NPEPPS aminopeptidase puromycin sensitive [Homo sapiens (human)]
| Gene Symbol | NPEPPS |
| Entrez Gene ID | 9520 |
| Full Name | aminopeptidase puromycin sensitive |
| Synonyms | AAP-S, MP100, PSA |
| Gene Type | protein-coding |
| Organism | Homo sapiens (human) |
| Genome |
17 17q21 |
| Summary | This gene encodes the puromycin-sensitive aminopeptidase, a zinc metallopeptidase which hydrolyzes amino acids from the N-terminus of its substrate. The protein has been localized to both the cytoplasm and to cellular membranes. This enzyme degrades enkaphalins in the brain, and studies in mouse suggest that it is involved in proteolytic events regulating the cell cycle. [provided by RefSeq]. |
| Disorder | MIM: 606793 |
| mRNA | NM_006310, 158937235 |
| Protein | NP_006301, 158937236 |
| Product | puromycin-sensitive aminopeptidase |
| RefSeq Status | REVIEWED |
| Homo sapiens (human) | NPEPPS | NP_006301.3 |
| Pan troglodytes (chimpanzee) | NPEPPS | XP_001173625.1 |
| Canis lupus familiaris (dog) | NPEPPS | XP_537659.2 |
| Bos taurus (cattle) | NPEPPS | XP_874738.2 |
| Mus musculus (house mouse) | Npepps | NP_032968.2 |
| Rattus norvegicus (Norway rat) | Npepps | XP_340890.1 |
| Gallus gallus (chicken) | NPEPPS | XP_001234986.1 |
| Danio rerio (zebrafish) | npepps | NP_001157499.1 |
| Drosophila melanogaster (fruit fly) | Psa | NP_728614.1 |
| Caenorhabditis elegans | pam-1 | NP_001023210.1 |
| Arabidopsis thaliana (thale cress) | APM1 | NP_195035.2 |
| ID | Name | Evidence |
| GO:0006508 | proteolysis | IEA |
Component
| ID | Name | Evidence |
| GO:0005634 | nucleus | IEA |
| GO:0005737 | cytoplasm | IEA |
| GO:0005829 | cytosol | IEA |
Function
| ID | Name | Evidence |
| GO:0004177 | aminopeptidase activity | IEA |
| GO:0005515 | protein binding | IPI |
| GO:0008233 | peptidase activity | IEA |
| GO:0008237 | metallopeptidase activity | IEA |
| GO:0008270 | zinc ion binding | IEA |
| GO:0046872 | metal ion binding | IEA |
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