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TNFRSF8 tumor necrosis factor receptor superfamily, member 8 [Homo sapiens (human)]


RefSeq Accession Definition Service Stock Status Price *Turnaround time Order
NM_001243 Homo sapiens tumor necrosis factor receptor superfamily, member 8 (TNFRSF8), transcript variant 1, mRNA. GenEZ ORF Cloning On-demand $849.00 20
NM_001281430 Homo sapiens tumor necrosis factor receptor superfamily, member 8 (TNFRSF8), transcript variant 3, mRNA. GenEZ ORF Cloning On-demand $699.00 18
XM_006711049 PREDICTED: Homo sapiens tumor necrosis factor receptor superfamily, member 8 (TNFRSF8), transcript variant X1, mRNA. GenEZ ORF Cloning On-demand $699.00 18

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Related Services

Gene Symbol TNFRSF8
Entrez Gene ID 943
Full Name tumor necrosis factor receptor superfamily, member 8
Synonyms CD30, D1S166E, Ki-1
General protein information
Preferred Names
tumor necrosis factor receptor superfamily member 8
Names
tumor necrosis factor receptor superfamily member 8
Ki-1 antigen
CD30L receptor
cytokine receptor CD30
lymphocyte activation antigen CD30
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

1

1p36

Summary The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is expressed by activated, but not by resting, T and B cells. TRAF2 and TRAF5 can interact with this receptor, and mediate the signal transduction that leads to the activation of NF-kappaB. This receptor is a positive regulator of apoptosis, and also has been shown to limit the proliferative potential of autoreactive CD8 effector T cells and protect the body against autoimmunity. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008].
Disorder

MIM: 153243

mRNA Protein Product Sequence Price Select
NM_001243, 597709794 NP_001234, 597709795 tumor necrosis factor receptor superfamily member 8 isoform 1 precursor ORF Sequence $700.00
NM_001281430, 597709796 NP_001268359, 597709797 tumor necrosis factor receptor superfamily member 8 isoform 3 ORF Sequence $550.00
XM_006711049, 578800120 XP_006711112, 578800121 tumor necrosis factor receptor superfamily member 8 isoform X1 ORF Sequence $550.00
KEGG
hsa04060Cytokine-cytokine receptor interaction
WikiPathways
WP231TNF-alpha/NF-kB Signaling Pathway
Homo sapiens (human)TNFRSF8NP_001234.2
Pan troglodytes (chimpanzee)TNFRSF8XP_514397.3
Macaca mulatta (Rhesus monkey)TNFRSF8XP_001118873.2
Canis lupus familiaris (dog)TNFRSF8XP_005618040.1
Bos taurus (cattle)TNFRSF8XP_002694100.2
Mus musculus (house mouse)Tnfrsf8NP_033427.1
Rattus norvegicus (Norway rat)Tnfrsf8NP_062008.1
Gallus gallus (chicken)TNFRSF8NP_989775.1
Process
IDNameEvidence
GO:0007165signal transductionTAS
GO:0008285negative regulation of cell proliferationTAS
GO:0033209tumor necrosis factor-mediated signaling pathwayRCA
GO:0042535positive regulation of tumor necrosis factor biosynthetic processIDA
GO:0043065positive regulation of apoptotic processIDA
GO:0045556positive regulation of TRAIL biosynthetic processIDA
GO:0071260cellular response to mechanical stimulusIEP
Component
IDNameEvidence
GO:0005737cytoplasmIEA
GO:0005886plasma membraneIEA
GO:0016021integral component of membraneIEA
GO:0070062extracellular vesicular exosomeIDA
Function
IDNameEvidence
GO:0004888transmembrane signaling receptor activityTAS
GO:0005031tumor necrosis factor-activated receptor activityRCA
GeneCards TNFRSF8
UniProt A5D8T4, P28908
Vega OTTHUMG00000001827
MIM 153243
Ensembl ENSG00000120949
HGNC 11923
HPRD 01074

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Interactant

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