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ITM2B integral membrane protein 2B [Homo sapiens (human)]

RefSeq Accession Definition Service Stock Status Price *Turnaround time Order
NM_021999 Homo sapiens integral membrane protein 2B (ITM2B), mRNA. GenEZ ORF Cloning On-demand $449.00 14

*Business Day

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Gene Symbol ITM2B
Entrez Gene ID 9445
Full Name integral membrane protein 2B
Synonyms ABRI, BRI, BRI2, BRICD2B, E25B, E3-16, FBD
Gene Type protein-coding
Organism Homo sapiens (human)



Summary Amyloid precursor proteins are processed by beta-secretase and gamma-secretase to produce beta-amyloid peptides which form the characteristic plaques of Alzheimer disease. This gene encodes a transmembrane protein which is processed at the C-terminus by furin or furin-like proteases to produce a small secreted peptide which inhibits the deposition of beta-amyloid. Mutations which result in extension of the C-terminal end of the encoded protein, thereby increasing the size of the secreted peptide, are associated with two neurogenerative diseases, familial British dementia and familial Danish dementia. [provided by RefSeq, Oct 2009].

MIM: 603904

Dementia, familial British, 176500 (3); Dementia, familial Danish,

mRNA Protein Product Sequence Price Select
NM_021999, 221316670 NP_068839, 11527402 integral membrane protein 2B ORF Sequence $300.00
WP49IL-2 Signaling Pathway
Homo sapiens (human)ITM2BNP_068839.1
Pan troglodytes (chimpanzee)ITM2BNP_001092017.1
Macaca mulatta (Rhesus monkey)ITM2BXP_002800791.1
Canis lupus familiaris (dog)ITM2BXP_534119.3
Bos taurus (cattle)ITM2BNP_001030265.1
Mus musculus (house mouse)Itm2bNP_032436.1
Rattus norvegicus (Norway rat)Itm2bNP_001006964.1
Gallus gallus (chicken)ITM2BNP_990416.1
Danio rerio (zebrafish)itm2baNP_955940.1
GeneCards ITM2B
UniProt Q5W0A3, Q9Y287
MIM 603904
Ensembl ENSG00000136156
HGNC 6174
HPRD 04878

GeneRIFs: Gene References Into Functions What's a GeneRIF?

General protein information

Preferred Names
integral membrane protein 2B
integral membrane protein 2B
immature BRI2
ABri/ADan amyloid peptide
transmembrane protein BRI
BRICHOS domain containing 2B


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