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Sequence in raw or FASTA format:


Blast Method:


ITM2B integral membrane protein 2B [Homo sapiens (human)]

RefSeq Accession Definition Service Stock Status Price *Turnaround time Order
NM_021999 Homo sapiens integral membrane protein 2B (ITM2B), mRNA. GenEZ ORF Cloning On-demand $449.00 14

*Business Day

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Gene Symbol ITM2B
Entrez Gene ID 9445
Full Name integral membrane protein 2B
Synonyms ABRI, BRI, BRI2, BRICD2B, E25B, E3-16, FBD, imBRI2
General protein information
Preferred Names
integral membrane protein 2B
integral membrane protein 2B
immature BRI2
ABri/ADan amyloid peptide
transmembrane protein BRI
BRICHOS domain containing 2B
Gene Type protein-coding
Organism Homo sapiens (human)



Summary Amyloid precursor proteins are processed by beta-secretase and gamma-secretase to produce beta-amyloid peptides which form the characteristic plaques of Alzheimer disease. This gene encodes a transmembrane protein which is processed at the C-terminus by furin or furin-like proteases to produce a small secreted peptide which inhibits the deposition of beta-amyloid. Mutations which result in extension of the C-terminal end of the encoded protein, thereby increasing the size of the secreted peptide, are associated with two neurogenerative diseases, familial British dementia and familial Danish dementia. [provided by RefSeq, Oct 2009].

MIM: 603904

Dementia, familial British, 176500 (3); Dementia, familial Danish,

mRNA Protein Product Sequence Price Select
NM_021999, 221316670 NP_068839, 11527402 integral membrane protein 2B ORF Sequence $300.00
Homo sapiens (human)ITM2BNP_068839.1
Pan troglodytes (chimpanzee)ITM2BNP_001092017.1
Macaca mulatta (Rhesus monkey)ITM2BXP_002800791.1
Canis lupus familiaris (dog)ITM2BXP_005633935.1
Bos taurus (cattle)ITM2BNP_001030265.1
Mus musculus (house mouse)Itm2bNP_032436.1
Rattus norvegicus (Norway rat)Itm2bNP_001006964.1
Gallus gallus (chicken)ITM2BNP_990416.1
Danio rerio (zebrafish)itm2baNP_955940.1
Xenopus (Silurana) tropicalis (western clawed frog)itm2bNP_989241.1
GO:0007399nervous system developmentTAS
GO:0042985negative regulation of amyloid precursor protein biosynthetic processIDA
GO:0097192extrinsic apoptotic signaling pathway in absence of ligandIEA
GO:0005576extracellular regionTAS
GO:0005615extracellular spaceIDA
GO:0005794Golgi apparatusIDA
GO:0005886plasma membraneIDA
GO:0010008endosome membraneIEA
GO:0030660Golgi-associated vesicle membraneIDA
GO:0031301integral component of organelle membraneIDA
GO:0043231intracellular membrane-bounded organelleIDA
GO:0070062extracellular vesicular exosomeIDA
GO:0001540beta-amyloid bindingIPI
GO:0005515protein bindingIPI
GO:0005524ATP bindingIEA
GeneCards ITM2B
UniProt Q9Y287
Vega OTTHUMG00000016894
MIM 603904
Ensembl ENSG00000136156
HGNC 6174
HPRD 04878

GeneRIFs: Gene References Into Functions What's a GeneRIF?

What is the normal function of the ITM2B gene?

The ITM2B gene provides instructions for producing a protein called the integral membrane protein 2B (ITM2B), which is found in all tissues. The function of the ITM2B protein is unclear. It is thought to play a role in triggering the self-destruction of cells (apoptosis) and in keeping cells from growing and dividing too fast or in an uncontrolled way (suppressing tumor formation). Additionally, the ITM2B protein may be involved in processing the amyloid precursor protein, which is produced by the APP gene. Not much is known about amyloid precursor protein function, but it is thought to be involved in nerve cell function in the brain in early development. Processing this protein creates different forms of the protein that can carry out various functions. Research suggests that the ITM2B protein is also involved in preventing (inhibiting) a form of the amyloid precursor protein from accumulating in the body's cells and tissues.


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