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Homo sapiens coagulation factor VII (serum prothrombin conversion accelerator) (F7), transcript variant 1, mRNA.

Clone ID Definition Vector Stock Status Price *Turnaround time Order
OHu25117 Homo sapiens coagulation factor VII (serum prothrombin conversion accelerator) (F7), transcript variant 1, mRNA. pcDNA3.1+-DYK In-stock $99.00 5-7
OHu25117C Homo sapiens coagulation factor VII (serum prothrombin conversion accelerator) (F7), transcript variant 1, mRNA. Customized vector In-stock $149.00 5-7

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Sequence Information ORF Nucleotide Sequence
Protein sequence
Vector pcDNA3.1+-DYK or customized vector
Clone information Clone Map
Tag on pcDNA3.1+-DYK N terminal DYKDDDK tags
ORF Insert Method CloneEZ® Seamless cloning technology
RefSeq Version NM_000131.4, 388890241
Length 1401 bp
Update Date 17-MAY-2014
Organism Homo sapiens (human)
Definition Homo sapiens coagulation factor VII (serum prothrombin conversion accelerator) (F7), transcript variant 1, mRNA.
Product coagulation factor VII isoform a preproprotein

Summary: This gene encodes coagulation factor VII which is a vitamin K-dependent factor essential for hemostasis. This factor circulates in the blood in a zymogen form, and is converted to an active form by either factor IXa, factor Xa, factor XIIa, or thrombin by minor proteolysis. Upon activation of the factor VII, a heavy chain containing a catalytic domain and a light chain containing 2 EGF-like domains are generated, and two chains are held together by a disulfide bond. In the presence of factor III and calcium ions, the activated factor then further activates the coagulation cascade by converting factor IX to factor IXa and/or factor X to factor Xa. Defects in this gene can cause coagulopathy. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, May 2012].

Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a).

Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. A downstream translational start codon is selected for this RefSeq based on its better conservation in mammalian species. An upstream in-frame start codon is also present and would result in a protein that is 15 aa longer at the N-terminus, but this start codon is poorly conserved and located within a protein-binding site identified in the promoter region, as described in PubMed: 8576177. Leaky scanning by ribosomes may allow translation initiation at the downstream start codon.

