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POLR1C polymerase (RNA) I polypeptide C, 30kDa [Homo sapiens (human)]


Clone ID RefSeq Accession Definition Vector Stock Status *Turnaround time Price Order
OHu17883 NM_203290 Homo sapiens polymerase (RNA) I polypeptide C, 30kDa (POLR1C), mRNA. pcDNA3.1+-DYK In-stock 5-7 $99.00
OHu40541 XM_005249491 PREDICTED: Homo sapiens polymerase (RNA) I polypeptide C, 30kDa (POLR1C), transcript variant X1, mRNA. pcDNA3.1+-DYK On-demand 7-9 $219.00
OHu17883C NM_203290 Homo sapiens polymerase (RNA) I polypeptide C, 30kDa (POLR1C), mRNA. Customized vector In-stock 5-7 $149.00
OHu40541C XM_005249491 PREDICTED: Homo sapiens polymerase (RNA) I polypeptide C, 30kDa (POLR1C), transcript variant X1, mRNA. Customized vector On-demand 7-9 $269.00

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Gene Symbol POLR1C
Entrez Gene ID 9533
Full Name polymerase (RNA) I polypeptide C, 30kDa
Synonyms RPA39, RPA40, RPA5, RPAC1, TCS3
General protein information
Preferred Names
DNA-directed RNA polymerases I and III subunit RPAC1
Names
DNA-directed RNA polymerases I and III subunit RPAC1
AC40
RPC40
RNA polymerases I and III subunit AC1
DNA-directed RNA polymerase I subunit C
DNA-directed RNA polymerases I and III 40 kDa polypeptide
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

6

6p21.1

Summary The protein encoded by this gene is a subunit of both RNA polymerase I and RNA polymerase III complexes. The encoded protein is part of the Pol core element. Defects in this gene have been associated with Treacher Collins syndrome (TCS). [provided by RefSeq, Mar 2011].
Disorder

MIM: 610060

Treacher Collins syndrome 3, 248390 (3)

mRNA Protein Product Sequence Price Select
NM_203290, 327365362 NP_976035, 42560246 DNA-directed RNA polymerases I and III subunit RPAC1 ORF Sequence $269.00
XM_005249491, 530382818 XP_005249548, 530382819 DNA-directed RNA polymerases I and III subunit RPAC1 isoform X1 ORF Sequence $400.00
KEGG
hsa00240Pyrimidine metabolism
hsa00230Purine metabolism
hsa03020RNA polymerase
hsa04623Cytosolic DNA-sensing pathway
hsa_M00181RNA polymerase III, eukaryotes
hsa_M00182RNA polymerase I, eukaryotes
hsa05169Epstein-Barr virus infection
WikiPathways
WP231TNF-alpha/NF-kB Signaling Pathway
Reactome
REACT_71Gene Expression
REACT_6802Innate Immune System
REACT_6900Immune System
REACT_2204RNA Polymerase I Chain Elongation
REACT_1913RNA Polymerase I Promoter Escape
REACT_1074RNA Polymerase I Transcription Termination
REACT_1371RNA Polymerase III Transcription
REACT_1974RNA Polymerase I Promoter Clearance
REACT_281RNA Polymerase III Transcription Initiation
REACT_953RNA Polymerase I Transcription Initiation
REACT_571RNA Polymerase III Transcription Initiation From Type 3 Promoter
REACT_756RNA Polymerase III Chain Elongation
REACT_1309RNA Polymerase I Transcription
REACT_347RNA Polymerase III Transcription Initiation From Type 1 Promoter
REACT_1036RNA Polymerase III Transcription Initiation From Type 2 Promoter
REACT_63RNA Polymerase III Transcription Termination
REACT_22339RNA Polymerase III Abortive And Retractive Initiation
REACT_21352RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription
REACT_118823Cytosolic sensors of pathogen-associated DNA
REACT_200834Negative epigenetic regulation of rRNA expression
REACT_200857Epigenetic regulation of gene expression
REACT_200856NoRC negatively regulates rRNA expression
Homo sapiens (human)POLR1CNP_976035.1
Pan troglodytes (chimpanzee)POLR1CXP_001136605.2
Canis lupus familiaris (dog)POLR1CXP_532147.1
Bos taurus (cattle)POLR1CNP_001033213.1
Mus musculus (house mouse)Polr1cNP_033111.2
Rattus norvegicus (Norway rat)Polr1cNP_001008331.1
Gallus gallus (chicken)POLR1CNP_001264559.1
Danio rerio (zebrafish)polr1cNP_956860.1
Drosophila melanogaster (fruit fly)CG3756NP_608885.1
Caenorhabditis elegansH43I07.2NP_504166.2
Arabidopsis thaliana (thale cress)ATRPAC42NP_849833.1
Arabidopsis thaliana (thale cress)RPAC43NP_176261.1
Xenopus (Silurana) tropicalis (western clawed frog)polr1cXP_002942192.2
Process
IDNameEvidence
GO:0006360transcription from RNA polymerase I promoterTAS
GO:0006361transcription initiation from RNA polymerase I promoterTAS
GO:0006362transcription elongation from RNA polymerase I promoterTAS
GO:0006363termination of RNA polymerase I transcriptionTAS
GO:0006383transcription from RNA polymerase III promoterTAS
GO:0006385transcription elongation from RNA polymerase III promoterTAS
GO:0006386termination of RNA polymerase III transcriptionTAS
GO:0010467gene expressionTAS
GO:0032481positive regulation of type I interferon productionTAS
GO:0045087innate immune responseTAS
Component
IDNameEvidence
GO:0005654nucleoplasmTAS
GO:0005666DNA-directed RNA polymerase III complexIBA
GO:0005666DNA-directed RNA polymerase III complexIDA
GO:0005736DNA-directed RNA polymerase I complexTAS
GO:0005829cytosolTAS
Function
IDNameEvidence
GO:0001054RNA polymerase I activityIBA
GO:0001056RNA polymerase III activityIBA
GO:0003677DNA bindingIEA
GO:0003899DNA-directed RNA polymerase activityTAS
GO:0046983protein dimerization activityIEA
GeneCards POLR1C
UniProt O15160
Vega OTTHUMG00000014739
MIM 610060
Ensembl ENSG00000171453
HGNC 20194
HPRD 09661

GeneRIFs: Gene References Into Functions What's a GeneRIF?

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