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PHOX2B paired-like homeobox 2b [Homo sapiens (human)]


RefSeq Accession Definition Services Price Order
NM_003924 Homo sapiens paired-like homeobox 2b (PHOX2B), mRNA. ORF Sequence $274.05
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Gene Symbol PHOX2B
Entrez Gene ID 8929
Full Name paired-like homeobox 2b
Synonyms NBLST2, NBPhox, PMX2B
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

4

4p12

Summary The DNA-associated protein encoded by this gene is a member of the paired family of homeobox proteins localized to the nucleus. The protein functions as a transcription factor involved in the development of several major noradrenergic neuron populations and the determination of neurotransmitter phenotype. The gene product is linked to enhancement of second messenger-mediated activation of the dopamine beta-hydroylase, c-fos promoters and several enhancers, including cyclic amp-response element and serum-response element. [provided by RefSeq, Jul 2008].
Disorder

MIM: 603851

Central hypoventilation syndrome, congenital, 209880 (3);

mRNA Protein Product Sequence Price Select
NM_003924, 172072680 NP_003915, 12707580 paired mesoderm homeobox protein 2B Full Length $1061.55
ORF Sequence $274.05
WikiPathways
WP706SIDS Susceptibility Pathways
WP2064Neural Crest Differentiation
Homo sapiens (human)PHOX2BNP_003915.2
Pan troglodytes (chimpanzee)PHOX2BXP_001149518.1
Macaca mulatta (Rhesus monkey)PHOX2BXP_001098028.1
Canis lupus familiaris (dog)PHOX2BXP_852840.1
Bos taurus (cattle)PHOX2BXP_002688259.1
Mus musculus (house mouse)Phox2bNP_032914.1
Rattus norvegicus (Norway rat)Phox2bXP_344240.3
Gallus gallus (chicken)PHOX2BXP_001234151.2
Danio rerio (zebrafish)phox2bbNP_001014818.1
Danio rerio (zebrafish)LOC100535138XP_003199912.1
GeneCards PHOX2B
UniProt Q99453
MIM 603851
Ensembl ENSG00000109132
HGNC 9143
HPRD 09157

GeneRIFs: Gene References Into Functions What's a GeneRIF?

General protein information

Preferred Names
paired mesoderm homeobox protein 2B
Names
paired mesoderm homeobox protein 2B
neuroblastoma Phox
PHOX2B homeodomain protein
paired mesoderm homeobox 2b
neuroblastoma paired-type homeobox protein

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