• THAT   AND
  • THAT   AND


Sequence in raw or FASTA format:

Database:

Blast Method:

 
 


Homo sapiens mutS homolog 2 (MSH2), transcript variant 1, mRNA.


Clone ID Definition Vector Stock Status Price *Turnaround time Order
OHu20167 Homo sapiens mutS homolog 2 (MSH2), transcript variant 1, mRNA. pcDNA3.1+-DYK On-demand $279.00 12-14
OHu20167C Homo sapiens mutS homolog 2 (MSH2), transcript variant 1, mRNA. Customized vector On-demand $329.00 12-14

*Business Day

Mutation services

Sequence Information ORF Nucleotide Sequence
Protein sequence
Vector pcDNA3.1+-DYK or customized vector
Clone information Clone Map
Tag on pcDNA3.1+-DYK N terminal DYKDDDK tags
ORF Insert Method CloneEZ® Seamless cloning technology
RefSeq Version NM_000251.2, 384871700
Length 2805 bp
Structure linear
Update Date 04-MAY-2014
Organism Homo sapiens (human)
Definition Homo sapiens mutS homolog 2 (MSH2), transcript variant 1, mRNA.
Product DNA mismatch repair protein Msh2 isoform 1
Comment

Summary: This locus is frequently mutated in hereditary nonpolyposis colon cancer (HNPCC). When cloned, it was discovered to be a human homolog of the E. coli mismatch repair gene mutS, consistent with the characteristic alterations in microsatellite sequences (RER+ phenotype) found in HNPCC. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2012].


Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).

RefSeq NP_000242.1
CDS 126..2930
Misc Feature(1)111..113
Misc Feature(2)129..131
Misc Feature(3)129..131
Misc Feature(4)177..521
Misc Feature(5)192..2684
Misc Feature(6)597..977
Misc Feature(7)1038..1955
Misc Feature(8)1788..1790
Misc Feature(9)1926..2138
Misc Feature(10)2022..2681
Misc Feature(11)2130..2153
Misc Feature(12)order(2139..2144,2148..2156,2262..2264,2367..2372,
Misc Feature(13)2253..2264
Misc Feature(14)2277..2318
Misc Feature(15)2355..2372
Misc Feature(16)2379..2390
Misc Feature(17)2460..2480
Misc Feature(18)2703..2705
Exon (1)1..336
Gene:MSH2
Gene Synonym:COCA1; FCC1; HNPCC; HNPCC1; LCFS2
Exon (2)337..491
Gene:MSH2
Gene Synonym:COCA1; FCC1; HNPCC; HNPCC1; LCFS2
Exon (3)492..770
Gene:MSH2
Gene Synonym:COCA1; FCC1; HNPCC; HNPCC1; LCFS2
Exon (4)771..917
Gene:MSH2
Gene Synonym:COCA1; FCC1; HNPCC; HNPCC1; LCFS2
Exon (5)918..1067
Gene:MSH2
Gene Synonym:COCA1; FCC1; HNPCC; HNPCC1; LCFS2
Exon (6)1068..1201
Gene:MSH2
Gene Synonym:COCA1; FCC1; HNPCC; HNPCC1; LCFS2
Exon (7)1202..1401
Gene:MSH2
Gene Synonym:COCA1; FCC1; HNPCC; HNPCC1; LCFS2
Exon (8)1402..1511
Gene:MSH2
Gene Synonym:COCA1; FCC1; HNPCC; HNPCC1; LCFS2
Exon (9)1512..1635
Gene:MSH2
Gene Synonym:COCA1; FCC1; HNPCC; HNPCC1; LCFS2
Exon (10)1636..1786
Gene:MSH2
Gene Synonym:COCA1; FCC1; HNPCC; HNPCC1; LCFS2
Exon (11)1787..1884
Gene:MSH2
Gene Synonym:COCA1; FCC1; HNPCC; HNPCC1; LCFS2
Exon (12)1885..2130
Gene:MSH2
Gene Synonym:COCA1; FCC1; HNPCC; HNPCC1; LCFS2
Exon (13)2131..2335
Gene:MSH2
Gene Synonym:COCA1; FCC1; HNPCC; HNPCC1; LCFS2
Exon (14)2336..2583
Gene:MSH2
Gene Synonym:COCA1; FCC1; HNPCC; HNPCC1; LCFS2
Exon (15)2584..2759
Gene:MSH2
Gene Synonym:COCA1; FCC1; HNPCC; HNPCC1; LCFS2
