• THAT   AND

Sequence in raw or FASTA format:


Blast Method:


NOG noggin [Homo sapiens (human)]

RefSeq Accession Definition Service Stock Status Price *Turnaround time Order
NM_005450 Homo sapiens noggin (NOG), mRNA. GenEZ ORF Cloning In-stock $308.00 $259.00 TBD

*Business Day

Related Services

Gene Symbol NOG
Entrez Gene ID 9241
Full Name noggin
Synonyms SYM1, SYNS1
Gene Type protein-coding
Organism Homo sapiens (human)



Summary The secreted polypeptide, encoded by this gene, binds and inactivates members of the transforming growth factor-beta (TGF-beta) superfamily signaling proteins, such as bone morphogenetic protein-4 (BMP4). By diffusing through extracellular matrices more efficiently than members of the TGF-beta superfamily, this protein may have a principal role in creating morphogenic gradients. The protein appears to have pleiotropic effect, both early in development as well as in later stages. It was originally isolated from Xenopus based on its ability to restore normal dorsal-ventral body axis in embryos that had been artificially ventralized by UV treatment. The results of the mouse knockout of the ortholog suggest that it is involved in numerous developmental processes, such as neural tube fusion and joint formation. Recently, several dominant human NOG mutations in unrelated families with proximal symphalangism (SYM1) and multiple synostoses syndrome (SYNS1) were identified; both SYM1 and SYNS1 have multiple joint fusion as their principal feature, and map to the same region (17q22) as this gene. All of these mutations altered evolutionarily conserved amino acid residues. The amino acid sequence of this human gene is highly homologous to that of Xenopus, rat and mouse. [provided by RefSeq, Jul 2008].

MIM: 602991

Symphalangism, proximal, 185800 (3); Synostoses syndrome, multiple,

mRNA Protein Product Sequence Price Select
NM_005450, 189339247 NP_005441, 4885523 noggin precursor ORF Sequence $159.00
hsa04350TGF-beta signaling pathway
Pathway Interaction Database
bmppathwayBMP receptor signaling
WP1425BMP signalling and regulation
WP560TGF Beta Signaling Pathway
REACT_111102Signal Transduction
REACT_12034Signaling by BMP
Homo sapiens (human)NOGNP_005441.1
Pan troglodytes (chimpanzee)NOGXP_523802.2
Macaca mulatta (Rhesus monkey)NOGXP_001104355.1
Canis lupus familiaris (dog)NOGXP_003639322.1
Bos taurus (cattle)NOGXP_002695600.1
Mus musculus (house mouse)NogNP_032737.1
Rattus norvegicus (Norway rat)NogNP_037122.1
Gallus gallus (chicken)NOGNP_989454.1
Danio rerio (zebrafish)nog3NP_571057.1
Danio rerio (zebrafish)LOC100333103XP_002664025.1
Danio rerio (zebrafish)nog1NP_571058.2
GeneCards NOG
UniProt Q13253
MIM 602991
Ensembl ENSG00000183691
HGNC 7866
HPRD 04291

GeneRIFs: Gene References Into Functions What's a GeneRIF?

General protein information

Preferred Names
symphalangism 1 (proximal)


Our customer service representatives are available 24 hours a day, Monday through Friday; please contact us anytime for assistance.

Learn more about the GenEZ ORF Cloning Service.