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Homo sapiens coagulation factor VII (serum prothrombin conversion accelerator) (F7), transcript variant 1, mRNA.

RefSeq Accession Definition Service Stock Status Price *Turnaround time Order
NM_000131 Homo sapiens coagulation factor VII (serum prothrombin conversion accelerator) (F7), transcript variant 1, mRNA. GenEZ ORF Cloning In-stock $509.00 $460.00 12

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RefSeq Version NM_000131.4, 388890241
Length 3144 bp
Structure linear
Update Date 20-APR-2013
Organism Homo sapiens (human)
Definition Homo sapiens coagulation factor VII (serum prothrombin conversion accelerator) (F7), transcript variant 1, mRNA.
Product coagulation factor VII isoform a preproprotein

Summary: This gene encodes coagulation factor VII which is a vitamin K-dependent factor essential for hemostasis. This factor circulates in the blood in a zymogen form, and is converted to an active form by either factor IXa, factor Xa, factor XIIa, or thrombin by minor proteolysis. Upon activation of the factor VII, a heavy chain containing a catalytic domain and a light chain containing 2 EGF-like domains are generated, and two chains are held together by a disulfide bond. In the presence of factor III and calcium ions, the activated factor then further activates the coagulation cascade by converting factor IX to factor IXa and/or factor X to factor Xa. Defects in this gene can cause coagulopathy. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, May 2012].

Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a).

Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. A downstream translational start codon is selected for this RefSeq based on its better conservation in mammalian species. An upstream in-frame start codon is also present and would result in a protein that is 15 aa longer at the N-terminus, but this start codon is poorly conserved and located within a protein-binding site identified in the promoter region, as described in PubMed: 8576177. Leaky scanning by ribosomes may allow translation initiation at the downstream start codon.