RefSeq NP_000122.1
CDS 55..1455
Misc Feature(1)4
Misc Feature(2)178..366
Misc Feature(3)250..252
Misc Feature(4)253..255
Misc Feature(5)274..276
Misc Feature(6)280..282
Misc Feature(7)289..291
Misc Feature(8)292..294
Misc Feature(9)307..309
Misc Feature(10)310..312
Misc Feature(11)319..321
Misc Feature(12)337..339
Misc Feature(13)337..339
Misc Feature(14)370..480
Misc Feature(15)order(370..372,379..381,421..423)
Misc Feature(16)421..423
Misc Feature(17)505..615
Misc Feature(18)667..669
Misc Feature(19)688..1392
Misc Feature(20)688..693
Misc Feature(21)688..690
Misc Feature(22)691..1401
Misc Feature(23)691..693
Misc Feature(24)order(811..813,958..960,1264..1266)
Misc Feature(25)1198..1200
Misc Feature(26)order(1246..1248,1321..1323,1327..1329)
Exon (1)1..118
Gene Synonym:SPCA
Exon (2)119..184
Gene Synonym:SPCA
Exon (3)185..345
Gene Synonym:SPCA
Exon (4)346..370
Gene Synonym:SPCA
Exon (5)371..484
Gene Synonym:SPCA
Exon (6)485..625
Gene Synonym:SPCA
Exon (7)626..735
Gene Synonym:SPCA
Exon (8)736..859
Gene Synonym:SPCA
Exon (9)860..3128
Gene Synonym:SPCA
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Position Chain Variation Link
1+a, gdbSNP:367732974
69+c, tdbSNP:150465470
92+c, tdbSNP:387906507
107+a, gdbSNP:370843454
118+a, gdbSNP:376168927
120+c, tdbSNP:189409610
121+a, gdbSNP:138470706
139+a, gdbSNP:371824980
162+a, gdbSNP:3093238
184+a, gdbSNP:368272420
199+a, gdbSNP:139015882
208+c, tdbSNP:376971927
261+a, gdbSNP:368856514
262+c, tdbSNP:373376565
265+a, gdbSNP:376384665
272+a, tdbSNP:45572939
307+a, gdbSNP:121964935
339+a, gdbSNP:36208758
368+a, gdbSNP:370535984
396+a, tdbSNP:367552672
403+a, gdbSNP:121964932
417+a, cdbSNP:121964933
463+a, gdbSNP:141678243
470+a, gdbSNP:150525536
483+a, gdbSNP:200693831
484+c, g, tdbSNP:181538903
513+c, tdbSNP:139304588
514+a, gdbSNP:146795869
521+a, gdbSNP:372307787
533+a, gdbSNP:200016360
558+c, gdbSNP:149461706
563+a, gdbSNP:375134790
566+c, tdbSNP:143855920
571+c, tdbSNP:148226963
579+c, tdbSNP:6042
592+c, gdbSNP:140716599
603+c, tdbSNP:6040
604+a, gdbSNP:372005651
637+c, tdbSNP:372577568
653+g, tdbSNP:141219108
682+c, tdbSNP:267606790
706+a, gdbSNP:139309572
710+a, gdbSNP:377468591
741+a, gdbSNP:144076693
767+a, gdbSNP:121964928
804+c, tdbSNP:146035766
807+a, gdbSNP:374575808
815+c, gdbSNP:139958478
819+c, tdbSNP:376480781
861+c, tdbSNP:200478651
893+a, cdbSNP:211694395
904+c, tdbSNP:149779477
905+a, gdbSNP:77121822
912+a, gdbSNP:368187411
933+a, gdbSNP:148965964
936+c, tdbSNP:199567176
938+a, tdbSNP:6045
948+c, tdbSNP:6043
965+c, tdbSNP:121964931
966+a, c, gdbSNP:200316840
973+c, tdbSNP:147680958
974+a, gdbSNP:121964929
987+c, tdbSNP:142547010
988+a, gdbSNP:201991361
1004+a, tdbSNP:372225534
1031+a, gdbSNP:146698837
1037+c, tdbSNP:387906508
1049+c, tdbSNP:200212201
1050+a, gdbSNP:202240468
1059+c, tdbSNP:368893306
1060+a, gdbSNP:374305125
1063+c, tdbSNP:139372641
1107+c, tdbSNP:140590804
1108+a, gdbSNP:3093267
1115+c, tdbSNP:36209567
1128+a, gdbSNP:149283257
1145+a, gdbSNP:121964926
1156+c, tdbSNP:377734791
1163+g, tdbSNP:121964927
1177+c, tdbSNP:137919286
1178+a, gdbSNP:201058276
1188+a, gdbSNP:142587242
1195+c, tdbSNP:370207115
1198+a, gdbSNP:373135581
1206+a, gdbSNP:145994193
1217+c, g, tdbSNP:121964938
1219+g, tdbSNP:121964934
1224+c, tdbSNP:6044
1225+a, gdbSNP:190485816
1278+g, tdbSNP:121964936
complement(1292)-t, g, c, adbSNP:6046
1294+g, tdbSNP:121964937
1310+c, tdbSNP:121964930
1318+a, gdbSNP:377384453
1351+c, tdbSNP:373731019
1359+a, gdbSNP:375522562
1386+c, tdbSNP:369621823
1387+a, gdbSNP:3093248
1389+a, gdbSNP:376365387
1409+a, gdbSNP:369006583
1418+c, tdbSNP:150837417
1420+c, tdbSNP:139256317
1439+a, gdbSNP:372452455
1460+g, tdbSNP:373888539
1494+c, tdbSNP:199979441
1526+a, tdbSNP:143748941
1537+c, tdbSNP:368359845
1609..1610+, aadbSNP:3093249
1609+a, cdbSNP:367914219
1610..1611+, aadbSNP:397976621
1611+a, gdbSNP:2476324
1611+c, tdbSNP:111155253
1664+a, gdbSNP:374974621
1761+a, gdbSNP:180783132
1845+a, gdbSNP:115484165
1853+c, tdbSNP:113386992
