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NOG noggin [Homo sapiens (human)]


RefSeq Accession Definition Sequence Price Select
NM_005450 Homo sapiens noggin (NOG), mRNA. Full Length $548.68
ORF Sequence $202.71


Gene Symbol NOG
Entrez Gene ID 9241
Full Name noggin
Synonyms SYM1, SYNS1
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

17

17q22
Summary The secreted polypeptide, encoded by this gene, binds and inactivates members of the transforming growth factor-beta (TGF-beta) superfamily signaling proteins, such as bone morphogenetic protein-4 (BMP4). By diffusing through extracellular matrices more efficiently than members of the TGF-beta superfamily, this protein may have a principal role in creating morphogenic gradients. The protein appears to have pleiotropic effect, both early in development as well as in later stages. It was originally isolated from Xenopus based on its ability to restore normal dorsal-ventral body axis in embryos that had been artificially ventralized by UV treatment. The results of the mouse knockout of the ortholog suggest that it is involved in numerous developmental processes, such as neural tube fusion and joint formation. Recently, several dominant human NOG mutations in unrelated families with proximal symphalangism (SYM1) and multiple synostoses syndrome (SYNS1) were identified; both SYM1 and SYNS1 have multiple joint fusion as their principal feature, and map to the same region (17q22) as this gene. All of these mutations altered evolutionarily conserved amino acid residues. The amino acid sequence of this human gene is highly homologous to that of Xenopus, rat and mouse. [provided by RefSeq].
Disorder

MIM: 602991

Symphalangism, proximal, 185800 (3); Synostoses syndrome, multiple,
mRNA NM_005450, 189339247
Protein NP_005441, 4885523
Product noggin precursor
RefSeq Status REVIEWED
KEGG
hsa04350TGF-beta signaling pathway
Pathway Interaction Database
bmppathwayBMP receptor signaling
WikiPathways
WP560TGF Beta Signaling Pathway
Reactome
REACT_12034Signaling by BMP
Homo sapiens (human)NOGNP_005441.1
Pan troglodytes (chimpanzee)NOGXP_523802.2
Bos taurus (cattle)NOGXP_582573.3
Mus musculus (house mouse)NogNP_032737.1
Rattus norvegicus (Norway rat)NogXP_343955.3
Gallus gallus (chicken)NOGNP_989454.1
Danio rerio (zebrafish)LOC100333103XP_002664025.1
Danio rerio (zebrafish)nog3NP_571057.1
Danio rerio (zebrafish)nog1NP_571058.2
Process
IDNameEvidence
GO:0001501skeletal system developmentTAS
GO:0001649osteoblast differentiationISS
GO:0001655urogenital system developmentIEA
GO:0001657ureteric bud developmentIEA
GO:0001701in utero embryonic developmentIEA
GO:0001837epithelial to mesenchymal transitionISS
GO:0007389pattern specification processIEA
GO:0007399nervous system developmentTAS
GO:0008045motor axon guidanceIEA
GO:0009953dorsal/ventral pattern formationIDA
GO:0021533cell differentiation in hindbrainIMP
GO:0021915neural tube developmentIEA
GO:0021983pituitary gland developmentIEA
GO:0030336negative regulation of cell migrationIDA
GO:0030509BMP signaling pathwayEXP
GO:0030514negative regulation of BMP signaling pathwayIDA
GO:0030514negative regulation of BMP signaling pathwayISS
GO:0030900forebrain developmentIEA
GO:0035019somatic stem cell maintenanceIMP
GO:0042060wound healingISS
GO:0042474middle ear morphogenesisIMP
GO:0042733embryonic digit morphogenesisIMP
GO:0045664regulation of neuron differentiationIEA
GO:0045668negative regulation of osteoblast differentiationIDA
GO:0045944positive regulation of transcription from RNA polymerase II promoterIEA
GO:0048570notochord morphogenesisIEA
GO:0048646anatomical structure formation involved in morphogenesisIEA
GO:0048706embryonic skeletal system developmentIMP
GO:0048712negative regulation of astrocyte differentiationISS
GO:0048762mesenchymal cell differentiationIEA
GO:0050679positive regulation of epithelial cell proliferationIEA
GO:0060044negative regulation of cardiac muscle cell proliferationISS
GO:0060173limb developmentIMP
GO:0060272embryonic skeletal joint morphogenesisIMP
GO:0060302negative regulation of cytokine activityIPI
GO:0060513prostatic bud formationIEA
GO:0060676ureteric bud formationIEA
GO:0060825fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formationIMP
GO:0061037negative regulation of cartilage developmentIEA
GO:0090190positive regulation of branching involved in ureteric bud morphogenesisISS
GO:0090193positive regulation of glomerulus developmentISS
Component
IDNameEvidence
GO:0005576extracellular regionEXP
GO:0005615extracellular spaceIDA
Function
IDNameEvidence
GO:0005515protein bindingIPI
GO:0019955cytokine bindingIPI
GO:0042803protein homodimerization activityIDA
GeneCards NOG
PDB 1M4U
UniProt Q13253
MIM 602991
Ensembl ENSG00000183691
HGNC 7866
HPRD 04291

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