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Homo sapiens phosphoglycerate kinase 1 (PGK1), mRNA.

RefSeq Accession Definition Service Stock Status Price *Turnaround time Order
NM_000291 Homo sapiens phosphoglycerate kinase 1 (PGK1), mRNA. GenEZ ORF Cloning In-stock $509.00 $460.00 12

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RefSeq Version NM_000291.3, 183603937
Length 2439 bp
Structure linear
Update Date 29-APR-2013
Organism Homo sapiens (human)
Definition Homo sapiens phosphoglycerate kinase 1 (PGK1), mRNA.
Product phosphoglycerate kinase 1

Summary: The protein encoded by this gene is a glycolytic enzyme that catalyzes the conversion of 1,3-diphosphoglycerate to 3-phosphoglycerate. The encoded protein may also act as a cofactor for polymerase alpha. This gene lies on the X-chromosome, while a related pseudogene also has been found on the X-chromosome and another on chromosome 19. [provided by RefSeq, Oct 2008].

RefSeq NP_000282.1
CDS 173..1426
Misc Feature(1)50..52
Misc Feature(2)176..178
Misc Feature(3)176..178
Misc Feature(4)194..1390
Misc Feature(5)197..1420
Misc Feature(6)203..205
Misc Feature(7)order(242..244,248..250,287..289,359..361,539..541)
Misc Feature(8)242..250
Misc Feature(9)314..316
Misc Feature(10)359..370
Misc Feature(11)395..397
Misc Feature(12)428..430
Misc Feature(13)461..463
Misc Feature(14)563..565
Misc Feature(15)563..565
Misc Feature(16)608..610
Misc Feature(17)758..760
Misc Feature(18)758..760
Misc Feature(19)767..769
Misc Feature(20)order(773..784,1346..1354)
Misc Feature(21)779..781
Misc Feature(22)779..781
Misc Feature(23)order(887..889,1109..1111,1181..1183,1187..1189,
Misc Feature(24)971..973
Misc Feature(25)1043..1045
Misc Feature(26)1295..1297
Exon (1)1..237
Gene Synonym:MIG10; PGKA
Exon (2)238..288
Gene Synonym:MIG10; PGKA
Exon (3)289..444
Gene Synonym:MIG10; PGKA
Exon (4)445..589
Gene Synonym:MIG10; PGKA
Exon (5)590..693
Gene Synonym:MIG10; PGKA
Exon (6)694..813
Gene Synonym:MIG10; PGKA
Exon (7)814..928
Gene Synonym:MIG10; PGKA
Exon (8)929..1108
Gene Synonym:MIG10; PGKA
Exon (9)1109..1286
Gene Synonym:MIG10; PGKA
Exon (10)1287..1385
Gene Synonym:MIG10; PGKA
Exon (11)1386..2423
Gene Synonym:MIG10; PGKA
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Position Chain Variation Link
39+c, gdbSNP:182927805
60+c, tdbSNP:17139588
76+c, gdbSNP:187835265
103+g, tdbSNP:112702955
113+c, tdbSNP:192936390
155+c, gdbSNP:11541573
171+a, gdbSNP:202247339
279+a, cdbSNP:141397576
312+a, tdbSNP:137852536
315+a, gdbSNP:201833700
342+c, tdbSNP:200132648
343+a, g, tdbSNP:78165041
348+c, tdbSNP:11541572
355+g, tdbSNP:11541568
370+c, gdbSNP:201498142
389+c, tdbSNP:148077298
402+c, tdbSNP:141856989
403+c, tdbSNP:199906447
409+a, gdbSNP:201217519
413+g, tdbSNP:202138276
414+g, tdbSNP:150212804
420+c, tdbSNP:138851144
435+c, tdbSNP:137852531
477+c, tdbSNP:11541570
527+c, tdbSNP:11541569
528+c, tdbSNP:200351737
547+a, tdbSNP:142134146
558+, adbSNP:66656467
559+a, cdbSNP:5913638
562+a, gdbSNP:146350576
590+a, gdbSNP:201024012
598+c, tdbSNP:201516932
600+a, tdbSNP:200869673
609+a, tdbSNP:200372952
631+a, gdbSNP:139696991
636+c, gdbSNP:11541574
645+g, tdbSNP:137852532
658+c, gdbSNP:201708335
660+a, gdbSNP:185071030
663+a, tdbSNP:137852538
694+c, tdbSNP:199563733
789+c, gdbSNP:137852529
846+a, gdbSNP:143031509
907+a, tdbSNP:202023023
908+a, gdbSNP:144399762
