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Sequence in raw or FASTA format:

Database:

Blast Method:

 
 


NR1I3 nuclear receptor subfamily 1, group I, member 3 [Homo sapiens (human)]


Clone ID RefSeq Accession Definition Vector Stock Status *Turnaround time Price Order
OHu09315 NM_005122 Homo sapiens nuclear receptor subfamily 1, group I, member 3 (NR1I3), transcript variant 3, mRNA. pcDNA3.1+-DYK In-stock 5-7 $99.00
OHu09332 NM_001077471 Homo sapiens nuclear receptor subfamily 1, group I, member 3 (NR1I3), transcript variant 5, mRNA. pcDNA3.1+-DYK On-demand 7-9 $159.00
OHu09388 NM_001077476 Homo sapiens nuclear receptor subfamily 1, group I, member 3 (NR1I3), transcript variant 13, mRNA. pcDNA3.1+-DYK On-demand 7-9 $159.00
OHu09423 NM_001077472 Homo sapiens nuclear receptor subfamily 1, group I, member 3 (NR1I3), transcript variant 9, mRNA. pcDNA3.1+-DYK On-demand 7-9 $159.00
OHu09441 NM_001077475 Homo sapiens nuclear receptor subfamily 1, group I, member 3 (NR1I3), transcript variant 15, mRNA. pcDNA3.1+-DYK On-demand 7-9 $159.00
OHu09461 NM_001077473 Homo sapiens nuclear receptor subfamily 1, group I, member 3 (NR1I3), transcript variant 12, mRNA. pcDNA3.1+-DYK On-demand 7-9 $159.00
OHu09464 NM_001077477 Homo sapiens nuclear receptor subfamily 1, group I, member 3 (NR1I3), transcript variant 14, mRNA. pcDNA3.1+-DYK On-demand 7-9 $159.00
OHu09474 NM_001077470 Homo sapiens nuclear receptor subfamily 1, group I, member 3 (NR1I3), transcript variant 11, mRNA. pcDNA3.1+-DYK On-demand 7-9 $159.00
OHu09477 NM_001077478 Homo sapiens nuclear receptor subfamily 1, group I, member 3 (NR1I3), transcript variant 7, mRNA. pcDNA3.1+-DYK On-demand 7-9 $219.00
OHu09511 NM_001077474 Homo sapiens nuclear receptor subfamily 1, group I, member 3 (NR1I3), transcript variant 8, mRNA. pcDNA3.1+-DYK On-demand 7-9 $159.00
OHu09517 NM_001077469 Homo sapiens nuclear receptor subfamily 1, group I, member 3 (NR1I3), transcript variant 6, mRNA. pcDNA3.1+-DYK On-demand 7-9 $219.00
OHu09520 NM_001077479 Homo sapiens nuclear receptor subfamily 1, group I, member 3 (NR1I3), transcript variant 10, mRNA. pcDNA3.1+-DYK On-demand 7-9 $159.00
OHu10438 NM_001077480 Homo sapiens nuclear receptor subfamily 1, group I, member 3 (NR1I3), transcript variant 2, mRNA. pcDNA3.1+-DYK On-demand 7-9 $219.00
OHu12022 NM_001077481 Homo sapiens nuclear receptor subfamily 1, group I, member 3 (NR1I3), transcript variant 4, mRNA. pcDNA3.1+-DYK On-demand 7-9 $159.00
OHu18640 NM_001077482 Homo sapiens nuclear receptor subfamily 1, group I, member 3 (NR1I3), transcript variant 1, mRNA. pcDNA3.1+-DYK On-demand 7-9 $219.00
OHu34912 XM_005245693 PREDICTED: Homo sapiens nuclear receptor subfamily 1, group I, member 3 (NR1I3), transcript variant X1, mRNA. pcDNA3.1+-DYK On-demand 7-9 $219.00
OHu34913 XM_005245694 PREDICTED: Homo sapiens nuclear receptor subfamily 1, group I, member 3 (NR1I3), transcript variant X2, mRNA. pcDNA3.1+-DYK On-demand 7-9 $219.00
OHu34914 XM_005245697 PREDICTED: Homo sapiens nuclear receptor subfamily 1, group I, member 3 (NR1I3), transcript variant X5, mRNA. pcDNA3.1+-DYK On-demand 7-9 $219.00
OHu34915 XM_006711696 PREDICTED: Homo sapiens nuclear receptor subfamily 1, group I, member 3 (NR1I3), transcript variant X6, mRNA. pcDNA3.1+-DYK On-demand 7-9 $159.00
OHu09315C NM_005122 Homo sapiens nuclear receptor subfamily 1, group I, member 3 (NR1I3), transcript variant 3, mRNA. Customized vector In-stock 5-7 $149.00
OHu09332C NM_001077471 Homo sapiens nuclear receptor subfamily 1, group I, member 3 (NR1I3), transcript variant 5, mRNA. Customized vector On-demand 7-9 $209.00
OHu09388C NM_001077476 Homo sapiens nuclear receptor subfamily 1, group I, member 3 (NR1I3), transcript variant 13, mRNA. Customized vector On-demand 7-9 $209.00
OHu09423C NM_001077472 Homo sapiens nuclear receptor subfamily 1, group I, member 3 (NR1I3), transcript variant 9, mRNA. Customized vector On-demand 7-9 $209.00
OHu09441C NM_001077475 Homo sapiens nuclear receptor subfamily 1, group I, member 3 (NR1I3), transcript variant 15, mRNA. Customized vector On-demand 7-9 $209.00
OHu09461C NM_001077473 Homo sapiens nuclear receptor subfamily 1, group I, member 3 (NR1I3), transcript variant 12, mRNA. Customized vector On-demand 7-9 $209.00
OHu09464C NM_001077477 Homo sapiens nuclear receptor subfamily 1, group I, member 3 (NR1I3), transcript variant 14, mRNA. Customized vector On-demand 7-9 $209.00
OHu09474C NM_001077470 Homo sapiens nuclear receptor subfamily 1, group I, member 3 (NR1I3), transcript variant 11, mRNA. Customized vector On-demand 7-9 $209.00
OHu09477C NM_001077478 Homo sapiens nuclear receptor subfamily 1, group I, member 3 (NR1I3), transcript variant 7, mRNA. Customized vector On-demand 7-9 $269.00
OHu09511C NM_001077474 Homo sapiens nuclear receptor subfamily 1, group I, member 3 (NR1I3), transcript variant 8, mRNA. Customized vector On-demand 7-9 $209.00
OHu09517C NM_001077469 Homo sapiens nuclear receptor subfamily 1, group I, member 3 (NR1I3), transcript variant 6, mRNA. Customized vector On-demand 7-9 $269.00
OHu09520C NM_001077479 Homo sapiens nuclear receptor subfamily 1, group I, member 3 (NR1I3), transcript variant 10, mRNA. Customized vector On-demand 7-9 $209.00
OHu10438C NM_001077480 Homo sapiens nuclear receptor subfamily 1, group I, member 3 (NR1I3), transcript variant 2, mRNA. Customized vector On-demand 7-9 $269.00
OHu12022C NM_001077481 Homo sapiens nuclear receptor subfamily 1, group I, member 3 (NR1I3), transcript variant 4, mRNA. Customized vector On-demand 7-9 $209.00
OHu18640C NM_001077482 Homo sapiens nuclear receptor subfamily 1, group I, member 3 (NR1I3), transcript variant 1, mRNA. Customized vector On-demand 7-9 $269.00
OHu34912C XM_005245693 PREDICTED: Homo sapiens nuclear receptor subfamily 1, group I, member 3 (NR1I3), transcript variant X1, mRNA. Customized vector On-demand 7-9 $269.00
OHu34913C XM_005245694 PREDICTED: Homo sapiens nuclear receptor subfamily 1, group I, member 3 (NR1I3), transcript variant X2, mRNA. Customized vector On-demand 7-9 $269.00
OHu34914C XM_005245697 PREDICTED: Homo sapiens nuclear receptor subfamily 1, group I, member 3 (NR1I3), transcript variant X5, mRNA. Customized vector On-demand 7-9 $269.00
OHu34915C XM_006711696 PREDICTED: Homo sapiens nuclear receptor subfamily 1, group I, member 3 (NR1I3), transcript variant X6, mRNA. Customized vector On-demand 7-9 $209.00

