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Sequence in raw or FASTA format:


Blast Method:


Homo sapiens interleukin 6 (IL6), mRNA.

Clone ID Definition Vector Stock Status Price *Turnaround time Select
OHu23477D Homo sapiens interleukin 6 (IL6), mRNA. pcDNA3.1-C-(k)DYK In-stock Starting from $99 5-7
OHu23477C Homo sapiens interleukin 6 (IL6), mRNA. Your vector of choice In-stock Starting from $99 5-7
OHu23477M Mutant Clone for Homo sapiens interleukin 6 (IL6), mRNA. pcDNA3.1-C-(k)DYK In-stock Starting from $149 Additional 5 days
OHu23477CM Mutant Clone for Homo sapiens interleukin 6 (IL6), mRNA. Your vector of choice In-stock Starting from $149 Additional 5 days

*Business Day

Sequence Information ORF Nucleotide Sequence
Protein sequence
Vector pcDNA3.1-C-(k)DYK or customized vector
Clone information Clone Map
Tag on pcDNA3.1-C-(k)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ® Seamless cloning technology
RefSeq Version NM_000600.3, 224831235
Length 639 bp
Structure linear
Update Date 11-MAY-2014
Organism Homo sapiens (human)
Definition Homo sapiens interleukin 6 (IL6), mRNA.
Product interleukin-6 precursor

Summary: This gene encodes a cytokine that functions in inflammation and the maturation of B cells. In addition, the encoded protein has been shown to be an endogenous pyrogen capable of inducing fever in people with autoimmune diseases or infections. The protein is primarily produced at sites of acute and chronic inflammation, where it is secreted into the serum and induces a transcriptional inflammatory response through interleukin 6 receptor, alpha. The functioning of this gene is implicated in a wide variety of inflammation-associated disease states, including suspectibility to diabetes mellitus and systemic juvenile rheumatoid arthritis. [provided by RefSeq, Jun 2011].

