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CD40 CD40 molecule, TNF receptor superfamily member 5 [Homo sapiens (human)]


Clone ID RefSeq Accession Definition Vector Stock Status *Turnaround time Price Order
OHu12389 NM_152854 Homo sapiens CD40 molecule, TNF receptor superfamily member 5 (CD40), transcript variant 2, mRNA. pcDNA3.1+-DYK On-demand 7-9 $159.00
OHu20663 NM_001250 Homo sapiens CD40 molecule, TNF receptor superfamily member 5 (CD40), transcript variant 1, mRNA. pcDNA3.1+-DYK In-stock 5-7 $99.00
OHu53155 XM_005260617 PREDICTED: Homo sapiens CD40 molecule, TNF receptor superfamily member 5 (CD40), transcript variant X1, mRNA. pcDNA3.1+-DYK On-demand 7-9 $159.00
OHu53156 XM_005260618 PREDICTED: Homo sapiens CD40 molecule, TNF receptor superfamily member 5 (CD40), transcript variant X2, mRNA. pcDNA3.1+-DYK On-demand 7-9 $159.00
OHu53157 XM_006723889 PREDICTED: Homo sapiens CD40 molecule, TNF receptor superfamily member 5 (CD40), transcript variant X4, mRNA. pcDNA3.1+-DYK On-demand 7-9 $159.00
OHu53158 XM_005260619 PREDICTED: Homo sapiens CD40 molecule, TNF receptor superfamily member 5 (CD40), transcript variant X3, mRNA. pcDNA3.1+-DYK On-demand 7-9 $159.00
OHu12389C NM_152854 Homo sapiens CD40 molecule, TNF receptor superfamily member 5 (CD40), transcript variant 2, mRNA. Customized vector On-demand 7-9 $209.00
OHu20663C NM_001250 Homo sapiens CD40 molecule, TNF receptor superfamily member 5 (CD40), transcript variant 1, mRNA. Customized vector In-stock 5-7 $149.00
OHu53155C XM_005260617 PREDICTED: Homo sapiens CD40 molecule, TNF receptor superfamily member 5 (CD40), transcript variant X1, mRNA. Customized vector On-demand 7-9 $209.00
OHu53156C XM_005260618 PREDICTED: Homo sapiens CD40 molecule, TNF receptor superfamily member 5 (CD40), transcript variant X2, mRNA. Customized vector On-demand 7-9 $209.00
OHu53157C XM_006723889 PREDICTED: Homo sapiens CD40 molecule, TNF receptor superfamily member 5 (CD40), transcript variant X4, mRNA. Customized vector On-demand 7-9 $209.00
OHu53158C XM_005260619 PREDICTED: Homo sapiens CD40 molecule, TNF receptor superfamily member 5 (CD40), transcript variant X3, mRNA. Customized vector On-demand 7-9 $209.00

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Gene Symbol CD40
Entrez Gene ID 958
Full Name CD40 molecule, TNF receptor superfamily member 5
Synonyms Bp50, CDW40, TNFRSF5, p50
General protein information
Preferred Names
tumor necrosis factor receptor superfamily member 5
Names
tumor necrosis factor receptor superfamily member 5
CD40L receptor
CD40 type II isoform
B cell-associated molecule
B cell surface antigen CD40
B-cell surface antigen CD40
CD40 antigen (TNF receptor superfamily member 5)
tumor necrosis factor receptor superfamily, member 5
nerve growth factor receptor-related B-lymphocyte activation molecule
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

20

20q12-q13.2

Summary The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor has been found to be essential in mediating a broad variety of immune and inflammatory responses including T cell-dependent immunoglobulin class switching, memory B cell development, and germinal center formation. AT-hook transcription factor AKNA is reported to coordinately regulate the expression of this receptor and its ligand, which may be important for homotypic cell interactions. Adaptor protein TNFR2 interacts with this receptor and serves as a mediator of the signal transduction. The interaction of this receptor and its ligand is found to be necessary for amyloid-beta-induced microglial activation, and thus is thought to be an early event in Alzheimer disease pathogenesis. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008].
Disorder

