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Sequence in raw or FASTA format:

Database:

Blast Method:

 
 


Homo sapiens hemoglobin, beta (HBB), mRNA.


RefSeq Accession Definition Service Stock Status Price *Turnaround time Order
NM_000518 Homo sapiens hemoglobin, beta (HBB), mRNA. GenEZ ORF Cloning In-stock $248.00 $199.00 10

*Business Day

Related Services

RefSeq Version NM_000518.4, 28302128
Length 626 bp
Structure linear
Update Date 24-MAY-2014
Organism Homo sapiens (human)
Definition Homo sapiens hemoglobin, beta (HBB), mRNA.
Product hemoglobin subunit beta
Comment

Summary: The alpha (HBA) and beta (HBB) loci determine the structure of the 2 types of polypeptide chains in adult hemoglobin, Hb A. The normal adult hemoglobin tetramer consists of two alpha chains and two beta chains. Mutant beta globin causes sickle cell anemia. Absence of beta chain causes beta-zero-thalassemia. Reduced amounts of detectable beta globin causes beta-plus-thalassemia. The order of the genes in the beta-globin cluster is 5'-epsilon -- gamma-G -- gamma-A -- delta -- beta--3'. [provided by RefSeq, Jul 2008].

RefSeq NP_000509.1
CDS 51..494
Misc Feature(1)30..32
Misc Feature(2)54..56
Misc Feature(3)54..56
Misc Feature(4)54..56
Misc Feature(5)63..476
Misc Feature(6)75..77
Misc Feature(7)order(135..137,165..167,174..179,240..242,249..251,
Misc Feature(8)228..230
Misc Feature(9)228..230
Misc Feature(10)249..251
Misc Feature(11)297..299
Misc Feature(12)297..299
Misc Feature(13)330..332
Misc Feature(14)330..332
Misc Feature(15)330..332
Misc Feature(16)336..338
Misc Feature(17)411..413
Misc Feature(18)441..443
Misc Feature(19)474..476
Misc Feature(20)483..485
Exon (1)1..142
Gene:HBB
Gene Synonym:beta-globin; CD113t-C
Exon (2)143..365
Gene:HBB
Gene Synonym:beta-globin; CD113t-C
Exon (3)366..626
Gene:HBB
Gene Synonym:beta-globin; CD113t-C
Translation MVHLTPEEKSAVTALWGKVNVDEVGGEALGRLLVVYPWTQRFFESFGDLSTPDAVMGNPK VKAHGKKVLGAFSDGLAHLDNLKGTFATLSELHCDKLHVDPENFRLLGNVLVCVLAHHFG KEFTPPVQAAYQKVVAGVANALAHKYH
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Position Chain Variation Link
10+, tdbSNP:35352549
20+c, tdbSNP:63750628
33+c, gdbSNP:34135787
36+a, cdbSNP:193922550
39+c, tdbSNP:113115948
40..43+, aaacdbSNP:34196559
51+a, gdbSNP:34563000
52+a, c, g, tdbSNP:33941849
53+a, c, g, tdbSNP:33930702
54+a, g, tdbSNP:33958358
54+, gdbSNP:63750475
55+a, c, g, tdbSNP:33949930
57+c, tdbSNP:35906307
58..63+atctga, ctgaggtgaagtctgcctgaggagaagtdbSNP:63750407
58..59+, cdbSNP:63750898
58+a, c, g, tdbSNP:33983205
59..60+, tdbSNP:34058656
complement(59)-t, g, c, adbSNP:713040
60+a, c, gdbSNP:34126315
61+a, c, tdbSNP:63750720
63+a, cdbSNP:281864509
64+a, cdbSNP:63750605
66+, cdbSNP:63750729
66+c, g, tdbSNP:33912272
