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Sequence in raw or FASTA format:


Blast Method:


Homo sapiens tumor protein p53 (TP53), transcript variant 1, mRNA.

Clone ID Definition Vector Stock Status Price *Turnaround time Order
OHu20059 Homo sapiens tumor protein p53 (TP53), transcript variant 1, mRNA. pcDNA3.1+-DYK In-stock $99.00 5-7
OHu20059C Homo sapiens tumor protein p53 (TP53), transcript variant 1, mRNA. Customized vector In-stock $149.00 5-7

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Sequence Information ORF Nucleotide Sequence
Protein sequence
Vector pcDNA3.1+-DYK or customized vector
Clone information Clone Map
Tag on pcDNA3.1+-DYK N terminal DYKDDDK tags
ORF Insert Method CloneEZ® Seamless cloning technology
RefSeq Version NM_000546.5, 371502114
Length 1182 bp
Update Date 04-MAY-2014
Organism Homo sapiens (human)
Definition Homo sapiens tumor protein p53 (TP53), transcript variant 1, mRNA.
Product cellular tumor antigen p53 isoform a

Summary: This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expression of target genes, thereby inducing cell cycle arrest, apoptosis, senescence, DNA repair, or changes in metabolism. Mutations in this gene are associated with a variety of human cancers, including hereditary cancers such as Li-Fraumeni syndrome. Alternative splicing of this gene and the use of alternate promoters result in multiple transcript variants and isoforms. Additional isoforms have also been shown to result from the use of alternate translation initiation codons (PMIDs: 12032546, 20937277). [provided by RefSeq, Feb 2013].

Transcript Variant: This variant (1) can initiate translation from two in-frame AUG start codons. The isoform represented in this variant (a, also known as p53alpha) results from translation initiation at the upstream start codon. Both variants 1 and 2 encode isoform a, which is the longest isoform.