*Business Day

Related Services

Gene Symbol NR1I3
Entrez Gene ID 9970
Full Name nuclear receptor subfamily 1, group I, member 3
Synonyms CAR, CAR1, MB67
General protein information
Preferred Names
nuclear receptor subfamily 1 group I member 3
Names
nuclear receptor subfamily 1 group I member 3
constitutive active receptor
constitutive active response
orphan nuclear receptor MB67
orphan nuclear hormone receptor
constitutive androstane receptor
constitutive activator of retinoid response
constitutive androstane nuclear receptor variant 2
constitutive androstane nuclear receptor variant 3
constitutive androstane nuclear receptor variant 4
constitutive androstane nuclear receptor variant 5
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

1

1q23.3

Summary This gene encodes a member of the nuclear receptor superfamily, and is a key regulator of xenobiotic and endobiotic metabolism. The protein binds to DNA as a monomer or a heterodimer with the retinoid X receptor and regulates the transcription of target genes involved in drug metabolism and bilirubin clearance, such as cytochrome P450 family members. Unlike most nuclear receptors, this transcriptional regulator is constitutively active in the absence of ligand but is regulated by both agonists and inverse agonists. Ligand binding results in translocation of this protein to the nucleus, where it activates or represses target gene transcription. These ligands include bilirubin, a variety of foreign compounds, steroid hormones, and prescription drugs. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].
Disorder

