Sequence in raw or FASTA format:
MMP20 matrix metallopeptidase 20 [Homo sapiens (human)]
|Entrez Gene ID||9313|
|Full Name||matrix metallopeptidase 20|
|General protein information||
|Organism||Homo sapiens (human)|
|Summary||Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. The protein encoded by this gene degrades amelogenin, the major protein component of dental enamel matrix, and thus thought to play a role in tooth enamel formation. A mutation in this gene, which alters the normal splice pattern and results in premature termination of the encoded protein, has been associated with amelogenesis imperfecta. This gene is part of a cluster of MMP genes located on chromosome 11q22.3. [provided by RefSeq, Aug 2011].|
Amelogenesis imperfecta, type IIA2, 612529 (3)
|REACT_118572||Degradation of the extracellular matrix|
|REACT_118779||Extracellular matrix organization|
|REACT_150180||Assembly of collagen fibrils and other multimeric structures|
|Homo sapiens (human)||MMP20||NP_004762.2|
|Pan troglodytes (chimpanzee)||MMP20||XP_001153208.1|
|Macaca mulatta (Rhesus monkey)||MMP20||XP_001097602.1|
|Canis lupus familiaris (dog)||MMP20||XP_854639.1|
|Bos taurus (cattle)||MMP20||NP_776816.1|
|Mus musculus (house mouse)||Mmp20||NP_038931.1|
|Rattus norvegicus (Norway rat)||Mmp20||NP_001100270.1|
|Danio rerio (zebrafish)||LOC100329766||XP_002664668.3|
|Xenopus (Silurana) tropicalis (western clawed frog)||mmp20||XP_002934967.2|
|GO:0022617||extracellular matrix disassembly||TAS|
|GO:0030198||extracellular matrix organization||TAS|
|GO:0030574||collagen catabolic process||TAS|
|GO:0070173||regulation of enamel mineralization||TAS|
|GO:0005578||proteinaceous extracellular matrix||IEA|
|GO:0005509||calcium ion binding||IEA|
|GO:0008270||zinc ion binding||IEA|
What is the normal function of the MMP20 gene?
The MMP20 gene provides instructions for making a protein called enamelysin, which is essential for normal tooth development. Enamelysin is involved in the formation of enamel, which is the hard, white material that forms the protective outer layer of each tooth. Enamel is composed mainly of mineral-containing crystals. These microscopic crystals are arranged in organized bundles that give enamel its strength and durability.
Certain proteins are needed to shape and organize the crystals as they form, but these proteins must be removed for enamel to harden normally. Enamelysin cuts (cleaves) other proteins involved in enamel formation, such as amelogenin and ameloblastin, into smaller pieces. Cleavage of these proteins makes them easier to remove when they are no longer needed.
Our customer service representatives are available 24 hours a day, Monday through Friday; please contact us anytime for assistance.