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Database:

Blast Method:

 
 


Homo sapiens albumin (ALB), mRNA.


RefSeq Accession Definition Services Price Order
NM_000477 Homo sapiens albumin (ALB), mRNA. ORF Sequence $530.70
Peptide Services
Antibody Services
Protein Services


RefSeq Version NM_000477.5, 215982788
Length 2264 bp
Structure linear
Update Date 29-APR-2013
Organism Homo sapiens (human)
Definition Homo sapiens albumin (ALB), mRNA.
Product serum albumin preproprotein
Comment

Summary: Albumin is a soluble, monomeric protein which comprises about one-half of the blood serum protein. Albumin functions primarily as a carrier protein for steroids, fatty acids, and thyroid hormones and plays a role in stabilizing extracellular fluid volume. Albumin is a globular unglycosylated serum protein of molecular weight 65,000. Albumin is synthesized in the liver as preproalbumin which has an N-terminal peptide that is removed before the nascent protein is released from the rough endoplasmic reticulum. The product, proalbumin, is in turn cleaved in the Golgi vesicles to produce the secreted albumin. [provided by RefSeq, Jul 2008].

RefSeq NP_000468.1
CDS 74..1903
Misc Feature(1)14..16
Misc Feature(2)14..16
Misc Feature(3)155..157
Misc Feature(4)158..700
Misc Feature(5)179..181
Misc Feature(6)203..205
Misc Feature(7)order(224..226,236..238,281..283,344..346,356..358,
Misc Feature(8)266..268
Misc Feature(9)order(302..304,329..331)
Misc Feature(10)317..319
Misc Feature(11)335..337
Misc Feature(12)362..364
Misc Feature(13)order(368..370,416..418)
Misc Feature(14)order(413..415,446..448)
Misc Feature(15)422..424
Misc Feature(16)461..463
Misc Feature(17)order(515..517,650..652)
Misc Feature(18)order(548..550,557..562,569..571,617..619,626..628)
Misc Feature(19)551..553
Misc Feature(20)563..565
Misc Feature(21)620..622
Misc Feature(22)order(647..649,674..676)
Misc Feature(23)665..667
Misc Feature(24)686..688
Misc Feature(25)713..715
Misc Feature(26)728..730
Misc Feature(27)734..1276
Misc Feature(28)740..742
Misc Feature(29)740..742
Misc Feature(30)740..742
Misc Feature(31)order(743..745,881..883)
Misc Feature(32)758..760
Misc Feature(33)779..781
Misc Feature(34)order(800..802,812..814,857..859,914..916,926..928,
Misc Feature(35)842..844
Misc Feature(36)863..865
Misc Feature(37)order(878..880,902..904)
Misc Feature(38)929..931
Misc Feature(39)order(938..940,980..982)
Misc Feature(40)965..967
Misc Feature(41)order(977..979,1010..1012)
Misc Feature(42)986..988
Misc Feature(43)1001..1003
Misc Feature(44)1067..1069
Misc Feature(45)order(1091..1093,1226..1228)
Misc Feature(46)1094..1096
Misc Feature(47)order(1124..1126,1133..1138,1145..1147,1193..1195,
Misc Feature(48)1196..1198
Misc Feature(49)1220..1222
Misc Feature(50)order(1223..1225,1250..1252)
Misc Feature(51)1259..1261
Misc Feature(52)1310..1870
Misc Feature(53)1310..1312
Misc Feature(54)order(1319..1321,1457..1459)
