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Sequence in raw or FASTA format:

Database:

Blast Method:

 
 


Homo sapiens tumor protein p53 (TP53), transcript variant 1, mRNA.


RefSeq Accession Definition Service Stock Status Price *Turnaround time Order
NM_000546 Homo sapiens tumor protein p53 (TP53), transcript variant 1, mRNA. GenEZ ORF Cloning In-stock $418.00 $369.00 10

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RefSeq Version NM_000546.5, 371502114
Length 2591 bp
Structure linear
Update Date 17-APR-2013
Organism Homo sapiens (human)
Definition Homo sapiens tumor protein p53 (TP53), transcript variant 1, mRNA.
Product cellular tumor antigen p53 isoform a
Comment

Summary: This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expression of target genes, thereby inducing cell cycle arrest, apoptosis, senescence, DNA repair, or changes in metabolism. Mutations in this gene are associated with a variety of human cancers, including hereditary cancers such as Li-Fraumeni syndrome. Alternative splicing of this gene and the use of alternate promoters result in multiple transcript variants and isoforms. Additional isoforms have also been shown to result from the use of alternate translation initiation codons (PMIDs: 12032546, 20937277). [provided by RefSeq, Feb 2013].


Transcript Variant: This variant (1) can initiate translation from two in-frame AUG start codons. The isoform represented in this variant (a, also known as p53alpha) results from translation initiation at the upstream start codon. Both variants 1 and 2 encode isoform a, which is the longest isoform.

