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Database:

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Homo sapiens cytochrome P450, family 1, subfamily A, polypeptide 1 (CYP1A1), mRNA.


RefSeq Accession Definition Services Price Order
NM_000499 Homo sapiens cytochrome P450, family 1, subfamily A, polypeptide 1 (CYP1A1), mRNA. ORF Sequence $446.31
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RefSeq Version NM_000499.3, 189339226
Length 2608 bp
Structure linear
Update Date 29-APR-2013
Organism Homo sapiens (human)
Definition Homo sapiens cytochrome P450, family 1, subfamily A, polypeptide 1 (CYP1A1), mRNA.
Product cytochrome P450 1A1
Comment

Summary: This gene, CYP1A1, encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by some polycyclic aromatic hydrocarbons (PAHs), some of which are found in cigarette smoke. The enzyme's endogenous substrate is unknown; however, it is able to metabolize some PAHs to carcinogenic intermediates. The gene has been associated with lung cancer risk. A related family member, CYP1A2, is located approximately 25 kb away from CYP1A1 on chromosome 15. [provided by RefSeq, Jul 2008].


Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments.

RefSeq NP_000490.1
CDS 123..1661
Misc Feature(1)159..1625
Misc Feature(2)159..1625
Misc Feature(3)240..1601
Misc Feature(4)1200..1202
Misc Feature(5)1491..1493
Exon (1)1..96
Gene:CYP1A1
Gene Synonym:AHH; AHRR; CP11; CYP1; P1-450; P450-C; P450DX
Exon (2)97..947
Gene:CYP1A1
Gene Synonym:AHH; AHRR; CP11; CYP1; P1-450; P450-C; P450DX
Exon (3)948..1074
Gene:CYP1A1
Gene Synonym:AHH; AHRR; CP11; CYP1; P1-450; P450-C; P450DX
Exon (4)1075..1164
Gene:CYP1A1
Gene Synonym:AHH; AHRR; CP11; CYP1; P1-450; P450-C; P450DX
Exon (5)1165..1288
Gene:CYP1A1
Gene Synonym:AHH; AHRR; CP11; CYP1; P1-450; P450-C; P450DX
Exon (6)1289..1375
Gene:CYP1A1
Gene Synonym:AHH; AHRR; CP11; CYP1; P1-450; P450-C; P450DX
Exon (7)1376..2608
Gene:CYP1A1
Gene Synonym:AHH; AHRR; CP11; CYP1; P1-450; P450-C; P450DX
Translation MLFPISMSATEFLLASVIFCLVFWVIRASRPQVPKGLKNPPGPWGWPLIGHMLTLGKNPH LALSRMSQQYGDVLQIRIGSTPVVVLSGLDTIRQALVRQGDDFKGRPDLYTFTLISNGQS MSFSPDSGPVWAARRRLAQNGLKSFSIASDPASSTSCYLEEHVSKEAEVLISTLQELMAG PGHFNPYRYVVVSVTNVICAICFGRRYDHNHQELLSLVNLNNNFGEVVGSGNPADFIPIL RYLPNPSLNAFKDLNEKFYSFMQKMVKEHYKTFEKGHIRDITDSLIEHCQEKQLDENANV QLSDEKIINIVLDLFGAGFDTVTTAISWSLMYLVMNPRVQRKIQEELDTVIGRSRRPRLS DRSHLPYMEAFILETFRHSSFVPFTIPHSTTRDTSLKGFYIPKGRCVFVNQWQINHDQKL WVNPSEFLPERFLTPDGAIDKVLSEKVIIFGMGKRKCIGETIARWEVFLFLAILLQRVEF SVPLGVKVDMTPIYGLTMKHACCEHFQMQLRS
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Position Chain Variation Link
complement(145)-g, adbSNP:148505285
complement(152)-t, cdbSNP:184128730
complement(194)-t, cdbSNP:145924908
complement(256)-g, adbSNP:4646422
complement(298)-g, adbSNP:149846182
complement(306)-g, cdbSNP:143070677
complement(318)-g, adbSNP:35035798
complement(331)-t, cdbSNP:112517897
complement(338)-g, adbSNP:139919943
complement(355)-g, adbSNP:17861094
complement(362)-g, adbSNP:55864856
complement(364)-g, adbSNP:138474634
complement(368)-g, adbSNP:112522537
complement(384)-t, cdbSNP:77425771
complement(399)-t, cdbSNP:2229150
complement(400)-g, adbSNP:45528935
complement(423)-t, cdbSNP:141173079
complement(437..438)-cc, adbSNP:34045449
