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MMP20 matrix metallopeptidase 20 [Homo sapiens (human)]


Clone ID RefSeq Accession Definition Vector Stock Status *Turnaround time Price Order
OHu20263 NM_004771 Homo sapiens matrix metallopeptidase 20 (MMP20), mRNA. pcDNA3.1+-DYK On-demand 7-9 $219.00
OHu20263C NM_004771 Homo sapiens matrix metallopeptidase 20 (MMP20), mRNA. Customized vector On-demand 7-9 $269.00

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Gene Symbol MMP20
Entrez Gene ID 9313
Full Name matrix metallopeptidase 20
Synonyms AI2A2, MMP-20
General protein information
Preferred Names
matrix metalloproteinase-20
Names
matrix metalloproteinase-20
enamel metalloproteinase
matrix metalloproteinase 20 (enamelysin)
NP_004762.2
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

11

11q22.3

Summary Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. The protein encoded by this gene degrades amelogenin, the major protein component of dental enamel matrix, and thus thought to play a role in tooth enamel formation. A mutation in this gene, which alters the normal splice pattern and results in premature termination of the encoded protein, has been associated with amelogenesis imperfecta. This gene is part of a cluster of MMP genes located on chromosome 11q22.3. [provided by RefSeq, Aug 2011].
Disorder

MIM: 604629

Amelogenesis imperfecta, type IIA2, 612529 (3)

mRNA Protein Product Sequence Price Select
NM_004771, 45359864 NP_004762, 45359865 matrix metalloproteinase-20 preproprotein ORF Sequence $550.00
WikiPathways
WP129Matrix Metalloproteinases
Reactome
REACT_118572Degradation of the extracellular matrix
REACT_118779Extracellular matrix organization
REACT_120729Collagen formation
REACT_150180Assembly of collagen fibrils and other multimeric structures
REACT_150401Collagen degradation
Homo sapiens (human)MMP20NP_004762.2
Pan troglodytes (chimpanzee)MMP20XP_001153208.1
Macaca mulatta (Rhesus monkey)MMP20XP_001097602.1
Canis lupus familiaris (dog)MMP20XP_854639.1
Bos taurus (cattle)MMP20NP_776816.1
Mus musculus (house mouse)Mmp20NP_038931.1
Rattus norvegicus (Norway rat)Mmp20NP_001100270.1
Danio rerio (zebrafish)LOC100329766XP_002664668.3
Xenopus (Silurana) tropicalis (western clawed frog)mmp20XP_002934967.2
Process
IDNameEvidence
GO:0006508proteolysisIEA
GO:0022617extracellular matrix disassemblyTAS
GO:0030198extracellular matrix organizationTAS
GO:0030574collagen catabolic processTAS
GO:0070173regulation of enamel mineralizationTAS
GO:0097186amelogenesisIEA
Component
IDNameEvidence
GO:0005576extracellular regionTAS
GO:0005578proteinaceous extracellular matrixIEA
GO:0005615extracellular spaceTAS
Function
IDNameEvidence
GO:0004222metalloendopeptidase activityIEA
GO:0005509calcium ion bindingIEA
GO:0005515protein bindingIPI
GO:0008270zinc ion bindingIEA
GeneCards MMP20
PDB 2JSD
UniProt O60882
Vega OTTHUMG00000168081
MIM 604629
Ensembl ENSG00000137674
HGNC 7167
HPRD 05218

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Interactant

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