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Homo sapiens phosphoglycerate kinase 1 (PGK1), mRNA.


Clone ID Definition Vector Stock Status Price *Turnaround time Order
OHu19088 Homo sapiens phosphoglycerate kinase 1 (PGK1), mRNA. pcDNA3.1+-DYK In-stock $99.00 5-7
OHu19088C Homo sapiens phosphoglycerate kinase 1 (PGK1), mRNA. Customized vector In-stock $149.00 5-7

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Sequence Information ORF Nucleotide Sequence
Protein sequence
Vector pcDNA3.1+-DYK or customized vector
Clone information Clone Map
Tag on pcDNA3.1+-DYK N terminal DYKDDDK tags
ORF Insert Method CloneEZ® Seamless cloning technology
RefSeq Version NM_000291.3, 183603937
Length 1254 bp
Structure linear
Update Date 03-MAY-2014
Organism Homo sapiens (human)
Definition Homo sapiens phosphoglycerate kinase 1 (PGK1), mRNA.
Product phosphoglycerate kinase 1
Comment

Summary: The protein encoded by this gene is a glycolytic enzyme that catalyzes the conversion of 1,3-diphosphoglycerate to 3-phosphoglycerate. The encoded protein may also act as a cofactor for polymerase alpha. Additionally, this protein is secreted by tumor cells where it participates in angiogenesis by functioning to reduce disulfide bonds in the serine protease, plasmin, which consequently leads to the release of the tumor blood vessel inhibitor angiostatin. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. Deficiency of the enzyme is associated with a wide range of clinical phenotypes hemolytic anemia and neurological impairment. Pseudogenes of this gene have been defined on chromosomes 19, 21 and the X chromosome. [provided by RefSeq, Jan 2014].