RefSeq NP_000537.3
CDS 203..1384
Misc Feature(1)95..97
Misc Feature(2)203..451
Misc Feature(3)203..451
Misc Feature(4)203..334
Misc Feature(5)215..289
Misc Feature(6)218..220
Misc Feature(7)227..229
Misc Feature(8)227..229
Misc Feature(9)227..229
Misc Feature(10)245..247
Misc Feature(11)245..247
Misc Feature(12)245..247
Misc Feature(13)245..247
Misc Feature(14)245..247
Misc Feature(15)245..247
Misc Feature(16)245..247
Misc Feature(17)245..247
Misc Feature(18)251..277
Misc Feature(19)254..256
Misc Feature(20)254..256
Misc Feature(21)254..256
Misc Feature(22)254..256
Misc Feature(23)254..256
Misc Feature(24)254..256
Misc Feature(25)254..256
Misc Feature(26)254..256
Misc Feature(27)260..262
Misc Feature(28)260..262
Misc Feature(29)260..262
Misc Feature(30)260..262
Misc Feature(31)260..262
Misc Feature(32)260..262
Misc Feature(33)260..262
Misc Feature(34)269..271
Misc Feature(35)299..301
Misc Feature(36)299..301
Misc Feature(37)299..301
Misc Feature(38)299..301
Misc Feature(39)299..301
Misc Feature(40)299..301
Misc Feature(41)299..301
Misc Feature(42)311..313
Misc Feature(43)311..313
Misc Feature(44)311..313
Misc Feature(45)311..313
Misc Feature(46)311..313
Misc Feature(47)311..313
Misc Feature(48)320..322
Misc Feature(49)338..340
Misc Feature(50)338..340
Misc Feature(51)338..340
Misc Feature(52)344..370
Misc Feature(53)365..367
Misc Feature(54)365..367
Misc Feature(55)365..367
Misc Feature(56)398..532
Misc Feature(57)443..445
Misc Feature(58)443..445
Misc Feature(59)497..499
Misc Feature(60)500..1312
Misc Feature(61)500..1102
Misc Feature(62)527..1066
Misc Feature(63)539..910
Misc Feature(64)548..1078
Misc Feature(65)560..562
Misc Feature(66)560..562
Misc Feature(67)665..667
Misc Feature(68)order(728..730,737..739,914..916,926..928)
Misc Feature(69)order(731..739,743..745)
Misc Feature(70)749..751
Misc Feature(71)order(917..919,923..925,944..946,1019..1021,1025..1033,
Misc Feature(72)923..946
Misc Feature(73)968..1084
Misc Feature(74)1007..1009
Misc Feature(75)1019..1042
Misc Feature(76)1052..1054
Misc Feature(77)1076..1078
Misc Feature(78)1100..1381
Misc Feature(79)1115..1165
Misc Feature(80)1115..1117
Misc Feature(81)1115..1117
Misc Feature(82)1145..1147
Misc Feature(83)1145..1147
Misc Feature(84)1145..1147
Misc Feature(85)1145..1147
Misc Feature(86)1145..1147
Misc Feature(87)1145..1147
Misc Feature(88)1145..1147
Misc Feature(89)1157..1282
Misc Feature(90)1157..1159
Misc Feature(91)1160..1162
Misc Feature(92)1160..1162
Misc Feature(93)1160..1162
Misc Feature(94)1163..1165
Misc Feature(95)1163..1165
Misc Feature(96)1172..1279
Misc Feature(97)1175..1270
Misc Feature(98)1217..1252
Misc Feature(99)1253..1255
Misc Feature(100)1271..1273
Misc Feature(101)1277..1291
Misc Feature(102)1298..1300
Misc Feature(103)1304..1363
Misc Feature(104)1310..1318
Misc Feature(105)1310..1312
Misc Feature(106)1310..1312
Misc Feature(107)1310..1312
Misc Feature(108)1310..1312
Misc Feature(109)1310..1312
Misc Feature(110)1313..1315
Misc Feature(111)1316..1318
Misc Feature(112)1316..1318
Misc Feature(113)1316..1318
Misc Feature(114)1316..1318
Misc Feature(115)1316..1318
Misc Feature(116)1319..1321
Misc Feature(117)1319..1321
Misc Feature(118)1319..1321
Misc Feature(119)1319..1321
Misc Feature(120)1319..1321
Misc Feature(121)1319..1321
Misc Feature(122)1334..1336
Misc Feature(123)1343..1345
Misc Feature(124)1343..1345
Misc Feature(125)1343..1345
Misc Feature(126)1343..1345
Misc Feature(127)1346..1348
Misc Feature(128)1346..1348
Misc Feature(129)1346..1348
Misc Feature(130)1346..1348
Misc Feature(131)1346..1348
Misc Feature(132)1346..1348
Misc Feature(133)1358..1360
Misc Feature(134)1358..1360
Misc Feature(135)1358..1360
Misc Feature(136)1376..1378
Misc Feature(137)1376..1378
Misc Feature(138)1376..1378
Misc Feature(139)1376..1378
Misc Feature(140)1376..1378
Misc Feature(141)1376..1378
Exon (1)1..174
Gene Synonym:BCC7; LFS1; P53; TRP53
Exon (2)175..276
Gene Synonym:BCC7; LFS1; P53; TRP53
Exon (3)277..298
Gene Synonym:BCC7; LFS1; P53; TRP53