RefSeq NP_000537.3
CDS 203..1384
Misc Feature(1)95..97
Misc Feature(2)203..451
Misc Feature(3)203..451
Misc Feature(4)203..334
Misc Feature(5)215..289
Misc Feature(6)218..220
Misc Feature(7)227..229
Misc Feature(8)227..229
Misc Feature(9)227..229
Misc Feature(10)245..247
Misc Feature(11)245..247
Misc Feature(12)245..247
Misc Feature(13)245..247
Misc Feature(14)245..247
Misc Feature(15)245..247
Misc Feature(16)245..247
Misc Feature(17)245..247
Misc Feature(18)251..277
Misc Feature(19)254..256
Misc Feature(20)254..256
Misc Feature(21)254..256
Misc Feature(22)254..256
Misc Feature(23)254..256
Misc Feature(24)254..256
Misc Feature(25)254..256
Misc Feature(26)254..256
Misc Feature(27)260..262
Misc Feature(28)260..262
Misc Feature(29)260..262
Misc Feature(30)260..262
Misc Feature(31)260..262
Misc Feature(32)260..262
Misc Feature(33)260..262
Misc Feature(34)269..271
Misc Feature(35)299..301
Misc Feature(36)299..301
Misc Feature(37)299..301
Misc Feature(38)299..301
Misc Feature(39)299..301
Misc Feature(40)299..301
Misc Feature(41)299..301
Misc Feature(42)311..313
Misc Feature(43)311..313
Misc Feature(44)311..313
Misc Feature(45)311..313
Misc Feature(46)311..313
Misc Feature(47)311..313
Misc Feature(48)320..322
Misc Feature(49)338..340
Misc Feature(50)338..340
Misc Feature(51)338..340
Misc Feature(52)344..370
Misc Feature(53)365..367
Misc Feature(54)365..367
Misc Feature(55)365..367
Misc Feature(56)398..532
Misc Feature(57)443..445
Misc Feature(58)443..445
Misc Feature(59)497..499
Misc Feature(60)500..1312
Misc Feature(61)527..1066
Misc Feature(62)539..910
Misc Feature(63)548..1078
Misc Feature(64)560..562
Misc Feature(65)665..667
Misc Feature(66)order(728..730,737..739,914..916,926..928)
Misc Feature(67)order(731..739,743..745)
Misc Feature(68)749..751
Misc Feature(69)order(917..919,923..925,944..946,1019..1021,1025..1033,
Misc Feature(70)923..946
Misc Feature(71)968..1084
Misc Feature(72)1007..1009
Misc Feature(73)1019..1042
Misc Feature(74)1052..1054
Misc Feature(75)1076..1078
Misc Feature(76)1100..1381
Misc Feature(77)1115..1165
Misc Feature(78)1115..1117
Misc Feature(79)1115..1117
Misc Feature(80)1145..1147
Misc Feature(81)1145..1147
Misc Feature(82)1145..1147
Misc Feature(83)1145..1147
Misc Feature(84)1145..1147
Misc Feature(85)1145..1147
Misc Feature(86)1145..1147
Misc Feature(87)1157..1282
Misc Feature(88)1157..1279
Misc Feature(89)1157..1159
Misc Feature(90)1160..1162
Misc Feature(91)1160..1162
Misc Feature(92)1160..1162
Misc Feature(93)1163..1165
Misc Feature(94)1163..1165
Misc Feature(95)1175..1270
Misc Feature(96)1217..1252
Misc Feature(97)1253..1255
Misc Feature(98)1271..1273
Misc Feature(99)1277..1291
Misc Feature(100)1298..1300
Misc Feature(101)1304..1363
Misc Feature(102)1310..1318
Misc Feature(103)1310..1312
Misc Feature(104)1310..1312
Misc Feature(105)1310..1312
Misc Feature(106)1310..1312
Misc Feature(107)1310..1312
Misc Feature(108)1313..1315
Misc Feature(109)1316..1318
Misc Feature(110)1316..1318
Misc Feature(111)1316..1318
Misc Feature(112)1316..1318
Misc Feature(113)1316..1318
Misc Feature(114)1319..1321
Misc Feature(115)1319..1321
Misc Feature(116)1319..1321
Misc Feature(117)1319..1321
Misc Feature(118)1319..1321
Misc Feature(119)1319..1321
Misc Feature(120)1334..1336
Misc Feature(121)1343..1345
Misc Feature(122)1343..1345
Misc Feature(123)1343..1345
Misc Feature(124)1343..1345
Misc Feature(125)1346..1348
Misc Feature(126)1346..1348
Misc Feature(127)1346..1348
Misc Feature(128)1346..1348
Misc Feature(129)1346..1348
Misc Feature(130)1346..1348
Misc Feature(131)1358..1360
Misc Feature(132)1358..1360
