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Homo sapiens cytochrome P450, family 1, subfamily A, polypeptide 1 (CYP1A1), mRNA.


Clone ID Definition Vector Stock Status Price *Turnaround time Order
OHu26754 Homo sapiens cytochrome P450, family 1, subfamily A, polypeptide 1 (CYP1A1), mRNA. pcDNA3.1+-DYK In-stock $99.00 5-7
OHu26754C Homo sapiens cytochrome P450, family 1, subfamily A, polypeptide 1 (CYP1A1), mRNA. Customized vector In-stock $149.00 5-7

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Sequence Information ORF Nucleotide Sequence
Protein sequence
Vector pcDNA3.1+-DYK or customized vector
Clone information Clone Map
Tag on pcDNA3.1+-DYK N terminal DYKDDDK tags
ORF Insert Method CloneEZ® Seamless cloning technology
RefSeq Version NM_000499.3, 189339226
Length 1539 bp
Structure linear
Update Date 25-MAY-2014
Organism Homo sapiens (human)
Definition Homo sapiens cytochrome P450, family 1, subfamily A, polypeptide 1 (CYP1A1), mRNA.
Product cytochrome P450 1A1
Comment

Summary: This gene, CYP1A1, encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by some polycyclic aromatic hydrocarbons (PAHs), some of which are found in cigarette smoke. The enzyme's endogenous substrate is unknown; however, it is able to metabolize some PAHs to carcinogenic intermediates. The gene has been associated with lung cancer risk. A related family member, CYP1A2, is located approximately 25 kb away from CYP1A1 on chromosome 15. [provided by RefSeq, Jul 2008].


Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments.

RefSeq NP_000490.1
CDS 123..1661
Misc Feature(1)240..1601
Misc Feature(2)240..1601
Misc Feature(3)1200..1202
Misc Feature(4)1491..1493
Exon (1)1..96
Gene:CYP1A1
Gene Synonym:AHH; AHRR; CP11; CYP1; P1-450; P450-C; P450DX
Exon (2)97..947
Gene:CYP1A1
Gene Synonym:AHH; AHRR; CP11; CYP1; P1-450; P450-C; P450DX
Exon (3)948..1074
Gene:CYP1A1
Gene Synonym:AHH; AHRR; CP11; CYP1; P1-450; P450-C; P450DX
Exon (4)1075..1164
Gene:CYP1A1
Gene Synonym:AHH; AHRR; CP11; CYP1; P1-450; P450-C; P450DX
Exon (5)1165..1288
Gene:CYP1A1
Gene Synonym:AHH; AHRR; CP11; CYP1; P1-450; P450-C; P450DX
Exon (6)1289..1375
Gene:CYP1A1
Gene Synonym:AHH; AHRR; CP11; CYP1; P1-450; P450-C; P450DX
Exon (7)1376..2608
Gene:CYP1A1
Gene Synonym:AHH; AHRR; CP11; CYP1; P1-450; P450-C; P450DX
Translation MLFPISMSATEFLLASVIFCLVFWVIRASRPQVPKGLKNPPGPWGWPLIGHMLTLGKNPH LALSRMSQQYGDVLQIRIGSTPVVVLSGLDTIRQALVRQGDDFKGRPDLYTFTLISNGQS MSFSPDSGPVWAARRRLAQNGLKSFSIASDPASSTSCYLEEHVSKEAEVLISTLQELMAG PGHFNPYRYVVVSVTNVICAICFGRRYDHNHQELLSLVNLNNNFGEVVGSGNPADFIPIL RYLPNPSLNAFKDLNEKFYSFMQKMVKEHYKTFEKGHIRDITDSLIEHCQEKQLDENANV QLSDEKIINIVLDLFGAGFDTVTTAISWSLMYLVMNPRVQRKIQEELDTVIGRSRRPRLS DRSHLPYMEAFILETFRHSSFVPFTIPHSTTRDTSLKGFYIPKGRCVFVNQWQINHDQKL WVNPSEFLPERFLTPDGAIDKVLSEKVIIFGMGKRKCIGETIARWEVFLFLAILLQRVEF SVPLGVKVDMTPIYGLTMKHACCEHFQMQLRS
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Position Chain Variation Link
complement(145)-g, adbSNP:148505285
complement(152)-t, cdbSNP:184128730
complement(193)-t, cdbSNP:375315082
