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CCNA1 cyclin A1 [Homo sapiens (human)]


RefSeq Accession Definition Service Stock Status Price *Turnaround time Order
NM_001111045 Homo sapiens cyclin A1 (CCNA1), transcript variant 2, mRNA. GenEZ ORF Cloning In-stock $509.00 $460.00 12
NM_001111046 Homo sapiens cyclin A1 (CCNA1), transcript variant 3, mRNA. GenEZ ORF Cloning In-stock $509.00 $460.00 12
NM_001111047 Homo sapiens cyclin A1 (CCNA1), transcript variant 4, mRNA. GenEZ ORF Cloning In-stock $509.00 $460.00 12
NM_003914 Homo sapiens cyclin A1 (CCNA1), transcript variant 1, mRNA. GenEZ ORF Cloning On-demand $699.00 18

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Related Services

Gene Symbol CCNA1
Entrez Gene ID 8900
Full Name cyclin A1
Synonyms CT146
General protein information
Preferred Names
cyclin-A1
Names
cyclin-A1
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

13

13q12.3-q13

Summary The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. The cyclin encoded by this gene was shown to be expressed in testis and brain, as well as in several leukemic cell lines, and is thought to primarily function in the control of the germline meiotic cell cycle. This cyclin binds both CDK2 and CDC2 kinases, which give two distinct kinase activities, one appearing in S phase, the other in G2, and thus regulate separate functions in cell cycle. This cyclin was found to bind to important cell cycle regulators, such as Rb family proteins, transcription factor E2F-1, and the p21 family proteins. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].
Disorder

MIM: 604036

mRNA Protein Product Sequence Price Select
NM_001111045, 161377467 NP_001104515, 161377468 cyclin-A1 isoform b ORF Sequence $360.00
NM_001111046, 161377469 NP_001104516, 161377470 cyclin-A1 isoform c ORF Sequence $360.00
NM_001111047, 161377471 NP_001104517, 161377472 cyclin-A1 isoform c ORF Sequence $360.00
NM_003914, 161377466 NP_003905, 4502611 cyclin-A1 isoform a ORF Sequence $550.00
KEGG
hsa04110Cell cycle
hsa05221Acute myeloid leukemia
hsa05200Pathways in cancer
hsa04914Progesterone-mediated oocyte maturation
hsa05161Hepatitis B
hsa05202Transcriptional misregulation in cancer
hsa05169Epstein-Barr virus infection
hsa05203Viral carcinogenesis
hsa04152AMPK signaling pathway
WikiPathways
WP45G1 to S cell cycle control
WP179Cell cycle
WP1403AMPK signaling
WP2361Gastric cancer network 1
Pathway Interaction Database
cmyb_pathwayC-MYB transcription factor network
Reactome
REACT_152Cell Cycle, Mitotic
REACT_9003SCF(Skp2)-mediated degradation of p27/p21
REACT_1783G1/S Transition
REACT_683G1/S-Specific Transcription
REACT_9029Cyclin A:Cdk2-associated events at S phase entry
REACT_899S Phase
REACT_471E2F mediated regulation of DNA replication
REACT_2203G2/M Transition
REACT_2014Synthesis of DNA
REACT_1857Cyclin A/B1 associated events during G2/M transition
REACT_6828APC/C-mediated degradation of cell cycle proteins
REACT_2148Switching of origins to a post-replicative state
REACT_6362Phosphorylation of proteins involved in the G2/M transition by Cyclin A:Cdc2 complexes
REACT_6837Regulation of APC/C activators between G1/S and early anaphase
REACT_1915G2 Phase
REACT_1574Cyclin E associated events during G1/S transition
REACT_1156Orc1 removal from chromatin
REACT_207Removal of licensing factors from origins
REACT_829Regulation of DNA replication
REACT_383DNA Replication
REACT_21279Regulation of mitotic cell cycle
REACT_21267Mitotic G1-G1/S phases
REACT_21391Mitotic G2-G2/M phases
REACT_111214G0 and Early G1
REACT_115566Cell Cycle
REACT_120956Cellular responses to stress
REACT_169168Senescence-Associated Secretory Phenotype (SASP)
REACT_169274Cellular Senescence
REACT_169185DNA Damage/Telomere Stress Induced Senescence
Homo sapiens (human)CCNA1NP_003905.1
Pan troglodytes (chimpanzee)CCNA1NP_001233366.1
Macaca mulatta (Rhesus monkey)CCNA1XP_001084161.1
Canis lupus familiaris (dog)CCNA1XP_005635513.1
Bos taurus (cattle)CCNA1XP_005213798.1
Mus musculus (house mouse)Ccna1NP_031654.2
Rattus norvegicus (Norway rat)Ccna1NP_001011949.1
Gallus gallus (chicken)CCNA1XP_417097.1
Danio rerio (zebrafish)ccna1NP_997983.1
Arabidopsis thaliana (thale cress)CYCA3;4NP_175156.1
Arabidopsis thaliana (thale cress)CYCA3;3NP_175155.1
Arabidopsis thaliana (thale cress)CYCA3;2NP_564499.3
Arabidopsis thaliana (thale cress)CYCA3;1NP_199122.1
Xenopus (Silurana) tropicalis (western clawed frog)ccna1NP_001016239.1
Process
IDNameEvidence
GO:0000079regulation of cyclin-dependent protein serine/threonine kinase activityIEA
GO:0000082G1/S transition of mitotic cell cycleTAS
GO:0000083regulation of transcription involved in G1/S transition of mitotic cell cycleTAS
GO:0000086G2/M transition of mitotic cell cycleTAS
GO:0000278mitotic cell cycleTAS
GO:0007067mitotic nuclear divisionIEA
GO:0007141male meiosis ITAS
GO:0007283spermatogenesisTAS
GO:0010389regulation of G2/M transition of mitotic cell cycleIEA
Component
IDNameEvidence
GO:0005654nucleoplasmTAS
GO:0005829cytosolTAS
GO:0015630microtubule cytoskeletonIDA
Function
IDNameEvidence
GO:0005515protein bindingIPI
GO:0019901protein kinase bindingIEA
GeneCards CCNA1
UniProt P78396
Vega OTTHUMG00000016733
MIM 604036
Ensembl ENSG00000133101
HGNC 1577
HPRD 04946

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Interactant

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