Exon (16)2760..3209
Gene:MSH2
Gene Synonym:COCA1; FCC1; HNPCC; HNPCC1; LCFS2
Translation MAVQPKETLQLESAAEVGFVRFFQGMPEKPTTTVRLFDRGDFYTAHGEDALLAAREVFKT QGVIKYMGPAGAKNLQSVVLSKMNFESFVKDLLLVRQYRVEVYKNRAGNKASKENDWYLA YKASPGNLSQFEDILFGNNDMSASIGVVGVKMSAVDGQRQVGVGYVDSIQRKLGLCEFPD NDQFSNLEALLIQIGPKECVLPGGETAGDMGKLRQIIQRGGILITERKKADFSTKDIYQD LNRLLKGKKGEQMNSAVLPEMENQVAVSSLSAVIKFLELLSDDSNFGQFELTTFDFSQYM KLDIAAVRALNLFQGSVEDTTGSQSLAALLNKCKTPQGQRLVNQWIKQPLMDKNRIEERL NLVEAFVEDAELRQTLQEDLLRRFPDLNRLAKKFQRQAANLQDCYRLYQGINQLPNVIQA LEKHEGKHQKLLLAVFVTPLTDLRSDFSKFQEMIETTLDMDQVENHEFLVKPSFDPNLSE LREIMNDLEKKMQSTLISAARDLGLDPGKQIKLDSSAQFGYYFRVTCKEEKVLRNNKNFS TVDIQKNGVKFTNSKLTSLNEEYTKNKTEYEEAQDAIVKEIVNISSGYVEPMQTLNDVLA QLDAVVSFAHVSNGAPVPYVRPAILEKGQGRIILKASRHACVEVQDEIAFIPNDVYFEKD KQMFHIITGPNMGGKSTYIRQTGVIVLMAQIGCFVPCESAEVSIVDCILARVGAGDSQLK GVSTFMAEMLETASILRSATKDSLIIIDELGRGTSTYDGFGLAWAISEYIATKIGAFCMF ATHFHELTALANQIPTVNNLHVTALTTEETLTMLYQVKKGVCDQSFGIHVAELANFPKHV IECAKQKALELEEFQYIGESQGYDIMEPAAKKCYLEREQGEKIIQEFLSKVKQMPFTEMS EENITIKLKQLKAEVIAKNNSFVNEIISRIKVTT
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Position Chain Variation Link
8+dbSNP:
8+c, tdbSNP:2303425
24+c, tdbSNP:17217709
30+a, gdbSNP:56062561
36+c, gdbSNP:372200074
50+a, gdbSNP:34355730
97+c, tdbSNP:199841800
102+a, gdbSNP:183204578
103+c, g, tdbSNP:368949534
126+a, c, g, tdbSNP:267607911
129+a, gdbSNP:63750466
131+g, tdbSNP:368270856
139+a, cdbSNP:56170584
143+c, gdbSNP:146017810
144+a, gdbSNP:375561490
145+, adbSNP:267607915
146..147+, gcggtgcagccgaaggagdbSNP:281864943
148+c, tdbSNP:17217716
153+a, c, tdbSNP:63751099
154..155+, adbSNP:63750589
159..160+, gdbSNP:63750614
163+g, tdbSNP:63749907
167+a, gdbSNP:374396150
174+g, tdbSNP:63750966
176+c, tdbSNP:397515879
179+c, gdbSNP:63750777
180+c, tdbSNP:141711342
185+a, gdbSNP:368874228
191+c, tdbSNP:200632093
192+c, tdbSNP:372619120
206+, gdbSNP:63751091
207+g, tdbSNP:63751246
219..228+, accacagtgcdbSNP:63750728
222+a, c, gdbSNP:63751107
224+a, cdbSNP:267607912
226+a, tdbSNP:63751424
235+, tdbSNP:63751056
242+a, gdbSNP:63750974
243+a, gdbSNP:63751260
244+, gdbSNP:63750984
253+a, gdbSNP:17217723
254+a, g, tdbSNP:63750894
259..287+, cgcacggcgaggacgcgctgctggccgccdbSNP:63750089
259+c, tdbSNP:63750285
261..289+, cacggcgaggacgcgctgctggccgcccgdbSNP:63751482
263+c, gdbSNP:33946261
267+g, tdbSNP:63750615
270..271+, gadbSNP:63750334
270+, gdbSNP:63750644
271+a, tdbSNP:63750335
279..280+, gdbSNP:63750352
288+, cdbSNP:63750337
291+, gdbSNP:63750087
294+a, gdbSNP:267607913
299+c, tdbSNP:372189599
306+c, tdbSNP:63750951
312..313+, g, ggdbSNP:281864942
312+, gdbSNP:63750160
329+, gdbSNP:63750199
344+dbSNP:
344+a, gdbSNP:1800150
345+a, cdbSNP:150548839
348..349+, ctdbSNP:63750712
351+c, tdbSNP:63750042
354..355+, agdbSNP:63749848
372..373+, adbSNP:63749912
380..381+, tdbSNP:63751158
380..381+, tgdbSNP:267607921
388..389+, ttdbSNP:267607920
402..404+, cttdbSNP:267607918
402+c, tdbSNP:63751429
403..404+, ttdbSNP:63749872
403+c, tdbSNP:63751456
404..406+, tctdbSNP:267607919
412+a, gdbSNP:63750002
414..415+, aaagatcttcttctggttcgtcdbSNP:63751295
