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Homo sapiens phosphatase and tensin homolog (PTEN), mRNA.


RefSeq Accession Definition Service Stock Status Price *Turnaround time Order
NM_000314 Homo sapiens phosphatase and tensin homolog (PTEN), mRNA. GenEZ ORF Cloning In-stock $418.00 $369.00 10

*Business Day

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RefSeq Version NM_000314.4, 110224474
Length 5572 bp
Structure linear
Update Date 29-APR-2013
Organism Homo sapiens (human)
Definition Homo sapiens phosphatase and tensin homolog (PTEN), mRNA.
Product phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN
Comment

Summary: This gene was identified as a tumor suppressor that is mutated in a large number of cancers at high frequency. The protein encoded this gene is a phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase. It contains a tensin like domain as well as a catalytic domain similar to that of the dual specificity protein tyrosine phosphatases. Unlike most of the protein tyrosine phosphatases, this protein preferentially dephosphorylates phosphoinositide substrates. It negatively regulates intracellular levels of phosphatidylinositol-3,4,5-trisphosphate in cells and functions as a tumor suppressor by negatively regulating AKT/PKB signaling pathway. [provided by RefSeq, Jul 2008].

RefSeq NP_000305.3
CDS 1032..2243
Misc Feature(1)318..320
Misc Feature(2)<1290..1583
Misc Feature(3)<1290..1583
Misc Feature(4)order(1305..1307,1398..1403,1410..1412,1419..1424)
Misc Feature(5)1593..2078
Misc Feature(6)1749..1751
Misc Feature(7)1974..1976
Misc Feature(8)2037..2039
Misc Feature(9)2127..2129
Misc Feature(10)2127..2129
Misc Feature(11)2127..2129
Misc Feature(12)2139..2141
Misc Feature(13)2139..2141
Misc Feature(14)2139..2141
Misc Feature(15)2169..2171
Misc Feature(16)2169..2171
Misc Feature(17)2175..2177
Misc Feature(18)2175..2177
Misc Feature(19)2178..2180
Misc Feature(20)2178..2180
Misc Feature(21)2184..2186
Misc Feature(22)2184..2186
Misc Feature(23)2184..2186
Misc Feature(24)2232..2240
Misc Feature(25)2232..2234
Exon (1)1..1110
Gene:PTEN
Gene Synonym:10q23del; BZS; CWS1; DEC; GLM2; MHAM; MMAC1; PTEN1; TEP1
Exon (2)1111..1195
Gene:PTEN
Gene Synonym:10q23del; BZS; CWS1; DEC; GLM2; MHAM; MMAC1; PTEN1; TEP1
Exon (3)1196..1240
Gene:PTEN
Gene Synonym:10q23del; BZS; CWS1; DEC; GLM2; MHAM; MMAC1; PTEN1; TEP1
Exon (4)1241..1284
Gene:PTEN
Gene Synonym:10q23del; BZS; CWS1; DEC; GLM2; MHAM; MMAC1; PTEN1; TEP1
Exon (5)1285..1523
Gene:PTEN
Gene Synonym:10q23del; BZS; CWS1; DEC; GLM2; MHAM; MMAC1; PTEN1; TEP1
Exon (6)1524..1665
Gene:PTEN
Gene Synonym:10q23del; BZS; CWS1; DEC; GLM2; MHAM; MMAC1; PTEN1; TEP1
Exon (7)1666..1832
Gene:PTEN
Gene Synonym:10q23del; BZS; CWS1; DEC; GLM2; MHAM; MMAC1; PTEN1; TEP1
Exon (8)1833..2057
Gene:PTEN
Gene Synonym:10q23del; BZS; CWS1; DEC; GLM2; MHAM; MMAC1; PTEN1; TEP1
Exon (9)2058..5546
Gene:PTEN
Gene Synonym:10q23del; BZS; CWS1; DEC; GLM2; MHAM; MMAC1; PTEN1; TEP1
Translation MTAIIKEIVSRNKRRYQEDGFDLDLTYIYPNIIAMGFPAERLEGVYRNNIDDVVRFLDSK HKNHYKIYNLCAERHYDTAKFNCRVAQYPFEDHNPPQLELIKPFCEDLDQWLSEDDNHVA AIHCKAGKGRTGVMICAYLLHRGKFLKAQEALDFYGEVRTRDKKGVTIPSQRRYVYYYSY LLKNHLDYRPVALLFHKMMFETIPMFSGGTCNPQFVVCQLKVKIYSSNSGPTRREDKFMY FEFPQPLPVCGDIKVEFFHKQNKMLKKDKMFHFWVNTFFIPGPEETSEKVENGSLCDQEI DSICSIERADNDKEYLVLTLTKNDLDKANKDKANRYFSPNFKVKLYFTKTVEEPSNPEAS SSTSVTPDVSDNEPDHYRYSDTTDSDPENEPFDEDQHTQITKV