complement(1865)-t, cdbSNP:139474305
1907..1908+, cadbSNP:149716932
1936..1937+, agdbSNP:36209570
1988+a, cdbSNP:116688254
2060+a, gdbSNP:144204350
complement(2075)-t, cdbSNP:151109093
2093+c, tdbSNP:185229430
2094+a, c, g, tdbSNP:3093250
2094+c, tdbSNP:111154878
2113+c, tdbSNP:141116208
2118+c, tdbSNP:376163218
2119+a, gdbSNP:150239572
2128+a, c, g, tdbSNP:3093251
2128+c, tdbSNP:111154879
2135+c, gdbSNP:145837821
2157..2160+, cacadbSNP:3093252
2185+a, gdbSNP:36209571
2211+c, gdbSNP:372580388
2225+a, gdbSNP:3093253
2256+, gdbSNP:35430957
2343+a, gdbSNP:79733913
2349+c, tdbSNP:181035432
2398+a, gdbSNP:73578957
2439+c, tdbSNP:113160701
2446+a, gdbSNP:3093254
2460+c, gdbSNP:375905345
2510+c, tdbSNP:191700778
complement(2512)-t, cdbSNP:141219406
2601+a, gdbSNP:3093255
2632+c, tdbSNP:183528916
2634+c, tdbSNP:188967863
2637+a, cdbSNP:77952740
2695+c, gdbSNP:3093256
2728+a, gdbSNP:146946028
2730+a, gdbSNP:3093257
2736+a, gdbSNP:192084788
2838+c, tdbSNP:117025399
2897+a, gdbSNP:138013294
2930+a, gdbSNP:3093258
2982..2985+, cactdbSNP:139426699
2985..2988+, tcacdbSNP:45457194
3022+a, gdbSNP:34306925
3062+a, gdbSNP:368666322
3079+g, tdbSNP:182274553
3104+a, gdbSNP:3093259
Gene SymbolF7
Gene SynonymSPCA
Locus Map13q34
Title Factor VII and protein C are phosphatidic acid-binding proteins .
Author Tavoosi N, Smith SA, Davis-Harrison RL and Morrissey JH.
Journal Biochemistry 52 (33), 5545-5552 (2013)
Title Structural and functional studies of gamma-carboxyglutamic acid domains of factor VIIa and activated Protein C: role of magnesium at physiological calcium .
Author Vadivel K, Agah S, Messer AS, Cascio D, Bajaj MS, Krishnaswamy S, Esmon CT, Padmanabhan K and Bajaj SP.
Journal J. Mol. Biol. 425 (11), 1961-1981 (2013)
Title Factor VII assay performance: an analysis of the North American Specialized Coagulation Laboratory Association proficiency testing results .
Author Zantek ND, Hsu P, Refaai MA, Ledford-Kraemer M, Meijer P and Van Cott EM.
Journal Int J Lab Hematol 35 (3), 314-321 (2013)
Title A recombinant adenovirus vector encoding the light chain of human coagulation factor VII and IgG1 Fc fragment to targeting tissue factor for colorectal cancer immunotherapy in the mouse model .
Author Rao B, Gao Y, Zhou Q, Xiao P, Xia S, Ma J, Luo J, Xiao T, Le S, Huang M and Wang J.
Journal J. Cancer Res. Clin. Oncol. 139 (6), 1015-1023 (2013)
Title Rab GTPases regulate endothelial cell protein C receptor-mediated endocytosis and trafficking of factor VIIa .
Author Nayak RC, Keshava S, Esmon CT, Pendurthi UR and Rao LV.
Journal PLoS ONE 8 (3), E59304 (2013)
Title Functional characterization of the human factor VII 5'-flanking region .
Author Pollak ES, Hung HL, Godin W, Overton GC and High KA.
Journal J. Biol. Chem. 271 (3), 1738-1747 (1996)
Title Detection of two missense mutations and characterization of a repeat polymorphism in the factor VII gene (F7) .
Author Marchetti G, Patracchini P, Gemmati D, DeRosa V, Pinotti M, Rodorigo G, Casonato A, Girolami A and Bernardi F.
Journal Hum. Genet. 89 (5), 497-502 (1992)
Title Purification and characterization of factor VII 304-Gln: a variant molecule with reduced activity isolated from a clinically unaffected male .
Author O'Brien DP, Gale KM, Anderson JS, McVey JH, Miller GJ, Meade TW and Tuddenham EG.
Journal Blood 78 (1), 132-140 (1991)
Title Human plasma and recombinant factor VII. Characterization of O-glycosylations at serine residues 52 and 60 and effects of site-directed mutagenesis of serine 52 to alanine .
Author Bjoern S, Foster DC, Thim L, Wiberg FC, Christensen M, Komiyama Y, Pedersen AH and Kisiel W.
Journal J. Biol. Chem. 266 (17), 11051-11057 (1991)
Title A new trisaccharide sugar chain linked to a serine residue in the first EGF-like domain of clotting factors VII and IX and protein Z .
Author Iwanaga S, Nishimura H, Kawabata S, Kisiel W, Hase S and Ikenaka T.
Journal Adv. Exp. Med. Biol. 281, 121-131 (1990)

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