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Homo sapiens synuclein, alpha (non A4 component of amyloid precursor) (SNCA), transcript variant 1, mRNA.


RefSeq Accession Definition Service Stock Status Price *Turnaround time Order
NM_000345 Homo sapiens synuclein, alpha (non A4 component of amyloid precursor) (SNCA), transcript variant 1, mRNA. GenEZ ORF Cloning In-stock $248.00 $199.00 10

*Business Day

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RefSeq Version NM_000345.3, 225690599
Length 3215 bp
Structure linear
Update Date 21-APR-2013
Organism Homo sapiens (human)
Definition Homo sapiens synuclein, alpha (non A4 component of amyloid precursor) (SNCA), transcript variant 1, mRNA.
Product alpha-synuclein isoform NACP140
Comment

Summary: Alpha-synuclein is a member of the synuclein family, which also includes beta- and gamma-synuclein. Synucleins are abundantly expressed in the brain and alpha- and beta-synuclein inhibit phospholipase D2 selectively. SNCA may serve to integrate presynaptic signaling and membrane trafficking. Defects in SNCA have been implicated in the pathogenesis of Parkinson disease. SNCA peptides are a major component of amyloid plaques in the brains of patients with Alzheimer's disease. Four alternatively spliced transcripts encoding two different isoforms have been identified for this gene. [provided by RefSeq, Mar 2009].


Transcript Variant: This variant (1, also known as NACP140) is the longest transcript and encodes the longer isoform (NACP140). Variants 1, 2, and 3 all encode the same isoform.


Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments.

