• THAT   AND
  • THAT   AND


Sequence in raw or FASTA format:

Database:

Blast Method:

 
 


Homo sapiens mutS homolog 2, colon cancer, nonpolyposis type 1 (E. coli) (MSH2), transcript variant 1, mRNA.


RefSeq Accession Definition Services Price Order
NM_000251 Homo sapiens mutS homolog 2, colon cancer, nonpolyposis type 1 (E. coli) (MSH2), transcript variant 1, mRNA. ORF Sequence $813.45
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RefSeq Version NM_000251.2, 384871700
Length 3226 bp
Structure linear
Update Date 29-APR-2013
Organism Homo sapiens (human)
Definition Homo sapiens mutS homolog 2, colon cancer, nonpolyposis type 1 (E. coli) (MSH2), transcript variant 1, mRNA.
Product DNA mismatch repair protein Msh2 isoform 1
Comment

Summary: This locus is frequently mutated in hereditary nonpolyposis colon cancer (HNPCC). When cloned, it was discovered to be a human homolog of the E. coli mismatch repair gene mutS, consistent with the characteristic alterations in microsatellite sequences (RER+ phenotype) found in HNPCC. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2012].


Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).

RefSeq NP_000242.1
CDS 126..2930
Misc Feature(1)111..113
Misc Feature(2)177..521
Misc Feature(3)177..521
Misc Feature(4)180..2684
Misc Feature(5)597..977
Misc Feature(6)1542..1802
Misc Feature(7)1788..1790
Misc Feature(8)1926..2138
Misc Feature(9)2022..2681
Misc Feature(10)2130..2153
Misc Feature(11)order(2139..2144,2148..2156,2262..2264,2367..2372,
Misc Feature(12)2253..2264
Misc Feature(13)2277..2318
Misc Feature(14)2355..2372
Misc Feature(15)2379..2390
Misc Feature(16)2460..2480
Misc Feature(17)2703..2705
Exon (1)1..336
Gene:MSH2
Gene Synonym:COCA1; FCC1; HNPCC; HNPCC1; LCFS2
Exon (2)337..491
Gene:MSH2
Gene Synonym:COCA1; FCC1; HNPCC; HNPCC1; LCFS2
Exon (3)492..770
Gene:MSH2
Gene Synonym:COCA1; FCC1; HNPCC; HNPCC1; LCFS2
Exon (4)771..917
Gene:MSH2
Gene Synonym:COCA1; FCC1; HNPCC; HNPCC1; LCFS2
Exon (5)918..1067
Gene:MSH2
Gene Synonym:COCA1; FCC1; HNPCC; HNPCC1; LCFS2
Exon (6)1068..1201
Gene:MSH2
Gene Synonym:COCA1; FCC1; HNPCC; HNPCC1; LCFS2
Exon (7)1202..1401
Gene:MSH2
Gene Synonym:COCA1; FCC1; HNPCC; HNPCC1; LCFS2
Exon (8)1402..1511
Gene:MSH2
Gene Synonym:COCA1; FCC1; HNPCC; HNPCC1; LCFS2
Exon (9)1512..1635
Gene:MSH2
Gene Synonym:COCA1; FCC1; HNPCC; HNPCC1; LCFS2
Exon (10)1636..1786
Gene:MSH2
Gene Synonym:COCA1; FCC1; HNPCC; HNPCC1; LCFS2
Exon (11)1787..1884
Gene:MSH2
Gene Synonym:COCA1; FCC1; HNPCC; HNPCC1; LCFS2
Exon (12)1885..2130
Gene:MSH2
Gene Synonym:COCA1; FCC1; HNPCC; HNPCC1; LCFS2
Exon (13)2131..2335
Gene:MSH2
Gene Synonym:COCA1; FCC1; HNPCC; HNPCC1; LCFS2
Exon (14)2336..2583
Gene:MSH2
Gene Synonym:COCA1; FCC1; HNPCC; HNPCC1; LCFS2
Exon (15)2584..2759
Gene:MSH2
Gene Synonym:COCA1; FCC1; HNPCC; HNPCC1; LCFS2
Exon (16)2760..3209
Gene:MSH2
Gene Synonym:COCA1; FCC1; HNPCC; HNPCC1; LCFS2