RefSeq NP_000591.1
CDS 117..755
Misc Feature(1)30..32
Misc Feature(2)285..746
Misc Feature(3)order(330..332,348..350)
Misc Feature(4)333..335
Misc Feature(5)357..359
Misc Feature(6)order(417..419,447..449)
Misc Feature(7)612..614
Misc Feature(8)624..626
Misc Feature(9)627..629
Exon (1)1..135
Gene Synonym:BSF2; HGF; HSF; IFNB2; IL-6
Exon (2)136..326
Gene Synonym:BSF2; HGF; HSF; IFNB2; IL-6
Exon (3)327..440
Gene Synonym:BSF2; HGF; HSF; IFNB2; IL-6
Exon (4)441..587
Gene Synonym:BSF2; HGF; HSF; IFNB2; IL-6
Exon (5)588..1184
Gene Synonym:BSF2; HGF; HSF; IFNB2; IL-6
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Position Chain Variation Link
17+a, cdbSNP:201575115
61+c, tdbSNP:199671830
67+g, tdbSNP:13306438
69+a, cdbSNP:2069857
73+a, cdbSNP:185230192
74+a, gdbSNP:199546667
84+c, gdbSNP:3087226
94+a, gdbSNP:368772259
121+a, tdbSNP:200700194
125+c, tdbSNP:200815144
137+a, cdbSNP:199941251
140+a, cdbSNP:200637969
159..160+, cdbSNP:34280821
176+a, gdbSNP:201852608
180+c, tdbSNP:148516576
207+a, cdbSNP:142759801
210+c, tdbSNP:2069830
220+a, tdbSNP:201787553
246+a, cdbSNP:199957016
279+a, gdbSNP:202138427
284+a, cdbSNP:199925567
290+a, gdbSNP:200999878
291+c, tdbSNP:201822486
299+c, tdbSNP:140764737
311+a, cdbSNP:201410817
329+a, gdbSNP:145242107
330+c, tdbSNP:370818995
332+c, tdbSNP:147625275
345+a, gdbSNP:201121373
351+c, gdbSNP:190436077
353+a, gdbSNP:200987147
356+c, tdbSNP:201523057
365+a, g, tdbSNP:142164099
374+a, cdbSNP:375470014
376+a, gdbSNP:199990564
388+a, tdbSNP:200745306
427+a, cdbSNP:202210223
442+a, gdbSNP:200263800
462+a, tdbSNP:148171375
472+c, tdbSNP:11544633
486+a, gdbSNP:371302236
499+a, gdbSNP:201371019
522+a, gdbSNP:56383910
568..569+, cdbSNP:34012176
572+c, gdbSNP:182812860
575+c, tdbSNP:199569510
593+c, gdbSNP:200477775
598+c, tdbSNP:369953112
601+a, tdbSNP:2069860
602+a, tdbSNP:13306435
615+c, gdbSNP:200641450
620+a, c, gdbSNP:201947383
646+c, tdbSNP:148828876
647+a, gdbSNP:373214858
665+a, cdbSNP:199857749
666+c, gdbSNP:376403172
677+a, gdbSNP:201335041
683..684+, adbSNP:34709428
703+a, gdbSNP:143432552
716+c, gdbSNP:201777722
719+c, tdbSNP:2069849
758+c, tdbSNP:111490870
782+a, gdbSNP:201868479
786+a, gdbSNP:200852701
792+c, tdbSNP:2069850
793+c, tdbSNP:368219445
800+c, tdbSNP:199619831
802+a, gdbSNP:41477054
805+a, tdbSNP:201107891
818+c, tdbSNP:202198528
822+c, gdbSNP:200226108
844+c, tdbSNP:201743553
847+a, gdbSNP:199652344
859+a, gdbSNP:13306436
866+c, tdbSNP:201150447
867+a, gdbSNP:2069851
890+g, tdbSNP:200697926
914+a, gdbSNP:201769340
949+a, gdbSNP:199606490
967+g, tdbSNP:55773150
981+c, gdbSNP:202045132
1005+a, cdbSNP:200126515
1039+a, gdbSNP:201131164
1091+c, tdbSNP:201722624
1095+c, tdbSNP:199889619
1115+c, tdbSNP:201176371
1119+c, tdbSNP:202085240
1135+c, tdbSNP:183160679
Gene SymbolIL6
Gene SynonymBSF2; HGF; HSF; IFNB2; IL-6
Locus Map7p21
All Transcripts
RefSeq Accession Definition Stock Status Price Turnaround time Business Day Select
NM_000600 Homo sapiens interleukin 6 (IL6), mRNA. In-stock Starting from $99 5-7
NM_000600 Homo sapiens interleukin 6 (IL6), mRNA. In-stock Starting from $99 5-7
Title A non-canonical function of eukaryotic elongation factor 1A1: regulation of interleukin-6 expression .
Author Schulz I, Engel C, Niestroj AJ, Kehlen A, Rahfeld JU, Kleinschmidt M, Lehmann K, Rossner S and Demuth HU.
Journal Biochim. Biophys. Acta 1843 (5), 965-975 (2014)
Title Association of IL-6-174G > C and -572C > G polymorphisms with risk of young ischemic stroke patients .
Author Yang X, Feng L, Li C and Li Y.
Journal Gene 539 (2), 258-262 (2014)
Title Aberrant histone acetylation contributes to elevated interleukin-6 production in rheumatoid arthritis synovial fibroblasts .
Author Wada TT, Araki Y, Sato K, Aizaki Y, Yokota K, Kim YT, Oda H, Kurokawa R and Mimura T.
Journal Biochem. Biophys. Res. Commun. 444 (4), 682-686 (2014)
Title Hopelessness the 'active ingredient'? Associations of hopelessness and depressive symptoms with interleukin-6 .
Author Mitchell AM, Possel P, Sjogren E and Kristenson M.
Journal Int J Psychiatry Med 46 (1), 109-117 (2013)
Title Cytokine induction by pyrogens: comparison of whole blood, mononuclear cells, and TLR-transfectants .
Author Kikkert R, de Groot ER and Aarden LA.
Journal J. Immunol. Methods 336 (1), 45-55 (2008)
Title Infection, fever, and exogenous and endogenous pyrogens: some concepts have changed .
Author Dinarello CA.
Journal J. Endotoxin Res. 10 (4), 201-222 (2004)
Title [Stable and efficient expression of human interleukin-6 cDNA in mammalian cells after gene transfer] .
Author Chen QY.
Journal Zhonghua Zhong Liu Za Zhi 14 (5), 340-344 (1992)
Title Phosphorylation of interleukin-6 at serine54: an early event in the secretory pathway in human fibroblasts .
Author May LT and Sehgal PB.
Journal Biochem. Biophys. Res. Commun. 185 (2), 524-530 (1992)
Title Marked cell-type-specific differences in glycosylation of human interleukin-6 .
Author May LT, Shaw JE, Khanna AK, Zabriskie JB and Sehgal PB.
Journal Cytokine 3 (3), 204-211 (1991)
Title A case of meningitis admitted as schizophrenia .
Author Sandler,N.H.
Journal J Ky Med Assoc 73 (1), 25-26 (1975)

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