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Position Chain Variation Link
6+dbSNP:
6+a, cdbSNP:34149102
129+c, tdbSNP:1044322
442+a, gdbSNP:35736544
501..502+, ggcdbSNP:34413673
522+a, gdbSNP:12573787
706+c, gdbSNP:2943772
764+c, tdbSNP:11538382
1023+c, gdbSNP:11202592
1048..1049+, aadbSNP:121913290
1086+a, gdbSNP:121909233
1135+dbSNP:
1135+g, tdbSNP:121909225
1163+c, tdbSNP:150651961
1190+a, gdbSNP:189583426
1212+dbSNP:
1212+c, gdbSNP:121909236
1240+c, tdbSNP:121909226
1265+dbSNP:
1265+c, tdbSNP:35917308
1266+a, gdbSNP:202004587
1292+dbSNP:
1292+a, gdbSNP:149772796
1309+a, gdbSNP:121909238
1310+c, tdbSNP:145695240
1350+a, gdbSNP:57374291
1366+c, tdbSNP:121909230
1374+a, gdbSNP:145124907
1386+c, gdbSNP:139767111
1393+c, gdbSNP:121909237
1399+a, gdbSNP:121909222
1401+c, tdbSNP:121909223
1417+a, gdbSNP:121909218
1419+c, g, tdbSNP:121909224
1420+a, gdbSNP:121909229
1420+, gdbSNP:121913292
1426+g, tdbSNP:121909241
1442+a, gdbSNP:144545031
1488+c, gdbSNP:9651492
1500+g, tdbSNP:121909220
1523+a, gdbSNP:146629065
1541+dbSNP:
1541+a, tdbSNP:121909221
1548+c, tdbSNP:121913293
1549+a, gdbSNP:121913294
1565+a, g, tdbSNP:104894184
1664+a, cdbSNP:121909232
1671+dbSNP:
1671+c, tdbSNP:121909227
1680+a, gdbSNP:121909234
1690+c, tdbSNP:141373793
1728+c, tdbSNP:121909219
1732+a, gdbSNP:121909235
1751+c, tdbSNP:190070312
1753+c, tdbSNP:121909240
1754+c, tdbSNP:17849090
1786+a, gdbSNP:121909239
1797+g, tdbSNP:121909228
1831+, adbSNP:121913289
1843+dbSNP:
1843+c, tdbSNP:142420551
1899+c, gdbSNP:35600253
1913+g, tdbSNP:143335584
1986..1989+, acttdbSNP:146650273
1999+, adbSNP:121913291
2034+c, tdbSNP:121909231
2135+dbSNP:
2135+c, tdbSNP:35979531
2308+a, gdbSNP:1044487
2318+a, tdbSNP:74535369
2320+a, tdbSNP:74489567
2468+g, tdbSNP:3895069
2563+g, tdbSNP:3895070
2596+c, tdbSNP:181234898
2664+c, tdbSNP:141648241
2707+a, gdbSNP:2673835
2746+c, gdbSNP:1044492
2833+a, tdbSNP:183510626
3031+c, tdbSNP:138309082
3200+g, tdbSNP:2735347
3376+c, tdbSNP:2736630
3588+a, gdbSNP:188246270
3638+a, cdbSNP:79395513
3673+g, tdbSNP:35460383
3674..3688+, tttttttttttttttdbSNP:201131651
3674..3675+, ttdbSNP:148791838
3674+, ttdbSNP:5786797
3684+g, tdbSNP:34885400
3703+a, tdbSNP:35632884
3706..3707+, tttdbSNP:78439318
3708+g, tdbSNP:11202606
3742+c, tdbSNP:180953647
3759+c, tdbSNP:701848
3808+a, c, gdbSNP:34140758
3874..3875+, tdbSNP:201650436
3887+a, gdbSNP:2142135
3938+a, cdbSNP:141857855
3940+a, gdbSNP:35481105
3945+a, gdbSNP:150265244
3988+a, gdbSNP:116248217
4197+a, tdbSNP:35914322
4198+a, tdbSNP:41284072
4226+c, tdbSNP:138981406
4308+a, gdbSNP:192484947
4357+a, gdbSNP:181468070
4416+c, tdbSNP:186996550
4428+c, tdbSNP:11202607
4658+c, gdbSNP:34761252
4675+a, tdbSNP:190099872
4748+c, tdbSNP:149401400
5064+a, tdbSNP:11591427
5070+g, tdbSNP:182746814
5199+a, gdbSNP:187266004
5471+c, tdbSNP:189780354
Gene SymbolPTEN
Gene Synonym10q23del; BZS; CWS1; DEC; GLM2; MHAM; MMAC1; PTEN1; TEP1
Chromosome10
Locus Map10q23.3
All Transcripts
RefSeq Accession Definition Stock Status Price Turnaround time Business Day Select