Translation MAVQPKETLQLESAAEVGFVRFFQGMPEKPTTTVRLFDRGDFYTAHGEDALLAAREVFKT QGVIKYMGPAGAKNLQSVVLSKMNFESFVKDLLLVRQYRVEVYKNRAGNKASKENDWYLA YKASPGNLSQFEDILFGNNDMSASIGVVGVKMSAVDGQRQVGVGYVDSIQRKLGLCEFPD NDQFSNLEALLIQIGPKECVLPGGETAGDMGKLRQIIQRGGILITERKKADFSTKDIYQD LNRLLKGKKGEQMNSAVLPEMENQVAVSSLSAVIKFLELLSDDSNFGQFELTTFDFSQYM KLDIAAVRALNLFQGSVEDTTGSQSLAALLNKCKTPQGQRLVNQWIKQPLMDKNRIEERL NLVEAFVEDAELRQTLQEDLLRRFPDLNRLAKKFQRQAANLQDCYRLYQGINQLPNVIQA LEKHEGKHQKLLLAVFVTPLTDLRSDFSKFQEMIETTLDMDQVENHEFLVKPSFDPNLSE LREIMNDLEKKMQSTLISAARDLGLDPGKQIKLDSSAQFGYYFRVTCKEEKVLRNNKNFS TVDIQKNGVKFTNSKLTSLNEEYTKNKTEYEEAQDAIVKEIVNISSGYVEPMQTLNDVLA QLDAVVSFAHVSNGAPVPYVRPAILEKGQGRIILKASRHACVEVQDEIAFIPNDVYFEKD KQMFHIITGPNMGGKSTYIRQTGVIVLMAQIGCFVPCESAEVSIVDCILARVGAGDSQLK GVSTFMAEMLETASILRSATKDSLIIIDELGRGTSTYDGFGLAWAISEYIATKIGAFCMF ATHFHELTALANQIPTVNNLHVTALTTEETLTMLYQVKKGVCDQSFGIHVAELANFPKHV IECAKQKALELEEFQYIGESQGYDIMEPAAKKCYLEREQGEKIIQEFLSKVKQMPFTEMS EENITIKLKQLKAEVIAKNNSFVNEIISRIKVTT
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Position Chain Variation Link
24+dbSNP:
24+c, tdbSNP:17217709
30+a, gdbSNP:56062561
50+a, gdbSNP:34355730
97+c, tdbSNP:199841800
101+, adbSNP:68154274
102+a, gdbSNP:183204578
126+a, c, g, tdbSNP:267607911
129+a, gdbSNP:63750466
139+a, cdbSNP:56170584
143+c, gdbSNP:146017810
145+, adbSNP:267607915
146..147+, gcggtgcagccgaaggagdbSNP:281864943
148+c, tdbSNP:17217716
153+c, tdbSNP:63751099
154..155+, adbSNP:63750589
156+, tdbSNP:66818250
159..160+, gdbSNP:63750614
163+g, tdbSNP:63749907
174+g, tdbSNP:63750966
179+c, gdbSNP:63750777
180+c, tdbSNP:141711342
191+c, tdbSNP:200632093
192..193+, tdbSNP:66513409
206+, gdbSNP:63751091
207+g, tdbSNP:63751246
219..228+, accacagtgcdbSNP:63750728
222+a, c, gdbSNP:63751107
224+a, cdbSNP:267607912
226+a, tdbSNP:63751424
235+, tdbSNP:63751056
242+a, gdbSNP:63750974
243+a, gdbSNP:63751260
244+, gdbSNP:63750984
253+a, gdbSNP:17217723
254+a, g, tdbSNP:63750894
259..287+, cgcacggcgaggacgcgctgctggccgccdbSNP:63750089
259+c, tdbSNP:63750285
261..289+, cacggcgaggacgcgctgctggccgcccgdbSNP:63751482
263+c, gdbSNP:33946261
267+g, tdbSNP:63750615
270..271+, gadbSNP:63750334
270+, gdbSNP:63750644
271+a, tdbSNP:63750335
279..280+, gdbSNP:63750352
288+, cdbSNP:63750337
291+, gdbSNP:63750087
294+a, gdbSNP:267607913
306+c, tdbSNP:63750951
312..313+, g, ggdbSNP:281864942
312+, gdbSNP:63750160
329+, gdbSNP:63750199
344+dbSNP:
344+a, gdbSNP:1800150
345+a, cdbSNP:150548839
348..349+, ctdbSNP:63750712
351+c, tdbSNP:63750042
354..355+, agdbSNP:63749848
372..373+, adbSNP:63749912
380..381+, tdbSNP:63751158
380..381+, tgdbSNP:267607921
388..389+, ttdbSNP:267607920
398..400+, tctdbSNP:34722983
402..404+, cttdbSNP:267607918
402+c, tdbSNP:63751429
403..404+, ttdbSNP:63749872
403+c, tdbSNP:63751456
404..406+, tctdbSNP:267607919
412+a, gdbSNP:63750002
414..415+, aaagatcttcttctggttcgtcdbSNP:63751295
414+c, tdbSNP:63750970