Misc Feature(133)1358..1360
Misc Feature(134)1376..1378
Misc Feature(135)1376..1378
Misc Feature(136)1376..1378
Misc Feature(137)1376..1378
Misc Feature(138)1376..1378
Misc Feature(139)1376..1378
Exon (1)1..174
Gene:TP53
Gene Synonym:BCC7; LFS1; P53; TRP53
Exon (2)175..276
Gene:TP53
Gene Synonym:BCC7; LFS1; P53; TRP53
Exon (3)277..298
Gene:TP53
Gene Synonym:BCC7; LFS1; P53; TRP53
Exon (4)299..577
Gene:TP53
Gene Synonym:BCC7; LFS1; P53; TRP53
Exon (5)578..761
Gene:TP53
Gene Synonym:BCC7; LFS1; P53; TRP53
Exon (6)762..874
Gene:TP53
Gene Synonym:BCC7; LFS1; P53; TRP53
Exon (7)875..984
Gene:TP53
Gene Synonym:BCC7; LFS1; P53; TRP53
Exon (8)985..1121
Gene:TP53
Gene Synonym:BCC7; LFS1; P53; TRP53
Exon (9)1122..1195
Gene:TP53
Gene Synonym:BCC7; LFS1; P53; TRP53
Exon (10)1196..1302
Gene:TP53
Gene Synonym:BCC7; LFS1; P53; TRP53
Exon (11)1303..2591
Gene:TP53
Gene Synonym:BCC7; LFS1; P53; TRP53
Translation MEEPQSDPSVEPPLSQETFSDLWKLLPENNVLSPLPSQAMDDLMLSPDDIEQWFTEDPGP DEAPRMPEAAPPVAPAPAAPTPAAPAPAPSWPLSSSVPSQKTYQGSYGFRLGFLHSGTAK SVTCTYSPALNKMFCQLAKTCPVQLWVDSTPPPGTRVRAMAIYKQSQHMTEVVRRCPHHE RCSDSDGLAPPQHLIRVEGNLRVEYLDDRNTFRHSVVVPYEPPEVGSDCTTIHYNYMCNS SCMGGMNRRPILTIITLEDSSGNLLGRNSFEVRVCACPGRDRRTEEENLRKKGEPHHELP PGSTKRALPNNTSSSPQPKKKPLDGEYFTLQIRGRERFEMFRELNEALELKDAQAGKEPG GSRAHSSHLKSKKGQSTSRHKKLMFKTEGPDSD
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Position Chain Variation Link
complement(92)-dbSNP:
complement(92)-g, adbSNP:17884410
complement(208)-t, cdbSNP:143458271
complement(233)-g, cdbSNP:201382018
complement(265)-t, cdbSNP:1800369
complement(293)-dbSNP:
complement(293)-t, cdbSNP:201753350
complement(304)-dbSNP:
complement(304)-c, adbSNP:11575998
complement(307)-t, gdbSNP:121912661
complement(310)-g, adbSNP:1800370
complement(341)-t, cdbSNP:1800371
complement(343)-t, cdbSNP:201741778
complement(375)-g, cdbSNP:144386518
complement(382)-t, gdbSNP:142216275
complement(400)-, cdbSNP:66702588
complement(417)-g, cdbSNP:1042522
complement(418)-g, c, adbSNP:56275308
complement(450)-g, adbSNP:201717599
complement(451)-t, cdbSNP:55754907
complement(468..469)-, gdbSNP:66998338
complement(531)-t, g, cdbSNP:11540654
complement(560)-t, adbSNP:121912658
complement(577)-c, adbSNP:55863639
complement(588)-dbSNP:
complement(588)-t, cdbSNP:137852792
complement(600)-t, cdbSNP:28934873
complement(614)-g, cdbSNP:28934875
complement(615)-, cdbSNP:137852794
complement(650..661)-, acacccccgcccdbSNP:137852790
complement(652..661)-, acccccgcccdbSNP:137852791
complement(653)-t, c, adbSNP:28934874
complement(661)-t, cdbSNP:72661116
complement(662)-g, adbSNP:137852789
complement(664)-t, cdbSNP:137852793
complement(671)-t, gdbSNP:121912654
complement(676)-g, adbSNP:139200646
complement(683)-g, adbSNP:193920817
complement(690)-t, cdbSNP:148924904
complement(715..716)-, cdbSNP:66983534
complement(725)-g, cdbSNP:138729528
complement(726)-g, adbSNP:28934578
complement(731)-g, adbSNP:147002414
complement(734)-, gdbSNP:68130327
complement(752)-g, adbSNP:72661117
complement(756)-t, cdbSNP:150607408
complement(768)-dbSNP:
complement(768)-t, cdbSNP:121912665
complement(769)-t, gdbSNP:55764374
complement(820)-t, cdbSNP:142813240
complement(841)-t, g, adbSNP:1800372
complement(850)-g, cdbSNP:199693249
complement(851)-g, adbSNP:35163653
complement(861)-c, adbSNP:121912666
complement(867)-g, adbSNP:146340390
complement(868)-t, g, adbSNP:72661118
complement(870)-t, gdbSNP:138983188
complement(906)-dbSNP:
complement(906)-t, cdbSNP:144340710
complement(916)-t, gdbSNP:193920789
complement(924)-t, cdbSNP:28934573
complement(927)-g, adbSNP:121912655