RefSeq NP_000282.1
CDS 173..1426
Misc Feature(1)50..52
Misc Feature(2)176..178
Misc Feature(3)176..178
Misc Feature(4)197..1420
Misc Feature(5)203..205
Misc Feature(6)order(242..244,248..250,287..289,359..361,539..541)
Misc Feature(7)242..250
Misc Feature(8)314..316
Misc Feature(9)359..370
Misc Feature(10)395..397
Misc Feature(11)428..430
Misc Feature(12)461..463
Misc Feature(13)563..565
Misc Feature(14)563..565
Misc Feature(15)608..610
Misc Feature(16)758..760
Misc Feature(17)758..760
Misc Feature(18)767..769
Misc Feature(19)order(773..784,1346..1354)
Misc Feature(20)779..781
Misc Feature(21)779..781
Misc Feature(22)order(887..889,1109..1111,1181..1183,1187..1189,
Misc Feature(23)971..973
Misc Feature(24)1043..1045
Misc Feature(25)1295..1297
Exon (1)1..237
Gene:PGK1
Gene Synonym:HEL-S-68p; MIG10; PGKA
Exon (2)238..288
Gene:PGK1
Gene Synonym:HEL-S-68p; MIG10; PGKA
Exon (3)289..444
Gene:PGK1
Gene Synonym:HEL-S-68p; MIG10; PGKA
Exon (4)445..589
Gene:PGK1
Gene Synonym:HEL-S-68p; MIG10; PGKA
Exon (5)590..693
Gene:PGK1
Gene Synonym:HEL-S-68p; MIG10; PGKA
Exon (6)694..813
Gene:PGK1
Gene Synonym:HEL-S-68p; MIG10; PGKA
Exon (7)814..928
Gene:PGK1
Gene Synonym:HEL-S-68p; MIG10; PGKA
Exon (8)929..1108
Gene:PGK1
Gene Synonym:HEL-S-68p; MIG10; PGKA
Exon (9)1109..1286
Gene:PGK1
Gene Synonym:HEL-S-68p; MIG10; PGKA
Exon (10)1287..1385
Gene:PGK1
Gene Synonym:HEL-S-68p; MIG10; PGKA
Exon (11)1386..2423
Gene:PGK1
Gene Synonym:HEL-S-68p; MIG10; PGKA
Translation MSLSNKLTLDKLDVKGKRVVMRVDFNVPMKNNQITNNQRIKAAVPSIKFCLDNGAKSVVL MSHLGRPDGVPMPDKYSLEPVAVELKSLLGKDVLFLKDCVGPEVEKACANPAAGSVILLE NLRFHVEEEGKGKDASGNKVKAEPAKIEAFRASLSKLGDVYVNDAFGTAHRAHSSMVGVN LPQKAGGFLMKKELNYFAKALESPERPFLAILGGAKVADKIQLINNMLDKVNEMIIGGGM AFTFLKVLNNMEIGTSLFDEEGAKIVKDLMSKAEKNGVKITLPVDFVTADKFDENAKTGQ ATVASGIPAGWMGLDCGPESSKKYAEAVTRAKQIVWNGPVGVFEWEAFARGTKALMDEVV KATSRGCITIIGGGDTATCCAKWNTEDKVSHVSTGGGASLELLEGKVLPGVDALSNI
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Position Chain Variation Link
21+dbSNP:
21+c, gdbSNP:377286545
39+c, gdbSNP:182927805
60+c, tdbSNP:17139588
76+c, gdbSNP:187835265
103+g, tdbSNP:112702955
113+c, tdbSNP:192936390
121+c, gdbSNP:372263316
129+a, cdbSNP:369013360
152+c, gdbSNP:373149332
155+c, gdbSNP:11541573
164+a, gdbSNP:375219335
171+a, gdbSNP:202247339
279+dbSNP:
279+a, cdbSNP:141397576
298+dbSNP:
298+c, tdbSNP:371495517
312+a, tdbSNP:137852536
315+a, gdbSNP:201833700
342+c, tdbSNP:200132648
343+a, g, tdbSNP:78165041
348+c, tdbSNP:11541572
355+a, g, tdbSNP:11541568
370+c, gdbSNP:201498142
384+c, tdbSNP:377351700
389+c, tdbSNP:148077298
402+c, tdbSNP:141856989
403+c, tdbSNP:199906447
409+a, gdbSNP:201217519
413+g, tdbSNP:202138276
414+g, tdbSNP:150212804
420+c, tdbSNP:138851144
435+c, tdbSNP:137852531
477+dbSNP:
477+c, tdbSNP:11541570
524+a, cdbSNP:374169747
527+c, tdbSNP:11541569
528+c, tdbSNP:200351737
547+a, tdbSNP:142134146
559+a, cdbSNP:5913638
562+a, gdbSNP:146350576
590+dbSNP:
590+a, gdbSNP:201024012
598+c, tdbSNP:201516932
600+a, tdbSNP:200869673
609+a, tdbSNP:200372952
613+a, gdbSNP:375971289
636+c, gdbSNP:11541574
645+g, tdbSNP:137852532
658+c, gdbSNP:201708335
660+a, gdbSNP:185071030
663+a, tdbSNP:137852538
694+dbSNP:
694+c, tdbSNP:199563733
717+c, tdbSNP:377001714
737+g, tdbSNP:369648803
746..748+, aagdbSNP:431905502
789+c, gdbSNP:137852529
825+dbSNP:
825+c, tdbSNP:374068404
846+a, gdbSNP:143031509
907+a, tdbSNP:202023023
908+a, gdbSNP:144399762
930+dbSNP:
930+c, tdbSNP:137852534
933+c, gdbSNP:148399096
968..970+atg, gtcdbSNP:431905501
974+a, gdbSNP:137852528
991+c, tdbSNP:368624839
1004+a, gdbSNP:199571497
1026+a, tdbSNP:137852535
1030+c, tdbSNP:11541567
1059+c, tdbSNP:200543437
1070+a, cdbSNP:201707198
1081+c, gdbSNP:142525614
1086+c, gdbSNP:200778983
1101+a, gdbSNP:201238498
1118+dbSNP:
1118+c, tdbSNP:137852533
1131+a, gdbSNP:137852537
1216+c, tdbSNP:371615868
1220+c, tdbSNP:183087139
1227+a, cdbSNP:137852530
1235+c, tdbSNP:369320831
1268+c, gdbSNP:150956842
1304+dbSNP:
1304+a, cdbSNP:137852539
1324+c, tdbSNP:187714418
1364+a, gdbSNP:199644680
1437+dbSNP:
1437+c, tdbSNP:201597074
1461+c, tdbSNP:192518940
1465+c, gdbSNP:373973773
1670+a, gdbSNP:185867522
1702..1703+, gadbSNP:371436001
1715+a, gdbSNP:187560233
1739+a, gdbSNP:369088358
1790..1791+, cdbSNP:35437581
1882+, tdbSNP:375714288
2082+a, tdbSNP:192787948
2253+a, tdbSNP:1136457
2378+c, tdbSNP:199863795
2379..2380+, actcdbSNP:368968169
2380..2381+, gtgadbSNP:16657
2402+a, gdbSNP:184668156
Gene SymbolPGK1
Gene SynonymHEL-S-68p; MIG10; PGKA
ChromosomeX
Locus MapXq13.3
Title Phosphoglycerate kinase 1 promotes radioresistance in U251 human glioma cells .
Author Ding H, Cheng YJ, Yan H, Zhang R, Zhao JB, Qian CF, Zhang WB, Xiao
Journal Oncol. Rep. 31 (2), 894-900 (2014)
Title PGK1 as predictor of CXCR4 expression, bone marrow metastases and survival in neuroblastoma .
Author Ameis HM, Drenckhan A, von Loga K, Escherich G, Wenke K, Izbicki JR, Reinshagen K and Gros SJ.
Journal PLoS ONE 8 (12), E83701 (2013)
Title Phosphoglycerate kinase 1 as a promoter of metastasis in colon cancer .
Author Ahmad SS, Glatzle J, Bajaeifer K, Buhler S, Lehmann T, Konigsrainer I, Vollmer JP, Sipos B, Ahmad SS, Northoff H, Konigsrainer A and Zieker D.
Journal Int. J. Oncol. 43 (2), 586-590 (2013)
Title Conformational dynamics in phosphoglycerate kinase, an open and shut case? .
Author Bowler MW.
Journal FEBS Lett. 587 (13), 1878-1883 (2013)
Title Phosphoglycerate kinase acts in tumour angiogenesis as a disulphide reductase .
Author Lay AJ, Jiang XM, Kisker O, Flynn E, Underwood A, Condron R and Hogg PJ.
Journal Nature 408 (6814), 869-873 (2000)
Title Molecular abnormalities of a phosphoglycerate kinase variant generated by spontaneous mutation .
Author Maeda M, Bawle EV, Kulkarni R, Beutler E and Yoshida A.
Journal Blood 79 (10), 2759-2762 (1992)
Title Treatment of Haemophilus aphrophilus endocarditis with ciprofloxacin .
Author Dawson SJ and White LA.
Journal J. Infect. 24 (3), 317-320 (1992)
Title A single amino acid substitution (157 Gly----Val) in a phosphoglycerate kinase variant (PGK Shizuoka) associated with chronic hemolysis and myoglobinuria .
Author Fujii H, Kanno H, Hirono A, Shiomura T and Miwa S.
Journal Blood 79 (6), 1582-1585 (1992)
Title The role of primer recognition proteins in DNA replication: association with nuclear matrix in HeLa cells .
Author Vishwanatha JK, Jindal HK and Davis RG.
Journal J. Cell. Sci. 101 (PT 1), 25-34 (1992)
Title Functional identity of a primer recognition protein as phosphoglycerate kinase .
Author Jindal HK and Vishwanatha JK.
Journal J. Biol. Chem. 265 (12), 6540-6543 (1990)

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