67..68+, ctdbSNP:34889882
67+c, g, tdbSNP:34769005
68..69+, tgdbSNP:281864519
69..70+at, gadbSNP:193922552
69+a, c, gdbSNP:33930165
70+, adbSNP:63749819
70+a, c, g, tdbSNP:334
72..74+, gagdbSNP:63750928
72+a, c, gdbSNP:34948328
73+a, gdbSNP:34387455
complement(74)-t, c, adbSNP:138405215
75..76+, aadbSNP:35497102
75+a, c, gdbSNP:33926764
76+a, c, g, tdbSNP:33932981
77..78+, gdbSNP:35699606
77+c, gdbSNP:35198910
79+a, c, gdbSNP:33918131
80..81+, tdbSNP:34548294
81+a, gdbSNP:63750717
82+a, c, tdbSNP:33947457
83+a, cdbSNP:35799536
84+a, g, tdbSNP:33974228
85+a, tdbSNP:35140348
86+, tdbSNP:34856846
91+a, cdbSNP:35203747
94+c, g, tdbSNP:33935445
95..96+, gdbSNP:35383398
96+a, c, g, tdbSNP:33946157
96+, tdbSNP:63749960
97+a, gdbSNP:63750783
98+a, gdbSNP:34716011
99+c, g, tdbSNP:63751285
100+a, gdbSNP:33962676
101+a, cdbSNP:370075492
101+, cdbSNP:35662066
102..107+, aaggtgdbSNP:63749958
103+a, gdbSNP:369865419
104+c, g, tdbSNP:36006214
105+a, g, tdbSNP:35802118
106+g, tdbSNP:35382661
108+a, gdbSNP:34866629
110+a, c, g, tdbSNP:63750840
111+a, g, tdbSNP:35890959
112+a, g, tdbSNP:33918474
114+a, c, g, tdbSNP:33950093
115+a, g, tdbSNP:33977536
116+g, tdbSNP:373362317
117..128+, gaagttggtggtdbSNP:281864496
117+a, c, g, tdbSNP:33959855
118..124+, aagttggdbSNP:281864898
118+a, c, g, tdbSNP:33936254
119+a, g, tdbSNP:281864513
120..122+, gttdbSNP:34160180
120+a, g, tdbSNP:33929459
121+a, c, g, tdbSNP:33945546
123..125+, ggtdbSNP:267607294
123+c, gdbSNP:33972975
124+a, g, tdbSNP:33968721
124+cac, gdbSNP:281864899
125+a, g, tdbSNP:33951465
126..128+, ggtdbSNP:63749918
126+c, gdbSNP:34404985
127+a, gdbSNP:35474880
128..129+, tdbSNP:35619688
128+g, tdbSNP:373379910
129..130+, tdbSNP:35477349
129+a, c, g, tdbSNP:33950507
130+a, c, g, tdbSNP:33915112
131+c, g, tdbSNP:281864581
134..135+, cdbSNP:35532010
135+a, c, tdbSNP:33958088
135+, cdbSNP:63750655
138+a, gdbSNP:33974277
138+, gdbSNP:267607295
140+a, c, tdbSNP:35578002
141+a, c, gdbSNP:35684407
142+a, c, gdbSNP:33960103
143..144+dbSNP:
143..144+, cggdbSNP:35348864
143+c, g, tdbSNP:1135071
144+, cdbSNP:63749977
144+c, gdbSNP:33956555
145+c, g, tdbSNP:33920173
147+c, gdbSNP:34314652
148+a, c, g, tdbSNP:33948578
complement(149)-t, cdbSNP:148298007
150..152+, gtgdbSNP:35699671
150+a, g, tdbSNP:1141370
151..156+, tggtctdbSNP:35389895
complement(152)-t, cdbSNP:375797635
153+c, g, tdbSNP:1141387
154+a, c, tdbSNP:1135101
156+c, tdbSNP:281864514
157+a, tdbSNP:35857380
158+a, cdbSNP:33982568
158+, cdbSNP:267607297
162+a, c, g, tdbSNP:33994623
162+, tdbSNP:63750532
163+a, c, gdbSNP:33991059
163+, gdbSNP:281865474
164..170+, gacccagdbSNP:63750099
164+a, g, tdbSNP:33974936
166..167+, ccdbSNP:267607298
166+a, c, tdbSNP:34703513
168+, cdbSNP:267607291