930+c, tdbSNP:137852534
933+c, gdbSNP:148399096
974+a, gdbSNP:137852528
1004+a, gdbSNP:199571497
1026+a, tdbSNP:137852535
1030+c, tdbSNP:11541567
1059+c, tdbSNP:200543437
1070+a, cdbSNP:201707198
1081+c, gdbSNP:142525614
1086+c, gdbSNP:200778983
1101+a, gdbSNP:201238498
1118+c, tdbSNP:137852533
1131+a, gdbSNP:137852537
1220+c, tdbSNP:183087139
1227+a, cdbSNP:137852530
1268+c, gdbSNP:150956842
1304+a, cdbSNP:137852539
1324+c, tdbSNP:187714418
1364+a, gdbSNP:199644680
1437+c, tdbSNP:201597074
1461+c, tdbSNP:192518940
1670+a, gdbSNP:185867522
1715+a, gdbSNP:187560233
1790..1791+, cdbSNP:35437581
1870+, tdbSNP:71658552
2082+a, tdbSNP:192787948
2253+a, tdbSNP:1136457
2378+c, tdbSNP:199863795
2380..2381+, gtgadbSNP:16657
2402+a, gdbSNP:184668156
Gene SymbolPGK1
Gene SynonymMIG10; PGKA
Locus MapXq13.3
All Transcripts
RefSeq Accession Definition Stock Status Price Turnaround time Business Day Select
NM_000291 Homo sapiens phosphoglycerate kinase 1 (PGK1), mRNA. In-stock $509.00 $460.00 12
Title Structural and energetic basis of protein kinetic destabilization in human phosphoglycerate kinase 1 deficiency .
Author Pey,A.L., Mesa-Torres,N., Chiarelli,L.R. and Valentini,G.
Journal Biochemistry 52 (7), 1160-1170 (2013)
Title Over-expression of cofilin-1 and phosphoglycerate kinase 1 in astrocytomas involved in pathogenesis of radioresistance .
Author Yan,H., Yang,K., Xiao,H., Zou,Y.J., Zhang,W.B. and Liu,H.Y.
Journal CNS Neurosci Ther 18 (9), 729-736 (2012)
Title A proteomic study of protein variation between osteopenic and age-matched control bone tissue .
Author Chaput,C.D., Dangott,L.J., Rahm,M.D., Hitt,K.D., Stewart,D.S. and Wayne Sampson,H.
Journal Exp. Biol. Med. (Maywood) 237 (5), 491-498 (2012)
Title Molecular insights on pathogenic effects of mutations causing phosphoglycerate kinase deficiency .
Author Chiarelli,L.R., Morera,S.M., Bianchi,P., Fermo,E., Zanella,A., Galizzi,A. and Valentini,G.
Journal PLoS ONE 7 (2), E32065 (2012)
Title PPARgamma disease gene network and identification of therapeutic targets for prostate cancer .
Author Venkatachalam,G., Kumar,A.P., Sakharkar,K.R., Thangavel,S., Clement,M.V. and Sakharkar,M.K.
Journal J Drug Target 19 (9), 781-796 (2011)
Title Molecular abnormalities of a phosphoglycerate kinase variant generated by spontaneous mutation .
Author Maeda,M., Bawle,E.V., Kulkarni,R., Beutler,E. and Yoshida,A.
Journal Blood 79 (10), 2759-2762 (1992)
Title Treatment of Haemophilus aphrophilus endocarditis with ciprofloxacin .
Author Dawson,S.J. and White,L.A.
Journal J. Infect. 24 (3), 317-320 (1992)
Title A single amino acid substitution (157 Gly----Val) in a phosphoglycerate kinase variant (PGK Shizuoka) associated with chronic hemolysis and myoglobinuria .
Author Fujii,H., Kanno,H., Hirono,A., Shiomura,T. and Miwa,S.
Journal Blood 79 (6), 1582-1585 (1992)
Title The role of primer recognition proteins in DNA replication: association with nuclear matrix in HeLa cells .
Author Vishwanatha,J.K., Jindal,H.K. and Davis,R.G.
Journal J. Cell. Sci. 101 (PT 1), 25-34 (1992)
Title Immunoelectron microscopic analysis of the intracellular distribution of primer recognition proteins, annexin 2 and phosphoglycerate kinase, in normal and transformed cells .
Author Kumble,K.D. and Vishwanatha,J.K.
Journal J. Cell. Sci. 99 (PT 4), 751-758 (1991)

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