418+a, gdbSNP:63750887
420+a, cdbSNP:63750230
421+, gdbSNP:63749861
422..427+, agttgadbSNP:63750506
426+g, tdbSNP:63750318
429+a, gdbSNP:193922373
433+a, gdbSNP:63751173
442+a, gdbSNP:41295286
452+c, tdbSNP:63751437
454+a, gdbSNP:63751040
461+a, cdbSNP:34312619
464+a, gdbSNP:35898375
469+, adbSNP:63751195
472..475+, attgdbSNP:63750501
488+g, tdbSNP:63750458
493+dbSNP:
493+, cdbSNP:63750210
505..506+, atdbSNP:63751227
505+a, gdbSNP:17217772
507+c, gdbSNP:145649774
512..513+, tcdbSNP:63750924
513..514+, cadbSNP:63750704
524+, cdbSNP:63751290
524+c, tdbSNP:61756462
528+c, tdbSNP:193096019
533+, tdbSNP:63750408
541+, adbSNP:63750401
546+a, gdbSNP:193922374
550+c, gdbSNP:63750910
560+g, tdbSNP:63750124
579+, adbSNP:63751449
584+c, tdbSNP:63751065
596+a, cdbSNP:61756463
597+c, tdbSNP:63751226
603+c, tdbSNP:63751426
606+a, gdbSNP:149511545
607+a, tdbSNP:63750126
609+a, gdbSNP:63750624
610+c, gdbSNP:63750773
613+a, tdbSNP:63750214
615+a, g, tdbSNP:63750582
620+g, tdbSNP:63749949
624+c, gdbSNP:63750255
630+a, gdbSNP:63750716
631..634+, tacadbSNP:63751013
633+c, tdbSNP:63750843
637+a, gdbSNP:63750902
638+, gdbSNP:63750933
642..653+a, ctaggactgtgtdbSNP:63751067
643+c, g, tdbSNP:63750070
643+, tdbSNP:63750069
646+a, gdbSNP:147346837
648..689+, ctgtgtgaattccctgataatgatcagttctccaatcttgagdbSNP:63750705
649+c, tdbSNP:63751291
654+a, g, tdbSNP:63750382
655..656+, aadbSNP:63750551
672+c, tdbSNP:63750037
676+, tdbSNP:267607928
682+a, gdbSNP:151129360
685+c, g, tdbSNP:63751444
686..694+, tgaggctctdbSNP:63750088
689..690+, tcagttctccaatcttgagdbSNP:63750080
690+g, tdbSNP:63750821
691+c, gdbSNP:141021599
694..695+ct, tcdbSNP:267607927
698+c, tdbSNP:1800151
702+c, tdbSNP:63751326
712+, cdbSNP:63750682
714+a, cdbSNP:146543705
717..718+, gdbSNP:63750786
718+a, gdbSNP:63750327
720+c, tdbSNP:63751110
721+a, gdbSNP:63751136
731+c, tdbSNP:63750600
735+g, tdbSNP:63750574
738+c, g, tdbSNP:63749984
741..742+, adbSNP:63750995
744+a, g, tdbSNP:63750913
748+, gdbSNP:63750121
763..764+, tgdbSNP:63751622
767..770+, acagdbSNP:63751695
768+c, tdbSNP:63751274
771+dbSNP:
771+a, gdbSNP:63749936
775..779+, ttcaadbSNP:63751602
807+a, gdbSNP:200313142
812..813+, adbSNP:63750364
812+, adbSNP:63749897
821..822+, ttdbSNP:63750426
829..830+, aadbSNP:281864944
830+, adbSNP:281864945
834+a, gdbSNP:63751307
836..839+, ttatdbSNP:63751288
840+c, tdbSNP:63750488
841+a, gdbSNP:199676483
842..846+ggacc, ttadbSNP:63750690
852+c, tdbSNP:138857091
853+a, gdbSNP:63751455
860..861+, gdbSNP:63750107
861+a, c, tdbSNP:63750881
871+, adbSNP:63749832
871+a, cdbSNP:61756464
876+a, gdbSNP:147389443
879+c, tdbSNP:63750347
881..882+, cdbSNP:35170366
884..887+, gaatdbSNP:267607931
884+, gdbSNP:63751160
888..891+agtg, ttdbSNP:63750329
907+c, tdbSNP:63749969
907+, tdbSNP:63749968
913..914+, atdbSNP:63751614
920+dbSNP:
920+c, g, tdbSNP:63749903
920+, tdbSNP:63749902
931+c, tdbSNP:63750058