Misc Feature(55)1349..1351
Misc Feature(56)order(1376..1378,1388..1390,1433..1435,1502..1504,
Misc Feature(57)1385..1387
Misc Feature(58)1400..1402
Misc Feature(59)1403..1405
Misc Feature(60)1409..1411
Misc Feature(61)1412..1414
Misc Feature(62)1439..1441
Misc Feature(63)1451..1453
Misc Feature(64)order(1454..1456,1487..1489)
Misc Feature(65)1460..1462
Misc Feature(66)order(1526..1528,1574..1576)
Misc Feature(67)1541..1543
Misc Feature(68)1568..1570
Misc Feature(69)order(1571..1573,1604..1606)
Misc Feature(70)1634..1636
Misc Feature(71)1643..1645
Misc Feature(72)order(1685..1687,1820..1822)
Misc Feature(73)1700..1702
Misc Feature(74)1715..1717
Misc Feature(75)order(1718..1720,1727..1732,1739..1741,1787..1789,
Misc Feature(76)1718..1720
Misc Feature(77)1745..1747
Misc Feature(78)1757..1759
Misc Feature(79)1766..1768
Misc Feature(80)1814..1816
Misc Feature(81)order(1817..1819,1844..1846)
Misc Feature(82)1823..1825
Misc Feature(83)1835..1837
Misc Feature(84)1865..1867
Exon (1)1..152
Gene:ALB
Gene Synonym:PRO0883; PRO0903; PRO1341
Exon (2)153..210
Gene:ALB
Gene Synonym:PRO0883; PRO0903; PRO1341
Exon (3)211..343
Gene:ALB
Gene Synonym:PRO0883; PRO0903; PRO1341
Exon (4)344..555
Gene:ALB
Gene Synonym:PRO0883; PRO0903; PRO1341
Exon (5)556..688
Gene:ALB
Gene Synonym:PRO0883; PRO0903; PRO1341
Exon (6)689..786
Gene:ALB
Gene Synonym:PRO0883; PRO0903; PRO1341
Exon (7)787..916
Gene:ALB
Gene Synonym:PRO0883; PRO0903; PRO1341
Exon (8)917..1131
Gene:ALB
Gene Synonym:PRO0883; PRO0903; PRO1341
Exon (9)1132..1264
Gene:ALB
Gene Synonym:PRO0883; PRO0903; PRO1341
Exon (10)1265..1362
Gene:ALB
Gene Synonym:PRO0883; PRO0903; PRO1341
Exon (11)1363..1501
Gene:ALB
Gene Synonym:PRO0883; PRO0903; PRO1341
Exon (12)1502..1725
Gene:ALB
Gene Synonym:PRO0883; PRO0903; PRO1341
Exon (13)1726..1858
Gene:ALB
Gene Synonym:PRO0883; PRO0903; PRO1341
Exon (14)1859..1926
Gene:ALB
Gene Synonym:PRO0883; PRO0903; PRO1341
Exon (15)1927..2247
Gene:ALB
Gene Synonym:PRO0883; PRO0903; PRO1341
Translation MKWVTFISLLFLFSSAYSRGVFRRDAHKSEVAHRFKDLGEENFKALVLIAFAQYLQQCPF EDHVKLVNEVTEFAKTCVADESAENCDKSLHTLFGDKLCTVATLRETYGEMADCCAKQEP ERNECFLQHKDDNPNLPRLVRPEVDVMCTAFHDNEETFLKKYLYEIARRHPYFYAPELLF FAKRYKAAFTECCQAADKAACLLPKLDELRDEGKASSAKQRLKCASLQKFGERAFKAWAV ARLSQRFPKAEFAEVSKLVTDLTKVHTECCHGDLLECADDRADLAKYICENQDSISSKLK ECCEKPLLEKSHCIAEVENDEMPADLPSLAADFVESKDVCKNYAEAKDVFLGMFLYEYAR RHPDYSVVLLLRLAKTYETTLEKCCAAADPHECYAKVFDEFKPLVEEPQNLIKQNCELFE QLGEYKFQNALLVRYTKKVPQVSTPTLVEVSRNLGKVGSKCCKHPEAKRMPCAEDYLSVV LNQLCVLHEKTPVSDRVTKCCTESLVNRRPCFSALEVDETYVPKEFNAETFTFHADICTL SEKERQIKKQTALVELVKHKPKATKEQLKAVMDDFAAFVEKCCKADDKETCFAEEGKKLV AASQAALGL
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Position Chain Variation Link
30+g, tdbSNP:191481965
76+a, gdbSNP:146708617
102+c, tdbSNP:11538209
104+a, tdbSNP:11538213
140+c, tdbSNP:80008208
141+a, gdbSNP:72552709
144+a, c, g, tdbSNP:74821926
147+a, tdbSNP:75353611
152+c, tdbSNP:141733599
175+dbSNP:
175+g, tdbSNP:11538230
