POLR1C polymerase (RNA) I polypeptide C, 30kDa [Homo sapiens (human)]
| Gene Symbol | POLR1C |
| Entrez Gene ID | 9533 |
| Full Name | polymerase (RNA) I polypeptide C, 30kDa |
| Synonyms | RPA39, RPA40, RPA5, RPAC1, TCS3 |
| Gene Type | protein-coding |
| Organism | Homo sapiens (human) |
| Genome |
6 6p21.1 |
| Summary | The protein encoded by this gene is a subunit of both RNA polymerase I and RNA polymerase III complexes. The encoded protein is part of the Pol core element. Defects in this gene have been associated with Treacher Collins syndrome (TCS). [provided by RefSeq]. |
| Disorder | MIM: 610060 Treacher Collins syndrome 3, 248390 (3) |
| mRNA | NM_203290, 327365362 |
| Protein | NP_976035, 42560246 |
| Product | DNA-directed RNA polymerases I and III subunit RPAC1 |
| RefSeq Status | REVIEWED |
| hsa03020 | RNA polymerase |
| hsa00230 | Purine metabolism |
| hsa01100 | Metabolic pathways |
| hsa00240 | Pyrimidine metabolism |
| hsa04623 | Cytosolic DNA-sensing pathway |
WikiPathways
| WP231 | TNF-alpha/NF-kB Signaling Pathway |
Reactome
| REACT_1309 | RNA Polymerase I Transcription |
| REACT_21352 | RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription |
| REACT_2204 | RNA Polymerase I Chain Elongation |
| REACT_1913 | RNA Polymerase I Promoter Escape |
| REACT_1788 | Transcription |
| REACT_1974 | RNA Polymerase I Promoter Clearance |
| REACT_1074 | RNA Polymerase I Transcription Termination |
| REACT_953 | RNA Polymerase I Transcription Initiation |
| Homo sapiens (human) | POLR1C | NP_976035.1 |
| Pan troglodytes (chimpanzee) | POLR1C | XP_001136605.1 |
| Canis lupus familiaris (dog) | POLR1C | XP_532147.1 |
| Bos taurus (cattle) | POLR1C | NP_001033213.1 |
| Mus musculus (house mouse) | Polr1c | NP_033111.2 |
| Rattus norvegicus (Norway rat) | Polr1c | NP_001008331.1 |
| Gallus gallus (chicken) | POLR1C | XP_419502.1 |
| Danio rerio (zebrafish) | polr1c | NP_956860.1 |
| Drosophila melanogaster (fruit fly) | CG3756 | NP_608885.1 |
| Caenorhabditis elegans | transferase | NP_504166.2 |
| Arabidopsis thaliana (thale cress) | ATRPAC42 | NP_849833.1 |
| Arabidopsis thaliana (thale cress) | ATRPAC43 | NP_176261.1 |
| ID | Name | Evidence |
| GO:0006360 | transcription from RNA polymerase I promoter | TAS |
| GO:0006361 | transcription initiation from RNA polymerase I promoter | TAS |
| GO:0006362 | transcription elongation from RNA polymerase I promoter | TAS |
| GO:0006363 | termination of RNA polymerase I transcription | TAS |
Component
| ID | Name | Evidence |
| GO:0005634 | nucleus | IEA |
| GO:0005654 | nucleoplasm | EXP |
| GO:0005654 | nucleoplasm | TAS |
| GO:0005736 | DNA-directed RNA polymerase I complex | TAS |
Function
| ID | Name | Evidence |
| GO:0003677 | DNA binding | IEA |
| GO:0003899 | DNA-directed RNA polymerase activity | IEA |
| GO:0005515 | protein binding | IPI |
| GO:0046983 | protein dimerization activity | IEA |
Our customer service representatives are available 24 hours a day, Monday through Friday; please contact us anytime for assistance.
 |
Secured Online Quotation |
 |
Email: gene@genscript.com |
 |
Phone: 1-877-436-7274 (Toll-Free) 1-732-885-9188 |
 |
Fax: 1-732-210-0262 1-732-885-5878 |