932..933+, adbSNP:63750225
933..936+, ctgtdbSNP:63750326
935..938+, gtctdbSNP:63749978
935..936+, gtdbSNP:63751133
937+c, tdbSNP:139891783
940+c, tdbSNP:34136999
942..943+aa, gtdbSNP:63749840
943+c, tdbSNP:144288433
944+a, gdbSNP:146577635
961..963+, tctdbSNP:267607936
961+, tdbSNP:63751159
964..965+, tdbSNP:63750091
965+, adbSNP:63750154
967+c, gdbSNP:63749991
968+a, tdbSNP:150197753
972+g, tdbSNP:63750381
979+, adbSNP:63750701
983..984+, gdbSNP:34198889
984+g, tdbSNP:63750276
985..986+, gdbSNP:193922375
987+c, tdbSNP:63750097
999+a, tdbSNP:104895022
1006..1007+, ttdbSNP:63751115
1010+c, gdbSNP:201334592
1017+c, tdbSNP:63750934
1018+a, cdbSNP:267607998
1024..1025+, atdbSNP:63750885
1026+a, tdbSNP:63749915
1030+a, tdbSNP:63749914
1038+a, gdbSNP:63751454
1047..1048+, agcagtcadbSNP:63750046
1054+c, tdbSNP:63750640
1059+, cdbSNP:267607937
1069+dbSNP:
1069+g, tdbSNP:202026056
1083..1084+, adbSNP:63749852
1090+a, gdbSNP:4987188
1093+a, c, gdbSNP:63750732
1095..1096+, cadbSNP:63751044
1095+c, tdbSNP:63750502
1097+a, gdbSNP:63750505
1098..1099+, tdbSNP:63749945
1109+c, tdbSNP:4987189
1114+c, tdbSNP:63750630
1116+a, gdbSNP:267607938
1122+c, tdbSNP:63750468
1123+a, gdbSNP:63750828
1129..1132+, ccccdbSNP:63751289
1129+c, tdbSNP:63750602
1131+c, tdbSNP:63751062
1134+c, tdbSNP:63750778
1137+a, gdbSNP:63751004
1142..1143+, aadbSNP:63750703
1147+c, tdbSNP:63751147
1149+a, gdbSNP:63749879
1155+c, tdbSNP:63750245
1159+a, gdbSNP:63751027
1160+a, gdbSNP:63750396
1163..1164+, ttdbSNP:63751483
1170+c, gdbSNP:267607939
1176+a, gdbSNP:138026880
1195+a, cdbSNP:150503781
1201+g, tdbSNP:63751604
1202+dbSNP:
1202+a, tdbSNP:63751617
1211+a, tdbSNP:63751699
1222..1223+, adbSNP:267607693
1224+a, g, tdbSNP:80285180
1233+, gdbSNP:63749814
1234+c, gdbSNP:139652783
1244+, gdbSNP:63750516
1245+c, tdbSNP:63750558
1253..1254+, tadbSNP:63751219
1254+c, tdbSNP:63750267
1256+a, gdbSNP:181852377
1264+, tdbSNP:63750039
1269..1270+, cdbSNP:63750496
1270+a, gdbSNP:267607947
1272+c, tdbSNP:63749849
1285+c, tdbSNP:63750485
1293+c, tdbSNP:17224367
1300+a, tdbSNP:61756465
1307..1308+, tdbSNP:63750901
1308+c, tdbSNP:63750302
1314+c, tdbSNP:63750611
1317..1318+, gdbSNP:63751169
1322..1323+, cadbSNP:63749850
1328..1329+, adbSNP:63750586
1329+, cdbSNP:63751413
1329+c, tdbSNP:63751412
1340+a, cdbSNP:63751271
1341+c, tdbSNP:63751108
1342+a, gdbSNP:146567853
1343..1344+, ccgadbSNP:267607946
1344..1345+, cgacdbSNP:63751192
1346+c, g, tdbSNP:63750813
1347..1348+, tdbSNP:63751142
1348+a, gdbSNP:63750379
1349+c, tdbSNP:63750132
1350+a, c, gdbSNP:151244108
1351..1352+, agdbSNP:63750086
1360..1392+, atcaactacctaatgttatacaggctctggaaadbSNP:63751644
1368..1371+, cctadbSNP:63751206
1368+c, g, tdbSNP:35717997
1374+, gdbSNP:63751059
1380+a, c, tdbSNP:63750006
1386+a, cdbSNP:63750228
1389+g, tdbSNP:63751712
1392+a, gdbSNP:201059765
1394..1395+, adbSNP:63751667
1396+a, gdbSNP:200429136
