CCNA1 cyclin A1 [Homo sapiens (human)]
| Gene Symbol | CCNA1 |
| Entrez Gene ID | 8900 |
| Full Name | cyclin A1 |
| Synonyms | |
| Gene Type | protein-coding |
| Organism | Homo sapiens (human) |
| Genome |
13 13q12.3-q13 |
| Summary | The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. The cyclin encoded by this gene was shown to be expressed in testis and brain, as well as in several leukemic cell lines, and is thought to primarily function in the control of the germline meiotic cell cycle. This cyclin binds both CDK2 and CDC2 kinases, which give two distinct kinase activities, one appearing in S phase, the other in G2, and thus regulate separate functions in cell cycle. This cyclin was found to bind to important cell cycle regulators, such as Rb family proteins, transcription factor E2F-1, and the p21 family proteins. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq]. |
| Disorder | MIM: 604036 |
| mRNA | NM_003914, 161377466 |
| Protein | NP_003905, 4502611 |
| Product | cyclin-A1 isoform a |
| RefSeq Status | REVIEWED |
| mRNA | NM_001111047, 161377471 |
| Protein | NP_001104517, 161377472 |
| Product | cyclin-A1 isoform c |
| RefSeq Status | REVIEWED |
| mRNA | NM_001111045, 161377467 |
| Protein | NP_001104515, 161377468 |
| Product | cyclin-A1 isoform b |
| RefSeq Status | REVIEWED |
| mRNA | NM_001111046, 161377469 |
| Protein | NP_001104516, 161377470 |
| Product | cyclin-A1 isoform c |
| RefSeq Status | REVIEWED |
| hsa04110 | Cell cycle |
| hsa05221 | Acute myeloid leukemia |
| hsa04914 | Progesterone-mediated oocyte maturation |
| hsa05200 | Pathways in cancer |
Pathway Interaction Database
| cmyb_pathway | C-MYB transcription factor network |
WikiPathways
| WP45 | G1 to S cell cycle control |
| WP179 | Cell cycle |
Reactome
| REACT_2148 | Switching of origins to a post-replicative state |
| REACT_9029 | Cyclin A:Cdk2-associated events at S phase entry |
| REACT_6837 | Regulation of APC/C activators between G1/S and early anaphase |
| REACT_683 | G1/S-Specific Transcription |
| REACT_829 | Regulation of DNA replication |
| REACT_1857 | Cyclin A/B1 associated events during G2/M transition |
| REACT_383 | DNA Replication |
| REACT_207 | Removal of licensing factors from origins |
| REACT_1915 | G2 Phase |
| REACT_6828 | APC/C-mediated degradation of cell cycle proteins |
| REACT_21391 | Mitotic G2-G2/M phases |
| REACT_6362 | Phosphorylation of proteins involved in the G2/M transition by Cyclin A:Cdc2 complexes |
| REACT_1783 | G1/S Transition |
| REACT_21279 | Regulation of mitotic cell cycle |
| REACT_9003 | SCF(Skp2)-mediated degradation of p27/p21 |
| REACT_471 | E2F mediated regulation of DNA replication |
| REACT_1156 | Orc1 removal from chromatin |
| REACT_2203 | G2/M Transition |
| REACT_899 | S Phase |
| REACT_152 | Cell Cycle, Mitotic |
| REACT_2014 | Synthesis of DNA |
| REACT_1574 | Cyclin E associated events during G1/S transition |
| REACT_21267 | Mitotic G1-G1/S phases |
| Homo sapiens (human) | CCNA1 | NP_003905.1 |
| Pan troglodytes (chimpanzee) | CCNA1 | XP_522658.2 |
| Canis lupus familiaris (dog) | CCNA1 | XP_534494.2 |
| Bos taurus (cattle) | CCNA1 | XP_600212.3 |
| Mus musculus (house mouse) | Ccna1 | NP_031654.1 |
| Rattus norvegicus (Norway rat) | Ccna1 | NP_001011949.1 |
| Gallus gallus (chicken) | CCNA1 | XP_417097.1 |
| Danio rerio (zebrafish) | ccna1 | NP_997983.1 |
| Arabidopsis thaliana (thale cress) | CYCA1;2 | NP_177863.2 |
| ID | Name | Evidence |
| GO:0000079 | regulation of cyclin-dependent protein kinase activity | IEA |
| GO:0000082 | G1/S transition of mitotic cell cycle | TAS |
| GO:0000083 | regulation of transcription involved in G1/S phase of mitotic cell cycle | TAS |
| GO:0000086 | G2/M transition of mitotic cell cycle | TAS |
| GO:0000278 | mitotic cell cycle | TAS |
| GO:0007067 | mitosis | IEA |
| GO:0007141 | male meiosis I | TAS |
| GO:0007283 | spermatogenesis | TAS |
| GO:0051301 | cell division | IEA |
| GO:0071445 | cellular response to protein stimulus | IEA |
Component
| ID | Name | Evidence |
| GO:0005634 | nucleus | IEA |
| GO:0005654 | nucleoplasm | TAS |
| GO:0005829 | cytosol | TAS |
| GO:0015630 | microtubule cytoskeleton | IDA |
Function
| ID | Name | Evidence |
| GO:0005515 | protein binding | IPI |
| GO:0019901 | protein kinase binding | IEA |
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