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POLR1C polymerase (RNA) I polypeptide C, 30kDa [Homo sapiens (human)]


RefSeq Accession Definition Service Stock Status Price *Turnaround time Order
NM_203290 Homo sapiens polymerase (RNA) I polypeptide C, 30kDa (POLR1C), mRNA. GenEZ ORF Cloning In-stock $418.00 $369.00 10
XM_005249491 PREDICTED: Homo sapiens polymerase (RNA) I polypeptide C, 30kDa (POLR1C), transcript variant X1, mRNA. GenEZ ORF Cloning On-demand $549.00 14

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Gene Symbol POLR1C
Entrez Gene ID 9533
Full Name polymerase (RNA) I polypeptide C, 30kDa
Synonyms RPA39, RPA40, RPA5, RPAC1, TCS3
General protein information
Preferred Names
DNA-directed RNA polymerases I and III subunit RPAC1
Names
DNA-directed RNA polymerases I and III subunit RPAC1
AC40
RPC40
RNA polymerases I and III subunit AC1
DNA-directed RNA polymerase I subunit C
DNA-directed RNA polymerases I and III 40 kDa polypeptide
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

6

6p21.1

Summary The protein encoded by this gene is a subunit of both RNA polymerase I and RNA polymerase III complexes. The encoded protein is part of the Pol core element. Defects in this gene have been associated with Treacher Collins syndrome (TCS). [provided by RefSeq, Mar 2011].
Disorder

MIM: 610060

Treacher Collins syndrome 3, 248390 (3)

mRNA Protein Product Sequence Price Select
NM_203290, 327365362 NP_976035, 42560246 DNA-directed RNA polymerases I and III subunit RPAC1 ORF Sequence $269.00
XM_005249491, 530382818 XP_005249548, 530382819 DNA-directed RNA polymerases I and III subunit RPAC1 isoform X1 ORF Sequence $400.00
KEGG
hsa00240Pyrimidine metabolism
hsa00230Purine metabolism
hsa03020RNA polymerase
hsa04623Cytosolic DNA-sensing pathway
hsa_M00181RNA polymerase III, eukaryotes
hsa_M00182RNA polymerase I, eukaryotes
hsa05169Epstein-Barr virus infection
WikiPathways
WP231TNF-alpha/NF-kB Signaling Pathway
Reactome
REACT_71Gene Expression
REACT_6802Innate Immune System
REACT_6900Immune System
REACT_2204RNA Polymerase I Chain Elongation
REACT_1913RNA Polymerase I Promoter Escape
REACT_1074RNA Polymerase I Transcription Termination
REACT_1371RNA Polymerase III Transcription
REACT_1974RNA Polymerase I Promoter Clearance
REACT_281RNA Polymerase III Transcription Initiation
REACT_953RNA Polymerase I Transcription Initiation
REACT_571RNA Polymerase III Transcription Initiation From Type 3 Promoter
REACT_756RNA Polymerase III Chain Elongation
REACT_1309RNA Polymerase I Transcription
REACT_347RNA Polymerase III Transcription Initiation From Type 1 Promoter
REACT_1036RNA Polymerase III Transcription Initiation From Type 2 Promoter
REACT_63RNA Polymerase III Transcription Termination
REACT_22339RNA Polymerase III Abortive And Retractive Initiation
REACT_21352RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription
REACT_118823Cytosolic sensors of pathogen-associated DNA
REACT_200834Negative epigenetic regulation of rRNA expression
REACT_200857Epigenetic regulation of gene expression
REACT_200856NoRC negatively regulates rRNA expression
Homo sapiens (human)POLR1CNP_976035.1
Pan troglodytes (chimpanzee)POLR1CXP_001136605.2
Canis lupus familiaris (dog)POLR1CXP_532147.1
Bos taurus (cattle)POLR1CNP_001033213.1
Mus musculus (house mouse)Polr1cNP_033111.2
Rattus norvegicus (Norway rat)Polr1cNP_001008331.1
Gallus gallus (chicken)POLR1CNP_001264559.1
Danio rerio (zebrafish)polr1cNP_956860.1
Drosophila melanogaster (fruit fly)CG3756NP_608885.1
Caenorhabditis elegansH43I07.2NP_504166.2
Arabidopsis thaliana (thale cress)ATRPAC42NP_849833.1
Arabidopsis thaliana (thale cress)RPAC43NP_176261.1
Xenopus (Silurana) tropicalis (western clawed frog)polr1cXP_002942192.2
Process
IDNameEvidence
GO:0006360transcription from RNA polymerase I promoterTAS
GO:0006361transcription initiation from RNA polymerase I promoterTAS
GO:0006362transcription elongation from RNA polymerase I promoterTAS
GO:0006363termination of RNA polymerase I transcriptionTAS
GO:0006383transcription from RNA polymerase III promoterTAS
GO:0006385transcription elongation from RNA polymerase III promoterTAS
GO:0006386termination of RNA polymerase III transcriptionTAS
GO:0010467gene expressionTAS
GO:0032481positive regulation of type I interferon productionTAS
GO:0045087innate immune responseTAS
Component
IDNameEvidence
GO:0005654nucleoplasmTAS
GO:0005666DNA-directed RNA polymerase III complexIBA
GO:0005666DNA-directed RNA polymerase III complexIDA
GO:0005736DNA-directed RNA polymerase I complexTAS
GO:0005829cytosolTAS
Function
IDNameEvidence
GO:0001054RNA polymerase I activityIBA
GO:0001056RNA polymerase III activityIBA
GO:0003677DNA bindingIEA
GO:0003899DNA-directed RNA polymerase activityTAS
GO:0046983protein dimerization activityIEA
GeneCards POLR1C
UniProt O15160
Vega OTTHUMG00000014739
MIM 610060
Ensembl ENSG00000171453
HGNC 20194
HPRD 09661

GeneRIFs: Gene References Into Functions What's a GeneRIF?

What is the normal function of the POLR1C gene?

The POLR1C gene provides instructions for making one part (subunit) of two related enzymes called RNA polymerase I and RNA polymerase III. These enzymes are involved in the production (synthesis) of ribonucleic acid (RNA), a chemical cousin of DNA. Both enzymes help synthesize a form of RNA known as ribosomal RNA (rRNA). RNA polymerase III also plays a role in the synthesis of several other forms of RNA, including transfer RNA (tRNA). Ribosomal RNA and transfer RNA assemble protein building blocks (amino acids) into functioning proteins, which is essential for the normal functioning and survival of cells.

Based on its involvement in Treacher Collins syndrome (described below), the POLR1C gene appears to play a critical role in the early development of structures that become bones and other tissues of the face.

Interactant

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