1400+a, gdbSNP:63751650
1410+dbSNP:
1410+c, tdbSNP:63751693
1412..1413+, gdbSNP:63751626
1413+a, tdbSNP:63751646
1417+a, tdbSNP:63751315
1421+a, gdbSNP:141295984
1440..1442+, cctdbSNP:63751138
1441..1442+, ctdbSNP:63750251
1444..1451+cc, ttactgatdbSNP:63749931
1446..1447+, adbSNP:63750807
1464+g, tdbSNP:63751217
1465..1466+, ggdbSNP:267607696
1470..1473+, aagtdbSNP:267607955
1470+a, tdbSNP:63749920
1477..1478+, agdbSNP:63750957
1479+g, tdbSNP:267607954
1481+a, gdbSNP:63751212
1483+a, tdbSNP:63750697
1498+g, tdbSNP:63750521
1533+dbSNP:
1533+, gdbSNP:63750384
1534+a, tdbSNP:267607959
1543+c, g, tdbSNP:63751403
1565+a, gdbSNP:138049198
1569..1570+, adbSNP:63750436
1569+, adbSNP:63750068
1570..1574+, gagaadbSNP:267607961
1570..1571+, taagdbSNP:63750930
1572..1573+, gadbSNP:63750161
1572+g, tdbSNP:63749947
1577..1580+, aatgdbSNP:63750148
1582+, adbSNP:63750986
1586+c, gdbSNP:35107951
1601..1602+ct, gcdbSNP:63750583
1602+c, tdbSNP:63750936
1605+c, tdbSNP:55653533
1613+a, gdbSNP:267607960
1619..1620+, tdbSNP:63750362
1622+, adbSNP:63749963
1630+a, gdbSNP:148192104
1635+c, gdbSNP:63751600
1641+dbSNP:
1641+g, tdbSNP:63750492
1647+a, gdbSNP:267607968
1677..1678+, cadbSNP:63749930
1677+c, tdbSNP:63750780
1685+a, gdbSNP:63750820
1688+c, tdbSNP:63750330
1691+c, gdbSNP:63750224
1692+a, tdbSNP:267607966
1694+, tdbSNP:63749955
1696+c, g, tdbSNP:63751207
1701+, adbSNP:63750094
1703+, cdbSNP:63750738
1707+a, cdbSNP:199744440
1710+, gdbSNP:63751261
1712+, adbSNP:63750845
1718..1738+, agtccttcgtaacaataaaaadbSNP:63750510
1719..1720+, gdbSNP:63750104
1725+c, tdbSNP:63750029
1727+a, tdbSNP:267607965
1732+a, gdbSNP:201722703
1746+a, gdbSNP:141150847
1752+, gdbSNP:63750675
1764..1765+, gadbSNP:63750662
1765+a, gdbSNP:267607967
1767+g, tdbSNP:63750538
1779+a, cdbSNP:63750838
1785+a, c, g, tdbSNP:63751656
1786+c, gdbSNP:63750597
1790+dbSNP:
1790+, adbSNP:63751120
1791+c, tdbSNP:61756466
1792..1793+, adbSNP:267607694
1793+, gdbSNP:63751324
1794+a, cdbSNP:63750432
1795+c, gdbSNP:139920308
1797+, tdbSNP:63751303
1801+, tdbSNP:63750633
1804+, adbSNP:63750054
1805+c, tdbSNP:200056411
1806+a, gdbSNP:63750328
1808+, adbSNP:63750406
1810+a, tdbSNP:63750997
1813+a, cdbSNP:63751054
1815+a, gdbSNP:55778204
1821..1822+, aadbSNP:63750737
1824+a, tdbSNP:63751149
1825..1829+, aaacadbSNP:63750474
1829..1830+, agdbSNP:63751463
1830..1831+, gadbSNP:63750393
1831..1832+, aadbSNP:63749883
1831..1832+, ga, tdbSNP:281864941
1842+a, gdbSNP:200766962
1842+, gdbSNP:267607974
1845+, cdbSNP:63751299
1845+c, tdbSNP:63751298
1855+c, tdbSNP:63749910
1862..1863+, adbSNP:63750480
1862+a, gdbSNP:61756467
1863+g, tdbSNP:63751411
1866..1867+, adbSNP:63750141
1873+a, gdbSNP:201118107
1878+, tdbSNP:63751433
1880+c, tdbSNP:63750112
1884+c, gdbSNP:63751140
1885+dbSNP:
1885+, gdbSNP:63750103
1889+g, tdbSNP:63750844
1896..1897+, adbSNP:267607977
1898..1899+, adbSNP:63750015
1902+c, tdbSNP:63750200
