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Homo sapiens apolipoprotein E (APOE), mRNA.


Clone ID Definition Vector Stock Status Price *Turnaround time Order
OHu27296 Homo sapiens apolipoprotein E (APOE), mRNA. pcDNA3.1+-DYK In-stock $99.00 5-7
OHu27296C Homo sapiens apolipoprotein E (APOE), mRNA. Customized vector In-stock $149.00 5-7

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Sequence Information ORF Nucleotide Sequence
Protein sequence
Vector pcDNA3.1+-DYK or customized vector
Clone information Clone Map
Tag on pcDNA3.1+-DYK N terminal DYKDDDK tags
ORF Insert Method CloneEZ® Seamless cloning technology
RefSeq Version NM_000041.2, 48762938
Length 954 bp
Structure linear
Update Date 25-MAY-2014
Organism Homo sapiens (human)
Definition Homo sapiens apolipoprotein E (APOE), mRNA.
Product apolipoprotein E precursor
Comment

Summary: Chylomicron remnants and very low density lipoprotein (VLDL) remnants are rapidly removed from the circulation by receptor-mediated endocytosis in the liver. Apolipoprotein E, a main apoprotein of the chylomicron, binds to a specific receptor on liver cells and peripheral cells. ApoE is essential for the normal catabolism of triglyceride-rich lipoprotein constituents. The APOE gene is mapped to chromosome 19 in a cluster with APOC1 and APOC2. Defects in apolipoprotein E result in familial dysbetalipoproteinemia, or type III hyperlipoproteinemia (HLP III), in which increased plasma cholesterol and triglycerides are the consequence of impaired clearance of chylomicron and VLDL remnants. [provided by RefSeq, Jul 2008].

