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Sequence in raw or FASTA format:


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MED12 mediator complex subunit 12 [Homo sapiens (human)]

RefSeq Accession Definition Services Price Order
NM_005120 Homo sapiens mediator complex subunit 12 (MED12), mRNA. ORF Sequence $2940.30
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Gene Symbol MED12
Entrez Gene ID 9968
Full Name mediator complex subunit 12
Synonyms ARC240, CAGH45, FGS1, HOPA, KIAA0192, OKS, OPA1, TNRC11, TRAP230
Gene Type protein-coding
Organism Homo sapiens (human)



Summary The initiation of transcription is controlled in part by a large protein assembly known as the preinitiation complex. A component of this preinitiation complex is a 1.2 MDa protein aggregate called Mediator. This Mediator component binds with a CDK8 subcomplex which contains the protein encoded by this gene, mediator complex subunit 12 (MED12), along with MED13, CDK8 kinase, and cyclin C. The CDK8 subcomplex modulates Mediator-polymerase II interactions and thereby regulates transcription initiation and reinitation rates. The MED12 protein is essential for activating CDK8 kinase. Defects in this gene cause X-linked Opitz-Kaveggia syndrome, also known as FG syndrome, and Lujan-Fryns syndrome. [provided by RefSeq, Aug 2009].

MIM: 300188

Opitz-Kaveggia syndrome, 305450 (3); Lujan-Fryns syndrome, 309520 (3)

mRNA Protein Product Sequence Price Select
NM_005120, 110347428 NP_005111, 110347429 mediator of RNA polymerase II transcription subunit 12 Full Length $3143.25
ORF Sequence $2940.30
Pathway Interaction Database
wnt_beta_catenin_pathwayRegulation of Wnt-mediated beta catenin signaling and target gene transcription
REACT_22258Metabolism of lipids and lipoproteins
REACT_22279Fatty acid, triacylglycerol, and ketone body metabolism
REACT_116145PPARA Activates Gene Expression
REACT_111045Developmental Biology
REACT_27161Transcriptional Regulation of White Adipocyte Differentiation
REACT_71Gene Expression
REACT_12627Generic Transcription Pathway
REACT_19241Regulation of Lipid Metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
Homo sapiens (human)MED12NP_005111.2
Pan troglodytes (chimpanzee)MED12NP_001009019.1
Macaca mulatta (Rhesus monkey)MED12XP_001088424.2
Canis lupus familiaris (dog)LOC100855688XP_003640267.1
Bos taurus (cattle)MED12NP_001192807.1
Mus musculus (house mouse)Med12NP_067496.2
Rattus norvegicus (Norway rat)Med12XP_001054666.2
Gallus gallus (chicken)MED12XP_003641146.1
Danio rerio (zebrafish)med12NP_001034550.1
Caenorhabditis elegansdpy-22NP_509645.1
GeneCards MED12
UniProt Q93074
MIM 300188
Ensembl ENSG00000184634
HGNC 11957
HPRD 02176

GeneRIFs: Gene References Into Functions What's a GeneRIF?

General protein information

Preferred Names
mediator of RNA polymerase II transcription subunit 12
mediator of RNA polymerase II transcription subunit 12
CAG repeat protein 45
human opposite paired
OPA-containing protein
putative mediator subunit 12
activator-recruited cofactor 240 kDa component
trinucleotide repeat-containing gene 11 protein
thyroid hormone receptor-associated protein, 230 kDa subunit
mediator of RNA polymerase II transcription, subunit 12 homolog
thyroid hormone receptor-associated protein complex 230 kDa component
trinucleotide repeat containing 11 (THR-associated protein, 230 kDa subunit)


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