RefSeq NP_000122.1
CDS 55..1455
Misc Feature(1)4
Misc Feature(2)4
Misc Feature(3)178..366
Misc Feature(4)250..252
Misc Feature(5)253..255
Misc Feature(6)274..276
Misc Feature(7)280..282
Misc Feature(8)289..291
Misc Feature(9)292..294
Misc Feature(10)307..309
Misc Feature(11)310..312
Misc Feature(12)319..321
Misc Feature(13)337..339
Misc Feature(14)337..339
Misc Feature(15)370..480
Misc Feature(16)order(370..372,379..381,421..423)
Misc Feature(17)421..423
Misc Feature(18)505..615
Misc Feature(19)667..669
Misc Feature(20)688..693
Misc Feature(21)688..690
Misc Feature(22)691..1401
Misc Feature(23)691..693
Misc Feature(24)order(811..813,958..960,1264..1266)
Misc Feature(25)1198..1200
Misc Feature(26)order(1246..1248,1321..1323,1327..1329)
Exon (1)1..118
Gene Synonym:SPCA
Exon (2)119..184
Gene Synonym:SPCA
Exon (3)185..345
Gene Synonym:SPCA
Exon (4)346..370
Gene Synonym:SPCA
Exon (5)371..484
Gene Synonym:SPCA
Exon (6)485..625
Gene Synonym:SPCA
Exon (7)626..735
Gene Synonym:SPCA
Exon (8)736..859
Gene Synonym:SPCA
Exon (9)860..3128
Gene Synonym:SPCA
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Position Chain Variation Link
69+c, tdbSNP:150465470
120+c, tdbSNP:189409610
121+a, gdbSNP:138470706
162+a, gdbSNP:3093238
199+a, gdbSNP:139015882
272+a, tdbSNP:45572939
307+a, gdbSNP:121964935
339+a, gdbSNP:36208758
403+a, gdbSNP:121964932
417+a, cdbSNP:121964933
463+a, gdbSNP:141678243
470+a, gdbSNP:150525536
483+a, gdbSNP:200693831
484+c, tdbSNP:181538903
513+c, tdbSNP:139304588
514+a, gdbSNP:146795869
533+a, gdbSNP:200016360
558+c, gdbSNP:149461706
566+c, tdbSNP:143855920
571+c, tdbSNP:148226963
579+c, tdbSNP:6042
592+c, gdbSNP:140716599
603+c, tdbSNP:6040
653+g, tdbSNP:141219108
682+c, tdbSNP:267606790
706+a, gdbSNP:139309572
741+a, gdbSNP:144076693
767+a, gdbSNP:121964928
804+c, tdbSNP:146035766
815+c, gdbSNP:139958478
849..850+, cgcggtgctgggtgggtaccactctcccctgtccgacdbSNP:34946892
861+c, tdbSNP:200478651
893+a, cdbSNP:211694395
904+c, tdbSNP:149779477
905+a, gdbSNP:77121822
933+a, gdbSNP:148965964
936+c, tdbSNP:199567176
938+a, tdbSNP:6045
948+c, tdbSNP:6043
965+c, tdbSNP:121964931
966+a, c, gdbSNP:200316840
973+c, tdbSNP:147680958
974+a, gdbSNP:121964929
987+c, tdbSNP:142547010
988+a, gdbSNP:201991361
1031+a, gdbSNP:146698837
1049+c, tdbSNP:200212201
1050+a, gdbSNP:202240468
1063+c, tdbSNP:139372641
1107+c, tdbSNP:140590804
1108+a, gdbSNP:3093267
1115+c, tdbSNP:36209567
1128+a, gdbSNP:149283257
1145+a, gdbSNP:121964926
1163+g, tdbSNP:121964927
1177+c, tdbSNP:137919286
1178+a, gdbSNP:201058276
1188+a, gdbSNP:142587242
1206+a, gdbSNP:145994193
1217+c, g, tdbSNP:121964938
1219+g, tdbSNP:121964934
1224+c, tdbSNP:6044
1225+a, gdbSNP:190485816
1278+g, tdbSNP:121964936
1292+a, c, g, tdbSNP:6046
1294+g, tdbSNP:121964937
1310+c, tdbSNP:121964930
1387+a, gdbSNP:3093248
1418+c, tdbSNP:150837417
1420+c, tdbSNP:139256317
1494+c, tdbSNP:199979441
1526+a, tdbSNP:143748941
1608..1609+, aadbSNP:3093249
1610..1611+, aadbSNP:58290399
1611+a, gdbSNP:2476324
1761+a, gdbSNP:180783132
1845+a, gdbSNP:115484165
1853+c, tdbSNP:113386992
1865+c, tdbSNP:139474305
1907..1908+, cadbSNP:149716932
1936..1937+, agdbSNP:36209570
1988+a, cdbSNP:116688254
2060+a, gdbSNP:144204350
2075+c, tdbSNP:151109093
2093+c, tdbSNP:185229430
2094+c, tdbSNP:3093250
2113+c, tdbSNP:141116208
2119+a, gdbSNP:150239572
2128+c, tdbSNP:3093251
2135+c, gdbSNP:145837821
2157..2160+, cacadbSNP:3093252
2185+a, gdbSNP:36209571
2225+a, gdbSNP:3093253
2256+, gdbSNP:35430957
2343+a, gdbSNP:79733913
2349+c, tdbSNP:181035432
2398+a, gdbSNP:73578957
2439+c, tdbSNP:113160701
2446+a, gdbSNP:3093254
2510+c, tdbSNP:191700778
2512+c, tdbSNP:141219406
2601+a, gdbSNP:3093255
2632+c, tdbSNP:183528916
2634+c, tdbSNP:188967863