MIM: 603881

mRNA Protein Product Sequence Price Select
NM_001077469, 319063231 NP_001070937, 117938729 nuclear receptor subfamily 1 group I member 3 isoform 6 ORF Sequence $400.00
NM_001077470, 319065829 NP_001070938, 117938732 nuclear receptor subfamily 1 group I member 3 isoform 11 ORF Sequence $300.00
NM_001077471, 319067233 NP_001070939, 117938734 nuclear receptor subfamily 1 group I member 3 isoform 5 ORF Sequence $300.00
NM_001077472, 319068368 NP_001070940, 117938736 nuclear receptor subfamily 1 group I member 3 isoform 9 ORF Sequence $400.00
NM_001077473, 319047349 NP_001070941, 117938738 nuclear receptor subfamily 1 group I member 3 isoform 12 ORF Sequence $300.00
NM_001077474, 319051451 NP_001070942, 117938740 nuclear receptor subfamily 1 group I member 3 isoform 8 ORF Sequence $300.00
NM_001077475, 319057501 NP_001070943, 117938742 nuclear receptor subfamily 1 group I member 3 isoform 15 ORF Sequence $300.00
NM_001077476, 319059315 NP_001070944, 117938744 nuclear receptor subfamily 1 group I member 3 isoform 13 ORF Sequence $300.00
NM_001077477, 319059318 NP_001070945, 117938748 nuclear receptor subfamily 1 group I member 3 isoform 14 ORF Sequence $300.00
NM_001077478, 319060414 NP_001070946, 117938746 nuclear receptor subfamily 1 group I member 3 isoform 7 ORF Sequence $400.00
NM_001077479, 319061801 NP_001070947, 117938750 nuclear receptor subfamily 1 group I member 3 isoform 10 ORF Sequence $400.00
NM_001077480, 319039299 NP_001070948, 117938752 nuclear receptor subfamily 1 group I member 3 isoform 2 ORF Sequence $400.00
NM_001077481, 319039489 NP_001070949, 117938754 nuclear receptor subfamily 1 group I member 3 isoform 4 ORF Sequence $300.00
NM_001077482, 319043404 NP_001070950, 117938756 nuclear receptor subfamily 1 group I member 3 isoform 1 ORF Sequence $400.00
NM_005122, 319064507 NP_005113, 4826661 nuclear receptor subfamily 1 group I member 3 isoform 3 ORF Sequence $269.00
XM_005245693, 578801883 XP_005245750, 530365804 nuclear receptor subfamily 1 group I member 3 isoform X1 ORF Sequence $550.00
XM_005245694, 578801884 XP_005245751, 530365806 nuclear receptor subfamily 1 group I member 3 isoform X2 ORF Sequence $550.00
XM_005245697, 578801885 XP_005245754, 530365812 nuclear receptor subfamily 1 group I member 3 isoform X5 ORF Sequence $400.00
XM_006711696, 578801886 XP_006711759, 578801887 nuclear receptor subfamily 1 group I member 3 isoform X6 ORF Sequence $250.00
WikiPathways
WP170Nuclear Receptors
WP299Nuclear receptors in lipid metabolism and toxicity
WP2289Drug Induction of Bile Acid Pathway
Pathway Interaction Database
reg_gr_pathwayGlucocorticoid receptor regulatory network
Reactome
REACT_12627Generic Transcription Pathway
REACT_71Gene Expression
REACT_15525Nuclear Receptor transcription pathway
Homo sapiens (human)NR1I3NP_001070950.1
Pan troglodytes (chimpanzee)NR1I3NP_001129087.1
Macaca mulatta (Rhesus monkey)NR1I3NP_001028068.1
Canis lupus familiaris (dog)NR1I3XP_003434366.1
Bos taurus (cattle)NR1I3NP_001073236.1
Mus musculus (house mouse)Nr1i3NP_033933.2
Rattus norvegicus (Norway rat)Nr1i3NP_075230.1
Gallus gallus (chicken)NR1I3NP_990033.1
Process
IDNameEvidence
GO:0006367transcription initiation from RNA polymerase II promoterTAS
GO:0007165signal transductionTAS
GO:0010467gene expressionTAS
GO:0030521androgen receptor signaling pathwayTAS
GO:0030522intracellular receptor signaling pathwayTAS
GO:0043401steroid hormone mediated signaling pathwayIEA
GO:0045892negative regulation of transcription, DNA-templatedIEA
GO:0045944positive regulation of transcription from RNA polymerase II promoterIDA
Component
IDNameEvidence
GO:0005634nucleusIDA
GO:0005634nucleusISS
GO:0005654nucleoplasmTAS
GO:0005730nucleolusIDA
GO:0005737cytoplasmISS
GO:0005829cytosolIEA
GO:0005856cytoskeletonIEA
Function
IDNameEvidence
GO:0000977RNA polymerase II regulatory region sequence-specific DNA bindingIDA
GO:0001228RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcriptionIDA
GO:0003677DNA bindingTAS
GO:0003700sequence-specific DNA binding transcription factor activityTAS
GO:0003713transcription coactivator activityTAS
GO:0004879ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activityTAS
GO:0004882androgen receptor activityTAS
GO:0004887thyroid hormone receptor activityIEA
GO:0008270zinc ion bindingIEA
GeneCards NR1I3
UniProt Q14994, F1DAL4
Vega OTTHUMG00000034347
MIM 603881
Ensembl ENSG00000143257
HGNC 7969
HPRD 04858

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Interactant

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