169+, adbSNP:281864574
169+a, gdbSNP:35973315
173..174+, tdbSNP:36029927
173+c, g, tdbSNP:33918778
173+, gdbSNP:63749957
174..177+, ttctdbSNP:80356821
174..176+, ttc, ttctdbSNP:281864897
175+a, c, g, tdbSNP:33926796
176..179+, ctttdbSNP:281864900
176+, cdbSNP:35755331
176+c, gdbSNP:281864570
177..179+, tttdbSNP:41417446
178+c, g, tdbSNP:34378160
179..180+, g, tdbSNP:33979901
180..188+, gagtcctttdbSNP:35637840
180+a, c, g, tdbSNP:33922842
181+a, c, gdbSNP:35262412
183+c, tdbSNP:373212989
184+c, gdbSNP:34868397
185+, cdbSNP:80356820
186+, tdbSNP:35133315
187+a, c, g, tdbSNP:33978338
189+a, gdbSNP:34743882
190+a, gdbSNP:35303218
192+a, c, g, tdbSNP:33932070
193..194+, adbSNP:35894115
193+a, c, g, tdbSNP:33980484
196..197+, atctdbSNP:35619054
196+c, g, tdbSNP:33952850
198..216+agct, tccactcctgatgctgttadbSNP:281864583
199+c, g, tdbSNP:33960931
201+a, tdbSNP:63750336
202+a, cdbSNP:34676051
complement(203)-g, adbSNP:17850156
204+, cdbSNP:63750128
204+c, tdbSNP:281864894
205+a, c, gdbSNP:33969727
207+a, c, g, tdbSNP:33961886
208+a, c, g, tdbSNP:33919924
210+a, gdbSNP:36005841
212..213+, gdbSNP:35165357
214+a, tdbSNP:34037627
215..216+, adbSNP:35171933
215+, tdbSNP:34960334
217+a, tdbSNP:35094013
219..230+, ggcaaccctaagdbSNP:63751103
219+c, g, tdbSNP:33935983
220+a, gdbSNP:34439278
221+c, tdbSNP:193922551
222+a, c, gdbSNP:33988732
223+a, c, gdbSNP:34589620
224..225+, cdbSNP:35395625
224+a, c, gdbSNP:35278874
226+a, c, gdbSNP:33991472
228+, adbSNP:267607293
228+a, g, tdbSNP:33969400
229+a, cdbSNP:35537181
230+c, g, tdbSNP:34621955
231+c, gdbSNP:33990253
232+a, c, tdbSNP:33931779
234+a, c, g, tdbSNP:33995148
235+a, tdbSNP:34974709
236+c, g, tdbSNP:34446260
237+c, gdbSNP:34933455
238+a, cdbSNP:34151786
240+a, c, tdbSNP:33922873
241+a, c, gdbSNP:33985544
243+, gdbSNP:36107977
244+a, c, gdbSNP:33922018
246+a, cdbSNP:35353749
247+a, tdbSNP:33932548
248+c, g, tdbSNP:35747961
249+a, gdbSNP:34165323
250+a, cdbSNP:35939489
251+, adbSNP:193922553
251+a, g, tdbSNP:36092904
252..253+, gtdbSNP:34282684
252+a, gdbSNP:36008922
253..254+, tgdbSNP:193922554
253+a, c, g, tdbSNP:33918343
255+c, tdbSNP:33961459
256+a, c, tdbSNP:33972593
257+c, tdbSNP:112287010
259..260+, gctcggdbSNP:35902963
259+a, gdbSNP:34718174
261+c, gdbSNP:34409430
262+a, c, g, tdbSNP:33946401
265+c, tdbSNP:34362537
266..267+, a, tdbSNP:33969853
267..271+agtga, tdbSNP:63751218
269..270+, tdbSNP:281864520
269+a, tdbSNP:34860414
270+a, g, tdbSNP:33945705
271+a, g, tdbSNP:33967755
273..278+, ggcctgdbSNP:63750968
273+a, c, gdbSNP:33916541
274+a, g, tdbSNP:33976006
275+, cdbSNP:34218908
276..278+, ctgdbSNP:35452098
277+c, g, tdbSNP:33950542
279..280+, gcdbSNP:281864906
279+c, gdbSNP:35286210
280+a, c, tdbSNP:33985847
280+, cdbSNP:281864901
