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Homo sapiens apolipoprotein E (APOE), mRNA.


RefSeq Accession Definition Service Stock Status Price *Turnaround time Order
NM_000041 Homo sapiens apolipoprotein E (APOE), mRNA. GenEZ ORF Cloning In-stock $418.00 $369.00 TBD

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RefSeq Version NM_000041.2, 48762938
Length 1223 bp
Structure linear
Update Date 29-APR-2013
Organism Homo sapiens (human)
Definition Homo sapiens apolipoprotein E (APOE), mRNA.
Product apolipoprotein E precursor
Comment

Summary: Chylomicron remnants and very low density lipoprotein (VLDL) remnants are rapidly removed from the circulation by receptor-mediated endocytosis in the liver. Apolipoprotein E, a main apoprotein of the chylomicron, binds to a specific receptor on liver cells and peripheral cells. ApoE is essential for the normal catabolism of triglyceride-rich lipoprotein constituents. The APOE gene is mapped to chromosome 19 in a cluster with APOC1 and APOC2. Defects in apolipoprotein E result in familial dysbetalipoproteinemia, or type III hyperlipoproteinemia (HLP III), in which increased plasma cholesterol and triglycerides are the consequence of impaired clearance of chylomicron and VLDL remnants. [provided by RefSeq, Jul 2008].