184+c, tdbSNP:147177161
198+a, gdbSNP:11538232
208+a, cdbSNP:17854154
209..210+g, tdbSNP:17855652
239+dbSNP:
239+c, tdbSNP:75470261
288+a, tdbSNP:59066571
301..302+, atdbSNP:75152012
307+c, tdbSNP:11538229
315+a, gdbSNP:11538221
321+c, tdbSNP:200736287
323+a, gdbSNP:77050410
332+a, gdbSNP:78574148
339+c, tdbSNP:11538216
340+a, c, tdbSNP:59439476
342+c, tdbSNP:77892378
380+dbSNP:
380+a, gdbSNP:11538226
386+c, tdbSNP:138715514
389+a, gdbSNP:80296402
396+a, gdbSNP:142714816
457+a, gdbSNP:11538225
476+a, gdbSNP:200853688
485+c, g, tdbSNP:77238412
500+a, gdbSNP:75522063
510+a, tdbSNP:77752336
528+a, gdbSNP:80095457
545+c, tdbSNP:11538217
564+dbSNP:
564+a, gdbSNP:78283180
601+a, gdbSNP:139002023
604+a, tdbSNP:149432908
611+c, tdbSNP:202225218
634+c, tdbSNP:144813200
655..656+a, gdbSNP:11538219
656+a, gdbSNP:148571509
670+a, tdbSNP:281860282
672+c, tdbSNP:201281958
675+g, tdbSNP:77656691
685+a, gdbSNP:58639526
694+dbSNP:
694+g, tdbSNP:146587652
702+a, gdbSNP:58624704
712..713+a, gdbSNP:11538220
715+g, tdbSNP:17400586
716+a, gdbSNP:3210154
717+c, tdbSNP:3204504
721+a, gdbSNP:140065129
726+c, gdbSNP:11538228
732+a, tdbSNP:3210163
787+dbSNP:
787+a, gdbSNP:76454301
798+a, c, gdbSNP:75002628
818+a, cdbSNP:79804069
863+a, gdbSNP:79377490
874+a, gdbSNP:11538224
875..876+, adbSNP:36067576
875+g, tdbSNP:78340021
945..946+dbSNP:
945..946+, adbSNP:77449454
948+a, gdbSNP:80002911
951+a, gdbSNP:79744198
955+a, gdbSNP:143665140
964+c, tdbSNP:56167251
973+c, g, tdbSNP:74718349
1009+c, tdbSNP:140421861
1019+a, gdbSNP:150388973
1043+c, gdbSNP:201904433
1061+a, gdbSNP:11538222
1084+c, g, tdbSNP:72552710
1086+a, g, tdbSNP:76242087
1088+a, gdbSNP:200564366
1097+a, gdbSNP:11538223
1099+a, c, gdbSNP:77544362
1103+a, gdbSNP:78953271
1106+a, gdbSNP:72552711
1125+g, tdbSNP:3210210
1131+c, tdbSNP:79568748
1142+dbSNP:
1142+a, gdbSNP:77354753
1147+c, tdbSNP:200134813
1204+c, tdbSNP:145924167
1205+a, gdbSNP:76593094
1217+a, gdbSNP:75791663
1231+c, tdbSNP:201407867
1232+g, tdbSNP:149483745
1237+a, gdbSNP:17854155
1238+c, gdbSNP:77187142
1239+a, tdbSNP:78538497
1241+c, tdbSNP:141343001
1250+c, tdbSNP:11538215
1259+a, gdbSNP:78166690
1268+dbSNP:
1268+a, c, gdbSNP:77514449
1271+a, c, gdbSNP:79047363
1289+a, gdbSNP:76483862
1290+a, tdbSNP:11538214
1303+c, tdbSNP:35683929
1344+a, gdbSNP:147981653
1348+a, cdbSNP:281860283
1370+dbSNP:
1370+a, gdbSNP:141626688
1373+c, tdbSNP:78575701
1394+c, tdbSNP:200708705
1433+c, tdbSNP:11538212
1447+c, tdbSNP:150914884
1496+g, tdbSNP:1140449
1498+c, tdbSNP:1140450
1504+dbSNP:
1504+a, cdbSNP:149795719
1507+c, tdbSNP:139400924
1519+c, tdbSNP:59597814
1521+a, gdbSNP:146129389
1537+a, tdbSNP:140110916
1541+a, gdbSNP:1063469
1555+c, tdbSNP:11538231
1578+c, tdbSNP:60826059
1580+a, gdbSNP:80259813
1598+c, tdbSNP:78696173
1599+a, gdbSNP:200002649
1600+a, tdbSNP:17853503
1609+c, tdbSNP:143699485
1625+a, gdbSNP:75920790
1631+a, gdbSNP:148518742
1636+c, tdbSNP:142780781
1646+a, gdbSNP:75523493
