• THAT   AND
  • THAT   AND


Sequence in raw or FASTA format:

Database:

Blast Method:

 
 


HAND1 heart and neural crest derivatives expressed 1 [Homo sapiens (human)]


Clone ID RefSeq Accession Definition Vector Stock Status *Turnaround time Price Order
OHu26705 NM_004821 Homo sapiens heart and neural crest derivatives expressed 1 (HAND1), mRNA. pcDNA3.1+-DYK In-stock TBD $99.00
OHu39917 XM_005268531 PREDICTED: Homo sapiens heart and neural crest derivatives expressed 1 (HAND1), transcript variant X1, mRNA. pcDNA3.1+-DYK On-demand TBD TBD
OHu26705C NM_004821 Homo sapiens heart and neural crest derivatives expressed 1 (HAND1), mRNA. Customized vector In-stock TBD $149.00
OHu39917C XM_005268531 PREDICTED: Homo sapiens heart and neural crest derivatives expressed 1 (HAND1), transcript variant X1, mRNA. Customized vector On-demand TBD $209.00

*Business Day

Related Services

Gene Symbol HAND1
Entrez Gene ID 9421
Full Name heart and neural crest derivatives expressed 1
Synonyms Hxt, Thing1, bHLHa27, eHand
General protein information
Preferred Names
heart- and neural crest derivatives-expressed protein 1
Names
heart- and neural crest derivatives-expressed protein 1
class A basic helix-loop-helix protein 27
extraembryonic tissues, heart, autonomic nervous system and neural crest derivatives-expressed protein 1
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

5

5q33

Summary The protein encoded by this gene belongs to the basic helix-loop-helix family of transcription factors. This gene product is one of two closely related family members, the HAND proteins, which are asymmetrically expressed in the developing ventricular chambers and play an essential role in cardiac morphogenesis. Working in a complementary fashion, they function in the formation of the right ventricle and aortic arch arteries, implicating them as mediators of congenital heart disease. In addition, it has been suggested that this transcription factor may be required for early trophoblast differentiation. [provided by RefSeq, Jul 2008].
Disorder

MIM: 602406

mRNA Protein Product Sequence Price Select
NM_004821, 196259809 NP_004812, 4758506 heart- and neural crest derivatives-expressed protein 1 ORF Sequence $159.00
XM_005268531, 530380723 XP_005268588, 530380724 heart- and neural crest derivatives-expressed protein 1 isoform X1 ORF Sequence $250.00
WikiPathways
WP1591Heart Development
WP2064Neural Crest Differentiation
Homo sapiens (human)HAND1NP_004812.1
Pan troglodytes (chimpanzee)HAND1XP_518050.2
Macaca mulatta (Rhesus monkey)HAND1XP_001111722.1
Bos taurus (cattle)HAND1NP_001069229.1
Mus musculus (house mouse)Hand1NP_032239.1
Rattus norvegicus (Norway rat)Hand1NP_067603.1
Gallus gallus (chicken)HAND1NP_990296.1
Drosophila melanogaster (fruit fly)HandNP_609370.2
Xenopus (Silurana) tropicalis (western clawed frog)hand1NP_001016743.1
Process
IDNameEvidence
GO:0000122negative regulation of transcription from RNA polymerase II promoterIDA
GO:0001525angiogenesisISS
GO:0001707mesoderm formationIEA
GO:0001824blastocyst developmentIEP
GO:0001829trophectodermal cell differentiationIEP
GO:0001947heart loopingISS
GO:0003144embryonic heart tube formationIEA
GO:0003218cardiac left ventricle formationIMP
GO:0003219cardiac right ventricle formationIMP
GO:0006366transcription from RNA polymerase II promoterIDA
GO:0007507heart developmentISS
GO:0035050embryonic heart tube developmentISS
GO:0042475odontogenesis of dentin-containing toothIEA
GO:0043433negative regulation of sequence-specific DNA binding transcription factor activityIEA
GO:0045892negative regulation of transcription, DNA-templatedIDA
GO:0045944positive regulation of transcription from RNA polymerase II promoterIDA
GO:0055010ventricular cardiac muscle tissue morphogenesisIMP
GO:0060411cardiac septum morphogenesisIMP
GO:0060485mesenchyme developmentIEA
GO:0060536cartilage morphogenesisIEA
GO:0060707trophoblast giant cell differentiationIEA
Component
IDNameEvidence
GO:0005634nucleusIDA
GO:0005654nucleoplasmIEA
GO:0005730nucleolusIEA
GO:0005737cytoplasmIDA
Function
IDNameEvidence
GO:0003713transcription coactivator activityIDA
GO:0005515protein bindingIPI
GO:0005515protein bindingIPI
GO:0008134transcription factor bindingIPI
GO:0019899enzyme bindingIEA
GO:0042802identical protein bindingISS
GO:0042803protein homodimerization activityNAS
GO:0043425bHLH transcription factor bindingIPI
GO:0043565sequence-specific DNA bindingIEA
GO:0044212transcription regulatory region DNA bindingIDA
GO:0046982protein heterodimerization activityIEA
GeneCards HAND1
UniProt O96004
Vega OTTHUMG00000130193
MIM 602406
Ensembl ENSG00000113196
HGNC 4807
HPRD 03871

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Interactant

Our customer service representatives are available 24 hours a day, Monday through Friday; please contact us anytime for assistance.