MIM: 109535

Immunodeficiency with hyper-IgM, type 3, 606843 (3)

mRNA Protein Product Sequence Price Select
NM_001250, 91105420 NP_001241, 4507581 tumor necrosis factor receptor superfamily member 5 isoform 1 precursor ORF Sequence $199.00
NM_152854, 91105277 NP_690593, 23312371 tumor necrosis factor receptor superfamily member 5 isoform 2 precursor ORF Sequence $250.00
XM_005260617, 530418532 XP_005260674, 530418533 tumor necrosis factor receptor superfamily member 5 isoform X1 ORF Sequence $300.00
XM_005260618, 530418534 XP_005260675, 530418535 tumor necrosis factor receptor superfamily member 5 isoform X2 ORF Sequence $250.00
XM_005260619, 530418536 XP_005260676, 530418537 tumor necrosis factor receptor superfamily member 5 isoform X3 ORF Sequence $250.00
XM_006723889, 578836239 XP_006723952, 578836240 tumor necrosis factor receptor superfamily member 5 isoform X4 ORF Sequence $250.00
KEGG
hsa04060Cytokine-cytokine receptor interaction
hsa04620Toll-like receptor signaling pathway
hsa04514Cell adhesion molecules (CAMs)
hsa05320Autoimmune thyroid disease
hsa05340Primary immunodeficiency
hsa05310Asthma
hsa05322Systemic lupus erythematosus
hsa05330Allograft rejection
hsa05416Viral myocarditis
hsa04672Intestinal immune network for IgA production
hsa05145Toxoplasmosis
hsa05144Malaria
hsa05166HTLV-I infection
hsa05202Transcriptional misregulation in cancer
hsa04064NF-kappa B signaling pathway
hsa05169Epstein-Barr virus infection
WikiPathways
WP453Inflammatory Response Pathway
WP75Toll-like receptor signaling pathway
WP288NLR proteins
WP364IL-6 Signaling Pathway
WP1449Regulation of toll-like receptor signaling pathway
WP2328Allograft Rejection
Pathway Interaction Database
cd40_pathwayCD40/CD40L signaling
Reactome
REACT_6900Immune System
REACT_11152Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
REACT_75774Adaptive Immune System
Homo sapiens (human)CD40NP_001241.1
Pan troglodytes (chimpanzee)CD40XP_003317038.2
Macaca mulatta (Rhesus monkey)CD40XP_001104333.1
Canis lupus familiaris (dog)CD40NP_001002982.1
Bos taurus (cattle)CD40NP_001099081.1
Mus musculus (house mouse)Cd40NP_035741.2
Rattus norvegicus (Norway rat)Cd40NP_599187.1
Gallus gallus (chicken)CD40NP_989996.1
Xenopus (Silurana) tropicalis (western clawed frog)cd40NP_001138688.1
Process
IDNameEvidence
GO:0001934positive regulation of protein phosphorylationIMP
GO:0002768immune response-regulating cell surface receptor signaling pathwayIEA
GO:0006461protein complex assemblyTAS
GO:0006874cellular calcium ion homeostasisIMP
GO:0006954inflammatory responseIEA
GO:0030168platelet activationNAS
GO:0030890positive regulation of B cell proliferationIEA
GO:0032735positive regulation of interleukin-12 productionIEA
GO:0032855positive regulation of Rac GTPase activityIMP
GO:0042100B cell proliferationNAS
GO:0042511positive regulation of tyrosine phosphorylation of Stat1 proteinIMP
GO:0043089positive regulation of Cdc42 GTPase activityIMP
GO:0043123positive regulation of I-kappaB kinase/NF-kappaB signalingIEP
GO:0043406positive regulation of MAP kinase activityIMP
GO:0045944positive regulation of transcription from RNA polymerase II promoterIMP
GO:0048304positive regulation of isotype switching to IgG isotypesIEA
GO:0050776regulation of immune responseTAS
GO:0051023regulation of immunoglobulin secretionIEA
GO:0051092positive regulation of NF-kappaB transcription factor activityIMP
GO:0051607defense response to virusIEA
GO:0071222cellular response to lipopolysaccharideIEA
GO:0071260cellular response to mechanical stimulusIEP
GO:0090037positive regulation of protein kinase C signalingIMP
GO:2000353positive regulation of endothelial cell apoptotic processIDA
Component
IDNameEvidence
GO:0005615extracellular spaceIEA
GO:0005737cytoplasmIEA
GO:0005886plasma membraneISS
GO:0005886plasma membraneTAS
GO:0005887integral component of plasma membraneTAS
GO:0009897external side of plasma membraneIEA
GO:0035631CD40 receptor complexISS
GO:0043231intracellular membrane-bounded organelleIEA
GO:0070062extracellular vesicular exosomeIDA
Function
IDNameEvidence
GO:0003823antigen bindingIEA
GO:0004871signal transducer activityTAS
GO:0004872receptor activityTAS
GO:0005515protein bindingIPI
GO:0019899enzyme bindingIPI
GO:0031625ubiquitin protein ligase bindingIPI
GeneCards CD40
UniProt P25942
Vega OTTHUMG00000033053
MIM 109535
Ensembl ENSG00000101017
HGNC 11919
HPRD 00178

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Interactant

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