complement(194)-t, cdbSNP:145924908
256+a, gdbSNP:4646422
complement(256)-g, adbSNP:386594231
complement(298)-g, adbSNP:149846182
complement(306)-g, cdbSNP:143070677
318+a, gdbSNP:35035798
complement(331)-t, cdbSNP:112517897
complement(335)-t, cdbSNP:370225248
complement(336)-t, cdbSNP:376399672
complement(338)-g, adbSNP:139919943
complement(339)-t, cdbSNP:373568981
complement(351)-g, adbSNP:371190271
complement(355)-g, adbSNP:17861094
complement(361)-g, adbSNP:373246855
complement(362)-g, adbSNP:55864856
complement(364)-g, adbSNP:138474634
complement(368)-g, adbSNP:112522537
complement(384)-t, cdbSNP:77425771
complement(399)-t, cdbSNP:2229150
complement(399)-t, cdbSNP:386561708
400+a, gdbSNP:45528935
complement(406)-g, adbSNP:373137650
complement(415)-t, cdbSNP:368952331
complement(422)-g, adbSNP:377233098
complement(423)-t, cdbSNP:141173079
437..438+a, ccdbSNP:34045449
complement(441)-t, gdbSNP:372306597
443+c, tdbSNP:35267501
complement(444)-c, adbSNP:78901429
complement(445)-t, gdbSNP:373368945
complement(473)-g, adbSNP:375076919
complement(498)-t, cdbSNP:375219443
complement(506)-t, cdbSNP:149540202
complement(507)-g, adbSNP:372197865
516+c, gdbSNP:35196245
complement(523)-t, cdbSNP:367709511
525+c, tdbSNP:45442501
complement(528)-g, adbSNP:141291433
complement(529)-t, cdbSNP:202201538
complement(603)-t, cdbSNP:368890165
complement(604)-t, cdbSNP:202221673
complement(608)-g, adbSNP:375895657
complement(622)-g, cdbSNP:372215528
635+a, cdbSNP:28399426
640+c, gdbSNP:28399427
complement(641)-t, cdbSNP:150427960
complement(662)-c, adbSNP:201933340
complement(677)-t, gdbSNP:140459785
complement(695)-t, cdbSNP:199985203
complement(708)-t, cdbSNP:151244239
complement(733)-g, cdbSNP:142255433
complement(735)-g, adbSNP:201182659
complement(736)-t, cdbSNP:199734551
complement(738)-g, adbSNP:200600221
complement(739)-t, cdbSNP:371913955
complement(747)-t, gdbSNP:148803099
complement(768)-t, adbSNP:146622566
complement(794)-g, adbSNP:144413202
complement(795)-t, cdbSNP:373858916
complement(803)-g, cdbSNP:370787995
complement(834)-g, adbSNP:61747605
complement(843)-g, adbSNP:149687459
complement(865)-g, adbSNP:374229319
complement(914)-g, cdbSNP:139496485
complement(915)-t, cdbSNP:150514993
complement(957)-dbSNP:
complement(957)-t, g, cdbSNP:34260157
complement(979)-t, cdbSNP:4987133
complement(979)-g, adbSNP:386626650
complement(1001)-g, cdbSNP:369522545
complement(1022)-t, gdbSNP:147428559
complement(1049)-g, adbSNP:368742906
complement(1053)-t, cdbSNP:376586536
complement(1074)-t, cdbSNP:373178275
complement(1095)-dbSNP:
complement(1095)-c, adbSNP:201691396
complement(1102)-g, adbSNP:369465868
complement(1115)-t, c, adbSNP:56313657
complement(1148)-g, cdbSNP:199747074
complement(1185)-dbSNP:
complement(1185)-g, adbSNP:191792412
complement(1189)-t, cdbSNP:368650547
complement(1192)-g, adbSNP:148341881
complement(1194)-g, adbSNP:371074476
complement(1195)-t, cdbSNP:186168141
complement(1207)-c, adbSNP:200723875
complement(1234)-t, adbSNP:375093189
complement(1252)-t, cdbSNP:201174966
