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Sequence in raw or FASTA format:


Blast Method:


PHOX2B paired-like homeobox 2b [Homo sapiens (human)]

Clone ID RefSeq Accession Definition Vector Stock Status *Turnaround time Price Order
OHu26329D NM_003924 Homo sapiens paired-like homeobox 2b (PHOX2B), mRNA. pcDNA3.1-C-(k)DYK In-stock 0 Starting from $99
OHu26329C NM_003924 Homo sapiens paired-like homeobox 2b (PHOX2B), mRNA. Customized vector In-stock 0 Starting from $99

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Gene Symbol PHOX2B
Entrez Gene ID 8929
Full Name paired-like homeobox 2b
Synonyms NBLST2, NBPhox, PMX2B
General protein information
Preferred Names
paired mesoderm homeobox protein 2B
paired mesoderm homeobox protein 2B
neuroblastoma Phox
PHOX2B homeodomain protein
paired mesoderm homeobox 2b
neuroblastoma paired-type homeobox protein
Gene Type protein-coding
Organism Homo sapiens (human)



Summary The DNA-associated protein encoded by this gene is a member of the paired family of homeobox proteins localized to the nucleus. The protein functions as a transcription factor involved in the development of several major noradrenergic neuron populations and the determination of neurotransmitter phenotype. The gene product is linked to enhancement of second messenger-mediated activation of the dopamine beta-hydroylase, c-fos promoters and several enhancers, including cyclic amp-response element and serum-response element. [provided by RefSeq, Jul 2008].

MIM: 603851

Central hypoventilation syndrome, congenital, 209880 (3);

mRNA Protein Product Sequence Price Select
NM_003924, 172072680 NP_003915, 12707580 paired mesoderm homeobox protein 2B ORF Sequence $300.00
WP706SIDS Susceptibility Pathways
WP2064Neural Crest Differentiation
Homo sapiens (human)PHOX2BNP_003915.2
Pan troglodytes (chimpanzee)PHOX2BXP_001149518.1
Macaca mulatta (Rhesus monkey)PHOX2BXP_001098028.1
Canis lupus familiaris (dog)PHOX2BXP_852840.1
Mus musculus (house mouse)Phox2bNP_032914.1
Gallus gallus (chicken)PHOX2BXP_001234151.2
Danio rerio (zebrafish)phox2bbNP_001014818.1
Danio rerio (zebrafish)LOC101885818XP_005157278.1
Xenopus (Silurana) tropicalis (western clawed frog)phox2bNP_001116492.1
GO:0001764neuron migrationISS
GO:0002087regulation of respiratory gaseous exchange by neurological system processISS
GO:0003357noradrenergic neuron differentiationIC
GO:0003357noradrenergic neuron differentiationISS
GO:0003358noradrenergic neuron developmentISS
GO:0003360brainstem developmentIEP
GO:0006351transcription, DNA-templatedIEA
GO:0008285negative regulation of cell proliferationIEA
GO:0010001glial cell differentiationISS
GO:0010468regulation of gene expressionISS
GO:0010971positive regulation of G2/M transition of mitotic cell cycleISS
GO:0021533cell differentiation in hindbrainISS
GO:0021723medullary reticular formation developmentISS
GO:0021934hindbrain tangential cell migrationISS
GO:0035914skeletal muscle cell differentiationIEA
GO:0045665negative regulation of neuron differentiationIEA
GO:0045666positive regulation of neuron differentiationIEA
GO:0045944positive regulation of transcription from RNA polymerase II promoterIDA
GO:0045944positive regulation of transcription from RNA polymerase II promoterIMP
GO:0048483autonomic nervous system developmentIMP
GO:0048484enteric nervous system developmentIEP
GO:0048485sympathetic nervous system developmentISS
GO:0048486parasympathetic nervous system developmentISS
GO:0048839inner ear developmentISS
GO:0048894efferent axon development in a lateral line nerveISS
GO:0060541respiratory system developmentISS
GO:0061452retrotrapezoid nucleus neuron differentiationISS
GO:0061549sympathetic ganglion developmentISS
GO:0071157negative regulation of cell cycle arrestISS
GO:0071542dopaminergic neuron differentiationIC
GO:0071542dopaminergic neuron differentiationISS
GO:0071773cellular response to BMP stimulusISS
GO:1901166neural crest cell migration involved in autonomic nervous system developmentISS
GO:0000790nuclear chromatinIDA
GO:0000977RNA polymerase II regulatory region sequence-specific DNA bindingIDA
GO:0000978RNA polymerase II core promoter proximal region sequence-specific DNA bindingIDA
GO:0003700sequence-specific DNA binding transcription factor activityIEA
GeneCards PHOX2B
UniProt Q99453
Vega OTTHUMG00000099379
MIM 603851
Ensembl ENSG00000109132
HGNC 9143
HPRD 09157

GeneRIFs: Gene References Into Functions What's a GeneRIF?

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