1904..1907+, gacadbSNP:63750113
1906..1907+, ctdbSNP:267607691
1911..1913+, aatdbSNP:63749831
1912+a, gdbSNP:41295288
1913..1914+, tgdbSNP:63750495
1920+g, tdbSNP:112457919
1924+c, tdbSNP:63751236
1926+c, tdbSNP:63750047
1932+a, g, tdbSNP:63750657
1933+a, gdbSNP:267607985
1934+, tdbSNP:63751129
1940..1942+, tgtdbSNP:267607978
1950+g, tdbSNP:150980616
1951+c, tdbSNP:63750665
1953+a, cdbSNP:267607980
1960+c, gdbSNP:63750493
1962+a, cdbSNP:200147804
1978+, cdbSNP:267607984
1981+a, gdbSNP:63749982
1982+g, tdbSNP:63750312
1983..1984+, tgdbSNP:63750031
1984..1985+, gtdbSNP:63750806
1986+c, tdbSNP:63750508
1989+a, cdbSNP:63750280
1990+c, tdbSNP:28929483
1998+g, tdbSNP:63750669
2006+a, cdbSNP:63750626
2010+c, tdbSNP:63750203
2011+a, gdbSNP:61756468
2014..2017+, gaagdbSNP:63750960
2021..2022+, adbSNP:63751038
2031+c, gdbSNP:63750875
2032+c, tdbSNP:63750279
2036+, cdbSNP:63750893
2037+a, gdbSNP:267607981
2040+c, tdbSNP:28929484
2042+a, g, tdbSNP:1800152
2046+g, tdbSNP:63749946
2058+c, gdbSNP:267607982
2062+a, c, gdbSNP:41295290
2064+g, tdbSNP:63750078
2080+a, cdbSNP:267607983
2092+a, cdbSNP:185356145
2093+c, gdbSNP:63751317
2094+, tdbSNP:67187315
2098+a, gdbSNP:200827721
2104..2105+, atdbSNP:63750988
2108..2109+, adbSNP:63751055
2110..2111+, agdbSNP:63749976
2111+, gdbSNP:63749929
2121..2122+, atdbSNP:63751700
2130+a, gdbSNP:63751668
2131+dbSNP:
2131+a, gdbSNP:63751640
2134+c, tdbSNP:41294982
2135+, cdbSNP:63751123
2136+a, tdbSNP:63751232
2140+, tdbSNP:63751161
2143+, gdbSNP:63751462
2145+a, c, gdbSNP:63750234
2146..2147+, gtdbSNP:267608000
2146+c, gdbSNP:267607996
2149+a, gdbSNP:63751445
2151+c, tdbSNP:63751089
2156..2157+, atdbSNP:63749928
2163+c, tdbSNP:63749932
2169+a, gdbSNP:63751002
2172+a, gdbSNP:267607995
2181..2182+, atagdbSNP:63750422
2186+c, gdbSNP:63750032
2188+g, tdbSNP:63749993
2189+a, gdbSNP:63750790
2196..2197+, adbSNP:63749878
2199+c, gdbSNP:63750232
2200+g, tdbSNP:63751432
2205+c, tdbSNP:63751409
2207+, tdbSNP:63750689
2212+c, tdbSNP:267607994
2214+c, tdbSNP:63750961
2215+g, tdbSNP:63750398
2216+a, tdbSNP:63750872
2233+a, cdbSNP:267607999
2238+, gdbSNP:63749811
2248+a, tdbSNP:63750108
2256+c, tdbSNP:63750636
2257+a, gdbSNP:138465383
2260..2261+, tdbSNP:63751453
2264+c, gdbSNP:63750003
2266..2267+, cdbSNP:63750545
2266+c, tdbSNP:63751224
2279+a, gdbSNP:63750810
2285..2288+, aggadbSNP:63750722
2293+c, tdbSNP:63750794
2296+a, cdbSNP:63751125
2304+g, tdbSNP:104895026
2316+g, tdbSNP:63749802
2319..2321+, actdbSNP:63750562
2328+a, gdbSNP:2229061
2329+, tdbSNP:63750572
2335+c, gdbSNP:267607997
2353..2356+dbSNP:
2353..2356+, cattdbSNP:63751156
2353+a, c, gdbSNP:63751155
2356+g, tdbSNP:63750403
2358..2363+, ataatcdbSNP:267608008
2362..2363+, a, aatdbSNP:267607690
2364..2365+, atdbSNP:267607993
2365..2366+, tadbSNP:63751036
2367+g, tdbSNP:267608007
2370+a, g, tdbSNP:63751477
2376+a, gdbSNP:63751119
2386+, cdbSNP:267608009
