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IFT140 intraflagellar transport 140 [Homo sapiens (human)]


RefSeq Accession Definition Service Stock Status Price *Turnaround time Order
NM_014714 Homo sapiens intraflagellar transport 140 (IFT140), mRNA. GenEZ ORF Cloning In-stock $1198.00 $1149.00 16
XM_005255725 PREDICTED: Homo sapiens intraflagellar transport 140 homolog (Chlamydomonas) (IFT140), transcript variant X2, mRNA. GenEZ ORF Cloning On-demand $899.00 20
XM_005255726 PREDICTED: Homo sapiens intraflagellar transport 140 homolog (Chlamydomonas) (IFT140), transcript variant X3, mRNA. GenEZ ORF Cloning On-demand $899.00 20
XM_006720989 PREDICTED: Homo sapiens intraflagellar transport 140 homolog (Chlamydomonas) (IFT140), transcript variant X4, mRNA. GenEZ ORF Cloning On-demand $1699.00 25
XM_006720990 PREDICTED: Homo sapiens intraflagellar transport 140 homolog (Chlamydomonas) (IFT140), transcript variant X5, mRNA. GenEZ ORF Cloning On-demand $1699.00 25
XM_006720991 PREDICTED: Homo sapiens intraflagellar transport 140 homolog (Chlamydomonas) (IFT140), transcript variant X6, mRNA. GenEZ ORF Cloning On-demand $1699.00 25
XM_006720992 PREDICTED: Homo sapiens intraflagellar transport 140 homolog (Chlamydomonas) (IFT140), transcript variant X7, mRNA. GenEZ ORF Cloning On-demand $849.00 20

*Business Day

Related Services

Gene Symbol IFT140
Entrez Gene ID 9742
Full Name intraflagellar transport 140
Synonyms MZSDS, SRTD9, WDTC2, c305C8.4, c380F5.1, gs114
General protein information
Preferred Names
intraflagellar transport protein 140 homolog
Names
intraflagellar transport protein 140 homolog
WD and tetratricopeptide repeats protein 2
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

16

16p13.3

Summary This gene encodes one of the subunits of the intraflagellar transport (IFT) complex A. Intraflagellar transport is involved in the genesis, resorption and signaling of primary cilia. The primary cilium is a microtubule-based sensory organelle at the surface of most quiescent mammalian cells, that receives signals from its environment, such as the flow of fluid, light or odors, and transduces those signals to the nucleus. Loss of the corresponding protein in mouse results in renal cystic disease. [provided by RefSeq, Jun 2012].
Disorder

MIM: 614620

mRNA Protein Product Sequence Price Select
NM_014714, 215820638 NP_055529, 41281447 intraflagellar transport protein 140 homolog ORF Sequence $999.00
XM_005255725, 578828381 XP_005255782, 530409470 intraflagellar transport protein 140 homolog isoform X2 ORF Sequence $750.00
XM_005255726, 530409471 XP_005255783, 530409472 intraflagellar transport protein 140 homolog isoform X3 ORF Sequence $750.00
XM_006720989, 578828375 XP_006721052, 578828376 intraflagellar transport protein 140 homolog isoform X4 ORF Sequence $1500.00
XM_006720990, 578828377 XP_006721053, 578828378 intraflagellar transport protein 140 homolog isoform X5 ORF Sequence $1500.00
XM_006720991, 578828379 XP_006721054, 578828380 intraflagellar transport protein 140 homolog isoform X6 ORF Sequence $1500.00
XM_006720992, 578828382 XP_006721055, 578828383 intraflagellar transport protein 140 homolog isoform X7 ORF Sequence $700.00
Homo sapiens (human)IFT140NP_055529.2
Pan troglodytes (chimpanzee)IFT140XP_003314958.1
Macaca mulatta (Rhesus monkey)IFT140XP_001089057.1
Bos taurus (cattle)IFT140XP_002697959.3
Mus musculus (house mouse)Ift140NP_598887.3
Rattus norvegicus (Norway rat)Ift140XP_006246116.1
Gallus gallus (chicken)IFT140NP_001012810.1
Danio rerio (zebrafish)ift140XP_695732.4
Drosophila melanogaster (fruit fly)rempANP_995608.1
Caenorhabditis elegansche-11NP_506047.5
Xenopus (Silurana) tropicalis (western clawed frog)ift140NP_001116497.1
Process
IDNameEvidence
GO:0042384cilium assemblyIEA
GO:0048705skeletal system morphogenesisIMP
GO:0060041retina development in camera-type eyeIMP
GO:0061512protein localization to ciliumIMP
GO:0072001renal system developmentIMP
GO:1902017regulation of cilium assemblyIMP
Component
IDNameEvidence
GO:0005813centrosomeIDA
GO:0005930axonemeISS
GO:0030991intraciliary transport particle AIDA
GO:0032391photoreceptor connecting ciliumIEA
GO:0036064ciliary basal bodyIDA
Function
IDNameEvidence
GO:0003674molecular_functionND
GeneCards IFT140
UniProt Q96RY7
Vega OTTHUMG00000128585
MIM 614620
Ensembl ENSG00000187535
HGNC 29077
HPRD 11093

What is the normal function of the IFT140 gene?

The IFT140 gene provides instructions for making a protein that is involved in the formation and maintenance of cilia, which are microscopic, finger-like projections that stick out from the surface of cells and participate in signaling pathways that transmit information within and between cells. Cilia are important for the structure and function of many types of cells, including cells in the kidneys, liver, and brain. Light-sensing cells (photoreceptors) in the retina also contain cilia, which are essential for normal vision. Cilia also play a role in the development of the bones, although the mechanism is not well understood.

The movement of substances within cilia and similar structures called flagella is known as intraflagellar transport. This process is essential for the assembly and maintenance of these cell structures. During intraflagellar transport, cells use molecules called IFT particles to carry materials to and from the tips of cilia. IFT particles are made of proteins produced from related genes that belong to the IFT gene family. Each IFT particle is made up of two groups of IFT proteins: complex A, which includes at least 6 proteins, and complex B, which includes at least 15 proteins. The protein produced from the IFT140 gene forms part of IFT complex A (IFT-A).

Interactant

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