414+c, tdbSNP:63750970
418+a, gdbSNP:63750887
420+a, cdbSNP:63750230
421+, gdbSNP:63749861
422..427+, agttgadbSNP:63750506
426+g, tdbSNP:63750318
429+a, gdbSNP:193922373
433+a, gdbSNP:63751173
437+c, gdbSNP:372972328
442+a, gdbSNP:41295286
452+c, tdbSNP:63751437
454+a, gdbSNP:63751040
461+a, cdbSNP:34312619
464+a, gdbSNP:35898375
469+, adbSNP:63751195
472..475+, attgdbSNP:63750501
488+g, tdbSNP:63750458
489+a, cdbSNP:374127044
493+dbSNP:
493+, cdbSNP:63750210
505..506+, atdbSNP:63751227
505+a, gdbSNP:17217772
507+c, gdbSNP:145649774
512..513+, tcdbSNP:63750924
513..514+, cadbSNP:63750704
524+, cdbSNP:63751290
524+c, tdbSNP:61756462
528+c, g, tdbSNP:193096019
533+, tdbSNP:63750408
541+, adbSNP:63750401
546+a, gdbSNP:193922374
550+c, gdbSNP:63750910
560+g, tdbSNP:63750124
579+, adbSNP:63751449
584+c, tdbSNP:63751065
596+a, cdbSNP:61756463
597+c, tdbSNP:63751226
603+c, tdbSNP:63751426
606+a, gdbSNP:149511545
607+a, tdbSNP:63750126
608+g, tdbSNP:375202935
609+a, gdbSNP:63750624
610+c, gdbSNP:63750773
613+a, tdbSNP:63750214
615+a, g, tdbSNP:63750582
620+g, tdbSNP:63749949
624+c, gdbSNP:63750255
630+a, gdbSNP:63750716
631..634+, tacadbSNP:63751013
633+c, g, tdbSNP:63750843
637+a, gdbSNP:63750902
638+, gdbSNP:63750933
642..653+a, ctaggactgtgtdbSNP:63751067
643+c, g, tdbSNP:63750070
643+, tdbSNP:63750069
646+a, gdbSNP:147346837
648..689+, ctgtgtgaattccctgataatgatcagttctccaatcttgagdbSNP:63750705
649+c, tdbSNP:63751291
654+a, g, tdbSNP:63750382
655..656+, aadbSNP:63750551
672+c, tdbSNP:63750037
676+, tdbSNP:267607928
682+a, gdbSNP:151129360
685+c, g, tdbSNP:63751444
686..694+, tgaggctctdbSNP:63750088
689..690+, tcagttctccaatcttgagdbSNP:63750080
690+g, tdbSNP:63750821
691+c, gdbSNP:141021599
694..695+ct, tcdbSNP:267607927
698+c, tdbSNP:1800151
702+c, tdbSNP:63751326
712+, cdbSNP:63750682
717..718+, gdbSNP:63750786
718+a, gdbSNP:63750327
719+a, gdbSNP:369685768
720+c, tdbSNP:63751110
721+a, gdbSNP:63751136
731+c, g, tdbSNP:63750600
735+g, tdbSNP:63750574
738+c, g, tdbSNP:63749984
741..742+, adbSNP:63750995
744+a, g, tdbSNP:63750913
748+, gdbSNP:63750121
763..764+, tgdbSNP:63751622
767..770+, acagdbSNP:63751695
768+c, tdbSNP:63751274
771+dbSNP:
771+a, gdbSNP:63749936
775..779+, ttcaadbSNP:63751602
807+a, gdbSNP:200313142
812..813+, adbSNP:63750364
812+, adbSNP:63749897
821..822+, ttdbSNP:63750426
829..830+, aadbSNP:281864944
830+, adbSNP:281864945
834+a, gdbSNP:63751307
836..839+, ttatdbSNP:63751288
839+c, tdbSNP:369670665
840+c, tdbSNP:63750488
841+a, gdbSNP:199676483
842..846+ggacc, ttadbSNP:63750690
852+c, tdbSNP:138857091
853+a, gdbSNP:63751455
860..861+, gdbSNP:63750107
861+a, c, tdbSNP:63750881
871+, adbSNP:63749832
871+a, cdbSNP:61756464
876+a, gdbSNP:147389443
879+c, tdbSNP:63750347
880+a, gdbSNP:370906735
881..882+, cdbSNP:35170366
884..887+, gaatdbSNP:267607931
884+, gdbSNP:63751160
888..891+agtg, ttdbSNP:63750329
891+a, gdbSNP:377403073
907+c, tdbSNP:63749969
907+, tdbSNP:63749968
913..914+, atdbSNP:63751614
920+dbSNP:
920+c, g, tdbSNP:63749903
920+, tdbSNP:63749902
931+c, tdbSNP:63750058
932..933+, adbSNP:63750225
