CRLF1 cytokine receptor-like factor 1 [Homo sapiens (human)]
| Gene Symbol | CRLF1 |
| Entrez Gene ID | 9244 |
| Full Name | cytokine receptor-like factor 1 |
| Synonyms | CISS, CISS1, CLF, CLF-1, NR6, zcytor5 |
| Gene Type | protein-coding |
| Organism | Homo sapiens (human) |
| Genome |
19 19p12 |
| Summary | This gene encodes a member of the cytokine type I receptor family. The protein forms a secreted complex with cardiotrophin-like cytokine factor 1 and acts on cells expressing ciliary neurotrophic factor receptors. The complex can promote survival of neuronal cells. Mutations in this gene result in Crisponi syndrome and cold-induced sweating syndrome. [provided by RefSeq]. COMPLETENESS: complete on the 3' end. |
| Disorder | MIM: 604237 Cold-induced sweating syndrome, 272430 (3); Crisponi syndrome, |
| mRNA | NM_004750, 260655997 |
| Protein | NP_004741, 4758062 |
| Product | cytokine receptor-like factor 1 precursor |
| RefSeq Status | REVIEWED |
| Homo sapiens (human) | CRLF1 | NP_004741.1 |
| Pan troglodytes (chimpanzee) | CRLF1 | XP_001135263.1 |
| Canis lupus familiaris (dog) | CRLF1 | XP_541934.2 |
| Bos taurus (cattle) | CRLF1 | XP_588353.4 |
| Mus musculus (house mouse) | Crlf1 | NP_061297.1 |
| Rattus norvegicus (Norway rat) | Crlf1 | XP_214312.3 |
| Danio rerio (zebrafish) | crlf1a | NP_001002650.1 |
| Danio rerio (zebrafish) | crlf1b | NP_001107074.1 |
| Danio rerio (zebrafish) | LOC100329466 | XP_002666303.1 |
| ID | Name | Evidence |
| GO:0001657 | ureteric bud development | IEA |
| GO:0008284 | positive regulation of cell proliferation | IDA |
| GO:0042517 | positive regulation of tyrosine phosphorylation of Stat3 protein | IDA |
| GO:0043524 | negative regulation of neuron apoptosis | IDA |
Component
| ID | Name | Evidence |
| GO:0005576 | extracellular region | IEA |
| GO:0005615 | extracellular space | TAS |
Function
| ID | Name | Evidence |
| GO:0004872 | receptor activity | IEA |
| GO:0005125 | cytokine activity | IDA |
| GO:0005127 | ciliary neurotrophic factor receptor binding | IDA |
| GO:0005515 | protein binding | IPI |
| GO:0019955 | cytokine binding | IPI |
| GO:0046982 | protein heterodimerization activity | IDA |
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