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KL klotho [Homo sapiens (human)]

RefSeq Accession Definition Service Stock Status Price *Turnaround time Order
NM_004795 Homo sapiens klotho (KL), mRNA. GenEZ ORF Cloning On-demand TBD TBD

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Gene Symbol KL
Entrez Gene ID 9365
Full Name klotho
Gene Type protein-coding
Organism Homo sapiens (human)



Summary This gene encodes a type-I membrane protein that is related to beta-glucosidases. Reduced production of this protein has been observed in patients with chronic renal failure (CRF), and this may be one of the factors underlying the degenerative processes (e.g., arteriosclerosis, osteoporosis, and skin atrophy) seen in CRF. Also, mutations within this protein have been associated with ageing and bone loss. [provided by RefSeq, Jul 2008].

MIM: 604824

{Coronary artery disease, susceptibility to} (3); Tumoral calcinosis,

mRNA Protein Product Sequence Price Select
NM_004795, 209529721 NP_004786, 24497614 klotho precursor ORF Sequence $1500.00
hsa_M00129Ascorbate biosynthesis, animals, glucose-1P => ascorbate
hsa00500Starch and sucrose metabolism
hsa04961Endocrine and other factor-regulated calcium reabsorption
hsa00040Pentose and glucuronate interconversions
REACT_9484FGFR1c and Klotho ligand binding and activation
REACT_111102Signal Transduction
REACT_498Signaling by Insulin receptor
REACT_120736Signaling by FGFR in disease
REACT_118773Signaling by the B Cell Receptor (BCR)
REACT_147723PI3K/AKT Signaling in Cancer
REACT_762IRS-related events
REACT_21247FRS2-mediated cascade
REACT_147694DAP12 interactions
REACT_12464PI3K/AKT activation
REACT_115961PI3K events in ERBB4 signaling
REACT_75774Adaptive Immune System
REACT_115755Signaling by ERBB2
REACT_21272Downstream signaling of activated FGFR
REACT_115871Signaling by EGFR in Cancer
REACT_6802Innate Immune System
REACT_111040Signaling by SCF-KIT
REACT_332IRS-mediated signalling
REACT_11061Signalling by NGF
REACT_147814DAP12 signaling
REACT_9417Signaling by EGFR
REACT_116008PI3K events in ERBB2 signaling
REACT_118638Downstream Signaling Events Of B Cell Receptor (BCR)
REACT_17025Downstream signal transduction
REACT_147727Constitutive PI3K/AKT Signaling in Cancer
REACT_9396FGFR ligand binding and activation
REACT_21374SHC-mediated cascade
REACT_6900Immune System
REACT_12578GAB1 signalosome
REACT_9470Signaling by FGFR
REACT_115596Signaling by ERBB4
REACT_21270PI-3K cascade
REACT_12056NGF signalling via TRKA from the plasma membrane
REACT_111184Negative regulation of FGFR signaling
REACT_75829PIP3 activates AKT signaling
REACT_21310Phospholipase C-mediated cascade
REACT_976PI3K Cascade
REACT_1195Insulin receptor signalling cascade
REACT_111247Klotho-mediated ligand binding
REACT_16888Signaling by PDGF
Homo sapiens (human)KLNP_004786.2
Pan troglodytes (chimpanzee)KLXP_522655.2
Macaca mulatta (Rhesus monkey)LOC714042XP_001101127.1
Canis lupus familiaris (dog)KLXP_003433357.1
Bos taurus (cattle)KLNP_001178124.1
Mus musculus (house mouse)KlNP_038851.2
Rattus norvegicus (Norway rat)KlNP_112626.1
Gallus gallus (chicken)KLXP_417105.2
Danio rerio (zebrafish)LOC562316XP_690797.3
GeneCards KL
UniProt Q9UEF7
MIM 604824
Ensembl ENSG00000133116
HGNC 6344
HPRD 05316

GeneRIFs: Gene References Into Functions What's a GeneRIF?

General protein information

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