282+a, c, g, tdbSNP:33991294
282+, cdbSNP:63750504
283+a, c, g, tdbSNP:33952543
284+c, g, tdbSNP:33918483
285+, cdbSNP:281865475
286+g, tdbSNP:34870172
288+a, c, g, tdbSNP:33990858
289+a, gdbSNP:34173382
291+a, c, g, tdbSNP:63750519
292+a, gdbSNP:34240746
293+a, c, gdbSNP:35890380
294+c, gdbSNP:11549406
295+a, g, tdbSNP:33936967
complement(296)-t, g, cdbSNP:145669504
297+a, c, gdbSNP:33940051
298+a, c, g, tdbSNP:33987903
299+c, g, tdbSNP:33991993
300+c, g, tdbSNP:33930385
300+, gdbSNP:63751478
301+a, g, tdbSNP:1803195
301+, gdbSNP:193922555
303+a, gdbSNP:35960772
304+a, c, tdbSNP:35914488
305..306+, cdbSNP:35371965
307+c, tdbSNP:35693898
308..309+, tdbSNP:34831847
309+a, c, gdbSNP:33952147
310+a, c, tdbSNP:35819837
312..314+, acadbSNP:63751171
312+a, cdbSNP:35553496
313+a, c, tdbSNP:33993568
315+c, gdbSNP:34672591
316..317+, tdbSNP:34477959
316+c, g, tdbSNP:33940204
317+c, gdbSNP:11549405
318+a, cdbSNP:35351128
319..320+, gtdbSNP:34466953
319+a, c, gdbSNP:33917628
321+a, g, tdbSNP:33913712
322+a, gdbSNP:35068498
323+c, g, tdbSNP:35002698
324..338+, ctgcactgtgacaagdbSNP:34210688
325+c, g, tdbSNP:33917785
325+, tdbSNP:63751080
327+a, c, g, tdbSNP:33924775
328+a, c, gdbSNP:33974325
329+a, c, gdbSNP:34083951
330+c, tdbSNP:33972927
331+a, gdbSNP:35548921
333..334+, tgdbSNP:34533941
333+a, c, g, tdbSNP:33959340
334+a, gdbSNP:34579351
335..336+, gagctgcactgtgacdbSNP:63750620
336..337+, gagctgcactgtgacdbSNP:267607292
336+a, gdbSNP:33914359
337..338+, adbSNP:34937014
337+a, tdbSNP:35204496
338+c, g, tdbSNP:36038739
339+c, gdbSNP:34665886
340+c, tdbSNP:36081208
342+a, c, tdbSNP:33950993
343..345+, acgdbSNP:63750837
343+a, c, tdbSNP:33951978
344+a, c, g, tdbSNP:34515413
345+a, g, tdbSNP:33933298
346+a, c, g, tdbSNP:33985510
348+a, c, g, tdbSNP:33954595
349+a, c, g, tdbSNP:33971048
350+a, g, tdbSNP:34013622
351..352+cc, tctgagaactdbSNP:63750556
351+a, c, g, tdbSNP:34692941
352+c, g, tdbSNP:33965000
354+a, c, gdbSNP:33966487
356+c, g, tdbSNP:35209591
359+a, c, gdbSNP:34227486
360+a, g, tdbSNP:33921589
362+c, gdbSNP:35067717
363+a, g, tdbSNP:34740366
364+a, c, g, tdbSNP:33911434
364+, gdbSNP:63750774
365+c, g, tdbSNP:33914944
367+dbSNP:
367+c, tdbSNP:281864582
369..380+, ctgggcaacgtgdbSNP:281864526
369+c, gdbSNP:63750596
370+a, c, g, tdbSNP:33941844
371..372+, gdbSNP:35225141
372+c, gdbSNP:35017910
373+a, gdbSNP:35519485
374+c, tdbSNP:193922562
375+a, c, gdbSNP:33958637
376..387+, acgtgctggtctdbSNP:63750040
376+a, g, tdbSNP:33958739
377+a, c, gdbSNP:34933751
378+a, c, g, tdbSNP:33969677
378+, gdbSNP:63751201
385+c, tdbSNP:35871407
387+c, tdbSNP:35849199
388+a, g, tdbSNP:33932908
389+a, g, tdbSNP:33930977
390+c, g, tdbSNP:34400584
390+, gdbSNP:281865477
393..394+ct, gdbSNP:41443947
395..396+, tgtgctgdbSNP:281864527
