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BAG3 BCL2-associated athanogene 3 [Homo sapiens (human)]


RefSeq Accession Definition Service Stock Status Price *Turnaround time Order
NM_004281 Homo sapiens BCL2-associated athanogene 3 (BAG3), mRNA. GenEZ ORF Cloning On-demand $849.00 20
XM_005270287 PREDICTED: Homo sapiens BCL2-associated athanogene 3 (BAG3), transcript variant X1, mRNA. GenEZ ORF Cloning On-demand $849.00 20

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Gene Symbol BAG3
Entrez Gene ID 9531
Full Name BCL2-associated athanogene 3
Synonyms BAG-3, BIS, CAIR-1, MFM6
General protein information
Preferred Names
BAG family molecular chaperone regulator 3
Names
BAG family molecular chaperone regulator 3
docking protein CAIR-1
BCL2-binding athanogene 3
bcl-2-binding protein Bis
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

10

10q25.2-q26.2

Summary BAG proteins compete with Hip for binding to the Hsc70/Hsp70 ATPase domain and promote substrate release. All the BAG proteins have an approximately 45-amino acid BAG domain near the C terminus but differ markedly in their N-terminal regions. The protein encoded by this gene contains a WW domain in the N-terminal region and a BAG domain in the C-terminal region. The BAG domains of BAG1, BAG2, and BAG3 interact specifically with the Hsc70 ATPase domain in vitro and in mammalian cells. All 3 proteins bind with high affinity to the ATPase domain of Hsc70 and inhibit its chaperone activity in a Hip-repressible manner. [provided by RefSeq, Jul 2008].
Disorder

MIM: 603883

Myopathy, myofibrillar, BAG3-related, 612954 (3)

mRNA Protein Product Sequence Price Select
NM_004281, 62530382 NP_004272, 14043024 BAG family molecular chaperone regulator 3 ORF Sequence $700.00
XM_005270287, 530394627 XP_005270344, 530394628 BAG family molecular chaperone regulator 3 isoform X1 ORF Sequence $700.00
WikiPathways
WP1772Apoptosis Modulation and Signaling
Homo sapiens (human)BAG3NP_004272.2
Pan troglodytes (chimpanzee)BAG3XP_508072.3
Macaca mulatta (Rhesus monkey)BAG3XP_001104160.2
Canis lupus familiaris (dog)BAG3XP_544046.2
Bos taurus (cattle)BAG3NP_001075940.1
Mus musculus (house mouse)Bag3NP_038891.4
Rattus norvegicus (Norway rat)Bag3NP_001011936.1
Gallus gallus (chicken)BAG3XP_001233435.2
Danio rerio (zebrafish)bag3NP_001003533.1
Process
IDNameEvidence
GO:0006457protein foldingNAS
GO:0007420brain developmentIEA
GO:0008625extrinsic apoptotic signaling pathway via death domain receptorsIDA
GO:0010664negative regulation of striated muscle cell apoptotic processIEA
GO:0021510spinal cord developmentIEA
GO:0043066negative regulation of apoptotic processNAS
GO:0050821protein stabilizationIEA
GO:0071260cellular response to mechanical stimulusIEA
GO:0097192extrinsic apoptotic signaling pathway in absence of ligandIEA
Component
IDNameEvidence
GO:0005737cytoplasmIDA
GO:0005829cytosolIDA
GO:0005886plasma membraneIDA
GO:0030018Z discIEA
GO:0043005neuron projectionIEA
Function
IDNameEvidence
GO:0005515protein bindingIPI
GO:0032403protein complex bindingIEA
GO:0051087chaperone bindingIEA
GeneCards BAG3
UniProt O95817
Vega OTTHUMG00000019155
MIM 603883
Ensembl ENSG00000151929
HGNC 939
HPRD 04860

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Interactant

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