complement(1265)-t, gdbSNP:386575477
complement(1265)-c, adbSNP:2856833
complement(1266)-t, cdbSNP:201651069
complement(1278)-t, cdbSNP:367605080
complement(1336)-dbSNP:
complement(1336)-t, cdbSNP:56127934
complement(1356)-g, adbSNP:377421606
complement(1363)-g, adbSNP:201265044
complement(1377)-dbSNP:
complement(1377)-t, cdbSNP:138804663
complement(1397..1398)-, adbSNP:72547510
complement(1403)-g, adbSNP:375950006
complement(1439)-g, adbSNP:200091037
complement(1440)-t, cdbSNP:145198866
complement(1465)-t, adbSNP:72547509
complement(1484)-c, adbSNP:369745647
complement(1486)-t, cdbSNP:180744198
complement(1496)-g, adbSNP:147033233
complement(1497)-t, cdbSNP:371662141
1504+a, cdbSNP:1799814
complement(1504)-c, adbSNP:386626647
1506+a, c, g, tdbSNP:1048943
complement(1506)-g, adbSNP:386513458
complement(1508)-g, adbSNP:74465117
complement(1509)-c, adbSNP:141177861
complement(1510)-g, cdbSNP:2278970
complement(1512)-t, gdbSNP:41279188
1530+g, tdbSNP:36121583
complement(1543)-g, adbSNP:147634852
complement(1551)-g, c, adbSNP:56240201
complement(1552)-t, cdbSNP:140680363
1566+a, gdbSNP:28399429
complement(1566)-g, adbSNP:386574978
1569+c, tdbSNP:45500996
1595+c, tdbSNP:45460597
complement(1597)-g, cdbSNP:28399430
complement(1603)-t, cdbSNP:367604147
complement(1605)-c, adbSNP:142388113
complement(1653)-g, adbSNP:148638069
complement(1654)-t, c, adbSNP:56343424
complement(1661)-t, cdbSNP:371424602
complement(1662)-c, adbSNP:373796629
complement(1691)-t, cdbSNP:368793878
complement(1746)-t, cdbSNP:2606346
complement(1843)-g, cdbSNP:145262175
complement(1847)-t, cdbSNP:4986880
complement(1902)-g, cdbSNP:375879810
complement(1956)-t, cdbSNP:56403730
complement(2004)-t, g, cdbSNP:4986881
complement(2009)-t, cdbSNP:28399431
complement(2020)-g, adbSNP:4986882
complement(2107)-t, cdbSNP:139156785
2127+c, tdbSNP:35427048
complement(2143)-g, cdbSNP:370921123
2201+a, cdbSNP:151188660
complement(2204)-t, gdbSNP:142117193
complement(2256)-t, cdbSNP:1800031
complement(2256)-t, cdbSNP:386545566
complement(2274)-g, adbSNP:4986883
complement(2284)-t, cdbSNP:4986884
complement(2315..2316)-, gdbSNP:35228499
complement(2321)-g, adbSNP:145951947
complement(2369)-g, cdbSNP:17861086
complement(2370)-g, cdbSNP:377756240
2374..2375+c, gdbSNP:28399432
complement(2374)-c, adbSNP:17861085
complement(2375)-g, cdbSNP:368204973
complement(2376..2377)-, cdbSNP:200937928
complement(2418)-g, adbSNP:143987603
complement(2472)-t, gdbSNP:17861084
complement(2517)-c, adbSNP:185383134
complement(2579)-g, cdbSNP:28427336
Gene SymbolCYP1A1
Gene SynonymAHH; AHRR; CP11; CYP1; P1-450; P450-C; P450DX
Chromosome15
Locus Map15q24.1
All Transcripts
RefSeq Accession Definition Stock Status Price Turnaround time Business Day Select
NM_000499 Homo sapiens cytochrome P450, family 1, subfamily A, polypeptide 1 (CYP1A1), mRNA. In-stock $99.00 5-7
NM_000499 Homo sapiens cytochrome P450, family 1, subfamily A, polypeptide 1 (CYP1A1), mRNA. In-stock $99.00 5-7
Title CYP1A1 gene polymorphisms and smoking status as modifier factors for lung cancer risk .
