LPAR2 lysophosphatidic acid receptor 2 [Homo sapiens (human)]
| Gene Symbol | LPAR2 |
| Entrez Gene ID | 9170 |
| Full Name | lysophosphatidic acid receptor 2 |
| Synonyms | EDG-4, EDG4, FLJ93869, LPA-2, LPA2 |
| Gene Type | protein-coding |
| Organism | Homo sapiens (human) |
| Genome |
19 19p12 |
| Summary | This gene encodes a member of family I of the G protein-coupled receptors, as well as the EDG family of proteins. This protein functions as a lysophosphatidic acid (LPA) receptor and contributes to Ca2+ mobilization, a critical cellular response to LPA in cells, through association with Gi and Gq proteins. An alternative splice variant has been described but its full length sequence has not been determined. [provided by RefSeq]. |
| Disorder | MIM: 605110 |
| mRNA | NM_004720, 183396768 |
| Protein | NP_004711, 7305013 |
| Product | lysophosphatidic acid receptor 2 |
| RefSeq Status | REVIEWED |
| hsa04080 | Neuroactive ligand-receptor interaction |
Pathway Interaction Database
| lysophospholipid_pathway | LPA receptor mediated events |
Reactome
| REACT_18283 | G alpha (q) signalling events |
| REACT_14797 | Signaling by GPCR |
| REACT_19231 | G alpha (i) signalling events |
| REACT_19184 | GPCR downstream signaling |
| REACT_18365 | Lysosphingolipid and LPA receptors |
| REACT_14828 | Class A/1 (Rhodopsin-like receptors) |
| REACT_21340 | GPCR ligand binding |
| Homo sapiens (human) | LPAR2 | NP_004711.2 |
| Pan troglodytes (chimpanzee) | LPAR2 | XP_512529.2 |
| Canis lupus familiaris (dog) | LPAR2 | XP_541918.2 |
| Bos taurus (cattle) | LPAR2 | XP_586777.3 |
| Mus musculus (house mouse) | Lpar2 | NP_064412.2 |
| Rattus norvegicus (Norway rat) | Lpar2 | XP_573887.1 |
| Danio rerio (zebrafish) | zgc:101053 | NP_001003578.1 |
| Danio rerio (zebrafish) | zgc:123246 | NP_001032783.1 |
| ID | Name | Evidence |
| GO:0000187 | activation of MAPK activity | IEA |
| GO:0007186 | G-protein coupled receptor protein signaling pathway | TAS |
| GO:0007202 | activation of phospholipase C activity | TAS |
| GO:0007204 | elevation of cytosolic calcium ion concentration | TAS |
| GO:0035025 | positive regulation of Rho protein signal transduction | IEA |
| GO:0043410 | positive regulation of MAPKKK cascade | IEA |
Component
| ID | Name | Evidence |
| GO:0005886 | plasma membrane | EXP |
| GO:0005886 | plasma membrane | TAS |
| GO:0005887 | integral to plasma membrane | TAS |
| GO:0009986 | cell surface | IDA |
| GO:0030139 | endocytic vesicle | IDA |
Function
| ID | Name | Evidence |
| GO:0001619 | lysosphingolipid and lysophosphatidic acid receptor activity | IEA |
| GO:0004872 | receptor activity | IEA |
| GO:0004930 | G-protein coupled receptor activity | IEA |
| GO:0005515 | protein binding | IPI |
| GO:0008289 | lipid binding | TAS |
| GO:0030165 | PDZ domain binding | IEA |
| GO:0030274 | LIM domain binding | IPI |
| GeneCards | LPAR2 |
| UniProt | Q9HBW0 |
| MIM | 605110 |
| Ensembl | ENSG00000064547 |
| HGNC | 3168 |
Our customer service representatives are available 24 hours a day, Monday through Friday; please contact us anytime for assistance.
 |
Secured Online Quotation |
 |
Email: gene@genscript.com |
 |
Phone: 1-877-436-7274 (Toll-Free) 1-732-885-9188 |
 |
Fax: 1-732-210-0262 1-732-885-5878 |