933..936+, ctgtdbSNP:63750326
935..938+, gtctdbSNP:63749978
935..936+, gtdbSNP:63751133
937+c, tdbSNP:139891783
940+c, tdbSNP:34136999
941+a, gdbSNP:368912987
942..943+aa, gtdbSNP:63749840
943+c, tdbSNP:144288433
944+a, gdbSNP:146577635
945+a, gdbSNP:371944271
960+c, gdbSNP:375351205
961..963+, tctdbSNP:267607936
961+, tdbSNP:63751159
964..965+, tdbSNP:63750091
965+, adbSNP:63750154
967+c, gdbSNP:63749991
968+a, tdbSNP:150197753
972+g, tdbSNP:63750381
979+, adbSNP:63750701
983..984+, gdbSNP:34198889
984+g, tdbSNP:63750276
985..986+, gdbSNP:193922375
987+c, tdbSNP:63750097
999+a, tdbSNP:104895022
1006..1007+, ttdbSNP:63751115
1010+c, gdbSNP:201334592
1017+c, tdbSNP:63750934
1018+a, cdbSNP:267607998
1024..1025+, atdbSNP:63750885
1026+a, tdbSNP:63749915
1030+a, tdbSNP:63749914
1038+a, gdbSNP:63751454
1047..1048+, agcagtcadbSNP:63750046
1054+c, tdbSNP:63750640
1059+, cdbSNP:267607937
1069+dbSNP:
1069+g, tdbSNP:202026056
1083..1084+, adbSNP:63749852
1083+a, gdbSNP:368982417
1090+a, gdbSNP:4987188
1093+a, c, gdbSNP:63750732
1095..1096+, cadbSNP:63751044
1095+c, tdbSNP:63750502
1097+a, gdbSNP:63750505
1098..1099+, tdbSNP:63749945
1109+c, tdbSNP:4987189
1114+c, tdbSNP:63750630
1116+a, gdbSNP:267607938
1122+c, tdbSNP:63750468
1123+a, gdbSNP:63750828
1129..1132+, ccccdbSNP:63751289
1129+c, tdbSNP:63750602
1131+c, tdbSNP:63751062
1134+c, tdbSNP:63750778
1137+a, gdbSNP:63751004
1142..1143+, aadbSNP:63750703
1147+c, tdbSNP:63751147
1149+a, gdbSNP:63749879
1155+c, tdbSNP:63750245
1157+c, gdbSNP:375799148
1159+a, gdbSNP:63751027
1160+a, gdbSNP:63750396
1163..1164+, ttdbSNP:63751483
1170+c, gdbSNP:267607939
1176+a, gdbSNP:138026880
1178+c, gdbSNP:373122667
1195+a, cdbSNP:150503781
1201+g, tdbSNP:63751604
1202+dbSNP:
1202+a, tdbSNP:63751617
1211+a, tdbSNP:63751699
1212+g, tdbSNP:377345366
1222..1223+, adbSNP:267607693
1224+a, g, tdbSNP:80285180
1233+, gdbSNP:63749814
1234+c, tdbSNP:139652783
1244+, gdbSNP:63750516
1245+c, tdbSNP:63750558
1247+c, gdbSNP:370378607
1253..1254+, tadbSNP:63751219
1254+c, tdbSNP:63750267
1256+a, gdbSNP:181852377
1264+, tdbSNP:63750039
1269..1270+, cdbSNP:63750496
1270+a, gdbSNP:267607947
1272+c, tdbSNP:63749849
1273+c, gdbSNP:376934727
1285+c, tdbSNP:63750485
1293+c, tdbSNP:17224367
1300+a, tdbSNP:61756465
1307..1308+, tdbSNP:63750901
1307+g, tdbSNP:374135434
1308+c, tdbSNP:63750302
1314+c, tdbSNP:63750611
1317..1318+, gdbSNP:63751169
1322..1323+, cadbSNP:63749850
1328..1329+, adbSNP:63750586
1329+, cdbSNP:63751413
1329+c, tdbSNP:63751412
1340+a, cdbSNP:63751271
1341+c, tdbSNP:63751108
1342+a, gdbSNP:146567853
1343..1344+, ccgadbSNP:267607946
1344..1345+, cgacdbSNP:63751192
1346+c, g, tdbSNP:63750813
1347..1348+, tdbSNP:63751142
1348+a, gdbSNP:63750379
1349+c, tdbSNP:63750132
1350+a, c, gdbSNP:151244108
1351..1352+, agdbSNP:63750086
1360..1392+, atcaactacctaatgttatacaggctctggaaadbSNP:63751644
1368..1371+, cctadbSNP:63751206
1368+c, g, tdbSNP:35717997
1374+, gdbSNP:63751059
1380+a, c, tdbSNP:63750006
1386+a, cdbSNP:63750228
1389+g, tdbSNP:63751712
1392+a, gdbSNP:201059765
1394..1395+, adbSNP:63751667