Author Hussein AG, Pasha HF, El-Shahat HM, Gad DM and Toam MM.
Journal Gene 541 (1), 26-30 (2014)
Title Relationships between CYP1A1 genetic polymorphisms and bladder cancer risk: a meta-analysis .
Author Wang Y, Kong CZ, Zhang Z, Yang CM and Li J.
Journal DNA Cell Biol. 33 (3), 171-181 (2014)
Title Dephosphorylation of Sp1 at Ser-59 by protein phosphatase 2A (PP2A) is required for induction of CYP1A1 transcription after treatment with 2,3,7,8-tetrachlorodibenzo-p-dioxin or omeprazole .
Author Shimoyama S, Kasai S, Kahn-Perles B and Kikuchi H.
Journal Biochim. Biophys. Acta 1839 (2), 107-115 (2014)
Title Association between the CYP1A1 T3801C polymorphism and risk of cancer: evidence from 268 case-control studies .
Author He,X.F., Wei,W., Liu,Z.Z., Shen,X.L., Yang,X.B., Wang,S.L. and Xie,D.L.
Journal Gene 534 (2), 324-344 (2014)
Title Search for an association between the human CYP1A2 genotype and CYP1A2 metabolic phenotype .
Author Jiang Z, Dragin N, Jorge-Nebert LF, Martin MV, Guengerich FP, Aklillu E, Ingelman-Sundberg M, Hammons GJ, Lyn-Cook BD, Kadlubar FF, Saldana SN, Sorter M, Vinks AA, Nassr N, von Richter O, Jin L and Nebert DW.
Journal Pharmacogenet. Genomics 16 (5), 359-367 (2006)
Title Toward the evaluation of function in genetic variability: characterizing human SNP frequencies and establishing BAC-transgenic mice carrying the human CYP1A1_CYP1A2 locus .
Author Jiang Z, Dalton TP, Jin L, Wang B, Tsuneoka Y, Shertzer HG, Deka R and Nebert DW.
Journal Hum. Mutat. 25 (2), 196-206 (2005)
Title Comparison of cytochrome P450 (CYP) genes from the mouse and human genomes, including nomenclature recommendations for genes, pseudogenes and alternative-splice variants .
Author Nelson DR, Zeldin DC, Hoffman SM, Maltais LJ, Wain HM and Nebert DW.
Journal Pharmacogenetics 14 (1), 1-18 (2004)
Title Genetic linkage of lung cancer-associated MspI polymorphisms with amino acid replacement in the heme binding region of the human cytochrome P450IA1 gene .
Author Hayashi S, Watanabe J, Nakachi K and Kawajiri K.
Journal J. Biochem. 110 (3), 407-411 (1991)
Title Xenobiotic responsive element in the 5'-upstream region of the human P-450c gene .
Author Kubota M, Sogawa K, Kaizu Y, Sawaya T, Watanabe J, Kawajiri K, Gotoh O and Fujii-Kuriyama Y.
Journal J. Biochem. 110 (2), 232-236 (1991)
Title Identification of genetically high risk individuals to lung cancer by DNA polymorphisms of the cytochrome P450IA1 gene .
Author Kawajiri K, Nakachi K, Imai K, Yoshii A, Shinoda N and Watanabe J.
Journal FEBS Lett. 263 (1), 131-133 (1990)

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