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Homo sapiens serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 (SERPINE1), mRNA.


Clone ID Definition Vector Stock Status Price *Turnaround time Order
OHu27681 Homo sapiens serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 (SERPINE1), mRNA. pcDNA3.1+-DYK In-stock $99.00 5-7
OHu27681C Homo sapiens serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 (SERPINE1), mRNA. Customized vector In-stock $149.00 5-7

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Mutation services

Sequence Information ORF Nucleotide Sequence
Protein sequence
Vector pcDNA3.1+-DYK or customized vector
Clone information Data sheet
Tag on pcDNA3.1+-DYK N terminal DYKDDDK tags
Restriction Sites Hind III- EcoR I
RefSeq Version NM_000602.4, 383286745
Length 1209 bp
Structure linear
Update Date 26-MAY-2014
Organism Homo sapiens (human)
Definition Homo sapiens serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 (SERPINE1), mRNA.
Product plasminogen activator inhibitor 1 precursor
Comment

Summary: This gene encodes a member of the serine proteinase inhibitor (serpin) superfamily. This member is the principal inhibitor of tissue plasminogen activator (tPA) and urokinase (uPA), and hence is an inhibitor of fibrinolysis. Defects in this gene are the cause of plasminogen activator inhibitor-1 deficiency (PAI-1 deficiency), and high concentrations of the gene product are associated with thrombophilia. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009].