Exon (4)299..577
Gene Synonym:BCC7; LFS1; P53; TRP53
Exon (5)578..761
Gene Synonym:BCC7; LFS1; P53; TRP53
Exon (6)762..874
Gene Synonym:BCC7; LFS1; P53; TRP53
Exon (7)875..984
Gene Synonym:BCC7; LFS1; P53; TRP53
Exon (8)985..1121
Gene Synonym:BCC7; LFS1; P53; TRP53
Exon (9)1122..1195
Gene Synonym:BCC7; LFS1; P53; TRP53
Exon (10)1196..1302
Gene Synonym:BCC7; LFS1; P53; TRP53
Exon (11)1303..2591
Gene Synonym:BCC7; LFS1; P53; TRP53
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Position Chain Variation Link
92+a, gdbSNP:17884410
complement(92)-g, adbSNP:386545220
complement(191)-g, adbSNP:375229869
complement(208)-t, cdbSNP:143458271
complement(233)-g, cdbSNP:201382018
265+c, tdbSNP:1800369
279..282+aagaacgt, ttccdbSNP:397516438
complement(292)-g, adbSNP:370992294
complement(293)-t, cdbSNP:201753350
304+a, cdbSNP:11575998
307+g, tdbSNP:121912661
complement(310)-g, adbSNP:1800370
complement(325)-g, adbSNP:369129220
complement(341)-t, cdbSNP:1800371
complement(343)-t, cdbSNP:201741778
complement(351)-g, adbSNP:370502517
complement(375)-g, cdbSNP:144386518
complement(390)-g, adbSNP:372201428
417+c, gdbSNP:1042522
complement(418)-g, c, adbSNP:56275308
complement(436)-t, cdbSNP:375099397
complement(448)-t, cdbSNP:372397095
complement(450)-g, adbSNP:201717599
complement(451)-t, cdbSNP:55754907
complement(521)-g, adbSNP:368771578
531+c, g, tdbSNP:11540654
560+a, tdbSNP:121912658
complement(577)-c, adbSNP:55863639
588+c, tdbSNP:137852792
600+c, tdbSNP:28934873
complement(602)-g, adbSNP:267605077
614+c, gdbSNP:28934875
615+, cdbSNP:137852794
650..661+, acacccccgcccdbSNP:137852790
652..661+, acccccgcccdbSNP:137852791
653+a, c, tdbSNP:28934874
661+c, tdbSNP:72661116
662+a, gdbSNP:137852789
664+c, tdbSNP:137852793
complement(669)-t, cdbSNP:371524413
671+g, tdbSNP:121912654
complement(676)-g, adbSNP:139200646
complement(680)-t, adbSNP:377274728
683+a, gdbSNP:193920817
complement(690)-t, cdbSNP:148924904
complement(725)-g, cdbSNP:138729528
726+a, gdbSNP:28934578
complement(731)-g, adbSNP:147002414
744+g, tdbSNP:397514495
752+a, gdbSNP:72661117
complement(756)-t, cdbSNP:150607408
complement(757)-g, adbSNP:367560109
complement(760)-t, adbSNP:375275361
768+c, tdbSNP:121912665
complement(769)-t, gdbSNP:55764374
complement(784)-g, adbSNP:370216745
788+c, tdbSNP:397516435
complement(820)-t, cdbSNP:142813240
839+c, tdbSNP:397516436
complement(841)-t, g, adbSNP:1800372
complement(850)-g, cdbSNP:199693249
851+a, gdbSNP:35163653
861+a, cdbSNP:121912666
complement(867)-g, adbSNP:146340390
868+a, g, tdbSNP:72661118
complement(870)-t, gdbSNP:138983188
complement(874)-t, cdbSNP:267605076
complement(906)-t, cdbSNP:144340710
916+g, tdbSNP:193920789
920..943+, agttcctgcatgggcggcatgaacdbSNP:397516437
924+c, tdbSNP:28934573
927+a, gdbSNP:121912655
complement(928)-g, adbSNP:375874539
935+a, g, tdbSNP:28934575
936+a, gdbSNP:121912656
944+c, tdbSNP:121912651
945+a, gdbSNP:11540652
949+g, tdbSNP:28934571
957+c, tdbSNP:121912653
972+a, tdbSNP:28934577
974+a, gdbSNP:121912652
complement(986)-t, cdbSNP:200579969
989+a, gdbSNP:72661119
999+a, gdbSNP:193920774
complement(1001)-g, adbSNP:55832599
1016+g, tdbSNP:121912657
1019+c, tdbSNP:121913343
1020+a, gdbSNP:28934576
complement(1034)-g, cdbSNP:17849781
1041+c, g, tdbSNP:121912660
complement(1049)-g, adbSNP:149633775
complement(1050)-t, cdbSNP:371409680
complement(1055)-t, cdbSNP:112431538
1056+a, tdbSNP:121912667
complement(1071)-t, cdbSNP:55819519
complement(1075)-g, cdbSNP:372613518
1077+a, tdbSNP:121912663
complement(1087)-g, adbSNP:200073907
complement(1094)-t, c, adbSNP:201744589
1105+a, gdbSNP:72661120
1118+c, tdbSNP:121913344
complement(1134)-t, cdbSNP:56184981
complement(1135)-g, adbSNP:201601993
complement(1137)-g, cdbSNP:145151284
1176+g, tdbSNP:121912659
1195+a, gdbSNP:11575996
complement(1205)-g, adbSNP:375444154
1212+a, gdbSNP:121912664
complement(1216)-g, adbSNP:150293825
complement(1217)-t, cdbSNP:386545136
complement(1217)-g, adbSNP:17882252
complement(1227)-t, cdbSNP:375338359