396+c, gdbSNP:34945623
397+a, c, tdbSNP:35485099
399..400+, gtgtgctggccc, tgatdbSNP:63751306
399+c, tdbSNP:34049764
400..401+, gtgtgctggcccdbSNP:267607296
400+a, c, g, tdbSNP:33978082
401+a, g, tdbSNP:35209776
402+a, c, g, tdbSNP:33935527
403+a, c, gdbSNP:33935673
404+, cdbSNP:281864528
405+g, tdbSNP:63750530
405+, tdbSNP:35781690
406+a, c, g, tdbSNP:33928092
408+c, gdbSNP:281864584
409+a, c, g, tdbSNP:33947020
411+a, c, gdbSNP:33924134
412+a, tdbSNP:34303736
413..414+, adbSNP:34120553
413+a, cdbSNP:34726542
414+a, c, g, tdbSNP:33946267
415+a, c, g, tdbSNP:33987957
417+a, c, g, tdbSNP:33971848
418+c, tdbSNP:281864495
419+a, c, g, tdbSNP:33973589
420..428+, accccaccadbSNP:281864902
420+, adbSNP:35238478
421+a, c, tdbSNP:33935383
423+c, tdbSNP:35461710
424+a, c, g, tdbSNP:33983276
425..426+, adbSNP:281864544
425+, adbSNP:35323748
426..431+, ccagtgdbSNP:281864529
428..429+, ccadbSNP:34843844
complement(428)-, tdbSNP:34363638
429+c, gdbSNP:35658323
430..446+, 17 bp deleted, tgcaggctgcctatcagdbSNP:63749815
430+a, c, g, tdbSNP:33925391
430+, tdbSNP:63750022
432+a, c, g, tdbSNP:33971634
433..435+, aggdbSNP:34502690
433+a, c, gdbSNP:33910569
435..438+ccaca, gctgdbSNP:63750860
435+c, gdbSNP:34139813
436+a, c, tdbSNP:33957286
438+c, gdbSNP:35939430
439+aa, ac, ccdbSNP:369582912
439+a, c, tdbSNP:111645889
441+g, tdbSNP:35834416
442+a, c, gdbSNP:33937535
443+a, tdbSNP:281864530
444..445+, adbSNP:281864531
444+a, c, gdbSNP:33910209
445+a, c, gdbSNP:33950778
446..447+, gadbSNP:63750320
446+c, gdbSNP:34188626
447..457+, aaagtggtggcdbSNP:281864904
447+a, c, g, tdbSNP:33953406
448+a, cdbSNP:34398074
449+a, c, tdbSNP:33946775
450+a, c, gdbSNP:34095019
451+c, tdbSNP:35825479
452+c, gdbSNP:113082294
454..463+gcag, tggctggtgtdbSNP:63751152
454+a, c, g, tdbSNP:33966761
456+c, gdbSNP:35492035
457+a, c, tdbSNP:35669628
459+a, c, g, tdbSNP:33984863
460+a, c, gdbSNP:33949486
463..468+, tggctadbSNP:34068040
465..467+, gc, gctdbSNP:34359964
465+a, c, gdbSNP:33919821
466+c, tdbSNP:35594230
468+a, g, tdbSNP:33910475
469+a, cdbSNP:34407387
470+a, c, tdbSNP:34240441
471+a, gdbSNP:34980264
472+a, c, tdbSNP:33927093
474..476+, ctgdbSNP:33935780
474+, cdbSNP:63750694
474+c, gdbSNP:33970699
475..483+, tggcccacadbSNP:34383403
475+g, tdbSNP:35854892
477+a, c, gdbSNP:33931806
478..479+, ccdbSNP:281864497
478+a, c, tdbSNP:33921821
480+a, c, g, tdbSNP:33929415
481+, adbSNP:63749858
481+a, c, g, tdbSNP:33918338
482+a, c, g, tdbSNP:36020563
483+a, g, tdbSNP:33964352
484+, adbSNP:63751425
484+a, tdbSNP:33996892
485+a, c, g, tdbSNP:35020585
486..487+, ctdbSNP:35660883
486+a, c, g, tdbSNP:33949869
487+a, gdbSNP:35117167
488+a, tdbSNP:35291591
489+c, g, tdbSNP:33961444
490..491+, cadbSNP:387906543
490+a, c, g, tdbSNP:33954264