complement(935)-t, g, adbSNP:28934575
complement(936)-g, adbSNP:121912656
complement(944)-t, cdbSNP:121912651
complement(945)-g, adbSNP:11540652
complement(946..947)-, tdbSNP:67185453
complement(949)-t, gdbSNP:28934571
complement(951..952)-, gdbSNP:67026029
complement(957)-t, cdbSNP:121912653
complement(972)-t, adbSNP:28934577
complement(974)-g, adbSNP:121912652
complement(986)-dbSNP:
complement(986)-t, cdbSNP:200579969
complement(989)-g, adbSNP:72661119
complement(999)-g, adbSNP:193920774
complement(1001)-g, adbSNP:55832599
complement(1011..1012)-, adbSNP:67389650
complement(1016)-t, gdbSNP:121912657
complement(1019)-t, cdbSNP:121913343
complement(1020)-g, adbSNP:28934576
complement(1034)-g, cdbSNP:17849781
complement(1041)-t, g, cdbSNP:121912660
complement(1046)-t, cdbSNP:28934574
complement(1049)-g, adbSNP:149633775
complement(1055)-t, cdbSNP:112431538
complement(1056)-t, adbSNP:121912667
complement(1065..1066)-, adbSNP:66546779
complement(1071)-t, cdbSNP:55819519
complement(1077)-t, adbSNP:121912663
complement(1087)-g, adbSNP:200073907
complement(1094)-t, cdbSNP:201744589
complement(1103..1104)-, gdbSNP:68000243
complement(1105)-g, adbSNP:72661120
complement(1118)-t, cdbSNP:121913344
complement(1134)-dbSNP:
complement(1134)-t, cdbSNP:56184981
complement(1135)-g, adbSNP:201601993
complement(1137)-g, cdbSNP:145151284
complement(1176)-t, gdbSNP:121912659
complement(1195)-g, adbSNP:11575996
complement(1212)-dbSNP:
complement(1212)-g, adbSNP:121912664
complement(1216)-g, adbSNP:150293825
complement(1217)-g, adbSNP:17882252
complement(1233)-t, cdbSNP:121912662
complement(1253)-t, cdbSNP:141402957
complement(1281)-g, cdbSNP:35993958
complement(1298)-t, gdbSNP:17881470
complement(1334)-dbSNP:
complement(1334)-g, adbSNP:80184930
complement(1349)-g, adbSNP:150842067
complement(1393)-t, gdbSNP:8065799
complement(1421)-t, adbSNP:1042526
complement(1489)-t, cdbSNP:35919705
complement(1578..1579)-, tdbSNP:140346117
complement(1589)-t, cdbSNP:16956880
complement(1693)-c, adbSNP:79516338
complement(1698)-g, adbSNP:34486624
complement(1712)-g, adbSNP:17881366
complement(1793)-t, gdbSNP:191918079
complement(1869)-t, cdbSNP:4968187
complement(1875)-g, adbSNP:916131
complement(1898)-t, cdbSNP:916132
complement(1918..1919)-ag, gadbSNP:35944977
complement(1918)-t, cdbSNP:1811095
complement(1919)-t, cdbSNP:1811096
complement(1953..1954)-, acdbSNP:202099016
complement(1954)-, gtdbSNP:17886358
complement(1979)-, gdbSNP:34607064
complement(1995)-, tdbSNP:66759322
complement(1997)-c, adbSNP:17879353
complement(2018..2019)-g, cdbSNP:1042535
complement(2019)-g, adbSNP:1794291
complement(2060)-, gdbSNP:34182553
complement(2138)-t, cdbSNP:199729221
complement(2156)-, adbSNP:200757381
complement(2157)-g, adbSNP:200378797
complement(2183..2184)-, adbSNP:35940853
complement(2210)-g, adbSNP:17884306
complement(2239)-t, cdbSNP:17884586
complement(2270)-g, adbSNP:35659787
complement(2320)-t, cdbSNP:55817367
complement(2440..2441)-gg, ccdbSNP:34734132
complement(2440)-g, cdbSNP:1794292
complement(2441)-g, cdbSNP:1794293
complement(2454)-g, adbSNP:114831472
complement(2481)-t, adbSNP:139396032
complement(2559)-c, adbSNP:78378222
Gene SymbolTP53
Gene SynonymBCC7; LFS1; P53; TRP53
Chromosome17
Locus Map17p13.1
All Transcripts
RefSeq Accession Definition Stock Status Price Turnaround time Business Day Select
NM_000546 Homo sapiens tumor protein p53 (TP53), transcript variant 1, mRNA. In-stock $418.00 $369.00 10
NM_001126112 Homo sapiens tumor protein p53 (TP53), transcript variant 2, mRNA. In-stock $418.00 $369.00 10