2396+c, tdbSNP:56076152
2400+g, tdbSNP:63749854
2413+c, tdbSNP:144412585
2415+, tdbSNP:63749913
2417+a, gdbSNP:63751105
2418+a, gdbSNP:63750368
2419+, cdbSNP:63750346
2420+, tdbSNP:63751143
2429+a, gdbSNP:1800153
2430+, tdbSNP:63750896
2433+a, gdbSNP:63750684
2447+a, c, tdbSNP:56397910
2459+a, cdbSNP:63750618
2460..2461+, adbSNP:63750149
2462+a, gdbSNP:41295292
2469+c, tdbSNP:35784190
2472+, cdbSNP:63750233
2479+a, cdbSNP:200252727
2486..2487+, ttdbSNP:63750803
2487..2488+, adbSNP:63750463
2488..2489+, ctdbSNP:63750937
2513+, tdbSNP:63749983
2525+a, gdbSNP:201298777
2532+a, gdbSNP:63751168
2533..2534+, cadbSNP:63750060
2537+a, cdbSNP:141523959
2540+c, tdbSNP:139317211
2545+c, gdbSNP:41295294
2547+g, tdbSNP:34986638
2550+a, gdbSNP:202145681
2552..2553+, gdbSNP:63751079
2557+g, tdbSNP:63751018
2562+a, gdbSNP:63749841
2571+c, tdbSNP:63749917
2591..2592+dbSNP:
2591..2592+, tgdbSNP:63751621
2591+a, tdbSNP:63749846
2595+c, g, tdbSNP:63750623
2604+a, gdbSNP:63750478
2610+, cdbSNP:63751117
2625+a, gdbSNP:63750757
2626..2632+, ctaatttdbSNP:267608014
2627..2633+, taatttcdbSNP:63751447
2628+a, cdbSNP:41295296
2632+, tdbSNP:63750008
2641+a, gdbSNP:63750027
2642+a, tdbSNP:267608016
2654..2655+, tgdbSNP:63749975
2658+a, gdbSNP:63750571
2661+c, tdbSNP:63750857
2662+a, gdbSNP:140754514
2676+a, cdbSNP:267608015
2683+a, cdbSNP:63750797
2700+g, tdbSNP:63749830
2704+a, c, tdbSNP:63750849
2706+c, tdbSNP:63750291
2708+a, gdbSNP:63751093
2727+c, gdbSNP:63751400
2734+c, gdbSNP:63750709
2742+g, tdbSNP:63750795
2757..2758+, gadbSNP:267608013
2758..2759+, agdbSNP:63751618
2759+c, gdbSNP:63751624
2760+dbSNP:
2760+a, c, tdbSNP:63751469
2772..2773+, adbSNP:63750145
2772+, adbSNP:63750084
2776+g, tdbSNP:63750409
2778+c, tdbSNP:63750808
2782+a, gdbSNP:63750350
2787+, cdbSNP:63751007
2788+g, tdbSNP:63751205
2816+c, tdbSNP:148653184
2839+c, gdbSNP:267608022
2851+a, tdbSNP:34319539
2857+g, tdbSNP:41295182
2865+g, tdbSNP:267608024
2874+a, gdbSNP:200581817
2891+c, tdbSNP:55859129
2893+a, tdbSNP:146421227
2902+a, tdbSNP:199747712
2905+, tdbSNP:66726749
2908+a, cdbSNP:1802577
2917+a, cdbSNP:267608023
2927+a, c, gdbSNP:150259097
2962+c, gdbSNP:192502889
2991+a, tdbSNP:104895027
3071+g, tdbSNP:17225053
3081+a, tdbSNP:145007871
3103+, tdbSNP:66505139
3156+a, gdbSNP:17225060
Gene SymbolMSH2
Gene SynonymCOCA1; FCC1; HNPCC; HNPCC1; LCFS2
Chromosome2
Locus Map2p21
All Transcripts
RefSeq Accession Definition Sequence Price Select
NM_000251 Homo sapiens mutS homolog 2, colon cancer, nonpolyposis type 1 (E. coli) (MSH2), transcript variant 1, mRNA. Full Length $1129.10
ORF Sequence $813.45
NM_001258281 Homo sapiens mutS homolog 2, colon cancer, nonpolyposis type 1 (E. coli) (MSH2), transcript variant 2, mRNA. Full Length $1064.70
ORF Sequence $756.03
Title Bethesda criteria for microsatellite instability testing: impact on the detection of new cases of Lynch syndrome .