NM_000314 Homo sapiens phosphatase and tensin homolog (PTEN), mRNA. In-stock $418.00 $369.00 10
Title Vandetanib is effective in EGFR-mutant lung cancer cells with PTEN deficiency .
Author Takeda,H., Takigawa,N., Ohashi,K., Minami,D., Kataoka,I., Ichihara,E., Ochi,N., Tanimoto,M. and Kiura,K.
Journal Exp. Cell Res. 319 (4), 417-423 (2013)
Title Peptide inhibitors disrupt the serotonin 5-HT2C receptor interaction with phosphatase and tensin homolog to allosterically modulate cellular signaling and behavior .
Author Anastasio,N.C., Gilbertson,S.R., Bubar,M.J., Agarkov,A., Stutz,S.J., Jeng,Y., Bremer,N.M., Smith,T.D., Fox,R.G., Swinford,S.E., Seitz,P.K., Charendoff,M.N., Craft,J.W. Jr., Laezza,F.M., Watson,C.S., Briggs,J.M. and Cunningham,K.A.
Journal J. Neurosci. 33 (4), 1615-1630 (2013)
Title Aberrations of MET are associated with copy number gain of EGFR and loss of PTEN and predict poor outcome in patients with salivary gland cancer .
Author Ach,T., Zeitler,K., Schwarz-Furlan,S., Baader,K., Agaimy,A., Rohrmeier,C., Zenk,J., Gosau,M., Reichert,T.E., Brockhoff,G. and Ettl,T.
Journal Virchows Arch. 462 (1), 65-72 (2013)
Title Expression of PTEN and survivin in cervical cancer: promising biological markers for early diagnosis and prognostic evaluation .
Author Lu,D., Qian,J., Yin,X., Xiao,Q., Wang,C. and Zeng,Y.
Journal Br. J. Biomed. Sci. 69 (4), 143-146 (2012)
Title Impaired Pten expression in human malignant peripheral nerve sheath tumours .
Author Bradtmoller,M., Hartmann,C., Zietsch,J., Jaschke,S., Mautner,V.F., Kurtz,A., Park,S.J., Baier,M., Harder,A., Reuss,D., von Deimling,A., Heppner,F.L. and Holtkamp,N.
Journal PLoS ONE 7 (11), E47595 (2012)
Title TEP1, encoded by a candidate tumor suppressor locus, is a novel protein tyrosine phosphatase regulated by transforming growth factor beta .
Author Li,D.M. and Sun,H.
Journal Cancer Res. 57 (11), 2124-2129 (1997)
Title Germline mutations of the PTEN gene in Cowden disease, an inherited breast and thyroid cancer syndrome .
Author Liaw,D., Marsh,D.J., Li,J., Dahia,P.L., Wang,S.I., Zheng,Z., Bose,S., Call,K.M., Tsou,H.C., Peacocke,M., Eng,C. and Parsons,R.
Journal Nat. Genet. 16 (1), 64-67 (1997)
Title Identification of a candidate tumour suppressor gene, MMAC1, at chromosome 10q23.3 that is mutated in multiple advanced cancers .
Author Steck,P.A., Pershouse,M.A., Jasser,S.A., Yung,W.K., Lin,H., Ligon,A.H., Langford,L.A., Baumgard,M.L., Hattier,T., Davis,T., Frye,C., Hu,R., Swedlund,B., Teng,D.H. and Tavtigian,S.V.
Journal Nat. Genet. 15 (4), 356-362 (1997)
Title PTEN, a putative protein tyrosine phosphatase gene mutated in human brain, breast, and prostate cancer .
Author Li,J., Yen,C., Liaw,D., Podsypanina,K., Bose,S., Wang,S.I., Puc,J., Miliaresis,C., Rodgers,L., McCombie,R., Bigner,S.H., Giovanella,B.C., Ittmann,M., Tycko,B., Hibshoosh,H., Wigler,M.H. and Parsons,R.
Journal Science 275 (5308), 1943-1947 (1997)
Title Allelic loss of sequences from the long arm of chromosome 10 and replication errors in endometrial cancers .
Author Peiffer,S.L., Herzog,T.J., Tribune,D.J., Mutch,D.G., Gersell,D.J. and Goodfellow,P.J.
Journal Cancer Res. 55 (9), 1922-1926 (1995)


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