2637+a, cdbSNP:77952740
2695+c, gdbSNP:3093256
2728+a, gdbSNP:146946028
2730+a, gdbSNP:3093257
2736+a, gdbSNP:192084788
2838+c, tdbSNP:117025399
2897+a, gdbSNP:138013294
2930+a, gdbSNP:3093258
2982..2985+, cactdbSNP:139426699
2985..2988+, tcacdbSNP:45457194
3022+a, gdbSNP:34306925
3079+g, tdbSNP:182274553
3104+a, gdbSNP:3093259
Gene SymbolF7
Gene SynonymSPCA
Locus Map13q34
All Transcripts
RefSeq Accession Definition Stock Status Price Turnaround time Business Day Select
NM_000131 Homo sapiens coagulation factor VII (serum prothrombin conversion accelerator) (F7), transcript variant 1, mRNA. In-stock $509.00 $460.00 12
NM_001267554 Homo sapiens coagulation factor VII (serum prothrombin conversion accelerator) (F7), transcript variant 3, mRNA. On-demand $549.00 14
NM_019616 Homo sapiens coagulation factor VII (serum prothrombin conversion accelerator) (F7), transcript variant 2, mRNA. In-stock $509.00 $460.00 12
Title Ribavirin-induced intracellular GTP depletion activates transcription elongation in coagulation factor VII gene expression .
Author Suzuki,A., Miyawaki,Y., Okuyama,E., Murata,M., Ando,Y., Kato,I., Takagi,Y., Takagi,A., Murate,T., Saito,H. and Kojima,T.
Journal Biochem. J. 449 (1), 231-239 (2013)
Title Polymorphisms of genes encoding coagulation factors II, V, VII, and .
Author Kopyta,I.A., Emich-Widera,E., Balcerzyk,A., Niemiec,P., Zak,I., Pilarska,E., Kacinski,M., Wendorff,J., Nowak,T., Iwanicki,T., Pienczk-Reclawowicz,K. and Palatynska,K.
Journal Neurologist 18 (5), 282-286 (2012)
Title [Molecular genetics and clinical features of nine patients with inherited coagulation factor VII deficiency] .
Author Jin,Y.H., Wang,M.S., Zheng,F.X., Xie,Y.S., Xie,H.X. and Xu,P.F.
Journal Zhonghua Yi Xue Yi Chuan Xue Za Zhi 29 (4), 404-407 (2012)
Title Upregulation of the coagulation factor VII gene during glucose deprivation is mediated by activating transcription factor 4 .
Author Cronin,K.R., Mangan,T.P. and Carew,J.A.
Journal PLoS ONE 7 (7), E40994 (2012)
Title Functional epistatic interaction between rs6046G>A in F7 and rs5355C>T in SELE modifies systolic blood pressure levels .
Author El Shamieh,S., Ndiaye,N.C., Stathopoulou,M.G., Murray,H.A., Masson,C., Lamont,J.V., Fitzgerald,P., Benetos,A. and Visvikis-Siest,S.
Journal PLoS ONE 7 (7), E40777 (2012)
Title Functional characterization of the human factor VII 5'-flanking region .
Author Pollak,E.S., Hung,H.L., Godin,W., Overton,G.C. and High,K.A.
Journal J. Biol. Chem. 271 (3), 1738-1747 (1996)
Title Detection of two missense mutations and characterization of a repeat polymorphism in the factor VII gene (F7) .
Author Marchetti,G., Patracchini,P., Gemmati,D., DeRosa,V., Pinotti,M., Rodorigo,G., Casonato,A., Girolami,A. and Bernardi,F.
Journal Hum. Genet. 89 (5), 497-502 (1992)
Title Purification and characterization of factor VII 304-Gln: a variant molecule with reduced activity isolated from a clinically unaffected male .
Author O'Brien,D.P., Gale,K.M., Anderson,J.S., McVey,J.H., Miller,G.J., Meade,T.W. and Tuddenham,E.G.
Journal Blood 78 (1), 132-140 (1991)
Title Human plasma and recombinant factor VII. Characterization of O-glycosylations at serine residues 52 and 60 and effects of site-directed mutagenesis of serine 52 to alanine .
Author Bjoern,S., Foster,D.C., Thim,L., Wiberg,F.C., Christensen,M., Komiyama,Y., Pedersen,A.H. and Kisiel,W.
Journal J. Biol. Chem. 266 (17), 11051-11057 (1991)
Title A new trisaccharide sugar chain linked to a serine residue in the first EGF-like domain of clotting factors VII and IX and protein Z .
Author Iwanaga,S., Nishimura,H., Kawabata,S., Kisiel,W., Hase,S. and Ikenaka,T.
Journal Adv. Exp. Med. Biol. 281, 121-131 (1990)

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