RefSeq NP_000032.1
CDS 84..1037
Misc Feature(1)9..11
Misc Feature(2)9..11
Misc Feature(3)321..848
Misc Feature(4)360..362
Misc Feature(5)393..980
Misc Feature(6)555..587
Misc Feature(7)567..578
Misc Feature(8)717..719
Misc Feature(9)768..791
Misc Feature(10)939..941
Misc Feature(11)951..953
Exon (1)1..60
Gene:APOE
Gene Synonym:AD2; LDLCQ5; LPG
Exon (2)61..126
Gene:APOE
Gene Synonym:AD2; LDLCQ5; LPG
Exon (3)127..319
Gene:APOE
Gene Synonym:AD2; LDLCQ5; LPG
Exon (4)320..1180
Gene:APOE
Gene Synonym:AD2; LDLCQ5; LPG
Translation MKVLWAALLVTFLAGCQAKVEQAVETEPEPELRQQTEWQSGQRWELALGRFWDYLRWVQT LSEQVQEELLSSQVTQELRALMDETMKELKAYKSELEEQLTPVAEETRARLSKELQAAQA RLGADMEDVCGRLVQYRGEVQAMLGQSTEELRVRLASHLRKLRKRLLRDADDLQKRLAVY QAGAREGAERGLSAIRERLGPLVEQGRVRAATVGSLAGQPLQERAQAWGERLRARMEEMG SRTRDRLDEVKEQVAEVRAKLEEQAQQIRLQAEAFQARLKSWFEPLVEDMQRQWAGLVEK VQAAVGTSAAPVPSDNH
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Position Chain Variation Link
52+c, tdbSNP:72654467
104+c, gdbSNP:373321868
114+a, tdbSNP:144354013
138+dbSNP:
138+a, gdbSNP:11542036
144+a, gdbSNP:121918392
152+a, gdbSNP:111833428
167+a, gdbSNP:150688032
173+c, gdbSNP:370227413
174+a, gdbSNP:201672011
192+a, gdbSNP:142480126
203+c, tdbSNP:373020952
210+c, tdbSNP:121918399
211+a, gdbSNP:371694216
220+c, tdbSNP:769452
231+c, tdbSNP:11542029
233+c, tdbSNP:11542031
248+c, gdbSNP:376607258
261+a, gdbSNP:28931576
263+a, gdbSNP:11542038
266+g, tdbSNP:200125743
275+c, gdbSNP:370594287
288+c, tdbSNP:139948786
349+c, tdbSNP:368210726
362+a, gdbSNP:371331933
383+a, gdbSNP:267605543
387+a, cdbSNP:11542040
388+a, c, g, tdbSNP:11083750
389+a, gdbSNP:368495194
419+a, cdbSNP:11542033
428+a, gdbSNP:141549454
432+a, gdbSNP:28931577
433+c, tdbSNP:372938213
444+a, cdbSNP:11542037
471+c, tdbSNP:429358
477+a, cdbSNP:11542041
493+a, gdbSNP:11542035
499+a, tdbSNP:41382345
509+a, cdbSNP:11542039
517+a, gdbSNP:267606664
518..519+, gaggtgcaggccatgctcggcdbSNP:397514254
532+a, gdbSNP:11542034
538+a, gdbSNP:28931578
543+a, cdbSNP:121918393
544+c, gdbSNP:200703101
561+c, tdbSNP:387906567
570+c, tdbSNP:769455
571+a, c, gdbSNP:121918397
573+a, c, gdbSNP:121918394
586+a, gdbSNP:376170967
591+c, gdbSNP:267606662
609+c, tdbSNP:7412
648+a, gdbSNP:11542032
697+a, gdbSNP:11542030
727+c, tdbSNP:11542027
734+c, tdbSNP:72654468
766+a, gdbSNP:121918396
807+c, gdbSNP:387906568
808+a, gdbSNP:267606663
819+c, tdbSNP:121918395
844+a, tdbSNP:199768005
867+a, gdbSNP:140808909
870+a, gdbSNP:190853081
888+c, gdbSNP:267606661
909+c, tdbSNP:371110159
950+c, tdbSNP:77903069
958+a, gdbSNP:121918398
1023+a, cdbSNP:28931579
1057+g, tdbSNP:201463764
1062+c, tdbSNP:374329439
1064+c, tdbSNP:367866106
1076+a, gdbSNP:372055776
Gene SymbolAPOE
Gene SynonymAD2; LDLCQ5; LPG
Chromosome19
Locus Map19q13.2
Title Apolipoprotein E gene polymorphisms as risk factors for carotid atherosclerosis .
Author Zurnic,I., Djuric,T., Koncar,I., Stankovic,A., Dincic,D. and Zivkovic,M.
Journal Vojnosanit Pregl 71 (4), 362-367 (2014)
Title Mapping the effect of the apolipoprotein E genotype on 4-year atrophy rates in an Alzheimer disease-related brain network .
Author Hostage CA, Choudhury KR, Murali Doraiswamy P and Petrella JR.
Journal Radiology 271 (1), 211-219 (2014)
Title Elevated serum pesticide levels and risk for Alzheimer disease .
Author Richardson JR, Roy A, Shalat SL, von Stein RT, Hossain MM, Buckley B, Gearing M, Levey AI and German DC.
Journal JAMA Neurol 71 (3), 284-290 (2014)
Title [The effect of prolactin and apolipoprotein E gene polymorphism on cognitive functions of menopausal women] .
Author Bojar,I., Raczkiewicz,D., Wdowiak,A. and Owoc,A.
Journal Ginekol. Pol. 85 (2), 131-139 (2014)
Title Cognitive functions, apolipoprotein E genotype and hormonal replacement therapy of postmenopausal women .
Author Bojar I, Gujski M, Raczkiewicz D and Rothenberg KG.
Journal Neuro Endocrinol. Lett. 34 (7), 635-642 (2013)
Title Alzheimer Disease Overview .
Author Bird,T.D.
Journal (in) Pagon RA, Adam MP, Ardinger HH, Bird TD, Dolan CR, Fong CT, Smith RJH and Stephens K (Eds.); GENEREVIEWS(R); (1993)
Title Apolipoprotein E1 Lys-146----Glu with type III hyperlipoproteinemia .
Author Moriyama K, Sasaki J, Matsunaga A, Arakawa F, Takada Y, Araki K, Kaneko S and Arakawa K.
Journal Biochim. Biophys. Acta 1128 (1), 58-64 (1992)
Title Polymorphism of apolipoprotein E. III. Effect of a single polymorphic gene locus on plasma lipid levels in man .
Author Utermann,G., Pruin,N. and Steinmetz,A.
Journal Clin. Genet. 15 (1), 63-72 (1979)
Title Apoprotein (E--A-II) complex of human plasma lipoproteins. II. Receptor binding activity of a high density lipoprotein subfraction modulated by the apo(E--A-II) complex .
Author Innerarity,T.L., Mahley,R.W., Weisgraber,K.H. and Bersot,T.P.
Journal J. Biol. Chem. 253 (17), 6289-6295 (1978)
Title Apoprotein (E--A-II) complex of human plasma lipoproteins. I. Characterization of this mixed disulfide and its identification in a high density lipoprotein subfraction .
Author Weisgraber,K.H. and Mahley,R.W.
Journal J. Biol. Chem. 253 (17), 6281-6288 (1978)

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