complement(1229)-g, cdbSNP:375573770
1233+c, tdbSNP:121912662
1242+a, cdbSNP:397516434
complement(1253)-t, cdbSNP:141402957
1281+c, gdbSNP:35993958
complement(1295)-g, adbSNP:267605075
complement(1298)-t, gdbSNP:17881470
complement(1334)-g, adbSNP:80184930
complement(1349)-g, adbSNP:150842067
complement(1351)-g, adbSNP:373710656
complement(1390)-t, adbSNP:369567704
complement(1393)-t, gdbSNP:8065799
complement(1399)-g, adbSNP:374294340
1421+a, tdbSNP:1042526
1489+c, tdbSNP:35919705
complement(1490)-t, cdbSNP:375913211
complement(1528)-t, cdbSNP:371002418
complement(1578..1579)-, tdbSNP:140346117
complement(1589)-t, cdbSNP:16956880
complement(1693)-c, adbSNP:79516338
1698+a, gdbSNP:34486624
complement(1712)-g, adbSNP:17881366
complement(1793)-t, gdbSNP:191918079
complement(1851)-t, gdbSNP:377621596
complement(1869)-t, cdbSNP:4968187
1875+a, gdbSNP:916131
1898+c, tdbSNP:916132
1918..1919+c, tdbSNP:1811095
complement(1918..1919)-ag, gadbSNP:35944977
complement(1953..1954)-, acdbSNP:200962122
complement(1953..1954)-, acdbSNP:202099016
complement(1979)-, gdbSNP:34607064
complement(1997)-t, gdbSNP:386545010
complement(1997)-c, adbSNP:17879353
2018..2019+a, gdbSNP:1794291
2018+c, gdbSNP:1042535
complement(2018)-cg, tcdbSNP:371242826
complement(2058)-, gdbSNP:34182553
complement(2138)-t, cdbSNP:199729221
complement(2138)-, gdbSNP:368059785
complement(2156)-g, adbSNP:376415575
complement(2156)-, adbSNP:200757381
complement(2157)-g, adbSNP:200378797
complement(2181..2182)-, adbSNP:35940853
2210+a, gdbSNP:17884306
2239+c, tdbSNP:17884586
2270+a, gdbSNP:35659787
complement(2320)-t, cdbSNP:55817367
complement(2380)-t, adbSNP:373069673
2440..2441+c, gdbSNP:1794292
complement(2440..2441)-gg, ccdbSNP:34734132
complement(2454)-g, adbSNP:114831472
complement(2481)-t, adbSNP:139396032
2559+a, cdbSNP:78378222
Gene SymbolTP53
Gene SynonymBCC7; LFS1; P53; TRP53
Locus Map17p13.1
Title G-quadruplex structures in TP53 intron 3: role in alternative splicing and in production of p53 mRNA isoforms .
Author Marcel V, Tran PL, Sagne C, Martel-Planche G, Vaslin L, Teulade-Fichou MP, Hall J, Mergny JL, Hainaut P and Van Dyck E.
Journal Carcinogenesis 32 (3), 271-278 (2011)
Title Delta160p53 is a novel N-terminal p53 isoform encoded by Delta133p53 transcript .
Author Marcel V, Perrier S, Aoubala M, Ageorges S, Groves MJ, Diot A, Fernandes K, Tauro S and Bourdon JC.
Journal FEBS Lett. 584 (21), 4463-4468 (2010)
Title Does the nonsense-mediated mRNA decay mechanism prevent the synthesis of truncated BRCA1, CHK2, and p53 proteins? .
Author Anczukow O, Ware MD, Buisson M, Zetoune AB, Stoppa-Lyonnet D, Sinilnikova OM and Mazoyer S.
Journal Hum. Mutat. 29 (1), 65-73 (2008)
Title p53 Family isoforms .
Author Bourdon JC.
Journal Curr Pharm Biotechnol 8 (6), 332-336 (2007)
Title Li-Fraumeni Syndrome .
Author Schneider,K., Zelley,K., Nichols,K.E. and Garber,J.
Journal (in) Pagon RA, Adam MP, Ardinger HH, Bird TD, Dolan CR, Fong CT, Smith RJH and Stephens K (Eds.); GENEREVIEWS(R); (1993)
Title Characterization of the human p53 gene .
Author Lamb,P. and Crawford,L.
Journal Mol. Cell. Biol. 6 (5), 1379-1385 (1986)
Title Localization of gene for human p53 tumour antigen to band 17p13 .
Author Isobe,M., Emanuel,B.S., Givol,D., Oren,M. and Croce,C.M.
Journal Nature 320 (6057), 84-85 (1986)
Title Transformation associated p53 protein is encoded by a gene on human chromosome 17 .
Author Benchimol,S., Lamb,P., Crawford,L.V., Sheer,D., Shows,T.B., Bruns,G.A. and Peacock,J.
Journal Somat. Cell Mol. Genet. 11 (5), 505-510 (1985)
Title Molecular cloning and in vitro expression of a cDNA clone for human cellular tumor antigen p53 .
Author Harlow,E., Williamson,N.M., Ralston,R., Helfman,D.M. and Adams,T.E.
Journal Mol. Cell. Biol. 5 (7), 1601-1610 (1985)
Title Human p53 cellular tumor antigen: cDNA sequence and expression in .
Author Zakut-Houri,R., Bienz-Tadmor,B., Givol,D. and Oren,M.
Journal EMBO J. 4 (5), 1251-1255 (1985)

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