1658+a, gdbSNP:74826639
1663+a, gdbSNP:17853250
1681+c, tdbSNP:56042353
1683+, tdbSNP:77081291
1694+c, tdbSNP:11538227
1720+a, gdbSNP:142299078
1725+c, tdbSNP:149079814
1741+dbSNP:
1741+c, g, tdbSNP:962004
1742+a, gdbSNP:78284052
1751+a, gdbSNP:77645174
1753+c, gdbSNP:57636959
1763+a, cdbSNP:61579038
1766+a, gdbSNP:80345158
1777+c, tdbSNP:11538206
1778+a, gdbSNP:72552712
1788+a, tdbSNP:11538208
1794+a, c, gdbSNP:79738788
1799+a, gdbSNP:200401551
1823+a, gdbSNP:76671808
1832+a, gdbSNP:76587671
1838+a, gdbSNP:75709682
1844+, tdbSNP:74674594
1853+a, gdbSNP:79228041
1862+dbSNP:
1862+a, gdbSNP:80106970
1867..1868+, adbSNP:75000326
1871+c, gdbSNP:201202407
1874+c, gdbSNP:141283217
1883+a, cdbSNP:199476397
1883+, cdbSNP:77158239
1904+a, gdbSNP:11538207
1922+c, tdbSNP:61332165
1962..1963+dbSNP:
1962..1963+, gdbSNP:35283985
1991+a, cdbSNP:11538204
2068+a, tdbSNP:3205432
2071+a, tdbSNP:3211553
2092+a, tdbSNP:77580720
2232+a, gdbSNP:183802114
Gene SymbolALB
Gene SynonymPRO0883; PRO0903; PRO1341
Chromosome4
Locus Map4q13.3
All Transcripts
RefSeq Accession Definition Sequence Price Select
NM_000477 Homo sapiens albumin (ALB), mRNA. Full Length $656.56
ORF Sequence $530.70
Title Correspondence of fatty acid and drug binding sites on human serum albumin: a two-dimensional nuclear magnetic resonance study .
Author Krenzel,E.S., Chen,Z. and Hamilton,J.A.
Journal Biochemistry 52 (9), 1559-1567 (2013)
Title Mutations and polymorphisms of the gene of the major human blood protein, serum albumin .
Author Minchiotti,L., Galliano,M., Kragh-Hansen,U. and Peters,T. Jr.
Journal Hum. Mutat. 29 (8), 1007-1016 (2008)
Title Crystal structure of human serum albumin at 2.5 A resolution .
Author Sugio,S., Kashima,A., Mochizuki,S., Noda,M. and Kobayashi,K.
Journal Protein Eng. 12 (6), 439-446 (1999)
Title Atomic structure and chemistry of human serum albumin .
Author He,X.M. and Carter,D.C.
Journal Nature 358 (6383), 209-215 (1992)
Title Structure of human serum albumin .
Author Carter,D.C. and He,X.M.
Journal Science 249 (4966), 302-303 (1990)
Title The human albumin gene. Characterization of the 5' and 3' flanking regions and the polymorphic gene transcripts .
Author Urano,Y., Watanabe,K., Sakai,M. and Tamaoki,T.
Journal J. Biol. Chem. 261 (7), 3244-3251 (1986)
Title The human serum albumin gene: structure of a unique locus .
Author Hawkins,J.W. and Dugaiczyk,A.
Journal Gene 19 (1), 55-58 (1982)
Title Nucleotide sequence and the encoded amino acids of human serum albumin mRNA .
Author Dugaiczyk,A., Law,S.W. and Dennison,O.E.
Journal Proc. Natl. Acad. Sci. U.S.A. 79 (1), 71-75 (1982)
Title Limited pepsin digestion of human plasma albumin .
Author Heaney-Kieras,J. and King,T.P.
Journal J. Biol. Chem. 252 (12), 4326-4329 (1977)
Title Complete amino acid sequence of human serum albumin .
Author Meloun,B., Moravek,L. and Kostka,V.
Journal FEBS Lett. 58 (1), 134-137 (1975)

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