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NR1I3 nuclear receptor subfamily 1, group I, member 3 [Homo sapiens (human)]


RefSeq Accession Definition Service Stock Status Price *Turnaround time Order
NM_001077469 Homo sapiens nuclear receptor subfamily 1, group I, member 3 (NR1I3), transcript variant 6, mRNA. GenEZ ORF Cloning On-demand $549.00 14
NM_001077470 Homo sapiens nuclear receptor subfamily 1, group I, member 3 (NR1I3), transcript variant 11, mRNA. GenEZ ORF Cloning On-demand $449.00 14
NM_001077471 Homo sapiens nuclear receptor subfamily 1, group I, member 3 (NR1I3), transcript variant 5, mRNA. GenEZ ORF Cloning On-demand $449.00 14
NM_001077472 Homo sapiens nuclear receptor subfamily 1, group I, member 3 (NR1I3), transcript variant 9, mRNA. GenEZ ORF Cloning On-demand $549.00 14
NM_001077473 Homo sapiens nuclear receptor subfamily 1, group I, member 3 (NR1I3), transcript variant 12, mRNA. GenEZ ORF Cloning On-demand $449.00 14
NM_001077474 Homo sapiens nuclear receptor subfamily 1, group I, member 3 (NR1I3), transcript variant 8, mRNA. GenEZ ORF Cloning On-demand $449.00 14
NM_001077475 Homo sapiens nuclear receptor subfamily 1, group I, member 3 (NR1I3), transcript variant 15, mRNA. GenEZ ORF Cloning On-demand $449.00 14
NM_001077476 Homo sapiens nuclear receptor subfamily 1, group I, member 3 (NR1I3), transcript variant 13, mRNA. GenEZ ORF Cloning On-demand $449.00 14
NM_001077477 Homo sapiens nuclear receptor subfamily 1, group I, member 3 (NR1I3), transcript variant 14, mRNA. GenEZ ORF Cloning On-demand $449.00 14
NM_001077478 Homo sapiens nuclear receptor subfamily 1, group I, member 3 (NR1I3), transcript variant 7, mRNA. GenEZ ORF Cloning On-demand $549.00 14
NM_001077479 Homo sapiens nuclear receptor subfamily 1, group I, member 3 (NR1I3), transcript variant 10, mRNA. GenEZ ORF Cloning On-demand $549.00 14
NM_001077480 Homo sapiens nuclear receptor subfamily 1, group I, member 3 (NR1I3), transcript variant 2, mRNA. GenEZ ORF Cloning On-demand $549.00 14
NM_001077481 Homo sapiens nuclear receptor subfamily 1, group I, member 3 (NR1I3), transcript variant 4, mRNA. GenEZ ORF Cloning On-demand $449.00 14
NM_001077482 Homo sapiens nuclear receptor subfamily 1, group I, member 3 (NR1I3), transcript variant 1, mRNA. GenEZ ORF Cloning On-demand $549.00 14
NM_005122 Homo sapiens nuclear receptor subfamily 1, group I, member 3 (NR1I3), transcript variant 3, mRNA. GenEZ ORF Cloning In-stock $418.00 $369.00 10

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Related Services

Gene Symbol NR1I3
Entrez Gene ID 9970
Full Name nuclear receptor subfamily 1, group I, member 3
Synonyms CAR, CAR1, MB67, MGC150433, MGC97144, MGC97209
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

1

1q23.3

Summary This gene encodes a member of the nuclear receptor superfamily, and is a key regulator of xenobiotic and endobiotic metabolism. The protein binds to DNA as a monomer or a heterodimer with the retinoid X receptor and regulates the transcription of target genes involved in drug metabolism and bilirubin clearance, such as cytochrome P450 family members. Unlike most nuclear receptors, this transcriptional regulator is constitutively active in the absence of ligand but is regulated by both agonists and inverse agonists. Ligand binding results in translocation of this protein to the nucleus, where it activates or represses target gene transcription. These ligands include bilirubin, a variety of foreign compounds, steroid hormones, and prescription drugs. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].
Disorder