RefSeq NP_000593.1
CDS 158..1366
Misc Feature(1)230..1363
Misc Feature(2)851..853
Misc Feature(3)1019..1021
Misc Feature(4)1220..1297
Misc Feature(5)1235..1237
Misc Feature(6)1247..1249
Misc Feature(7)1262..1267
Misc Feature(8)1292..1294
Exon (1)1..156
Gene:SERPINE1
Gene Synonym:PAI; PAI-1; PAI1; PLANH1
Exon (2)157..428
Gene:SERPINE1
Gene Synonym:PAI; PAI-1; PAI1; PLANH1
Exon (3)429..662
Gene:SERPINE1
Gene Synonym:PAI; PAI-1; PAI1; PLANH1
Exon (4)663..857
Gene:SERPINE1
Gene Synonym:PAI; PAI-1; PAI1; PLANH1
Exon (5)858..1056
Gene:SERPINE1
Gene Synonym:PAI; PAI-1; PAI1; PLANH1
Exon (6)1057..1157
Gene:SERPINE1
Gene Synonym:PAI; PAI-1; PAI1; PLANH1
Exon (7)1158..1244
Gene:SERPINE1
Gene Synonym:PAI; PAI-1; PAI1; PLANH1
Exon (8)1245..1328
Gene:SERPINE1
Gene Synonym:PAI; PAI-1; PAI1; PLANH1
Exon (9)1329..3190
Gene:SERPINE1
Gene Synonym:PAI; PAI-1; PAI1; PLANH1
Translation MQMSPALTCLVLGLALVFGEGSAVHHPPSYVAHLASDFGVRVFQQVAQASKDRNVVFSPY GVASVLAMLQLTTGGETQQQIQAAMGFKIDDKGMAPALRHLYKELMGPWNKDEISTTDAI FVQRDLKLVQGFMPHFFRLFRSTVKQVDFSEVERARFIINDWVKTHTKGMISNLLGKGAV DQLTRLVLVNALYFNGQWKTPFPDSSTHRRLFHKSDGSTVSVPMMAQTNKFNYTEFTTPD GHYYDILELPYHGDTLSMFIAAPYEKEVPLSALTNILSAQLISHWKGNMTRLPRLLVLPK FSLETEVDLRKPLENLGMTDMFRQFQADFTSLSDQEPLHVAQALQKVKIEVNESGTVASS STAVIVSARMAPEEIIMDRPFLFVVRHNPTGTVLFMGQVMEP
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Position Chain Variation Link
4+dbSNP:
4+c, tdbSNP:2227634
66+a, gdbSNP:367883271
89+c, tdbSNP:2227635
120+c, tdbSNP:112880101
125+c, tdbSNP:13306844
138+c, gdbSNP:36228265
200+a, gdbSNP:6092
206+a, gdbSNP:6090
210+c, tdbSNP:370185023
231+a, cdbSNP:2227647
248+a, gdbSNP:141347752
319+c, tdbSNP:373294605
337+c, tdbSNP:376485687
349+a, gdbSNP:370646624
374+a, gdbSNP:374379570
397+c, gdbSNP:367935516
413+a, gdbSNP:370298461
448+dbSNP:
448+a, cdbSNP:145084838
452+c, tdbSNP:144953342
474+c, tdbSNP:61731296
493+c, tdbSNP:3177930
504+c, tdbSNP:373286742
505+c, tdbSNP:149070955
513+c, tdbSNP:143027028
514+a, gdbSNP:6091
520+c, tdbSNP:377652063
528+a, gdbSNP:199790102
542+a, gdbSNP:371649267
556+a, gdbSNP:140708600
578+c, tdbSNP:377193732
579+a, gdbSNP:145904727
610+a, gdbSNP:181510325
613+c, gdbSNP:200318916
616+a, gdbSNP:138393809
626+c, tdbSNP:375620822
630+c, tdbSNP:370663207
651+a, cdbSNP:78007052
666+dbSNP:
666+c, tdbSNP:200926782
681+c, tdbSNP:142959808
683+a, gdbSNP:372569598
694+c, tdbSNP:376407844
710+c, tdbSNP:371179958
712+c, gdbSNP:201293550
742+c, tdbSNP:150630227
743+a, gdbSNP:373629815
767+a, gdbSNP:138796302
777+c, tdbSNP:149389532
783+a, gdbSNP:2227669
785+c, tdbSNP:139905333
805+c, tdbSNP:2227670
807+a, gdbSNP:147436426
826+c, tdbSNP:139626071
852+a, gdbSNP:147003064
857+a, gdbSNP:376831061
870+dbSNP:
870+c, tdbSNP:201327802
874+c, tdbSNP:150996863
882+a, gdbSNP:140766181
885+a, gdbSNP:13306846
913+c, tdbSNP:200763116
921+a, cdbSNP:2227685
958+a, gdbSNP:61749911
967+c, gdbSNP:113010194
973+a, cdbSNP:199561546
980+a, cdbSNP:149701969
1023+c, tdbSNP:140246744
1067+dbSNP:
1067+a, gdbSNP:377501438
1117+a, cdbSNP:145850643
1146+c, tdbSNP:192692662
1155+c, tdbSNP:369508275
1177+dbSNP:
1177+c, tdbSNP:201351580
1179+c, tdbSNP:371573254
1185+c, tdbSNP:138483939
1205+a, gdbSNP:376197859
1225+a, gdbSNP:368895147
1231+c, tdbSNP:375309788
1266+dbSNP:
1266+a, tdbSNP:52795188
1286+a, gdbSNP:141469348
1297+a, cdbSNP:199603787
1366+dbSNP:
1366+a, cdbSNP:149110965
1367+c, tdbSNP:368514992
1386+c, tdbSNP:200019259
1392+a, gdbSNP:370173813
1399..1400+, adbSNP:34950159
1413+a, gdbSNP:186042546
1458+a, cdbSNP:374893237
1489+c, tdbSNP:2227695
1533+c, tdbSNP:2227696
1546+c, tdbSNP:41334349
1671+a, gdbSNP:2227697
1727+c, tdbSNP:11178
1735+c, tdbSNP:13306842
1791+c, tdbSNP:148235544
1797+c, tdbSNP:188845456
1806+c, tdbSNP:58167134
1821+c, tdbSNP:146323865
1854+a, gdbSNP:13306843
complement(1895)-g, adbSNP:11553533
complement(1904)-t, gdbSNP:11553532
1983+a, tdbSNP:186133446
2016+c, gdbSNP:200688827
2027+c, tdbSNP:138333231
2051+c, tdbSNP:1050766
2056+c, tdbSNP:7241
2063+a, tdbSNP:15196
2088+g, tdbSNP:7242
2111+a, cdbSNP:2227698
2118+a, cdbSNP:374321581
