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Homo sapiens serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 (SERPINE1), transcript variant 1, mRNA.


RefSeq Accession Definition Services Price Order
NM_000602 Homo sapiens serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 (SERPINE1), transcript variant 1, mRNA. ORF Sequence $350.61
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RefSeq Version NM_000602.4, 383286745
Length 3207 bp
Structure linear
Update Date 21-APR-2013
Organism Homo sapiens (human)
Definition Homo sapiens serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 (SERPINE1), transcript variant 1, mRNA.
Product plasminogen activator inhibitor 1 isoform 1 precursor
Comment

Summary: This gene encodes a member of the serine proteinase inhibitor (serpin) superfamily. This member is the principal inhibitor of tissue plasminogen activator (tPA) and urokinase (uPA), and hence is an inhibitor of fibrinolysis. Defects in this gene are the cause of plasminogen activator inhibitor-1 deficiency (PAI-1 deficiency), and high concentrations of the gene product are associated with thrombophilia. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009].

RefSeq NP_000593.1
CDS 158..1366
Misc Feature(1)230..1363
Misc Feature(2)851..853
Misc Feature(3)1019..1021
Misc Feature(4)1220..1297
Misc Feature(5)1235..1237
Misc Feature(6)1247..1249
Misc Feature(7)1262..1267
Misc Feature(8)1292..1294
Exon (1)1..156
Gene:SERPINE1
Gene Synonym:PAI; PAI-1; PAI1; PLANH1
Exon (2)157..428
Gene:SERPINE1
Gene Synonym:PAI; PAI-1; PAI1; PLANH1
Exon (3)429..662
Gene:SERPINE1
Gene Synonym:PAI; PAI-1; PAI1; PLANH1
Exon (4)663..857
Gene:SERPINE1
Gene Synonym:PAI; PAI-1; PAI1; PLANH1
Exon (5)858..1056
Gene:SERPINE1
Gene Synonym:PAI; PAI-1; PAI1; PLANH1
Exon (6)1057..1157
Gene:SERPINE1
Gene Synonym:PAI; PAI-1; PAI1; PLANH1
Exon (7)1158..1244
Gene:SERPINE1
Gene Synonym:PAI; PAI-1; PAI1; PLANH1
Exon (8)1245..1328
Gene:SERPINE1
Gene Synonym:PAI; PAI-1; PAI1; PLANH1
Exon (9)1329..3190
Gene:SERPINE1
Gene Synonym:PAI; PAI-1; PAI1; PLANH1
Translation MQMSPALTCLVLGLALVFGEGSAVHHPPSYVAHLASDFGVRVFQQVAQASKDRNVVFSPY GVASVLAMLQLTTGGETQQQIQAAMGFKIDDKGMAPALRHLYKELMGPWNKDEISTTDAI FVQRDLKLVQGFMPHFFRLFRSTVKQVDFSEVERARFIINDWVKTHTKGMISNLLGKGAV DQLTRLVLVNALYFNGQWKTPFPDSSTHRRLFHKSDGSTVSVPMMAQTNKFNYTEFTTPD GHYYDILELPYHGDTLSMFIAAPYEKEVPLSALTNILSAQLISHWKGNMTRLPRLLVLPK FSLETEVDLRKPLENLGMTDMFRQFQADFTSLSDQEPLHVAQALQKVKIEVNESGTVASS STAVIVSARMAPEEIIMDRPFLFVVRHNPTGTVLFMGQVMEP
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Position Chain Variation Link
4+dbSNP:
4+c, tdbSNP:2227634
89+c, tdbSNP:2227635
120+c, tdbSNP:112880101
125+c, tdbSNP:13306844
138+c, gdbSNP:36228265
200+a, gdbSNP:6092
206+a, gdbSNP:6090
231+a, cdbSNP:2227647
248+a, gdbSNP:141347752
448+dbSNP:
448+a, cdbSNP:145084838
452+c, tdbSNP:144953342
474+c, tdbSNP:61731296
493+c, tdbSNP:3177930
505+c, tdbSNP:149070955
513+c, tdbSNP:143027028
514+a, gdbSNP:6091
528+a, gdbSNP:199790102
541..542+, adbSNP:11416893
556+a, gdbSNP:140708600
579+a, gdbSNP:145904727
610+a, gdbSNP:181510325
613+c, gdbSNP:200318916
616+a, gdbSNP:138393809
651+a, cdbSNP:78007052
666+dbSNP:
666+c, tdbSNP:200926782
681+c, tdbSNP:142959808
712+c, gdbSNP:201293550
742+c, tdbSNP:150630227
767+a, gdbSNP:138796302
777+c, tdbSNP:149389532
783+a, gdbSNP:2227669
785+c, tdbSNP:139905333
805+c, tdbSNP:2227670
807+a, gdbSNP:147436426
826+c, tdbSNP:139626071
852+a, gdbSNP:147003064
870+dbSNP:
870+c, tdbSNP:201327802
874+c, tdbSNP:150996863
882+a, gdbSNP:140766181
885+a, gdbSNP:13306846
913+c, tdbSNP:200763116
921+a, cdbSNP:2227685
958+a, gdbSNP:61749911
967+c, gdbSNP:113010194
973+a, cdbSNP:199561546
980+a, cdbSNP:149701969
996+a, gdbSNP:146654894
1023+c, tdbSNP:140246744
1117+dbSNP:
1117+a, cdbSNP:145850643
1146+c, tdbSNP:192692662
1177+dbSNP:
1177+c, tdbSNP:201351580
1185+c, tdbSNP:138483939
1266+dbSNP:
1266+a, tdbSNP:52795188
1286+a, gdbSNP:141469348
1297+a, cdbSNP:199603787
1366+dbSNP:
1366+a, cdbSNP:149110965
1386+c, tdbSNP:200019259
1396..1397+, adbSNP:34950159
1413+a, gdbSNP:186042546
1489+c, tdbSNP:2227695
1533+c, tdbSNP:2227696
1546+c, tdbSNP:41334349
1671+a, gdbSNP:2227697
1727+c, tdbSNP:11178
1735+c, tdbSNP:13306842
1791+c, tdbSNP:148235544
1797+c, tdbSNP:188845456
1806+c, tdbSNP:58167134
1821+c, tdbSNP:146323865
1854+a, gdbSNP:13306843
1895+a, gdbSNP:11553533
1904+g, tdbSNP:11553532
1983+a, tdbSNP:186133446
2016+c, gdbSNP:200688827
2027+c, tdbSNP:138333231
2051+c, tdbSNP:1050766
2056+c, tdbSNP:7241
2063+a, tdbSNP:15196
2088+g, tdbSNP:7242
2111+a, cdbSNP:2227698
2197+c, tdbSNP:2854229
2200+c, tdbSNP:2854230
2258+a, gdbSNP:1050813
2286..2287+, gdbSNP:35674524
2354..2355+, cgcgcccc, cgcgcccccdbSNP:2227699
2354..2355+, ggggcgcgdbSNP:201752118
2354+c, tdbSNP:62483759
2355..2356+, ggggcgcgdbSNP:111774460
2357..2358+, cgccccccgdbSNP:71722834
2362..2363+, cccgcgcccdbSNP:72325242
2363..2364+, ccgcgcccc, gcgccccdbSNP:71685432
2371..2372+, ccgcgccccdbSNP:41423845
2372..2373+, ccg, ccgcgccccdbSNP:67258334
2372+a, gdbSNP:201434513
2386+a, cdbSNP:13230881
2552+c, tdbSNP:2227714
2596+a, tdbSNP:1801003
2631..2632+, gdbSNP:2227715
2640+g, tdbSNP:78314587
2724+c, tdbSNP:2227700
2754+a, gdbSNP:71557295
2815+c, tdbSNP:2227716
2827+a, gdbSNP:191126376
2887+a, tdbSNP:180692432
2983+c, tdbSNP:186602438
2998..2999+, tdbSNP:71720076
2999..3000+, tttcdbSNP:139055667
3011+a, gdbSNP:11553535
3016+c, tdbSNP:191350469
3103+a, gdbSNP:1050955
3143+, adbSNP:2227701
3153+c, tdbSNP:182671641
3168+c, tdbSNP:187612187
Gene SymbolSERPINE1
Gene SynonymPAI; PAI-1; PAI1; PLANH1
Chromosome7
Locus Map7q22.1
All Transcripts
RefSeq Accession Definition Sequence Price Select
NM_000602 Homo sapiens serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 (SERPINE1), transcript variant 1, mRNA. Full Length $1122.45
ORF Sequence $350.61
Title Preservation of peritoneal fibrinolysis owing to decreased transcription of plasminogen activator inhibitor-1 in peritoneal mesothelial cells suppresses postoperative adhesion formation in laparoscopic surgery .
Author Shimomura,M., Hinoi,T., Ikeda,S., Adachi,T., Kawaguchi,Y., Tokunaga,M., Sasada,T., Egi,H., Tanabe,K., Okajima,M. and Ohdan,H.
Journal Surgery 153 (3), 344-356 (2013)
Title Genome-wide association study for circulating levels of PAI-1 provides novel insights into its regulation .