Author Serrano,M., Lage,P., Belga,S., Filipe,B., Francisco,I., Rodrigues,P., Fonseca,R., Chaves,P., Claro,I., Albuquerque,C. and Pereira,A.D.
Journal Fam. Cancer 11 (4), 571-578 (2012)
Title Engineered disulfide-forming amino acid substitutions interfere with a conformational change in the mismatch recognition complex Msh2-Msh6 required for mismatch repair .
Author Hargreaves,V.V., Putnam,C.D. and Kolodner,R.D.
Journal J. Biol. Chem. 287 (49), 41232-41244 (2012)
Title MutSbeta and histone deacetylase complexes promote expansions of trinucleotide repeats in human cells .
Author Gannon,A.M., Frizzell,A., Healy,E. and Lahue,R.S.
Journal Nucleic Acids Res. 40 (20), 10324-10333 (2012)
Title Status of mismatch repair genes hMSH2 and hMSH6 in colorectal cancer in Saudi patients: an immunohistochemical analysis .
Author Alkhalidi,H. and Kfoury,H.
Journal East. Mediterr. Health J. 18 (11), 1114-1117 (2012)
Title miR-21 induces cell cycle at S phase and modulates cell proliferation by down-regulating hMSH2 in lung cancer .
Author Zhong,Z., Dong,Z., Yang,L. and Gong,Z.
Journal J. Cancer Res. Clin. Oncol. 138 (10), 1781-1788 (2012)
Title Differential cellular expression of the human MSH2 repair enzyme in small and large intestine .
Author Wilson,T.M., Ewel,A., Duguid,J.R., Eble,J.N., Lescoe,M.K., Fishel,R. and Kelley,M.R.
Journal Cancer Res. 55 (22), 5146-5150 (1995)
Title Simultaneous amplification of four DNA repair genes and beta-actin in human lymphocytes by multiplex reverse transcriptase-PCR .
Author Wei,Q., Xu,X., Cheng,L., Legerski,R.J. and Ali-Osman,F.
Journal Cancer Res. 55 (21), 5025-5029 (1995)
Title Isolation of an hMSH2-p160 heterodimer that restores DNA mismatch repair to tumor cells .
Author Drummond,J.T., Li,G.M., Longley,M.J. and Modrich,P.
Journal Science 268 (5219), 1909-1912 (1995)
Title Structure of the human MSH2 locus and analysis of two Muir-Torre kindreds for msh2 mutations .
Author Kolodner,R.D., Hall,N.R., Lipford,J., Kane,M.F., Rao,M.R., Morrison,P., Wirth,L., Finan,P.J., Burn,J. and Chapman,P.
Journal Genomics 24 (3), 516-526 (1994)
Title Hereditary nonpolyposis colorectal cancer (Lynch syndromes I and II). II. Biomarker studies .
Author Lynch,H.T., Schuelke,G.S., Kimberling,W.J., Albano,W.A., Lynch,J.F., Biscone,K.A., Lipkin,M.L., Deschner,E.E., Mikol,Y.B., Sandberg,A.A. et al.
Journal Cancer 56 (4), 939-951 (1985)

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