491..492+, ac, tadbSNP:33999427
491+a, c, gdbSNP:33985739
complement(498)-g, adbSNP:372503204
500+c, gdbSNP:34809925
complement(528)-t, cdbSNP:200399660
complement(531)-g, cdbSNP:369307975
complement(568)-t, cdbSNP:369101035
585..597+, gcatctggattctdbSNP:34171453
585+a, gdbSNP:193922549
590+c, tdbSNP:34029390
602..606+, aataadbSNP:35949130
603..604+, atdbSNP:281864905
604..605+a, gdbSNP:35676421
604..605+, tadbSNP:63750205
604+a, c, tdbSNP:33978907
605..606+, aadbSNP:281864532
605+a, gdbSNP:63751128
606+a, g, tdbSNP:63750954
607+a, gdbSNP:33985472
Gene SymbolHBB
Gene Synonymbeta-globin; CD113t-C
Chromosome11
Locus Map11p15.5
All Transcripts
RefSeq Accession Definition Stock Status Price Turnaround time Business Day Select
NM_000518 Homo sapiens hemoglobin, beta (HBB), mRNA. In-stock $248.00 $199.00 10
Title The regulatory role of the adrenergic agonists phenylephrine and isoproterenol on fetal hemoglobin expression and erythroid differentiation .
Author Mei Y, Yin N, Jin X, He J and Yin Z.
Journal Endocrinology 154 (12), 4640-4649 (2013)
Title Acute chest syndrome is associated with single nucleotide polymorphism-defined beta globin cluster haplotype in children with sickle cell anaemia .
Author Bean CJ, Boulet SL, Yang G, Payne AB, Ghaji N, Pyle ME, Hooper WC, Bhatnagar P, Keefer J, Barron-Casella EA, Casella JF and Debaun MR.
Journal Br. J. Haematol. 163 (2), 268-276 (2013)
Title Imputation-based meta-analysis of severe malaria in three African populations .
Author Band G, Le QS, Jostins L, Pirinen M, Kivinen K, Jallow M, Sisay-Joof F, Bojang K, Pinder M, Sirugo G, Conway DJ, Nyirongo V, Kachala D, Molyneux M, Taylor T, Ndila C, Peshu N, Marsh K, Williams TN, Alcock D, Andrews R, Edkins S, Gray E, Hubbart C, Jeffreys A, Rowlands K, Schuldt K, Clark TG, Small KS, Teo YY, Kwiatkowski DP, Rockett KA, Barrett JC and Spencer CC.
Journal PLoS Genet. 9 (5), E1003509 (2013)
Title The spectrum of beta-thalassemia mutations in Baghdad, Central Iraq .
Author Al-Allawi NA, Al-Mousawi BM, Badi AI and Jalal SD.
Journal Hemoglobin 37 (5), 444-453 (2013)
Title Upstream open reading frames cause widespread reduction of protein expression and are polymorphic among humans .
Author Calvo SE, Pagliarini DJ and Mootha VK.
Journal Proc. Natl. Acad. Sci. U.S.A. 106 (18), 7507-7512 (2009)
Title Beta-Thalassemia .
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Title The structure of hemoglobin Indianapolis [beta112(G14) arginine]. An unstable variant detectable only by isotopic labeling .
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Title Complete 3' noncoding region sequences of rabbit and human beta-globin messenger RNAs .
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