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Sequence in raw or FASTA format:


Blast Method:


Homo sapiens transthyretin (TTR), mRNA.

Clone ID Definition Vector Stock Status Price *Turnaround time Select
OHu27033D Homo sapiens transthyretin (TTR), mRNA. pcDNA3.1-C-(k)DYK In-stock Starting from $99 5-7
OHu27033C Homo sapiens transthyretin (TTR), mRNA. Your vector of choice In-stock Starting from $99 5-7
OHu27033M Mutant Clone for Homo sapiens transthyretin (TTR), mRNA. pcDNA3.1-C-(k)DYK In-stock Starting from $149 Additional 5 days
OHu27033CM Mutant Clone for Homo sapiens transthyretin (TTR), mRNA. Your vector of choice In-stock Starting from $149 Additional 5 days

*Business Day

Sequence Information ORF Nucleotide Sequence
Protein sequence
Vector pcDNA3.1-C-(k)DYK or customized vector
Clone information Clone Map
Tag on pcDNA3.1-C-(k)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ® Seamless cloning technology
RefSeq Version NM_000371.3, 221136767
Length 444 bp
Structure linear
Update Date 25-MAY-2014
Organism Homo sapiens (human)
Definition Homo sapiens transthyretin (TTR), mRNA.
Product transthyretin precursor

Summary: This gene encodes transthyretin, one of the three prealbumins including alpha-1-antitrypsin, transthyretin and orosomucoid. Transthyretin is a carrier protein; it transports thyroid hormones in the plasma and cerebrospinal fluid, and also transports retinol (vitamin A) in the plasma. The protein consists of a tetramer of identical subunits. More than 80 different mutations in this gene have been reported; most mutations are related to amyloid deposition, affecting predominantly peripheral nerve and/or the heart, and a small portion of the gene mutations is non-amyloidogenic. The diseases caused by mutations include amyloidotic polyneuropathy, euthyroid hyperthyroxinaemia, amyloidotic vitreous opacities, cardiomyopathy, oculoleptomeningeal amyloidosis, meningocerebrovascular amyloidosis, carpal tunnel syndrome, etc. [provided by RefSeq, Jan 2009].