RefSeq NP_000032.1
CDS 84..1037
Misc Feature(1)9..11
Misc Feature(2)9..11
Misc Feature(3)321..980
Misc Feature(4)321..848
Misc Feature(5)360..362
Misc Feature(6)555..587
Misc Feature(7)567..578
Misc Feature(8)717..719
Misc Feature(9)768..791
Misc Feature(10)939..941
Misc Feature(11)951..953
Exon (1)1..60
Gene:APOE
Gene Synonym:AD2; LDLCQ5; LPG
Exon (2)61..126
Gene:APOE
Gene Synonym:AD2; LDLCQ5; LPG
Exon (3)127..319
Gene:APOE
Gene Synonym:AD2; LDLCQ5; LPG
Exon (4)320..1180
Gene:APOE
Gene Synonym:AD2; LDLCQ5; LPG
Translation MKVLWAALLVTFLAGCQAKVEQAVETEPEPELRQQTEWQSGQRWELALGRFWDYLRWVQT LSEQVQEELLSSQVTQELRALMDETMKELKAYKSELEEQLTPVAEETRARLSKELQAAQA RLGADMEDVCGRLVQYRGEVQAMLGQSTEELRVRLASHLRKLRKRLLRDADDLQKRLAVY QAGAREGAERGLSAIRERLGPLVEQGRVRAATVGSLAGQPLQERAQAWGERLRARMEEMG SRTRDRLDEVKEQVAEVRAKLEEQAQQIRLQAEAFQARLKSWFEPLVEDMQRQWAGLVEK VQAAVGTSAAPVPSDNH
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Position Chain Variation Link
52+c, tdbSNP:72654467
114+a, g, tdbSNP:144354013
138+dbSNP:
138+a, gdbSNP:11542036
144+a, gdbSNP:121918392
152+a, gdbSNP:111833428
167+a, gdbSNP:150688032
174+a, gdbSNP:201672011
192+a, gdbSNP:142480126
210+c, tdbSNP:121918399
220+c, tdbSNP:769452
231+c, tdbSNP:11542029
233+c, tdbSNP:11542031
261+a, gdbSNP:28931576
263+a, gdbSNP:11542038
266+g, tdbSNP:200125743
288+c, tdbSNP:139948786
387+a, cdbSNP:11542040
388+a, c, gdbSNP:11083750
419+a, cdbSNP:11542033
428+a, gdbSNP:141549454
432+a, gdbSNP:28931577
444+a, cdbSNP:11542037
471+c, tdbSNP:429358
477+a, cdbSNP:11542041
493+a, gdbSNP:11542035
499+a, tdbSNP:41382345
509+a, cdbSNP:11542039
517+a, gdbSNP:267606664
532+a, gdbSNP:11542034
538+a, gdbSNP:28931578
543+a, cdbSNP:121918393
544+c, gdbSNP:200703101
570+c, tdbSNP:769455
571+a, c, gdbSNP:121918397
573+a, c, gdbSNP:121918394
591+c, gdbSNP:267606662
609+c, tdbSNP:7412
648+a, gdbSNP:11542032
697+a, gdbSNP:11542030
727+c, tdbSNP:11542027
734+c, tdbSNP:72654468
766+a, gdbSNP:121918396
808+a, gdbSNP:267606663
819+c, tdbSNP:121918395
844+a, tdbSNP:199768005
867+a, gdbSNP:140808909
870+a, gdbSNP:190853081
888+c, gdbSNP:267606661
950+c, tdbSNP:77903069
958+a, gdbSNP:121918398
1023+a, cdbSNP:28931579
1057+g, tdbSNP:201463764
Gene SymbolAPOE
Gene SynonymAD2; LDLCQ5; LPG
Chromosome19
Locus Map19q13.2
All Transcripts
RefSeq Accession Definition Stock Status Price Turnaround time Business Day Select
NM_000041 Homo sapiens apolipoprotein E (APOE), mRNA. In-stock $418.00 $369.00 TBD
Title Variants in the ATP-binding cassette transporter (ABCA7), apolipoprotein E 4,and the risk of late-onset Alzheimer disease in African Americans .
Author Reitz,C., Jun,G., Naj,A., Rajbhandary,R., Vardarajan,B.N., Wang,L.S., Valladares,O., Lin,C.F., Larson,E.B., Graff-Radford,N.R., Evans,D., De Jager,P.L., Crane,P.K., Buxbaum,J.D., Murrell,J.R., Raj,T., Ertekin-Taner,N., Logue,M., Baldwin,C.T., Green,R.C., Barnes,L.L., Cantwell,L.B., Fallin,M.D., Go,R.C., Griffith,P., Obisesan,T.O., Manly,J.J., Lunetta,K.L., Kamboh,M.I., Lopez,O.L., Bennett,D.A., Hendrie,H., Hall,K.S., Goate,A.M., Byrd,G.S., Kukull,W.A., Foroud,T.M., Haines,J.L., Farrer,L.A., Pericak-Vance,M.A., Schellenberg,G.D. and Mayeux,R.
Journal JAMA 309 (14), 1483-1492 (2013)
Title Levels of soluble apolipoprotein E/amyloid-beta (Abeta) complex are reduced and oligomeric Abeta increased with APOE4 and Alzheimer disease in a transgenic mouse model and human samples .
Author Tai,L.M., Bilousova,T., Jungbauer,L., Roeske,S.K., Youmans,K.L., Yu,C., Poon,W.W., Cornwell,L.B., Miller,C.A., Vinters,H.V., Van Eldik,L.J., Fardo,D.W., Estus,S., Bu,G., Gylys,K.H. and Ladu,M.J.
Journal J. Biol. Chem. 288 (8), 5914-5926 (2013)
Title APOE epsilon4 increases risk for dementia in pure synucleinopathies .
Author Tsuang,D., Leverenz,J.B., Lopez,O.L., Hamilton,R.L., Bennett,D.A., Schneider,J.A., Buchman,A.S., Larson,E.B., Crane,P.K., Kaye,J.A., Kramer,P., Woltjer,R., Trojanowski,J.Q., Weintraub,D., Chen-Plotkin,A.S., Irwin,D.J., Rick,J., Schellenberg,G.D., Watson,G.S., Kukull,W., Nelson,P.T., Jicha,G.A., Neltner,J.H., Galasko,D., Masliah,E., Quinn,J.F., Chung,K.A., Yearout,D., Mata,I.F., Wan,J.Y., Edwards,K.L., Montine,T.J. and Zabetian,C.P.
Journal JAMA Neurol 70 (2), 223-228 (2013)
Title Differential effect of APOE genotype on amyloid load and glucose metabolism in AD dementia .
Author Ossenkoppele,R., van der Flier,W.M., Zwan,M.D., Adriaanse,S.F., Boellaard,R., Windhorst,A.D., Barkhof,F., Lammertsma,A.A., Scheltens,P. and van Berckel,B.N.
Journal Neurology 80 (4), 359-365 (2013)
Title [CCR5, CCR2, apoe, p53, ITGB3 and HFE gene polymorphism in Western Siberia long-livers] .
Author Ivanoshchuk,D.E., Mikhailova,S.V., Kulikov,I.V., Maksimov,V.N., Voevoda,M.I. and Romashchenko,A.G.
Journal Adv Gerontol 25 (3), 394-397 (2012)
Title Apolipoprotein E1 Lys-146----Glu with type III hyperlipoproteinemia .
Author Moriyama,K., Sasaki,J., Matsunaga,A., Arakawa,F., Takada,Y., Araki,K., Kaneko,S. and Arakawa,K.
Journal Biochim. Biophys. Acta 1128 (1), 58-64 (1992)
Title Severe type III hyperlipoproteinemia associated with unusual apolipoprotein E1 phenotype and epsilon 1/'null' genotype .
Author Feussner,G., Funke,H., Weng,W., Assmann,G., Lackner,K.J. and Ziegler,R.
Journal Eur. J. Clin. Invest. 22 (9), 599-608 (1992)
Title Polymorphism of apolipoprotein E. III. Effect of a single polymorphic gene locus on plasma lipid levels in man .
Author Utermann,G., Pruin,N. and Steinmetz,A.
Journal Clin. Genet. 15 (1), 63-72 (1979)
Title Apoprotein (E--A-II) complex of human plasma lipoproteins. II. Receptor binding activity of a high density lipoprotein subfraction modulated by the apo(E--A-II) complex .
Author Innerarity,T.L., Mahley,R.W., Weisgraber,K.H. and Bersot,T.P.
Journal J. Biol. Chem. 253 (17), 6289-6295 (1978)
Title Apoprotein (E--A-II) complex of human plasma lipoproteins. I. Characterization of this mixed disulfide and its identification in a high density lipoprotein subfraction .
Author Weisgraber,K.H. and Mahley,R.W.
Journal J. Biol. Chem. 253 (17), 6281-6288 (1978)


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