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RBM8A RNA binding motif protein 8A [Homo sapiens (human)]


RefSeq Accession Definition Sequence Price Select
NM_005105 Homo sapiens RNA binding motif protein 8A (RBM8A), mRNA. Full Length $1740.55
ORF Sequence $159.00


Gene Symbol RBM8A
Entrez Gene ID 9939
Full Name RNA binding motif protein 8A
Synonyms BOV-1A, BOV-1B, BOV-1C, MDS014, RBM8, RBM8B, Y14, ZNRP, ZRNP1
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

1

1q12
Summary This gene encodes a protein with a conserved RNA-binding motif. The protein is found predominantly in the nucleus, although it is also present in the cytoplasm. It is preferentially associated with mRNAs produced by splicing, including both nuclear mRNAs and newly exported cytoplasmic mRNAs. It is thought that the protein remains associated with spliced mRNAs as a tag to indicate where introns had been present, thus coupling pre- and post-mRNA splicing events. Previously, it was thought that two genes encode this protein, RBM8A and RBM8B; it is now thought that the RBM8B locus is a pseudogene. Two alternative start codons result in two forms of the protein, and this gene also uses multiple polyadenylation sites. [provided by RefSeq].
Disorder

MIM: 605313
mRNA NM_005105, 324120942
Protein NP_005096, 4826972
Product RNA-binding protein 8A
RefSeq Status REVIEWED
KEGG
hsa03013RNA transport
hsa03015mRNA surveillance pathway
hsa03040Spliceosome
Reactome
REACT_467mRNA Splicing - Major Pathway
REACT_1366RNA Polymerase II Transcription
REACT_894RNA Polymerase II Transcription Termination
REACT_1735mRNA Splicing
REACT_71Gene Expression
REACT_1675mRNA Processing
REACT_2039Formation and Maturation of mRNA Transcript
REACT_1788Transcription
REACT_1597Transport of Mature mRNA derived from an Intron-Containing Transcript
REACT_125Processing of Capped Intron-Containing Pre-mRNA
REACT_387Cleavage of Growing Transcript in the Termination Region
REACT_1281Transport of Mature Transcript to Cytoplasm
REACT_1849mRNA 3'-end processing
Homo sapiens (human)RBM8ANP_005096.1
Pan troglodytes (chimpanzee)RBM8AXP_514419.2
Canis lupus familiaris (dog)RBM8AXP_533035.1
Bos taurus (cattle)RBM8ANP_001030401.1
Mus musculus (house mouse)Rbm8aNP_080151.1
Rattus norvegicus (Norway rat)Rbm8aXP_215637.1
Danio rerio (zebrafish)rbm8aNP_001013363.1
Drosophila melanogaster (fruit fly)tsuNP_610454.2
Caenorhabditis elegansrnp-4NP_497891.1
Arabidopsis thaliana (thale cress)Y14NP_564591.1
Process
IDNameEvidence
GO:0000184nuclear-transcribed mRNA catabolic process, nonsense-mediated decayIMP
GO:0000398nuclear mRNA splicing, via spliceosomeIC
GO:0000398nuclear mRNA splicing, via spliceosomeTAS
GO:0006366transcription from RNA polymerase II promoterTAS
GO:0006369termination of RNA polymerase II transcriptionTAS
GO:0006406mRNA export from nucleusTAS
GO:0006417regulation of translationIEA
GO:0006810transportIEA
GO:0008380RNA splicingEXP
GO:0010467gene expressionTAS
GO:0031124mRNA 3'-end processingTAS
Component
IDNameEvidence
GO:0005634nucleusIDA
GO:0005634nucleusNAS
GO:0005654nucleoplasmTAS
GO:0005730nucleolusIDA
GO:0005737cytoplasmNAS
GO:0005829cytosolTAS
GO:0016607nuclear speckIEA
GO:0035145exon-exon junction complexIDA
GO:0071013catalytic step 2 spliceosomeIDA
Function
IDNameEvidence
GO:0000166nucleotide bindingIEA
GO:0003723RNA bindingNAS
GO:0003729mRNA bindingNAS
GO:0005515protein bindingIPI
GeneCards RBM8A
PDB 2XB2, 2J0S, 1P27, 2J0Q, 3EX7, 2HYI
UniProt Q9Y5S9
MIM 605313
Ensembl ENSG00000131795
HGNC 9905
HPRD 05609

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