1396+a, gdbSNP:200429136
1400+a, gdbSNP:63751650
1410+dbSNP:
1410+c, tdbSNP:63751693
1412..1413+, gdbSNP:63751626
1413+a, tdbSNP:63751646
1417+a, tdbSNP:63751315
1421+a, gdbSNP:141295984
1440..1442+, cctdbSNP:63751138
1441..1442+, ctdbSNP:63750251
1444..1451+cc, ttactgatdbSNP:63749931
1446..1447+, adbSNP:63750807
1464+g, tdbSNP:63751217
1465..1466+, ggdbSNP:267607696
1470..1473+, aagtdbSNP:267607955
1470+a, tdbSNP:63749920
1477..1478+, agdbSNP:63750957
1479+g, tdbSNP:267607954
1481+a, gdbSNP:63751212
1483+a, tdbSNP:63750697
1498+g, tdbSNP:63750521
1533+dbSNP:
1533+, gdbSNP:63750384
1534+a, c, tdbSNP:267607959
1543+c, g, tdbSNP:63751403
1565+a, gdbSNP:138049198
1569..1570+, adbSNP:63750436
1569+, adbSNP:63750068
1570..1574+, gagaadbSNP:267607961
1570..1571+, taagdbSNP:63750930
1572..1573+, gadbSNP:63750161
1572+g, tdbSNP:63749947
1577..1580+, aatgdbSNP:63750148
1582+, adbSNP:63750986
1586+c, gdbSNP:35107951
1601..1602+ct, gcdbSNP:63750583
1602+c, tdbSNP:63750936
1603+a, tdbSNP:376990143
1605+c, tdbSNP:55653533
1606+c, tdbSNP:370970617
1613+a, gdbSNP:267607960
1619..1620+, tdbSNP:63750362
1622+, adbSNP:63749963
1627+a, gdbSNP:376677710
1630+a, gdbSNP:148192104
1635+c, gdbSNP:63751600
1641+dbSNP:
1641+g, tdbSNP:63750492
1647+a, gdbSNP:267607968
1672+a, gdbSNP:373564353
1677..1678+, cadbSNP:63749930
1677+c, tdbSNP:63750780
1685+a, gdbSNP:63750820
1688+c, tdbSNP:63750330
1691+c, gdbSNP:63750224
1692+a, tdbSNP:267607966
1694+, tdbSNP:63749955
1696+c, g, tdbSNP:63751207
1701+, adbSNP:63750094
1703+, cdbSNP:63750738
1707+a, cdbSNP:199744440
1710+, gdbSNP:63751261
1712+, adbSNP:63750845
1718..1738+, agtccttcgtaacaataaaaadbSNP:63750510
1719..1720+, gdbSNP:63750104
1725+c, g, tdbSNP:63750029
1727+a, tdbSNP:267607965
1732+a, gdbSNP:201722703
1746+a, gdbSNP:141150847
1752+, gdbSNP:63750675
1763+a, gdbSNP:372350768
1764..1765+, gadbSNP:63750662
1765+a, gdbSNP:267607967
1767+g, tdbSNP:63750538
1779+a, cdbSNP:63750838
1785+a, c, g, tdbSNP:63751656
1786+c, gdbSNP:63750597
1790+dbSNP:
1790+, adbSNP:63751120
1791+c, tdbSNP:61756466
1792..1793+, adbSNP:267607694
1793+, gdbSNP:63751324
1794+a, cdbSNP:63750432
1795+c, gdbSNP:139920308
1797+, tdbSNP:63751303
1801+, tdbSNP:63750633
1804+, adbSNP:63750054
1805+c, tdbSNP:200056411
1806+a, gdbSNP:63750328
1808+, adbSNP:63750406
1810+a, tdbSNP:63750997
1813+a, cdbSNP:63751054
1815+a, gdbSNP:55778204
1821..1822+, aadbSNP:63750737
1824+a, tdbSNP:63751149
1825..1829+, aaacadbSNP:63750474
1829..1830+, agdbSNP:63751463
1830..1831+, gadbSNP:63750393
1831..1832+, aadbSNP:63749883
1831..1832+, ga, tdbSNP:281864941
1842+a, gdbSNP:200766962
1842+, gdbSNP:267607974
1845+, cdbSNP:63751299
1845+c, tdbSNP:63751298
1849+a, gdbSNP:370330868
1855+c, tdbSNP:63749910
1862..1863+, adbSNP:63750480
1862+a, gdbSNP:61756467
1863+g, tdbSNP:63751411
1866..1867+, adbSNP:63750141
1873+a, gdbSNP:201118107
1878+, tdbSNP:63751433
1880+c, tdbSNP:63750112
1884+c, gdbSNP:63751140
1885+dbSNP:
1885+, gdbSNP:63750103
1889+g, tdbSNP:63750844
1896..1897+, adbSNP:267607977
1898..1899+, adbSNP:63750015
1899+a, gdbSNP:371614039
1902+c, tdbSNP:63750200