NM_001126113 Homo sapiens tumor protein p53 (TP53), transcript variant 4, mRNA. In-stock $418.00 $369.00 10
NM_001126114 Homo sapiens tumor protein p53 (TP53), transcript variant 3, mRNA. In-stock $418.00 $369.00 10
NM_001126115 Homo sapiens tumor protein p53 (TP53), transcript variant 5, mRNA. In-stock $348.00 $299.00 10
NM_001126116 Homo sapiens tumor protein p53 (TP53), transcript variant 6, mRNA. In-stock $308.00 $259.00 10
NM_001126117 Homo sapiens tumor protein p53 (TP53), transcript variant 7, mRNA. In-stock $308.00 $259.00 10
NM_001126118 Homo sapiens tumor protein p53 (TP53), transcript variant 8, mRNA. In-stock $418.00 $369.00 10
NM_001276695 Homo sapiens tumor protein p53 (TP53), transcript variant 4, mRNA. In-stock $348.00 $299.00 10
NM_001276696 Homo sapiens tumor protein p53 (TP53), transcript variant 3, mRNA. In-stock $348.00 $299.00 10
NM_001276697 Homo sapiens tumor protein p53 (TP53), transcript variant 5, mRNA. In-stock $308.00 $259.00 10
NM_001276698 Homo sapiens tumor protein p53 (TP53), transcript variant 6, mRNA. In-stock $308.00 $259.00 10
NM_001276699 Homo sapiens tumor protein p53 (TP53), transcript variant 7, mRNA. In-stock $308.00 $259.00 10
NM_001276760 Homo sapiens tumor protein p53 (TP53), transcript variant 1, mRNA. In-stock $418.00 $369.00 10
NM_001276761 Homo sapiens tumor protein p53 (TP53), transcript variant 2, mRNA. In-stock $418.00 $369.00 10
Title G-quadruplex structures in TP53 intron 3: role in alternative splicing and in production of p53 mRNA isoforms .
Author Marcel,V., Tran,P.L., Sagne,C., Martel-Planche,G., Vaslin,L., Teulade-Fichou,M.P., Hall,J., Mergny,J.L., Hainaut,P. and Van Dyck,E.
Journal Carcinogenesis 32 (3), 271-278 (2011)
Title Delta160p53 is a novel N-terminal p53 isoform encoded by Delta133p53 transcript .
Author Marcel,V., Perrier,S., Aoubala,M., Ageorges,S., Groves,M.J., Diot,A., Fernandes,K., Tauro,S. and Bourdon,J.C.
Journal FEBS Lett. 584 (21), 4463-4468 (2010)
Title Does the nonsense-mediated mRNA decay mechanism prevent the synthesis of truncated BRCA1, CHK2, and p53 proteins? .
Author Anczukow,O., Ware,M.D., Buisson,M., Zetoune,A.B., Stoppa-Lyonnet,D., Sinilnikova,O.M. and Mazoyer,S.
Journal Hum. Mutat. 29 (1), 65-73 (2008)
Title p53 Family isoforms .
Author Bourdon,J.C.
Journal Curr Pharm Biotechnol 8 (6), 332-336 (2007)
Title Expression of p53 and p53/47 are controlled by alternative mechanisms of messenger RNA translation initiation .
Author Candeias,M.M., Powell,D.J., Roubalova,E., Apcher,S., Bourougaa,K., Vojtesek,B., Bruzzoni-Giovanelli,H. and Fahraeus,R.
Journal Oncogene 25 (52), 6936-6947 (2006)
Title Characterization of the human p53 gene .
Author Lamb,P. and Crawford,L.
Journal Mol. Cell. Biol. 6 (5), 1379-1385 (1986)
Title Localization of gene for human p53 tumour antigen to band 17p13 .
Author Isobe,M., Emanuel,B.S., Givol,D., Oren,M. and Croce,C.M.
Journal Nature 320 (6057), 84-85 (1986)
Title Transformation associated p53 protein is encoded by a gene on human chromosome 17 .
Author Benchimol,S., Lamb,P., Crawford,L.V., Sheer,D., Shows,T.B., Bruns,G.A. and Peacock,J.
Journal Somat. Cell Mol. Genet. 11 (5), 505-510 (1985)
Title Molecular cloning and in vitro expression of a cDNA clone for human cellular tumor antigen p53 .
Author Harlow,E., Williamson,N.M., Ralston,R., Helfman,D.M. and Adams,T.E.
Journal Mol. Cell. Biol. 5 (7), 1601-1610 (1985)
Title Human p53 cellular tumor antigen: cDNA sequence and expression in .
Author Zakut-Houri,R., Bienz-Tadmor,B., Givol,D. and Oren,M.
Journal EMBO J. 4 (5), 1251-1255 (1985)


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