Author Huang,J., Sabater-Lleal,M., Asselbergs,F.W., Tregouet,D., Shin,S.Y., Ding,J., Baumert,J., Oudot-Mellakh,T., Folkersen,L., Johnson,A.D., Smith,N.L., Williams,S.M., Ikram,M.A., Kleber,M.E., Becker,D.M., Truong,V., Mychaleckyj,J.C., Tang,W., Yang,Q., Sennblad,B., Moore,J.H., Williams,F.M., Dehghan,A., Silbernagel,G., Schrijvers,E.M., Smith,S., Karakas,M., Tofler,G.H., Silveira,A., Navis,G.J., Lohman,K., Chen,M.H., Peters,A., Goel,A., Hopewell,J.C., Chambers,J.C., Saleheen,D., Lundmark,P., Psaty,B.M., Strawbridge,R.J., Boehm,B.O., Carter,A.M., Meisinger,C., Peden,J.F., Bis,J.C., McKnight,B., Ohrvik,J., Taylor,K., Franzosi,M.G., Seedorf,U., Collins,R., Franco-Cereceda,A., Syvanen,A.C., Goodall,A.H., Yanek,L.R., Cushman,M., Muller-Nurasyid,M., Folsom,A.R., Basu,S., Matijevic,N., van Gilst,W.H., Kooner,J.S., Hofman,A., Danesh,J., Clarke,R., Meigs,J.B., Kathiresan,S., Reilly,M.P., Klopp,N., Harris,T.B., Winkelmann,B.R., Grant,P.J., Hillege,H.L., Watkins,H., Spector,T.D., Becker,L.C., Tracy,R.P., Marz,W., Uitterlinden,A.G., Eriksson,P., Cambien,F., Morange,P.E., Koenig,W., Soranzo,N., van der Harst,P., Liu,Y., O'Donnell,C.J. and Hamsten,A.
Journal Blood 120 (24), 4873-4881 (2012)
Title Plasminogen activator inhibitor-1 (PAI-1) expression in relation to hypoxia and oncoproteins in clinical cervical tumors .
Author Lara,P.C., Lloret,M., Valenciano,A., Clavo,B., Pinar,B., Rey,A. and Henriquez-Hernandez,L.A.
Journal Strahlenther Onkol 188 (12), 1139-1145 (2012)
Title TLS-CHOP represses miR-486 expression, inducing upregulation of a metastasis regulator PAI-1 in human myxoid liposarcoma .
Author Borjigin,N., Ohno,S., Wu,W., Tanaka,M., Suzuki,R., Fujita,K., Takanashi,M., Oikawa,K., Goto,T., Motoi,T., Kosaka,T., Yamamoto,K. and Kuroda,M.
Journal Biochem. Biophys. Res. Commun. 427 (2), 355-360 (2012)
Title Protumorigenic activity of plasminogen activator inhibitor-1 through an antiapoptotic function .
Author Fang,H., Placencio,V.R. and DeClerck,Y.A.
Journal J. Natl. Cancer Inst. 104 (19), 1470-1484 (2012)
Title Brief report: complete deficiency of plasminogen-activator inhibitor type 1 due to a frame-shift mutation .
Author Fay,W.P., Shapiro,A.D., Shih,J.L., Schleef,R.R. and Ginsburg,D.
Journal N. Engl. J. Med. 327 (24), 1729-1733 (1992)
Title Concentration of plasminogen activators and inhibitor in the human endometrium at different phases of the menstrual cycle .
Author Koh,S.C., Wong,P.C., Yuen,R., Chua,S.E., Ng,B.L. and Ratnam,S.S.
Journal J. Reprod. Fertil. 96 (2), 407-413 (1992)
Title Plasminogen activator inhibitor-1 deposition in the extracellular matrix of cultured human mesangial cells .
Author Hagege,J., Peraldi,M.N., Rondeau,E., Adida,C., Delarue,F., Medcalf,R., Schleuning,W.D. and Sraer,J.D.
Journal Am. J. Pathol. 141 (1), 117-128 (1992)
Title Structural basis of latency in plasminogen activator inhibitor-1 .
Author Mottonen,J., Strand,A., Symersky,J., Sweet,R.M., Danley,D.E., Geoghegan,K.F., Gerard,R.D. and Goldsmith,E.J.
Journal Nature 355 (6357), 270-273 (1992)
Title Alteration of serpin specificity by a protein cofactor. Vitronectin endows plasminogen activator inhibitor 1 with thrombin inhibitory properties .
Author Ehrlich,H.J., Gebbink,R.K., Keijer,J., Linders,M., Preissner,K.T. and Pannekoek,H.
Journal J. Biol. Chem. 265 (22), 13029-13035 (1990)

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