2197+c, tdbSNP:2854229
2200+c, tdbSNP:2854230
2258+a, gdbSNP:1050813
2287..2288+, gdbSNP:35674524
2354..2355+, cgcgcccc, cgcgcccccdbSNP:2227699
complement(2354..2355)-, ggggcgcgdbSNP:111774460
2354+c, tdbSNP:62483759
2363..2364+, gcgccccdbSNP:71685432
2371..2372+, ccgcgccccdbSNP:41423845
2372+a, gdbSNP:201434513
2386+a, cdbSNP:13230881
2413+a, tdbSNP:368475944
2440+g, tdbSNP:367757456
2552+c, tdbSNP:2227714
2596+a, tdbSNP:1801003
2638..2639+, cdbSNP:386561638
2638..2639+, gdbSNP:2227715
2638..2639+, gdbSNP:397716438
2640+g, tdbSNP:78314587
2661+c, tdbSNP:372017980
2724+c, tdbSNP:2227700
2754+a, gdbSNP:71557295
2815+c, tdbSNP:2227716
2827+a, gdbSNP:191126376
2887+a, tdbSNP:180692432
2983+c, tdbSNP:186602438
2999..3000+, tttcdbSNP:139055667
complement(3011)-g, adbSNP:11553535
3016+c, tdbSNP:191350469
3103+a, gdbSNP:1050955
3149+, adbSNP:2227701
3153+c, tdbSNP:182671641
3168+c, tdbSNP:187612187
Gene SymbolSERPINE1
Gene SynonymPAI; PAI-1; PAI1; PLANH1
Chromosome7
Locus Map7q22.1
All Transcripts
RefSeq Accession Definition Stock Status Price Turnaround time Business Day Select
NM_000602 Homo sapiens serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 (SERPINE1), mRNA. In-stock $99.00 5-7
Title Plasma plasminogen activator inhibitor-1 (PAI-1) levels in breast cancer - relationship with clinical outcome .
Author Ferroni P, Roselli M, Portarena I, Formica V, Riondino S, LA Farina F, Costarelli L, Melino A, Massimiani G, Cavaliere F, Palmirotta R and Guadagni F.
Journal Anticancer Res. 34 (3), 1153-1161 (2014)
Title Association of five common polymorphisms in the plasminogen activator inhibitor-1 gene with primary ovarian insufficiency .
Author Jeon YJ, Kim YR, Lee BE, Cha SH, Moon MJ, Oh D, Lee WS and Kim NK.
Journal Fertil. Steril. 101 (3), 825-832 (2014)
Title [Polymorphism of the plasminogen activator inhibitor type 1 gene, plasminogen level and thrombosis in patients with antiphospholipid syndrome] .
Author Aisina,R.B., Mukhametova,L.I., Ostriakova,E.V., Seredavkina,N.V., Patrushev,L.I., Patrusheva,N.L., Reshetniak,T.M., Gulin,D.A., Gershkovich,K.B., Nasonov,E.L. and Varfolomeev,S.D.
Journal Biomed Khim 60 (1), 72-93 (2014)
Title Prothrombotic factors in histologically proven nonalcoholic fatty liver disease and nonalcoholic steatohepatitis .
Author Verrijken A, Francque S, Mertens I, Prawitt J, Caron S, Hubens G, Van Marck E, Staels B, Michielsen P and Van Gaal L.
Journal Hepatology 59 (1), 121-129 (2014)
Title Mechanistic characterization and crystal structure of a small molecule inactivator bound to plasminogen activator inhibitor-1 .
Author Li SH, Reinke AA, Sanders KL, Emal CD, Whisstock JC, Stuckey JA and Lawrence DA.
Journal Proc. Natl. Acad. Sci. U.S.A. 110 (51), E4941-E4949 (2013)
Title Brief report: complete deficiency of plasminogen-activator inhibitor type 1 due to a frame-shift mutation .
Author Fay WP, Shapiro AD, Shih JL, Schleef RR and Ginsburg D.
Journal N. Engl. J. Med. 327 (24), 1729-1733 (1992)
Title Concentration of plasminogen activators and inhibitor in the human endometrium at different phases of the menstrual cycle .
Author Koh SC, Wong PC, Yuen R, Chua SE, Ng BL and Ratnam SS.
Journal J. Reprod. Fertil. 96 (2), 407-413 (1992)
Title Plasminogen activator inhibitor-1 deposition in the extracellular matrix of cultured human mesangial cells .
Author Hagege J, Peraldi MN, Rondeau E, Adida C, Delarue F, Medcalf R, Schleuning WD and Sraer JD.
Journal Am. J. Pathol. 141 (1), 117-128 (1992)
Title Structural basis of latency in plasminogen activator inhibitor-1 .
Author Mottonen J, Strand A, Symersky J, Sweet RM, Danley DE, Geoghegan KF, Gerard RD and Goldsmith EJ.
Journal Nature 355 (6357), 270-273 (1992)
Title Alteration of serpin specificity by a protein cofactor. Vitronectin endows plasminogen activator inhibitor 1 with thrombin inhibitory properties .
Author Ehrlich HJ, Gebbink RK, Keijer J, Linders M, Preissner KT and Pannekoek H.
Journal J. Biol. Chem. 265 (22), 13029-13035 (1990)

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