13q12.3-q13
Summary The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. The cyclin encoded by this gene was shown to be expressed in testis and brain, as well as in several leukemic cell lines, and is thought to primarily function in the control of the germline meiotic cell cycle. This cyclin binds both CDK2 and CDC2 kinases, which give two distinct kinase activities, one appearing in S phase, the other in G2, and thus regulate separate functions in cell cycle. This cyclin was found to bind to important cell cycle regulators, such as Rb family proteins, transcription factor E2F-1, and the p21 family proteins. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].
Pathway Interaction Database
ID Name Evidence
GO:0000079 regulation of cyclin-dependent protein serine/threonine kinase activity IEA
GO:0000082 G1/S transition of mitotic cell cycle TAS
GO:0000083 regulation of transcription involved in G1/S transition of mitotic cell cycle TAS
GO:0000086 G2/M transition of mitotic cell cycle TAS
GO:0000278 mitotic cell cycle TAS
GO:0007067 mitotic nuclear division IEA
GO:0007141 male meiosis I TAS
GO:0007283 spermatogenesis TAS
GO:0010389 regulation of G2/M transition of mitotic cell cycle IEA
Related articles in PubMed Inverse relationship between TCTP/RhoA and p53 /cyclin A/actin expression in ovarian cancer cells. Kloc M, et al. Folia Histochem Cytobiol, 2012 Oct 8. PMID 23042265. Expression of cyclins A and E in melanocytic skin lesions and its correlation with some clinicopathologic features. Alekseenko A, et al. Folia Histochem Cytobiol, 2012 Jul 5. PMID 22763964. Foxo3a drives proliferation in anaplastic thyroid carcinoma through transcriptional regulation of cyclin A1: a paradigm shift that impacts current therapeutic strategies. Marlow LA, et al. J Cell Sci, 2012 Sep 15. PMID 22718346. Cyclin A1 shows age-related expression in benign tonsils, HPV16-dependent overexpression in HNSCC and predicts lower recurrence rate in HNSCC independently of HPV16. Weiss D, et al. BMC Cancer, 2012 Jun 19. PMID 22712549. Cyclin-A1 represents a new immunogenic targetable antigen expressed in acute myeloid leukemia stem cells with characteristics of a cancer-testis antigen. Ochsenreither S, et al. Blood, 2012 Jun 7. PMID 22529286. See all (109) citations in PubMed See citations in PubMed for homologs of this gene provided by HomoloGene
GeneRIFs: Gene References Into Functions
What's a GeneRIF?
Nuclear FoxO3a promotes cell cycle progression by transcriptional upregulation of cyclin A1, promoting proliferation of human anaplastic thyroid carcinoma cells.
Title: Foxo3a drives proliferation in anaplastic thyroid carcinoma through transcriptional regulation of cyclin A1: a paradigm shift that impacts current therapeutic strategies.
These findings indicate the possible involvement of cyclins A and E in the pathogenesis of malignant melanoma.
Title: Expression of cyclins A and E in melanocytic skin lesions and its correlation with some clinicopathologic features.
The organization of actin and cytokeratin cytoskeleton and the expression of TCTP, p53,cyclin A, RhoA and actin in HIO180 non-transformed ovarian epithelial cells, and OVCAR3 and SKOV3 ovarian epithelial cancer cells, was studied.
Title: Inverse relationship between TCTP/RhoA and p53 /cyclin A/actin expression in ovarian cancer cells.
Cyclin A1 as overexpressed in induced lpuripotent stem cells cells compared to embryonic stem cells, suggesting that during reprogramming, cyclin A1 protein expression levels are not set correctly.
Title: Cyclin A1 is essential for setting the pluripotent state and reducing tumorigenicity of induced pluripotent stem cells.
Cyclin A1 is an important cell cycle regulator with age-related increased expression in tonsils of children. HPV16 induces overexpression of Cyclin A1 in HNSCC despite promoter methylation.
Title: Cyclin A1 shows age-related expression in benign tonsils, HPV16-dependent overexpression in HNSCC and predicts lower recurrence rate in HNSCC independently of HPV16.
Increased cyclin A1 in human bladder cancer cells may be regulated by activity of the USP2a deubiquitinase.
Title: The ubiquitin-specific protease USP2a enhances tumor progression by targeting cyclin A1 in bladder cancer.
Cyclin-A1 is the first prototypic leukemia-testis-antigen to be expressed in acute myeloid leukemia leukemic stem cells.
Title: Cyclin-A1 represents a new immunogenic targetable antigen expressed in acute myeloid leukemia stem cells with characteristics of a cancer-testis antigen.
Oxidized low density lipoprotein induces cyclin A synthesis in a process involving ERK, JNK and NFkappaB
Title: Oxidized low density lipoprotein induces cyclin A synthesis. Involvement of ERK, JNK and NFkappaB.
The integrated form of HPV might lead to CCNA1 promoter methylation in cervical cancer by some mechanisms.
Title: Human papillomavirus's physical state and cyclin A1 promoter methylation in cervical cancer.
CCNA1 methylation may play a crucial role in HPV16-induced carcinogenesis of HNSCC independently of p53
Title: Promoter methylation of cyclin A1 is associated with human papillomavirus 16 induced head and neck squamous cell carcinoma independently of p53 mutation.
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