Sequence in raw or FASTA format:
IFT140 intraflagellar transport 140 [Homo sapiens (human)]
|Entrez Gene ID||9742|
|Full Name||intraflagellar transport 140|
|Synonyms||MZSDS, SRTD9, WDTC2, c305C8.4, c380F5.1, gs114|
|General protein information||
|Organism||Homo sapiens (human)|
|Summary||This gene encodes one of the subunits of the intraflagellar transport (IFT) complex A. Intraflagellar transport is involved in the genesis, resorption and signaling of primary cilia. The primary cilium is a microtubule-based sensory organelle at the surface of most quiescent mammalian cells, that receives signals from its environment, such as the flow of fluid, light or odors, and transduces those signals to the nucleus. Loss of the corresponding protein in mouse results in renal cystic disease. [provided by RefSeq, Jun 2012].|
|Homo sapiens (human)||IFT140||NP_055529.2|
|Pan troglodytes (chimpanzee)||IFT140||XP_003314958.1|
|Macaca mulatta (Rhesus monkey)||IFT140||XP_001089057.1|
|Bos taurus (cattle)||IFT140||XP_002697959.3|
|Mus musculus (house mouse)||Ift140||NP_598887.3|
|Rattus norvegicus (Norway rat)||Ift140||XP_006246116.1|
|Gallus gallus (chicken)||IFT140||NP_001012810.1|
|Danio rerio (zebrafish)||ift140||XP_695732.4|
|Drosophila melanogaster (fruit fly)||rempA||NP_995608.1|
|Xenopus (Silurana) tropicalis (western clawed frog)||ift140||NP_001116497.1|
|GO:0048705||skeletal system morphogenesis||IMP|
|GO:0060041||retina development in camera-type eye||IMP|
|GO:0061512||protein localization to cilium||IMP|
|GO:0072001||renal system development||IMP|
|GO:1902017||regulation of cilium assembly||IMP|
|GO:0030991||intraciliary transport particle A||IDA|
|GO:0032391||photoreceptor connecting cilium||IEA|
|GO:0036064||ciliary basal body||IDA|
What is the normal function of the IFT140 gene?
The IFT140 gene provides instructions for making a protein that is involved in the formation and maintenance of cilia, which are microscopic, finger-like projections that stick out from the surface of cells and participate in signaling pathways that transmit information within and between cells. Cilia are important for the structure and function of many types of cells, including cells in the kidneys, liver, and brain. Light-sensing cells (photoreceptors) in the retina also contain cilia, which are essential for normal vision. Cilia also play a role in the development of the bones, although the mechanism is not well understood.
The movement of substances within cilia and similar structures called flagella is known as intraflagellar transport. This process is essential for the assembly and maintenance of these cell structures. During intraflagellar transport, cells use molecules called IFT particles to carry materials to and from the tips of cilia. IFT particles are made of proteins produced from related genes that belong to the IFT gene family. Each IFT particle is made up of two groups of IFT proteins: complex A, which includes at least 6 proteins, and complex B, which includes at least 15 proteins. The protein produced from the IFT140 gene forms part of IFT complex A (IFT-A).
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