CCL4L1 chemokine (C-C motif) ligand 4-like 1 [Homo sapiens (human)]
| Gene Symbol | CCL4L1 |
| Entrez Gene ID | 9560 |
| Full Name | chemokine (C-C motif) ligand 4-like 1 |
| Synonyms | AT744.2, CCL4L, CCL4L2, LAG-1, LAG1, SCYA4L |
| Gene Type | protein-coding |
| Organism | Homo sapiens (human) |
| Genome |
17 17q12 |
| Summary | This gene is one of several cytokine genes clustered on the q-arm of chromosome 17. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. This protein is similar to CCL4 which inhibits HIV entry by binding to the cellular receptor CCR5. The copy number of this gene varies among individuals; most individuals have 1-5 copies in the diploid genome, although rare individuals do not contain this gene at all. The human genome reference assembly contains two copies of this gene. This record represents the more centromeric gene. [provided by RefSeq]. |
| Disorder | MIM: 603782 |
| mRNA | NM_001001435, 48949791 |
| Protein | NP_001001435, 47824887 |
| Product | C-C motif chemokine 4-like precursor |
| RefSeq Status | REVIEWED |
| hsa04062 | Chemokine signaling pathway |
| hsa04623 | Cytosolic DNA-sensing pathway |
| hsa04060 | Cytokine-cytokine receptor interaction |
Pathway Interaction Database
| il12_2pathway | IL12-mediated signaling events |
| Homo sapiens (human) | CCL4L1 | NP_001001435.1 |
| Homo sapiens (human) | CCL4L2 | NP_996890.1 |
| Pan troglodytes (chimpanzee) | CCL4 | XP_511774.1 |
| Pan troglodytes (chimpanzee) | CCL4 | XP_001173914.1 |
| ID | Name | Evidence |
| GO:0006935 | chemotaxis | IEA |
| GO:0006954 | inflammatory response | IEA |
| GO:0006955 | immune response | IEA |
Component
| ID | Name | Evidence |
| GO:0005576 | extracellular region | IEA |
| GO:0005615 | extracellular space | IEA |
Function
| ID | Name | Evidence |
| GO:0008009 | chemokine activity | IEA |
| GeneCards | CCL4L1 |
| MIM | 603782 |
| Ensembl | ENSG00000205020 |
| HGNC | 10631 |
| HPRD | 16030 |
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