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Sequence in raw or FASTA format:


Blast Method:


MMP20 matrix metallopeptidase 20 [Homo sapiens (human)]

RefSeq Accession Definition Service Stock Status Price *Turnaround time Order
NM_004771 Homo sapiens matrix metallopeptidase 20 (MMP20), mRNA. GenEZ ORF Cloning On-demand $699.00 18

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Gene Symbol MMP20
Entrez Gene ID 9313
Full Name matrix metallopeptidase 20
Synonyms AI2A2, MMP-20
General protein information
Preferred Names
matrix metalloproteinase-20
matrix metalloproteinase-20
enamel metalloproteinase
matrix metalloproteinase 20 (enamelysin)
Gene Type protein-coding
Organism Homo sapiens (human)



Summary Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. The protein encoded by this gene degrades amelogenin, the major protein component of dental enamel matrix, and thus thought to play a role in tooth enamel formation. A mutation in this gene, which alters the normal splice pattern and results in premature termination of the encoded protein, has been associated with amelogenesis imperfecta. This gene is part of a cluster of MMP genes located on chromosome 11q22.3. [provided by RefSeq, Aug 2011].

MIM: 604629

Amelogenesis imperfecta, type IIA2, 612529 (3)

mRNA Protein Product Sequence Price Select
NM_004771, 45359864 NP_004762, 45359865 matrix metalloproteinase-20 preproprotein ORF Sequence $550.00
WP129Matrix Metalloproteinases
REACT_118572Degradation of the extracellular matrix
REACT_118779Extracellular matrix organization
REACT_120729Collagen formation
REACT_150180Assembly of collagen fibrils and other multimeric structures
REACT_150401Collagen degradation
Homo sapiens (human)MMP20NP_004762.2
Pan troglodytes (chimpanzee)MMP20XP_001153208.1
Macaca mulatta (Rhesus monkey)MMP20XP_001097602.1
Canis lupus familiaris (dog)MMP20XP_854639.1
Bos taurus (cattle)MMP20NP_776816.1
Mus musculus (house mouse)Mmp20NP_038931.1
Rattus norvegicus (Norway rat)Mmp20NP_001100270.1
Danio rerio (zebrafish)LOC100329766XP_002664668.3
Xenopus (Silurana) tropicalis (western clawed frog)mmp20XP_002934967.2
GO:0022617extracellular matrix disassemblyTAS
GO:0030198extracellular matrix organizationTAS
GO:0030574collagen catabolic processTAS
GO:0070173regulation of enamel mineralizationTAS
GO:0005576extracellular regionTAS
GO:0005578proteinaceous extracellular matrixIEA
GO:0005615extracellular spaceTAS
GO:0004222metalloendopeptidase activityIEA
GO:0005509calcium ion bindingIEA
GO:0005515protein bindingIPI
GO:0008270zinc ion bindingIEA
GeneCards MMP20
UniProt O60882
Vega OTTHUMG00000168081
MIM 604629
Ensembl ENSG00000137674
HGNC 7167
HPRD 05218

GeneRIFs: Gene References Into Functions What's a GeneRIF?

What is the normal function of the MMP20 gene?

The MMP20 gene provides instructions for making a protein called enamelysin, which is essential for normal tooth development. Enamelysin is involved in the formation of enamel, which is the hard, white material that forms the protective outer layer of each tooth. Enamel is composed mainly of mineral-containing crystals. These microscopic crystals are arranged in organized bundles that give enamel its strength and durability.

Certain proteins are needed to shape and organize the crystals as they form, but these proteins must be removed for enamel to harden normally. Enamelysin cuts (cleaves) other proteins involved in enamel formation, such as amelogenin and ameloblastin, into smaller pieces. Cleavage of these proteins makes them easier to remove when they are no longer needed.


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