1904..1907+, gacadbSNP:63750113
1906..1907+, ctdbSNP:267607691
1911..1913+, aatdbSNP:63749831
1912+a, gdbSNP:41295288
1913..1914+, tgdbSNP:63750495
1920+g, tdbSNP:112457919
1924+c, tdbSNP:63751236
1926+c, tdbSNP:63750047
1932+a, g, tdbSNP:63750657
1933+a, gdbSNP:267607985
1934+, tdbSNP:63751129
1940..1942+, tgtdbSNP:267607978
1942+a, tdbSNP:376044376
1950+g, tdbSNP:150980616
1951+c, tdbSNP:63750665
1953+a, cdbSNP:267607980
1956+a, gdbSNP:369385048
1960+c, gdbSNP:63750493
1962+a, cdbSNP:200147804
1978+, cdbSNP:267607984
1981+a, gdbSNP:63749982
1982+g, tdbSNP:63750312
1983..1984+, tgdbSNP:63750031
1984..1985+, gtdbSNP:63750806
1986+c, tdbSNP:63750508
1989+a, cdbSNP:63750280
1990+c, tdbSNP:28929483
1998+g, tdbSNP:63750669
2006+a, cdbSNP:63750626
2007+a, gdbSNP:371776176
2010+c, tdbSNP:63750203
2011+a, gdbSNP:61756468
2014..2017+, gaagdbSNP:63750960
2021..2022+, adbSNP:63751038
2031+c, gdbSNP:63750875
2032+c, tdbSNP:63750279
2036+, cdbSNP:63750893
2037+a, gdbSNP:267607981
2040+c, tdbSNP:28929484
2042+a, g, tdbSNP:1800152
2046+g, tdbSNP:63749946
2052+a, gdbSNP:374840361
2058+c, gdbSNP:267607982
2062+a, c, gdbSNP:41295290
2064+g, tdbSNP:63750078
2067+a, gdbSNP:373475495
2080+a, cdbSNP:267607983
2092+a, cdbSNP:185356145
2093+c, gdbSNP:63751317
2098+a, gdbSNP:200827721
2104..2105+, atdbSNP:63750988
2108..2109+, adbSNP:63751055
2110..2111+, agdbSNP:63749976
2111+, gdbSNP:63749929
2121..2122+, atdbSNP:63751700
2130+a, gdbSNP:63751668
2131+dbSNP:
2131+a, gdbSNP:63751640
2134+c, tdbSNP:41294982
2135+, cdbSNP:63751123
2136+a, tdbSNP:63751232
2140+, tdbSNP:63751161
2143+, gdbSNP:63751462
2145+a, c, gdbSNP:63750234
2146..2147+, gtdbSNP:267608000
2146+c, gdbSNP:267607996
2149+a, gdbSNP:63751445
2151+c, tdbSNP:63751089
2156..2157+, atdbSNP:63749928
2163+c, tdbSNP:63749932
2169+a, gdbSNP:63751002
2172+a, gdbSNP:267607995
2181..2182+, atagdbSNP:63750422
2186+c, gdbSNP:63750032
2188+g, tdbSNP:63749993
2189+a, gdbSNP:63750790
2196..2197+, adbSNP:63749878
2199+c, gdbSNP:63750232
2200+g, tdbSNP:63751432
2205+c, tdbSNP:63751409
2207+, tdbSNP:63750689
2212+c, tdbSNP:267607994
2214+c, tdbSNP:63750961
2215+g, tdbSNP:63750398
2216+a, tdbSNP:63750872
2233+a, cdbSNP:267607999
2238+, gdbSNP:63749811
2245+a, gdbSNP:373226409
2248+a, tdbSNP:63750108
2254+a, cdbSNP:373717132
2256+c, tdbSNP:63750636
2257+a, gdbSNP:138465383
2260..2261+, tdbSNP:63751453
2264+c, gdbSNP:63750003
2266..2267+, cdbSNP:63750545
2266+c, tdbSNP:63751224
2279+a, gdbSNP:63750810
2285..2288+, aggadbSNP:63750722
2293+c, tdbSNP:63750794
2296+a, cdbSNP:63751125
2297+g, tdbSNP:370636719
2304+g, tdbSNP:104895026
2316+g, tdbSNP:63749802
2319..2321+, actdbSNP:63750562
2328+a, gdbSNP:2229061
2329+, tdbSNP:63750572
2335+c, gdbSNP:267607997
2353..2356+dbSNP:
2353..2356+, cattdbSNP:63751156
2353+a, c, gdbSNP:63751155
2356+g, tdbSNP:63750403
2358..2363+, ataatcdbSNP:267608008
2362..2363+, a, aatdbSNP:267607690
2364..2365+, atdbSNP:267607993
2365..2366+, tadbSNP:63751036
2367+g, tdbSNP:267608007
2370+a, g, tdbSNP:63751477
2376+a, gdbSNP:63751119
2386+, cdbSNP:267608009