RefSeq NP_000362.1
CDS 137..580
Misc Feature(1)83..85
Misc Feature(2)83..85
Misc Feature(3)206..568
Misc Feature(4)order(239..241,245..247,356..358,512..514,518..520,
Misc Feature(5)order(251..262,455..463,470..472,476..484,530..532,
Misc Feature(6)320..322
Misc Feature(7)539..553
Exon (1)1..205
Gene Synonym:CTS; CTS1; HEL111; HsT2651; PALB; TBPA
Exon (2)206..336
Gene Synonym:CTS; CTS1; HEL111; HsT2651; PALB; TBPA
Exon (3)337..472
Gene Synonym:CTS; CTS1; HEL111; HsT2651; PALB; TBPA
Exon (4)473..929
Gene Synonym:CTS; CTS1; HEL111; HsT2651; PALB; TBPA
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Position Chain Variation Link
112+c, tdbSNP:372544196
114+a, gdbSNP:13380912
121+a, gdbSNP:11541788
149+c, tdbSNP:144792001
150+a, gdbSNP:138657343
204+c, tdbSNP:377052919
212+a, gdbSNP:1800458
213+g, tdbSNP:17406960
217+a, gdbSNP:201164521
224+c, tdbSNP:121918083
231+c, tdbSNP:121918094
249+a, gdbSNP:121918098
252+c, tdbSNP:11541795
254+a, gdbSNP:121918093
263+a, gdbSNP:11541800
complement(266)-g, adbSNP:11541790
269+a, gdbSNP:104894664
276+a, gdbSNP:145551875
283+a, c, tdbSNP:11081703
284+a, c, gdbSNP:28933979
285+c, g, tdbSNP:79977247
293+a, c, tdbSNP:121918068
302+c, gdbSNP:121918077
314+a, gdbSNP:11541794
315+c, tdbSNP:113625622
321+a, gdbSNP:11541796
323+c, tdbSNP:1803083
326+c, tdbSNP:138065384
327+c, tdbSNP:104894665
329+a, gdbSNP:121918078
335+a, c, gdbSNP:387906523
336+c, gdbSNP:121918090
341+a, gdbSNP:121918081
344+a, cdbSNP:386134269
345+a, g, tdbSNP:121918080
346+a, g, tdbSNP:121918076
354+a, gdbSNP:121918097
360+c, tdbSNP:121918079
362+c, tdbSNP:1803084
363+a, gdbSNP:78230119
369+a, g, tdbSNP:121918069
374+a, gdbSNP:121918070
377+a, gdbSNP:121918086
386+c, tdbSNP:121918091
387+c, tdbSNP:121918099
395+a, gdbSNP:11541799
398+a, tdbSNP:121918085
401+c, tdbSNP:121918100
406+a, cdbSNP:267607160
408+c, tdbSNP:121918084
426+a, cdbSNP:121918071
434+a, gdbSNP:1804117
447+g, tdbSNP:121918072
449+c, tdbSNP:11541784
451+c, tdbSNP:11541787
461+c, gdbSNP:121918082
464+a, cdbSNP:121918074
474+c, tdbSNP:372141133
483+c, tdbSNP:1803082
485+g, tdbSNP:267607161
486+c, gdbSNP:121918087
490+a, c, tdbSNP:11541797
491+a, gdbSNP:76410435
494+c, tdbSNP:76591836
496+c, tdbSNP:150127220
501+a, cdbSNP:11541793
503+c, tdbSNP:371566010
504+a, gdbSNP:148538950
507+a, gdbSNP:121918095
515+a, gdbSNP:121918089
520+c, tdbSNP:143906738
521+a, gdbSNP:267607159
522+c, tdbSNP:121918092
527+a, cdbSNP:121918073
534+c, tdbSNP:11541785
536+c, tdbSNP:121918088
537+a, gdbSNP:121918075
549+a, cdbSNP:1804118
552+c, tdbSNP:28933981
553+a, gdbSNP:2276382
560..562+, gtcdbSNP:121918096
560+a, gdbSNP:76992529
562+c, tdbSNP:11541782
567+a, gdbSNP:144965179
570+a, cdbSNP:11541798
577+a, gdbSNP:370056601
583..591+, gacttctccdbSNP:143948820
601+a, cdbSNP:12226
602+c, tdbSNP:11541786
620+g, tdbSNP:189110724
660+c, gdbSNP:1061978
696+c, tdbSNP:11541783
727+a, cdbSNP:77192274
728+a, tdbSNP:74923234
762+c, tdbSNP:371935476
complement(829)-g, adbSNP:146228604
834+a, gdbSNP:193070048
841+c, tdbSNP:62093482
885+a, gdbSNP:184588853
925+a, gdbSNP:58172837
Gene SymbolTTR
Gene SynonymCTS; CTS1; HEL111; HsT2651; PALB; TBPA
Locus Map18q12.1
All Transcripts
RefSeq Accession Definition Stock Status Price Turnaround time Business Day Select
NM_000371 Homo sapiens transthyretin (TTR), mRNA. In-stock Starting from $99 5-7
Title Quantification of transthyretin kinetic stability in human plasma using subunit exchange .
Author Rappley I, Monteiro C, Novais M, Baranczak A, Solis G, Wiseman RL, Helmke S, Maurer MS, Coelho T, Powers ET and Kelly JW.
Journal Biochemistry 53 (12), 1993-2006 (2014)
Title Proteolytic cleavage of Ser52Pro variant transthyretin triggers its amyloid fibrillogenesis .
Author Mangione PP, Porcari R, Gillmore JD, Pucci P, Monti M, Porcari M, Giorgetti S, Marchese L, Raimondi S, Serpell LC, Chen W, Relini A, Marcoux J, Clatworthy IR, Taylor GW, Tennent GA, Robinson CV, Hawkins PN, Stoppini M, Wood SP, Pepys MB and Bellotti V.
Journal Proc. Natl. Acad. Sci. U.S.A. 111 (4), 1539-1544 (2014)
Title Transthyretin proteins regulate angiogenesis by conferring different molecular identities to endothelial cells .
Author Nunes RJ, de Oliveira P, Lages A, Becker JD, Marcelino P, Barroso E, Perdigoto R, Kelly JW, Quintas A and Santos SC.
Journal J. Biol. Chem. 288 (44), 31752-31760 (2013)
Title Mutation p.G83R in the transthyretin gene is associated with hereditary vitreous amyloidosis in Han Chinese families .
Author Zhang AM, Wang H, Sun P, Hu QX, He Y and Yao YG.
Journal Mol. Vis. 19, 1631-1638 (2013)
Title Unexplained cardiac failure leading to the identification of a Belgian family affected by hereditary amyloidosis .
Author De Pasqual A, Biessaux Y, Blettard N, Cremers S and Caers J.
Journal Acta Clin Belg 68 (4), 303-305 (2013)
Title Familial Transthyretin Amyloidosis .
Author Sekijima,Y., Yoshida,K., Tokuda,T. and Ikeda,S.
Journal (in) Pagon RA, Adam MP, Ardinger HH, Bird TD, Dolan CR, Fong CT, Smith RJH and Stephens K (Eds.); GENEREVIEWS(R); (1993)
Title Interaction between prealbumin and retinol-binding protein studied by affinity chromatography, gel filtration and two-phase partition .
Author Fex,G., Albertsson,P.A. and Hansson,B.
Journal Eur. J. Biochem. 99 (2), 353-360 (1979)
Title Structure of prealbumin: secondary, tertiary and quaternary interactions determined by Fourier refinement at 1.8 A .
Author Blake,C.C., Geisow,M.J., Oatley,S.J., Rerat,B. and Rerat,C.
Journal J. Mol. Biol. 121 (3), 339-356 (1978)
Title Protein-DNA and protein-hormone interactions in prealbumin: a model of the thyroid hormone nuclear receptor? .
Author Blake,C.C. and Oatley,S.J.
Journal Nature 268 (5616), 115-120 (1977)
Title The interaction between retinol-binding proteins and prealbumins studied by fluorescence polarization .
Author Kopelman,M., Cogan,U., Mokady,S. and Shinitzky,M.
Journal Biochim. Biophys. Acta 439 (2), 449-460 (1976)

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