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CD40 CD40 molecule, TNF receptor superfamily member 5 [Homo sapiens (human)]


RefSeq Accession Definition Service Stock Status Price *Turnaround time Order
NM_001250 Homo sapiens CD40 molecule, TNF receptor superfamily member 5 (CD40), transcript variant 1, mRNA. GenEZ ORF Cloning In-stock $348.00 $299.00 10
NM_152854 Homo sapiens CD40 molecule, TNF receptor superfamily member 5 (CD40), transcript variant 2, mRNA. GenEZ ORF Cloning On-demand $399.00 14

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Related Services

Gene Symbol CD40
Entrez Gene ID 958
Full Name CD40 molecule, TNF receptor superfamily member 5
Synonyms Bp50, CDW40, MGC9013, TNFRSF5, p50
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

20

20q12-q13.2

Summary The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor has been found to be essential in mediating a broad variety of immune and inflammatory responses including T cell-dependent immunoglobulin class switching, memory B cell development, and germinal center formation. AT-hook transcription factor AKNA is reported to coordinately regulate the expression of this receptor and its ligand, which may be important for homotypic cell interactions. Adaptor protein TNFR2 interacts with this receptor and serves as a mediator of the signal transduction. The interaction of this receptor and its ligand is found to be necessary for amyloid-beta-induced microglial activation, and thus is thought to be an early event in Alzheimer disease pathogenesis. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008].
Disorder

MIM: 109535

Immunodeficiency with hyper-IgM, type 3, 606843 (3)

mRNA Protein Product Sequence Price Select
NM_001250, 91105420 NP_001241, 4507581 tumor necrosis factor receptor superfamily member 5 isoform 1 precursor ORF Sequence $199.00
NM_152854, 91105277 NP_690593, 23312371 tumor necrosis factor receptor superfamily member 5 isoform 2 precursor ORF Sequence $250.00
KEGG
hsa05310Asthma
hsa05340Primary immunodeficiency
hsa04672Intestinal immune network for IgA production
hsa05322Systemic lupus erythematosus
hsa05144Malaria
hsa05145Toxoplasmosis
hsa04064NF-kappa B signaling pathway
hsa05416Viral myocarditis
hsa05169Epstein-Barr virus infection
hsa05330Allograft rejection
hsa04060Cytokine-cytokine receptor interaction
hsa05202Transcriptional misregulation in cancer
hsa04620Toll-like receptor signaling pathway
hsa05320Autoimmune thyroid disease
hsa04514Cell adhesion molecules (CAMs)
hsa05166HTLV-I infection
Pathway Interaction Database
cd40_pathwayCD40/CD40L signaling
WikiPathways
WP288NLR proteins
WP364IL-6 Signaling Pathway
WP453Inflammatory Response Pathway
WP75Toll-like receptor signaling pathway
Reactome
REACT_75774Adaptive Immune System
REACT_6900Immune System
REACT_11152Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
Homo sapiens (human)CD40NP_001241.1
Pan troglodytes (chimpanzee)CD40XP_003317038.2
Macaca mulatta (Rhesus monkey)CD40XP_001104333.1
Canis lupus familiaris (dog)CD40NP_001002982.1
Bos taurus (cattle)CD40NP_001099081.1
Mus musculus (house mouse)Cd40NP_035741.2
Rattus norvegicus (Norway rat)Cd40NP_599187.1
Gallus gallus (chicken)CD40NP_989996.1
GeneCards CD40
PDB 3QD6, 1D00, 1FLL, 1CDF, 1LB6, 1CZZ
UniProt P25942
MIM 109535
Ensembl ENSG00000101017
HGNC 11919
HPRD 00178

GeneRIFs: Gene References Into Functions What's a GeneRIF?

General protein information

Preferred Names
tumor necrosis factor receptor superfamily member 5
Names
tumor necrosis factor receptor superfamily member 5
CD40L receptor
CD40 type II isoform
B cell-associated molecule
B cell surface antigen CD40
B-cell surface antigen CD40
CD40 antigen (TNF receptor superfamily member 5)
tumor necrosis factor receptor superfamily, member 5
nerve growth factor receptor-related B-lymphocyte activation molecule

Interactant



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