Sequence in raw or FASTA format:
CRLF1 cytokine receptor-like factor 1 [Homo sapiens (human)]
|Entrez Gene ID||9244|
|Full Name||cytokine receptor-like factor 1|
|Synonyms||CISS, CISS1, CLF, CLF-1, NR6, zcytor5|
|General protein information||
|Organism||Homo sapiens (human)|
|Summary||This gene encodes a member of the cytokine type I receptor family. The protein forms a secreted complex with cardiotrophin-like cytokine factor 1 and acts on cells expressing ciliary neurotrophic factor receptors. The complex can promote survival of neuronal cells. Mutations in this gene result in Crisponi syndrome and cold-induced sweating syndrome. [provided by RefSeq, Oct 2009].|
Cold-induced sweating syndrome, 272430 (3); Crisponi syndrome,
|Homo sapiens (human)||CRLF1||NP_004741.1|
|Pan troglodytes (chimpanzee)||CRLF1||XP_001135263.3|
|Macaca mulatta (Rhesus monkey)||CRLF1||XP_001115478.2|
|Canis lupus familiaris (dog)||CRLF1||XP_005633255.1|
|Bos taurus (cattle)||CRLF1||XP_002688582.2|
|Mus musculus (house mouse)||Crlf1||NP_061297.1|
|Rattus norvegicus (Norway rat)||Crlf1||NP_001099544.1|
|Gallus gallus (chicken)||CRLF1||XP_004948964.1|
|Danio rerio (zebrafish)||crlf1a||NP_001002650.1|
|Xenopus (Silurana) tropicalis (western clawed frog)||crlf1||XP_002940253.2|
|GO:0001657||ureteric bud development||IEA|
|GO:0008284||positive regulation of cell proliferation||IDA|
|GO:0042517||positive regulation of tyrosine phosphorylation of Stat3 protein||IDA|
|GO:0043524||negative regulation of neuron apoptotic process||IDA|
|GO:2000672||negative regulation of motor neuron apoptotic process||IEA|
|GO:0005127||ciliary neurotrophic factor receptor binding||IDA|
|GO:0046982||protein heterodimerization activity||IDA|
What is the normal function of the CRLF1 gene?
The CRLF1 gene provides instructions for making a protein called cytokine receptor-like factor 1 (CRLF1). This protein partners with a similar protein called cardiotrophin-like cytokine factor 1 (CLCF1), which is produced from the CLCF1 gene. Together, these two proteins form a unit known as the CRLF1/CLCF1 protein complex. This complex attaches (binds) to a receptor protein known as the ciliary neurotrophic factor receptor (CNTFR) on the surface of many types of cells. When the CRLF1/CLCF1 protein complex is bound to CNTFR, it triggers signaling inside the cell that affects cell development and function.
The CNTFR signaling pathway is primarily involved in the development and maintenance of the nervous system. It promotes the survival of nerve cells (neurons), particularly nerve cells that control muscle movement (motor neurons). The CNTFR pathway also plays a role in a part of the nervous system called the sympathetic nervous system, specifically in the regulation of sweating in response to temperature changes and other factors. This signaling pathway appears to be critical for the normal development and maturation of nerve cells that control the activity of sweat glands.
Studies suggest that the CNTFR signaling pathway also has functions outside the nervous system. It may be involved in the body's inflammatory response, which helps fight infection and facilitate tissue repair following an injury. This pathway may also be important for the development and maintenance of bone tissue. However, little is known about the role of CNTFR signaling in these processes.
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