NR1I3 nuclear receptor subfamily 1, group I, member 3 [Homo sapiens (human)]
| Gene Symbol | NR1I3 |
| Entrez Gene ID | 9970 |
| Full Name | nuclear receptor subfamily 1, group I, member 3 |
| Synonyms | CAR, CAR1, MB67, MGC150433, MGC97144, MGC97209 |
| Gene Type | protein-coding |
| Organism | Homo sapiens (human) |
| Genome |
1 1q23.3 |
| Summary | This gene encodes a member of the nuclear receptor superfamily, and is a key regulator of xenobiotic and endobiotic metabolism. The protein binds to DNA as a monomer or a heterodimer with the retinoid X receptor and regulates the transcription of target genes involved in drug metabolism and bilirubin clearance, such as cytochrome P450 family members. Unlike most nuclear receptors, this transcriptional regulator is constitutively active in the absence of ligand but is regulated by both agonists and inverse agonists. Ligand binding results in translocation of this protein to the nucleus, where it activates or represses target gene transcription. These ligands include bilirubin, a variety of foreign compounds, steroid hormones, and prescription drugs. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq]. |
| Disorder | MIM: 603881 |
| mRNA | NM_001077480, 319039299 |
| Protein | NP_001070948, 117938752 |
| Product | nuclear receptor subfamily 1 group I member 3 isoform 2 |
| RefSeq Status | REVIEWED |
| mRNA | NM_001077481, 319039489 |
| Protein | NP_001070949, 117938754 |
| Product | nuclear receptor subfamily 1 group I member 3 isoform 4 |
| RefSeq Status | REVIEWED |
| mRNA | NM_001077482, 319043404 |
| Protein | NP_001070950, 117938756 |
| Product | nuclear receptor subfamily 1 group I member 3 isoform 1 |
| RefSeq Status | REVIEWED |
| mRNA | NM_001077478, 319060414 |
| Protein | NP_001070946, 117938746 |
| Product | nuclear receptor subfamily 1 group I member 3 isoform 7 |
| RefSeq Status | REVIEWED |
| mRNA | NM_001077469, 319063231 |
| Protein | NP_001070937, 117938729 |
| Product | nuclear receptor subfamily 1 group I member 3 isoform 6 |
| RefSeq Status | REVIEWED |
| mRNA | NM_005122, 319064507 |
| Protein | NP_005113, 4826661 |
| Product | nuclear receptor subfamily 1 group I member 3 isoform 3 |
| RefSeq Status | REVIEWED |
| mRNA | NM_001077471, 319067233 |
| Protein | NP_001070939, 117938734 |
| Product | nuclear receptor subfamily 1 group I member 3 isoform 5 |
| RefSeq Status | REVIEWED |
| mRNA | NM_001077472, 319068368 |
| Protein | NP_001070940, 117938736 |
| Product | nuclear receptor subfamily 1 group I member 3 isoform 9 |
| RefSeq Status | REVIEWED |
| mRNA | NM_001077473, 319047349 |
| Protein | NP_001070941, 117938738 |
| Product | nuclear receptor subfamily 1 group I member 3 isoform 12 |
| RefSeq Status | REVIEWED |
| mRNA | NM_001077474, 319051451 |
| Protein | NP_001070942, 117938740 |
| Product | nuclear receptor subfamily 1 group I member 3 isoform 8 |
| RefSeq Status | REVIEWED |
| mRNA | NM_001077475, 319057501 |
| Protein | NP_001070943, 117938742 |
| Product | nuclear receptor subfamily 1 group I member 3 isoform 15 |
| RefSeq Status | REVIEWED |
| mRNA | NM_001077476, 319059315 |
| Protein | NP_001070944, 117938744 |
| Product | nuclear receptor subfamily 1 group I member 3 isoform 13 |
| RefSeq Status | REVIEWED |
| mRNA | NM_001077477, 319059318 |
| Protein | NP_001070945, 117938748 |
| Product | nuclear receptor subfamily 1 group I member 3 isoform 14 |
| RefSeq Status | REVIEWED |
| mRNA | NM_001077479, 319061801 |
| Protein | NP_001070947, 117938750 |
| Product | nuclear receptor subfamily 1 group I member 3 isoform 10 |
| RefSeq Status | REVIEWED |
| mRNA | NM_001077470, 319065829 |
| Protein | NP_001070938, 117938732 |
| Product | nuclear receptor subfamily 1 group I member 3 isoform 11 |
| RefSeq Status | REVIEWED |
| WP170 | Nuclear Receptors |
| WP299 | Nuclear receptors in lipid metabolism and toxicity |
Pathway Interaction Database
| reg_gr_pathway | Glucocorticoid receptor regulatory network |
Reactome
| REACT_15525 | Nuclear Receptor transcription pathway |
| REACT_71 | Gene Expression |
| REACT_12627 | Generic Transcription Pathway |
| Homo sapiens (human) | NR1I3 | NP_005113.1 |
| Pan troglodytes (chimpanzee) | NR1I3 | XP_514444.2 |
| Canis lupus familiaris (dog) | NR1I3 | XP_545770.2 |
| Bos taurus (cattle) | NR1I3 | NP_001073236.1 |
| Mus musculus (house mouse) | Nr1i3 | NP_033933.2 |
| Rattus norvegicus (Norway rat) | Nr1i3 | NP_075230.1 |
| ID | Name | Evidence |
| GO:0006351 | transcription, DNA-dependent | TAS |
| GO:0006355 | regulation of transcription, DNA-dependent | IEA |
| GO:0007165 | signal transduction | TAS |
| GO:0010467 | gene expression | TAS |
| GO:0030521 | androgen receptor signaling pathway | TAS |
| GO:0034339 | regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor | TAS |
Component
| ID | Name | Evidence |
| GO:0005634 | nucleus | IEA |
| GO:0005654 | nucleoplasm | TAS |
Function
| ID | Name | Evidence |
| GO:0003677 | DNA binding | TAS |
| GO:0003700 | sequence-specific DNA binding transcription factor activity | IEA |
| GO:0003713 | transcription coactivator activity | TAS |
| GO:0004879 | ligand-dependent nuclear receptor activity | TAS |
| GO:0004882 | androgen receptor activity | TAS |
| GO:0004887 | thyroid hormone receptor activity | IEA |
| GO:0005515 | protein binding | IPI |
| GO:0008270 | zinc ion binding | IEA |
| GO:0043565 | sequence-specific DNA binding | IEA |
| GO:0046872 | metal ion binding | IEA |
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