complement(437)-t, gdbSNP:148193397
complement(443)-t, cdbSNP:35267501
complement(444)-c, adbSNP:78901429
complement(506)-t, cdbSNP:149540202
complement(516)-g, cdbSNP:35196245
complement(525)-t, cdbSNP:45442501
complement(528)-g, adbSNP:141291433
complement(529)-t, cdbSNP:202201538
complement(538)-t, gdbSNP:147704046
complement(604)-t, cdbSNP:202221673
complement(635)-c, adbSNP:28399426
complement(640)-g, cdbSNP:28399427
complement(641)-t, cdbSNP:150427960
complement(662)-c, adbSNP:201933340
complement(677)-t, gdbSNP:140459785
complement(695)-t, cdbSNP:199985203
complement(708)-t, cdbSNP:151244239
complement(733)-g, cdbSNP:142255433
complement(735)-g, adbSNP:201182659
complement(736)-t, cdbSNP:199734551
complement(738)-g, adbSNP:200600221
complement(747)-t, gdbSNP:148803099
complement(768)-t, adbSNP:146622566
complement(794)-g, adbSNP:144413202
complement(820)-t, gdbSNP:139687103
complement(834)-g, adbSNP:61747605
complement(843)-g, adbSNP:149687459
complement(914)-g, cdbSNP:139496485
complement(915)-t, cdbSNP:150514993
complement(957)-dbSNP:
complement(957)-t, g, cdbSNP:34260157
complement(979)-t, cdbSNP:4987133
complement(1022)-t, gdbSNP:147428559
complement(1095)-dbSNP:
complement(1095)-c, adbSNP:201691396
complement(1115)-t, c, adbSNP:56313657
complement(1148)-g, cdbSNP:199747074
complement(1185)-dbSNP:
complement(1185)-g, adbSNP:191792412
complement(1192)-g, adbSNP:148341881
complement(1195)-t, cdbSNP:186168141
complement(1207)-c, adbSNP:200723875
complement(1252)-t, cdbSNP:201174966
complement(1265)-c, adbSNP:2856833
complement(1266)-t, cdbSNP:201651069
complement(1296)-dbSNP:
complement(1296)-, ttgdbSNP:55786658
complement(1336)-t, cdbSNP:56127934
complement(1363)-g, adbSNP:201265044
complement(1377)-dbSNP:
complement(1377)-t, cdbSNP:138804663
complement(1397..1398)-, adbSNP:72547510
complement(1439)-g, adbSNP:200091037
complement(1440)-t, cdbSNP:145198866
complement(1465)-t, adbSNP:72547509
complement(1486)-t, cdbSNP:180744198
complement(1496)-g, adbSNP:147033233
complement(1504)-c, adbSNP:1799814
complement(1506)-t, g, c, adbSNP:1048943
complement(1508)-g, adbSNP:74465117
complement(1509)-c, adbSNP:141177861
complement(1510)-g, cdbSNP:2278970
complement(1512)-t, gdbSNP:41279188
complement(1530)-t, gdbSNP:36121583
complement(1543)-g, adbSNP:147634852
complement(1551)-g, c, adbSNP:56240201
complement(1552)-t, cdbSNP:140680363
complement(1566)-g, adbSNP:28399429
complement(1569)-t, cdbSNP:45500996
complement(1595)-t, cdbSNP:45460597
complement(1597)-g, cdbSNP:28399430
complement(1605)-c, adbSNP:142388113
complement(1653)-g, adbSNP:148638069
complement(1654)-t, c, adbSNP:56343424
complement(1746)-t, cdbSNP:2606346
complement(1843)-g, cdbSNP:145262175
complement(1847)-t, cdbSNP:4986880
complement(1956)-t, cdbSNP:56403730
complement(2004)-t, g, cdbSNP:4986881
complement(2009)-t, cdbSNP:28399431
complement(2020)-g, adbSNP:4986882
complement(2107)-t, cdbSNP:139156785
complement(2127)-t, cdbSNP:35427048
complement(2201)-c, adbSNP:151188660
complement(2204)-t, gdbSNP:142117193
complement(2256)-t, cdbSNP:1800031
complement(2274)-g, adbSNP:4986883
complement(2284)-t, cdbSNP:4986884
complement(2315..2316)-, gdbSNP:35228499
complement(2321)-g, adbSNP:145951947
complement(2369)-g, cdbSNP:17861086
