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GRHPR glyoxylate reductase/hydroxypyruvate reductase [Homo sapiens (human)]


RefSeq Accession Definition Service Stock Status Price *Turnaround time Order
NM_012203 Homo sapiens glyoxylate reductase/hydroxypyruvate reductase (GRHPR), mRNA. GenEZ ORF Cloning On-demand $549.00 14
XM_005251631 PREDICTED: Homo sapiens glyoxylate reductase/hydroxypyruvate reductase (GRHPR), transcript variant X1, mRNA. GenEZ ORF Cloning On-demand $399.00 14

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Gene Symbol GRHPR
Entrez Gene ID 9380
Full Name glyoxylate reductase/hydroxypyruvate reductase
Synonyms GLXR, GLYD, PH2
General protein information
Preferred Names
glyoxylate reductase/hydroxypyruvate reductase
Names
glyoxylate reductase/hydroxypyruvate reductase
glycerate-2-dehydrogenase
NP_036335.1
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

9

9q12

Summary This gene encodes an enzyme with hydroxypyruvate reductase, glyoxylate reductase, and D-glycerate dehydrogenase enzymatic activities. The enzyme has widespread tissue expression and has a role in metabolism. Type II hyperoxaluria is caused by mutations in this gene. [provided by RefSeq, Jul 2008].
Disorder

MIM: 604296

Hyperoxaluria, primary, type II, 260000 (3)

mRNA Protein Product Sequence Price Select
NM_012203, 6912395 NP_036335, 6912396 glyoxylate reductase/hydroxypyruvate reductase ORF Sequence $400.00
XM_005251631, 530390250 XP_005251688, 530390251 glyoxylate reductase/hydroxypyruvate reductase isoform X1 ORF Sequence $250.00
KEGG
hsa00260Glycine, serine and threonine metabolism
hsa00620Pyruvate metabolism
hsa00630Glyoxylate and dicarboxylate metabolism
Reactome
REACT_13Metabolism of amino acids and derivatives
REACT_16925Glyoxylate metabolism
REACT_111217Metabolism
Homo sapiens (human)GRHPRNP_036335.1
Pan troglodytes (chimpanzee)GRHPRXP_520581.3
Macaca mulatta (Rhesus monkey)LOC718494XP_002800095.1
Canis lupus familiaris (dog)GRHPRXP_005626882.1
Bos taurus (cattle)GRHPRNP_001178966.1
Mus musculus (house mouse)GrhprNP_525028.1
Rattus norvegicus (Norway rat)GrhprNP_001107226.1
Gallus gallus (chicken)GRHPRXP_424417.3
Danio rerio (zebrafish)grhpraNP_001018361.1
Drosophila melanogaster (fruit fly)CG1236NP_649579.2
Arabidopsis thaliana (thale cress)AT1G79870NP_178105.1
Xenopus (Silurana) tropicalis (western clawed frog)grhpr.2NP_001007896.1
Xenopus (Silurana) tropicalis (western clawed frog)grhpr.1NP_001072783.2
Process
IDNameEvidence
GO:0007588excretionIMP
GO:0008152metabolic processNAS
GO:0034641cellular nitrogen compound metabolic processTAS
GO:0043648dicarboxylic acid metabolic processIEA
GO:0044281small molecule metabolic processTAS
GO:0046487glyoxylate metabolic processTAS
GO:0051259protein oligomerizationIDA
GO:0055114oxidation-reduction processIDA
Component
IDNameEvidence
GO:0005737cytoplasmIDA
GO:0005782peroxisomal matrixTAS
GO:0005829cytosolIEA
GO:0070062extracellular vesicular exosomeIDA
Function
IDNameEvidence
GO:0008465glycerate dehydrogenase activityIDA
GO:0016618hydroxypyruvate reductase activityIDA
GO:0030267glyoxylate reductase (NADP) activityIDA
GO:0030267glyoxylate reductase (NADP) activityNAS
GO:0031406carboxylic acid bindingIEA
GO:0042803protein homodimerization activityIDA
GO:0051287NAD bindingTAS
GO:0070402NADPH bindingIDA
GeneCards GRHPR
PDB 2H1S, 2WWR, 2Q50, 2GCG
UniProt Q9UBQ7
Vega OTTHUMG00000019914
MIM 604296
Ensembl ENSG00000137106
HGNC 4570
HPRD 05052

Related articles in PubMed

GeneRIFs: Gene References Into Functions What's a GeneRIF?

What is the normal function of the GRHPR gene?

The GRHPR gene provides instructions for making an enzyme called glyoxylate reductase/hydroxypyruvate reductase, which is found primarily in the liver, with smaller amounts in the kidneys. This dual-action enzyme plays a role in preventing the buildup of a potentially harmful substance called glyoxylate by converting it to glycolate. Additionally, this enzyme can convert a compound called hydroxypyruvate to D-glycerate, which is eventually converted to glucose (by other enzymes) and used for energy.

Interactant

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