Sequence in raw or FASTA format:
MATR3 matrin 3 [Homo sapiens (human)]
|Entrez Gene ID||9782|
|Full Name||matrin 3|
|Synonyms||ALS21, MPD2, VCPDM|
|General protein information||
|Organism||Homo sapiens (human)|
|Summary||This gene encodes a nuclear matrix protein, which is proposed to stabilize certain messenger RNA species. Mutations of this gene are associated with distal myopathy 2, which often includes vocal cord and pharyngeal weakness. Alternatively spliced transcript variants, including read-through transcripts composed of the upstream small nucleolar RNA host gene 4 (non-protein coding) and matrin 3 gene sequence, have been identified. Pseudogenes of this gene are located on chromosomes 1 and X. [provided by RefSeq, Aug 2013].|
Myopathy, distal 2, 606070 (3)
|Homo sapiens (human)||MATR3||NP_954659.1|
|Pan troglodytes (chimpanzee)||MATR3||NP_001192161.1|
|Macaca mulatta (Rhesus monkey)||MATR3||XP_001114262.1|
|Canis lupus familiaris (dog)||MATR3||NP_001192187.1|
|Bos taurus (cattle)||MATR3||NP_001095956.1|
|Mus musculus (house mouse)||Matr3||NP_034901.2|
|Rattus norvegicus (Norway rat)||Matr3||NP_062022.2|
|Gallus gallus (chicken)||MATR3||NP_989478.1|
|Xenopus (Silurana) tropicalis (western clawed frog)||matr3||NP_001006792.2|
|GO:0005637||nuclear inner membrane||TAS|
|GO:0005198||structural molecule activity||TAS|
|GO:0008270||zinc ion binding||IEA|
|GO:0044822||poly(A) RNA binding||IDA|
|UniProt||B4DF66, B3KM87, Q9H4N1, P43243|
What is the normal function of the MATR3 gene?
The MATR3 gene provides instructions for making a protein called matrin 3, which is found in the nucleus of the cell as part of the nuclear matrix. The nuclear matrix is a network of proteins that provides structural support for the nucleus and aids in several important nuclear functions.
The function of the matrin 3 protein is unknown. This protein can attach to (bind) RNA, which is a chemical cousin of DNA. Some studies indicate that matrin 3 binds and stabilizes a type of RNA called messenger RNA (mRNA), which provides the genetic blueprint for proteins. Matrin 3 may also bind certain abnormal RNAs that could lead to nonfunctional or harmful proteins, thereby blocking the formation of such proteins. Other studies suggest that the matrin 3 protein may be involved in cell survival.
Our customer service representatives are available 24 hours a day, Monday through Friday; please contact us anytime for assistance.