RefSeq NP_000336.1
CDS 264..686
Misc Feature(1)246..248
Misc Feature(2)246..248
Misc Feature(3)264..659
Misc Feature(4)264..659
Misc Feature(5)264..266
Misc Feature(6)297..299
Misc Feature(7)321..464
Misc Feature(8)522..524
Misc Feature(9)531..533
Misc Feature(10)636..638
Misc Feature(11)645..647
Misc Feature(12)645..647
Misc Feature(13)645..647
Misc Feature(14)645..647
Misc Feature(15)645..647
Misc Feature(16)648..650
Misc Feature(17)657..659
Misc Feature(18)657..659
Misc Feature(19)657..659
Misc Feature(20)657..659
Misc Feature(21)657..659
Misc Feature(22)669..671
Misc Feature(23)678..680
Exon (1)1..238
Gene:SNCA
Gene Synonym:NACP; PARK1; PARK4; PD1
Exon (2)239..384
Gene:SNCA
Gene Synonym:NACP; PARK1; PARK4; PD1
Exon (3)385..426
Gene:SNCA
Gene Synonym:NACP; PARK1; PARK4; PD1
Exon (4)427..569
Gene:SNCA
Gene Synonym:NACP; PARK1; PARK4; PD1
Exon (5)570..653
Gene:SNCA
Gene Synonym:NACP; PARK1; PARK4; PD1
Exon (6)654..3215
Gene:SNCA
Gene Synonym:NACP; PARK1; PARK4; PD1
Translation MDVFMKGLSKAKEGVVAAAEKTKQGVAEAAGKTKEGVLYVGSKTKEGVVHGVATVAEKTK EQVTNVGGAVVTGVTAVAQKTVEGAGSIAAATGFVKKDQLGKNEEGAPQEGILEDMPVDP DNEAYEMPSEEGYQDYEPEA
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Position Chain Variation Link
complement(139)-dbSNP:
complement(139)-t, gdbSNP:186166223
complement(230)-t, gdbSNP:182006507
complement(351)-g, cdbSNP:104893878
complement(399)-dbSNP:
complement(399)-g, adbSNP:104893875
complement(410)-t, cdbSNP:141859659
complement(413)-c, adbSNP:201106962
complement(419)-c, adbSNP:148108612
complement(420)-g, adbSNP:104893877
complement(479)-dbSNP:
complement(479)-t, cdbSNP:144758871
complement(488)-t, adbSNP:149401968
complement(561)-g, adbSNP:138969470
complement(612)-dbSNP:
complement(612)-t, gdbSNP:145138372
complement(614)-t, adbSNP:143084604
complement(630)-t, cdbSNP:200056149
complement(644)-t, cdbSNP:191055637
complement(671)-dbSNP:
complement(671)-t, cdbSNP:76642636
complement(763)-t, gdbSNP:145304567
complement(802)-g, adbSNP:144511886
complement(803)-t, cdbSNP:184023281
complement(825)-c, adbSNP:10024743
complement(858)-g, adbSNP:192194319
complement(859)-t, cdbSNP:79726680
complement(860)-g, cdbSNP:187958987
complement(880)-t, cdbSNP:34825021
complement(888)-g, adbSNP:185476145
complement(889)-g, adbSNP:35716318
complement(959)-g, adbSNP:193289281
complement(1062)-t, cdbSNP:35733299
complement(1150)-t, gdbSNP:183204610
complement(1187)-g, adbSNP:17016074
complement(1279)-c, adbSNP:35101723
complement(1508)-g, adbSNP:35343095
complement(1538)-c, adbSNP:150645039
complement(1579)-g, adbSNP:356165
complement(1580)-t, cdbSNP:192179063
complement(1581)-g, adbSNP:187002185
complement(1607)-t, cdbSNP:148246747
complement(1688)-c, adbSNP:182722435
complement(1780)-, adbSNP:143570143
complement(1910)-t, cdbSNP:147204331
complement(1933)-t, adbSNP:77964369
complement(1960..1963)-, agagdbSNP:141457381
complement(1960)-, gagadbSNP:34094651
complement(1961..1962)-, gadbSNP:71797336
complement(1962..1963)-, agdbSNP:35270750
complement(1962)-g, adbSNP:201351609
complement(1962)-, gadbSNP:5860180
complement(1966)-g, adbSNP:200268319
complement(1979..1980)-g, adbSNP:1987877
complement(1994..1995)-, aaaaadbSNP:33988309
complement(2305)-, adbSNP:35290339
complement(2332)-g, adbSNP:190662034
complement(2363)-g, adbSNP:17016072
complement(2582)-g, adbSNP:186189862
complement(2584..2585)-, ccccccdbSNP:144110885
complement(2791)-t, cdbSNP:3857053
complement(2794)-t, adbSNP:1045722
complement(2916)-t, cdbSNP:183802441
complement(3059)-c, adbSNP:143616400
complement(3060..3061)-, cdbSNP:34094043
Gene SymbolSNCA
Gene SynonymNACP; PARK1; PARK4; PD1
Chromosome4
Locus Map4q21
All Transcripts
RefSeq Accession Definition Stock Status Price Turnaround time Business Day Select
NM_000345 Homo sapiens synuclein, alpha (non A4 component of amyloid precursor) (SNCA), transcript variant 1, mRNA. In-stock $248.00 $199.00 10
NM_001146054 Homo sapiens synuclein, alpha (non A4 component of amyloid precursor) (SNCA), transcript variant 2, mRNA. In-stock $248.00 $199.00 10
NM_001146055 Homo sapiens synuclein, alpha (non A4 component of amyloid precursor) (SNCA), transcript variant 3, mRNA. In-stock $248.00 $199.00 10
NM_007308 Homo sapiens synuclein, alpha (non A4 component of amyloid precursor) (SNCA), transcript variant 4, mRNA. In-stock $248.00 $199.00 10
Title The secreted oligomeric form of alpha-synuclein affects multiple steps of membrane trafficking .
Author Chai,Y.J., Kim,D., Park,J., Zhao,H., Lee,S.J. and Chang,S.
Journal FEBS Lett. 587 (5), 452-459 (2013)
Title alpha-Synuclein pathology is related to postoperative delirium in patients undergoing gastrectomy .
Author Sunwoo,M.K., Hong,J.Y., Choi,J., Park,H.J., Kim,S.H. and Lee,P.H.
Journal Neurology 80 (9), 810-813 (2013)
Title Mapping the subcellular distribution of alpha-synuclein in neurons using genetically encoded probes for correlated light and electron microscopy: implications for Parkinson's disease pathogenesis .
Author Boassa,D., Berlanga,M.L., Yang,M.A., Terada,M., Hu,J., Bushong,E.A., Hwang,M., Masliah,E., George,J.M. and Ellisman,M.H.
Journal J. Neurosci. 33 (6), 2605-2615 (2013)
Title A progressive dopaminergic phenotype associated with neurotoxic conversion of alpha-synuclein in BAC-transgenic rats .
Author Nuber,S., Harmuth,F., Kohl,Z., Adame,A., Trejo,M., Schonig,K., Zimmermann,F., Bauer,C., Casadei,N., Giel,C., Calaminus,C., Pichler,B.J., Jensen,P.H., Muller,C.P., Amato,D., Kornhuber,J., Teismann,P., Yamakado,H., Takahashi,R., Winkler,J., Masliah,E. and Riess,O.
Journal Brain 136 (PT 2), 412-432 (2013)
Title Alpha-synuclein pathology and axonal degeneration of the peripheral motor nerves innervating pharyngeal muscles in Parkinson disease .
Author Mu,L., Sobotka,S., Chen,J., Su,H., Sanders,I., Adler,C.H., Shill,H.A., Caviness,J.N., Samanta,J.E. and Beach,T.G.
Journal J. Neuropathol. Exp. Neurol. 72 (2), 119-129 (2013)
Title Assignment of human alpha-synuclein (SNCA) and beta-synuclein (SNCB) genes to chromosomes 4q21 and 5q35 .
Author Spillantini,M.G., Divane,A. and Goedert,M.
Journal Genomics 27 (2), 379-381 (1995)
Title The human NACP/alpha-synuclein gene: chromosome assignment to 4q21.3-q22 and TaqI RFLP analysis .
Author Chen,X., de Silva,H.A., Pettenati,M.J., Rao,P.N., St George-Hyslop,P., Roses,A.D., Xia,Y., Horsburgh,K., Ueda,K. and Saitoh,T.
Journal Genomics 26 (2), 425-427 (1995)
Title The NACP/synuclein gene: chromosomal assignment and screening for alterations in Alzheimer disease .
Author Campion,D., Martin,C., Heilig,R., Charbonnier,F., Moreau,V., Flaman,J.M., Petit,J.L., Hannequin,D., Brice,A. and Frebourg,T.
Journal Genomics 26 (2), 254-257 (1995)
Title Tissue-dependent alternative splicing of mRNA for NACP, the precursor of non-A beta component of Alzheimer's disease amyloid .
Author Ueda,K., Saitoh,T. and Mori,H.
Journal Biochem. Biophys. Res. Commun. 205 (2), 1366-1372 (1994)
Title Molecular cloning of cDNA encoding an unrecognized component of amyloid in Alzheimer disease .
Author Ueda,K., Fukushima,H., Masliah,E., Xia,Y., Iwai,A., Yoshimoto,M., Otero,D.A., Kondo,J., Ihara,Y. and Saitoh,T.
Journal Proc. Natl. Acad. Sci. U.S.A. 90 (23), 11282-11286 (1993)


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