MIM: 603881

mRNA Protein Product Sequence Price Select
NM_001077469, 319063231 NP_001070937, 117938729 nuclear receptor subfamily 1 group I member 3 isoform 6 ORF Sequence $400.00
NM_001077470, 319065829 NP_001070938, 117938732 nuclear receptor subfamily 1 group I member 3 isoform 11 ORF Sequence $300.00
NM_001077471, 319067233 NP_001070939, 117938734 nuclear receptor subfamily 1 group I member 3 isoform 5 ORF Sequence $300.00
NM_001077472, 319068368 NP_001070940, 117938736 nuclear receptor subfamily 1 group I member 3 isoform 9 ORF Sequence $400.00
NM_001077473, 319047349 NP_001070941, 117938738 nuclear receptor subfamily 1 group I member 3 isoform 12 ORF Sequence $300.00
NM_001077474, 319051451 NP_001070942, 117938740 nuclear receptor subfamily 1 group I member 3 isoform 8 ORF Sequence $300.00
NM_001077475, 319057501 NP_001070943, 117938742 nuclear receptor subfamily 1 group I member 3 isoform 15 ORF Sequence $300.00
NM_001077476, 319059315 NP_001070944, 117938744 nuclear receptor subfamily 1 group I member 3 isoform 13 ORF Sequence $300.00
NM_001077477, 319059318 NP_001070945, 117938748 nuclear receptor subfamily 1 group I member 3 isoform 14 ORF Sequence $300.00
NM_001077478, 319060414 NP_001070946, 117938746 nuclear receptor subfamily 1 group I member 3 isoform 7 ORF Sequence $400.00
NM_001077479, 319061801 NP_001070947, 117938750 nuclear receptor subfamily 1 group I member 3 isoform 10 ORF Sequence $400.00
NM_001077480, 319039299 NP_001070948, 117938752 nuclear receptor subfamily 1 group I member 3 isoform 2 ORF Sequence $400.00
NM_001077481, 319039489 NP_001070949, 117938754 nuclear receptor subfamily 1 group I member 3 isoform 4 ORF Sequence $300.00
NM_001077482, 319043404 NP_001070950, 117938756 nuclear receptor subfamily 1 group I member 3 isoform 1 ORF Sequence $400.00
NM_005122, 319064507 NP_005113, 4826661 nuclear receptor subfamily 1 group I member 3 isoform 3 ORF Sequence $269.00
Pathway Interaction Database
reg_gr_pathwayGlucocorticoid receptor regulatory network
WikiPathways
WP299Nuclear receptors in lipid metabolism and toxicity
WP2289Drug Induction of Bile Acid Pathway
WP170Nuclear Receptors
Reactome
REACT_12627Generic Transcription Pathway
REACT_15525Nuclear Receptor transcription pathway
REACT_71Gene Expression
Homo sapiens (human)NR1I3NP_001070950.1
Pan troglodytes (chimpanzee)NR1I3NP_001129087.1
Macaca mulatta (Rhesus monkey)NR1I3NP_001028068.1
Canis lupus familiaris (dog)NR1I3XP_545770.3
Bos taurus (cattle)NR1I3NP_001073236.1
Mus musculus (house mouse)Nr1i3NP_001229992.1
Rattus norvegicus (Norway rat)Nr1i3NP_075230.1
Gallus gallus (chicken)NR1I3NP_990033.1
GeneCards NR1I3
PDB 1XV9, 1XVP
UniProt Q6GZ79, E9PC13, E9PHC8, E9PDU3, Q14994, Q6GZ89, Q6GZ76, E9PB75, Q6GZ82
MIM 603881
Ensembl ENSG00000143257
HGNC 7969
HPRD 04858

GeneRIFs: Gene References Into Functions What's a GeneRIF?

General protein information

Preferred Names
nuclear receptor subfamily 1 group I member 3
Names
nuclear receptor subfamily 1 group I member 3
constitutive active receptor
constitutive active response
orphan nuclear receptor MB67
orphan nuclear hormone receptor
constitutive androstane receptor
constitutive activator of retinoid response
constitutive androstane nuclear receptor variant 2
constitutive androstane nuclear receptor variant 3
constitutive androstane nuclear receptor variant 4
constitutive androstane nuclear receptor variant 5

Interactant



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