2392+c, gdbSNP:372383829
2396+c, tdbSNP:56076152
2400+g, tdbSNP:63749854
2401+a, gdbSNP:386833406
2413+c, tdbSNP:144412585
2415+, tdbSNP:63749913
2417+a, gdbSNP:63751105
2418+a, gdbSNP:63750368
2419+, cdbSNP:63750346
2420+, tdbSNP:63751143
2421+a, gdbSNP:374399939
2429+a, gdbSNP:1800153
2430+, tdbSNP:63750896
2433+a, gdbSNP:63750684
2434+c, tdbSNP:371718349
2447+a, c, tdbSNP:56397910
2459+a, cdbSNP:63750618
2460..2461+, adbSNP:63750149
2462+a, gdbSNP:41295292
complement(2469)-t, cdbSNP:35784190
2472+, cdbSNP:63750233
2479+a, cdbSNP:200252727
2486..2487+, ttdbSNP:63750803
2487..2488+, adbSNP:63750463
2488..2489+, ctdbSNP:63750937
2513+, tdbSNP:63749983
2522+c, tdbSNP:368988823
2525+a, gdbSNP:201298777
2532+a, gdbSNP:63751168
2533..2534+, cadbSNP:63750060
2537+a, cdbSNP:141523959
2540+c, tdbSNP:139317211
2545+c, gdbSNP:41295294
2546+c, tdbSNP:372661586
2547+g, tdbSNP:34986638
2550+a, gdbSNP:202145681
2552..2553+, gdbSNP:63751079
2557+g, tdbSNP:63751018
2561+c, tdbSNP:375358440
2562+a, gdbSNP:63749841
2571+c, tdbSNP:63749917
2591..2592+dbSNP:
2591..2592+, tgdbSNP:63751621
2591+a, tdbSNP:63749846
2595+c, g, tdbSNP:63750623
2604+a, gdbSNP:63750478
2610+, cdbSNP:63751117
2625+a, gdbSNP:63750757
2626..2632+, ctaatttdbSNP:267608014
2627..2633+, taatttcdbSNP:63751447
2628+a, cdbSNP:41295296
2632+, tdbSNP:63750008
2641+a, gdbSNP:63750027
2642+a, tdbSNP:267608016
2650+a, tdbSNP:373393954
2654..2655+, tgdbSNP:63749975
2658+a, gdbSNP:63750571
2661+c, tdbSNP:63750857
2662+a, gdbSNP:140754514
2676+a, cdbSNP:267608015
2683+a, cdbSNP:63750797
2700+g, tdbSNP:63749830
2704+a, c, tdbSNP:63750849
2706+c, tdbSNP:63750291
2708+a, gdbSNP:63751093
2727+c, gdbSNP:63751400
2734+c, gdbSNP:63750709
2742+g, tdbSNP:63750795
2757..2758+, gadbSNP:267608013
2758..2759+, agdbSNP:63751618
2759+c, gdbSNP:63751624
2760+dbSNP:
2760+a, c, tdbSNP:63751469
2772..2773+, adbSNP:63750145
2772+, adbSNP:63750084
2776+g, tdbSNP:63750409
2778+c, tdbSNP:63750808
2782+a, gdbSNP:63750350
2787+, cdbSNP:63751007
2788+g, tdbSNP:63751205
2816+c, tdbSNP:148653184
2839+c, g, tdbSNP:267608022
2851+a, tdbSNP:34319539
2857+g, tdbSNP:41295182
2865+g, tdbSNP:267608024
2874+a, gdbSNP:200581817
2891+c, tdbSNP:55859129
2893+a, tdbSNP:146421227
2902+a, tdbSNP:199747712
2908+a, cdbSNP:1802577
2917+a, cdbSNP:267608023
2927+a, c, gdbSNP:150259097
2962+c, gdbSNP:192502889
2991+a, tdbSNP:104895027
3006+c, tdbSNP:368904632
3071+g, tdbSNP:17225053
3081+a, tdbSNP:145007871
3156+a, gdbSNP:17225060
Gene SymbolMSH2
Gene SynonymCOCA1; FCC1; HNPCC; HNPCC1; LCFS2
Chromosome2
Locus Map2p21
All Transcripts
RefSeq Accession Definition Stock Status Price Turnaround time Business Day Select
NM_000251 Homo sapiens mutS homolog 2 (MSH2), transcript variant 1, mRNA. On-demand $279.00 12-14
NM_000251 Homo sapiens mutS homolog 2 (MSH2), transcript variant 1, mRNA. On-demand $279.00 12-14
NM_000251 Homo sapiens mutS homolog 2 (MSH2), transcript variant 1, mRNA. On-demand $279.00 12-14
Title Mismatch repair protein hMSH2-hMSH6 recognizes mismatches and forms sliding clamps within a D-loop recombination intermediate .