complement(2374)-c, adbSNP:17861085
complement(2375)-g, cdbSNP:28399432
complement(2376..2377)-, cdbSNP:200937928
complement(2418)-g, adbSNP:143987603
complement(2472)-t, gdbSNP:17861084
complement(2517)-c, adbSNP:185383134
complement(2579)-g, cdbSNP:28427336
Gene SymbolCYP1A1
Gene SynonymAHH; AHRR; CP11; CYP1; P1-450; P450-C; P450DX
Chromosome15
Locus Map15q24.1
All Transcripts
RefSeq Accession Definition Sequence Price Select
NM_000499 Homo sapiens cytochrome P450, family 1, subfamily A, polypeptide 1 (CYP1A1), mRNA. Full Length $756.32
ORF Sequence $446.31
Title CYP1AI and CYP2E1 gene polymorphisms may increase susceptibility to Oral Submucous Fibrosis among betel quid chewers of Eastern India .
Author Chaudhuri,S.R., Mukherjee,S., Paul,R.R., Haldar,A. and Chaudhuri,K.
Journal Gene 513 (2), 268-271 (2013)
Title Role of CYP1A1 haplotypes in modulating susceptibility to coronary artery disease .
Author Lakshmi,S.V., Naushad,S.M., Saumya,K., Rao,D.S. and Kutala,V.K.
Journal Indian J. Biochem. Biophys. 49 (5), 349-355 (2012)
Title [LOH and genetic polymorphysms of breast cancer] .
Author Utsumi,T.
Journal Nippon Rinsho 70 (SUPPL 7), 71-75 (2012)
Title Theoretical investigation of differences in nitroreduction of aristolochic acid I by cytochromes P450 1A1, 1A2 and 1B1 .
Author Jerabek,P., Martinek,V. and Stiborova,M.
Journal Neuro Endocrinol. Lett. 33 (SUPPL 3), 25-32 (2012)
Title Search for an association between the human CYP1A2 genotype and CYP1A2 metabolic phenotype .
Author Jiang,Z., Dragin,N., Jorge-Nebert,L.F., Martin,M.V., Guengerich,F.P., Aklillu,E., Ingelman-Sundberg,M., Hammons,G.J., Lyn-Cook,B.D., Kadlubar,F.F., Saldana,S.N., Sorter,M., Vinks,A.A., Nassr,N., von Richter,O., Jin,L. and Nebert,D.W.
Journal Pharmacogenet. Genomics 16 (5), 359-367 (2006)
Title Toward the evaluation of function in genetic variability: characterizing human SNP frequencies and establishing BAC-transgenic mice carrying the human CYP1A1_CYP1A2 locus .
Author Jiang,Z., Dalton,T.P., Jin,L., Wang,B., Tsuneoka,Y., Shertzer,H.G., Deka,R. and Nebert,D.W.
Journal Hum. Mutat. 25 (2), 196-206 (2005)
Title Comparison of cytochrome P450 (CYP) genes from the mouse and human genomes, including nomenclature recommendations for genes, pseudogenes and alternative-splice variants .
Author Nelson,D.R., Zeldin,D.C., Hoffman,S.M., Maltais,L.J., Wain,H.M. and Nebert,D.W.
Journal Pharmacogenetics 14 (1), 1-18 (2004)
Title Genetic linkage of lung cancer-associated MspI polymorphisms with amino acid replacement in the heme binding region of the human cytochrome P450IA1 gene .
Author Hayashi,S., Watanabe,J., Nakachi,K. and Kawajiri,K.
Journal J. Biochem. 110 (3), 407-411 (1991)
Title Xenobiotic responsive element in the 5'-upstream region of the human P-450c gene .
Author Kubota,M., Sogawa,K., Kaizu,Y., Sawaya,T., Watanabe,J., Kawajiri,K., Gotoh,O. and Fujii-Kuriyama,Y.
Journal J. Biochem. 110 (2), 232-236 (1991)
Title Identification of genetically high risk individuals to lung cancer by DNA polymorphisms of the cytochrome P450IA1 gene .
Author Kawajiri,K., Nakachi,K., Imai,K., Yoshii,A., Shinoda,N. and Watanabe,J.
Journal FEBS Lett. 263 (1), 131-133 (1990)

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