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CRLF1 cytokine receptor-like factor 1 [Homo sapiens (human)]


RefSeq Accession Definition Service Stock Status Price *Turnaround time Order
NM_004750 Homo sapiens cytokine receptor-like factor 1 (CRLF1), mRNA. GenEZ ORF Cloning On-demand TBD TBD
XM_006722934 PREDICTED: Homo sapiens cytokine receptor-like factor 1 (CRLF1), transcript variant X1, mRNA. GenEZ ORF Cloning On-demand TBD TBD

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Gene Symbol CRLF1
Entrez Gene ID 9244
Full Name cytokine receptor-like factor 1
Synonyms CISS, CISS1, CLF, CLF-1, NR6, zcytor5
General protein information
Preferred Names
cytokine receptor-like factor 1
Names
cytokine receptor-like factor 1
cytokine-like factor 1
class I cytokine receptor
cytokine type 1 receptor CRLP-1
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

19

19p12

Summary This gene encodes a member of the cytokine type I receptor family. The protein forms a secreted complex with cardiotrophin-like cytokine factor 1 and acts on cells expressing ciliary neurotrophic factor receptors. The complex can promote survival of neuronal cells. Mutations in this gene result in Crisponi syndrome and cold-induced sweating syndrome. [provided by RefSeq, Oct 2009].
Disorder

MIM: 604237

Cold-induced sweating syndrome, 272430 (3); Crisponi syndrome,

mRNA Protein Product Sequence Price Select
NM_004750, 260655997 NP_004741, 4758062 cytokine receptor-like factor 1 precursor ORF Sequence $550.00
XM_006722934, 578833718 XP_006722997, 578833719 cytokine receptor-like factor 1 isoform X1 ORF Sequence $400.00
Homo sapiens (human)CRLF1NP_004741.1
Pan troglodytes (chimpanzee)CRLF1XP_001135263.3
Macaca mulatta (Rhesus monkey)CRLF1XP_001115478.2
Canis lupus familiaris (dog)CRLF1XP_005633255.1
Bos taurus (cattle)CRLF1XP_002688582.2
Mus musculus (house mouse)Crlf1NP_061297.1
Rattus norvegicus (Norway rat)Crlf1NP_001099544.1
Gallus gallus (chicken)CRLF1XP_004948964.1
Danio rerio (zebrafish)crlf1aNP_001002650.1
Xenopus (Silurana) tropicalis (western clawed frog)crlf1XP_002940253.2
Process
IDNameEvidence
GO:0001657ureteric bud developmentIEA
GO:0008284positive regulation of cell proliferationIDA
GO:0042517positive regulation of tyrosine phosphorylation of Stat3 proteinIDA
GO:0043524negative regulation of neuron apoptotic processIDA
GO:2000672negative regulation of motor neuron apoptotic processIEA
Component
IDNameEvidence
GO:0005615extracellular spaceTAS
GO:0097058CRLF-CLCF1 complexIDA
Function
IDNameEvidence
GO:0004872receptor activityTAS
GO:0005125cytokine activityIDA
GO:0005127ciliary neurotrophic factor receptor bindingIDA
GO:0005515protein bindingIPI
GO:0019955cytokine bindingIPI
GO:0046982protein heterodimerization activityIDA
GeneCards CRLF1
UniProt O75462
Vega OTTHUMG00000183111
MIM 604237
Ensembl ENSG00000006016
HGNC 2364
HPRD 09177

GeneRIFs: Gene References Into Functions What's a GeneRIF?

What is the normal function of the CRLF1 gene?

The CRLF1 gene provides instructions for making a protein called cytokine receptor-like factor 1 (CRLF1). This protein partners with a similar protein called cardiotrophin-like cytokine factor 1 (CLCF1), which is produced from the CLCF1 gene. Together, these two proteins form a unit known as the CRLF1/CLCF1 protein complex. This complex attaches (binds) to a receptor protein known as the ciliary neurotrophic factor receptor (CNTFR) on the surface of many types of cells. When the CRLF1/CLCF1 protein complex is bound to CNTFR, it triggers signaling inside the cell that affects cell development and function.

The CNTFR signaling pathway is primarily involved in the development and maintenance of the nervous system. It promotes the survival of nerve cells (neurons), particularly nerve cells that control muscle movement (motor neurons). The CNTFR pathway also plays a role in a part of the nervous system called the sympathetic nervous system, specifically in the regulation of sweating in response to temperature changes and other factors. This signaling pathway appears to be critical for the normal development and maturation of nerve cells that control the activity of sweat glands.

Studies suggest that the CNTFR signaling pathway also has functions outside the nervous system. It may be involved in the body's inflammatory response, which helps fight infection and facilitate tissue repair following an injury. This pathway may also be important for the development and maintenance of bone tissue. However, little is known about the role of CNTFR signaling in these processes.

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