Author Honda M, Okuno Y, Hengel SR, Martin-Lopez JV, Cook CP, Amunugama R, Soukup RJ, Subramanyam S, Fishel R and Spies M.
Journal Proc. Natl. Acad. Sci. U.S.A. 111 (3), E316-E325 (2014)
Title Tumor mismatch repair immunohistochemistry and DNA MLH1 methylation testing of patients with endometrial cancer diagnosed at age younger than 60 years optimizes triage for population-level germline mismatch repair gene mutation testing .
Author Buchanan DD, Tan YY, Walsh MD, Clendenning M, Metcalf AM, Ferguson K, Arnold ST, Thompson BA, Lose FA, Parsons MT, Walters RJ, Pearson SA, Cummings M, Oehler MK, Blomfield PB, Quinn MA, Kirk JA, Stewart CJ, Obermair A, Young JP, Webb PM and Spurdle AB.
Journal J. Clin. Oncol. 32 (2), 90-100 (2014)
Title Excess of extracolonic non-endometrial multiple primary cancers in MSH2 germline mutation carriers over MLH1 .
Author Lin-Hurtubise KM, Yheulon CG, Gagliano RA Jr and Lynch HT.
Journal J Surg Oncol 108 (7), 433-437 (2013)
Title Low expression of MSH2 DNA repair protein is associated with poor prognosis in head and neck squamous cell carcinoma .
Author Pereira CS, Oliveira MV, Barros LO, Bandeira GA, Santos SH, Basile JR, Guimaraes AL and De Paula AM.
Journal J Appl Oral Sci 21 (5), 416-421 (2013)
Title Functional examination of MLH1, MSH2, and MSH6 intronic mutations identified in Danish colorectal cancer patients .
Author Petersen SM, Dandanell M, Rasmussen LJ, Gerdes AM, Krogh LN, Bernstein I, Okkels H, Wikman F, Nielsen FC and Hansen TV.
Journal BMC Med. Genet. 14, 103 (2013)
Title Differential cellular expression of the human MSH2 repair enzyme in small and large intestine .
Author Wilson TM, Ewel A, Duguid JR, Eble JN, Lescoe MK, Fishel R and Kelley MR.
Journal Cancer Res. 55 (22), 5146-5150 (1995)
Title Simultaneous amplification of four DNA repair genes and beta-actin in human lymphocytes by multiplex reverse transcriptase-PCR .
Author Wei Q, Xu X, Cheng L, Legerski RJ and Ali-Osman F.
Journal Cancer Res. 55 (21), 5025-5029 (1995)
Title Isolation of an hMSH2-p160 heterodimer that restores DNA mismatch repair to tumor cells .
Author Drummond JT, Li GM, Longley MJ and Modrich P.
Journal Science 268 (5219), 1909-1912 (1995)
Title Lynch Syndrome .
Author Kohlmann,W. and Gruber,S.B.
Journal (in) Pagon RA, Adam MP, Ardinger HH, Bird TD, Dolan CR, Fong CT, Smith RJH and Stephens K (Eds.); GENEREVIEWS(R); (1993)
Title Hereditary nonpolyposis colorectal cancer (Lynch syndromes I and II). II. Biomarker studies .
Author Lynch,H.T., Schuelke,G.S., Kimberling,W.J., Albano,W.A., Lynch,J.F., Biscone,K.A., Lipkin,M.L., Deschner,E.E., Mikol,Y.B., Sandberg,A.A. et al.
Journal Cancer 56 (4), 939-951 (1985)

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