TNFRSF8 tumor necrosis factor receptor superfamily, member 8 [Homo sapiens (human)]
| Gene Symbol | TNFRSF8 |
| Entrez Gene ID | 943 |
| Full Name | tumor necrosis factor receptor superfamily, member 8 |
| Synonyms | CD30, D1S166E, Ki-1 |
| Gene Type | protein-coding |
| Organism | Homo sapiens (human) |
| Genome |
1 1p36 |
| Summary | The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is expressed by activated, but not by resting, T and B cells. TRAF2 and TRAF5 can interact with this receptor, and mediate the signal transduction that leads to the activation of NF-kappaB. This receptor is a positive regulator of apoptosis, and also has been shown to limit the proliferative potential of autoreactive CD8 effector T cells and protect the body against autoimmunity. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq]. |
| Disorder | MIM: 153243 |
| mRNA | NM_001243, 68348710 |
| Protein | NP_001234, 68348711 |
| Product | tumor necrosis factor receptor superfamily member 8 isoform 1 precursor |
| RefSeq Status | REVIEWED |
| mRNA | NM_152942, 68348712 |
| Protein | NP_694421, 23510437 |
| Product | tumor necrosis factor receptor superfamily member 8 isoform 2 |
| RefSeq Status | REVIEWED |
| hsa04060 | Cytokine-cytokine receptor interaction |
WikiPathways
| WP231 | TNF-alpha/NF-kB Signaling Pathway |
| Homo sapiens (human) | TNFRSF8 | NP_001234.2 |
| Pan troglodytes (chimpanzee) | TNFRSF8 | XP_514397.2 |
| Canis lupus familiaris (dog) | TNFRSF8 | XP_544563.2 |
| Bos taurus (cattle) | TNFRSF8 | XP_871494.2 |
| Mus musculus (house mouse) | Tnfrsf8 | NP_033427.1 |
| Rattus norvegicus (Norway rat) | Tnfrsf8 | NP_062008.1 |
| Gallus gallus (chicken) | TNFRSF8 | NP_989775.1 |
| Gallus gallus (chicken) | TNFRSF8 | XP_001236822.1 |
| ID | Name | Evidence |
| GO:0007165 | signal transduction | IEA |
| GO:0008285 | negative regulation of cell proliferation | TAS |
| GO:0033209 | tumor necrosis factor-mediated signaling pathway | RCA |
| GO:0042535 | positive regulation of tumor necrosis factor biosynthetic process | IDA |
| GO:0043065 | positive regulation of apoptosis | IDA |
| GO:0045556 | positive regulation of TRAIL biosynthetic process | IDA |
| GO:0051092 | positive regulation of NF-kappaB transcription factor activity | IEA |
| GO:0071260 | cellular response to mechanical stimulus | IEP |
Component
| ID | Name | Evidence |
| GO:0005737 | cytoplasm | IEA |
| GO:0005886 | plasma membrane | IEA |
| GO:0016021 | integral to membrane | IEA |
Function
| ID | Name | Evidence |
| GO:0004888 | transmembrane receptor activity | IEA |
| GO:0005031 | tumor necrosis factor receptor activity | RCA |
| GO:0005515 | protein binding | IPI |
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