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Database:

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Homo sapiens annexin A1 (ANXA1), mRNA.


Clone ID Definition Vector Stock Status Price *Turnaround time Order
OHu20291 Homo sapiens annexin A1 (ANXA1), mRNA. pcDNA3.1+-DYK On-demand $219.00 7-9
OHu20291C Homo sapiens annexin A1 (ANXA1), mRNA. Customized vector On-demand $269.00 7-9

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Sequence Information ORF Nucleotide Sequence
Protein sequence
Vector pcDNA3.1+-DYK or customized vector
Clone information Clone Map
Tag on pcDNA3.1+-DYK N terminal DYKDDDK tags
ORF Insert Method CloneEZ® Seamless cloning technology
RefSeq Version NM_000700.1, 4502100
Length 1041 bp
Structure linear
Update Date 04-MAY-2014
Organism Homo sapiens (human)
Definition Homo sapiens annexin A1 (ANXA1), mRNA.
Product annexin A1
Comment

Summary: Annexin I belongs to a family of Ca(2+)-dependent phospholipid binding proteins which have a molecular weight of approximately 35,000 to 40,000 and are preferentially located on the cytosolic face of the plasma membrane. Annexin I protein has an apparent relative molecular mass of 40 kDa, with phospholipase A2 inhibitory activity. Since phospholipase A2 is required for the biosynthesis of the potent mediators of inflammation, prostaglandins and leukotrienes, annexin I may have potential anti-inflammatory activity. [provided by RefSeq, Jul 2008].

RefSeq NP_000691.1
CDS 75..1115
Misc Feature(1)78..80
Misc Feature(2)78..80
Misc Feature(3)87..89
Misc Feature(4)87..89
Misc Feature(5)135..137
Misc Feature(6)135..137
Misc Feature(7)144..146
Misc Feature(8)153..155
Misc Feature(9)153..155
Misc Feature(10)183..185
Misc Feature(11)189..191
Misc Feature(12)213..407
Misc Feature(13)225..407
Misc Feature(14)426..623
Misc Feature(15)441..623
Misc Feature(16)678..875
Misc Feature(17)693..875
Misc Feature(18)693..695
Misc Feature(19)693..695
Misc Feature(20)720..722
Misc Feature(21)789..791
Misc Feature(22)903..1100
Misc Feature(23)918..1100
Misc Feature(24)1008..1010
Exon (1)1..60
Gene:ANXA1
Gene Synonym:ANX1; LPC1
Exon (2)61..140
Gene:ANXA1
Gene Synonym:ANX1; LPC1
Exon (3)141..249
Gene:ANXA1
Gene Synonym:ANX1; LPC1
Exon (4)250..344
Gene:ANXA1
Gene Synonym:ANX1; LPC1
Exon (5)345..458
Gene:ANXA1
Gene Synonym:ANX1; LPC1
Exon (6)459..549
Gene:ANXA1
Gene Synonym:ANX1; LPC1
Exon (7)550..629
Gene:ANXA1
Gene Synonym:ANX1; LPC1
Exon (8)630..686
Gene:ANXA1
Gene Synonym:ANX1; LPC1
Exon (9)687..780
Gene:ANXA1
Gene Synonym:ANX1; LPC1
Exon (10)781..876
Gene:ANXA1
Gene Synonym:ANX1; LPC1
Exon (11)877..935
Gene:ANXA1
Gene Synonym:ANX1; LPC1
Exon (12)936..1058
Gene:ANXA1
Gene Synonym:ANX1; LPC1
Exon (13)1059..1399
Gene:ANXA1
Gene Synonym:ANX1; LPC1
Translation MAMVSEFLKQAWFIENEEQEYVQTVKSSKGGPGSAVSPYPTFNPSSDVAALHKAIMVKGV DEATIIDILTKRNNAQRQQIKAAYLQETGKPLDETLKKALTGHLEEVVLALLKTPAQFDA DELRAAMKGLGTDEDTLIEILASRTNKEIRDINRVYREELKRDLAKDITSDTSGDFRNAL LSLAKGDRSEDFGVNEDLADSDARALYEAGERRKGTDVNVFNTILTTRSYPQLRRVFQKY TKYSKHDMNKVLDLELKGDIEKCLTAIVKCATSKPAFFAEKLHQAMKGVGTRHKALIRIM VSRSEIDMNDIKAFYQKMYGISLCQAILDETKGDYEKILVALCGGN
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Position Chain Variation Link
52+dbSNP:
52+c, gdbSNP:182007166
58+a, gdbSNP:1131072
97+a, tdbSNP:371854581
129+c, tdbSNP:11557056
170+dbSNP:
170+c, tdbSNP:200500450
171+a, gdbSNP:142849845
173+a, cdbSNP:199772708
178+c, tdbSNP:376171580
179+a, g, tdbSNP:35304764
201+a, gdbSNP:11557052
203+a, tdbSNP:368717717
206+a, gdbSNP:373357116
211+c, tdbSNP:377206672
212+a, gdbSNP:148187721
217+c, tdbSNP:11557058
219+a, gdbSNP:142511024
237+a, tdbSNP:141175221
260+dbSNP:
260+a, gdbSNP:11557057
288+c, tdbSNP:76459132
304+a, gdbSNP:144842081
311+c, gdbSNP:116080195
343+a, tdbSNP:200599744
401+dbSNP:
401+a, gdbSNP:1050305
444+c, tdbSNP:267602264
476+dbSNP:
476+a, gdbSNP:150294146
478+a, gdbSNP:111698970
580+dbSNP:
580+c, gdbSNP:368085989
616+c, tdbSNP:190998635
650+dbSNP:
650+c, tdbSNP:137860489
703+dbSNP:
703+a, gdbSNP:201875399
710+a, gdbSNP:149033255
725+a, c, tdbSNP:370232910
731+c, tdbSNP:369329871
742+a, cdbSNP:144643143
758+a, cdbSNP:200423132
760+a, gdbSNP:184644030
774+c, tdbSNP:138602190
775+a, gdbSNP:141725650
780+c, gdbSNP:200795528
799+dbSNP:
799+a, gdbSNP:377359805
803+c, tdbSNP:146251070
839+c, gdbSNP:367962910
855+a, gdbSNP:200321397
866+c, tdbSNP:148059788
884+dbSNP:
884+c, tdbSNP:376537013
885+a, gdbSNP:141810071
909+g, tdbSNP:150591447
911+a, cdbSNP:200843894
946+dbSNP:
946+c, tdbSNP:370997349
965+a, cdbSNP:375109829
1033+a, gdbSNP:139228721
1072+dbSNP:
1072+c, gdbSNP:149989764
1091+g, tdbSNP:147263644
1106+a, cdbSNP:111929339
1132+c, tdbSNP:371332879
1145+c, tdbSNP:145864257
1151+a, gdbSNP:199776886
1181+c, tdbSNP:11557051
1197+c, tdbSNP:9561
1295+c, tdbSNP:192689162
1297+a, tdbSNP:183339779
1390+a, gdbSNP:188620245
Gene SymbolANXA1
Gene SynonymANX1; LPC1
Chromosome9
Locus Map9q21.13
Title Identification of Annexin A1 protein expression in human gastric adenocarcinoma using proteomics and tissue microarray .
Author Zhang ZQ, Li XJ, Liu GT, Xia Y, Zhang XY and Wen H.
Journal World J. Gastroenterol. 19 (43), 7795-7803 (2013)
Title Annexin A1 is regulated by domains cross-talk through post-translational phosphorylation and SUMOYlation .
Author Caron D, Maaroufi H, Michaud S, Tanguay RM and Faure RL.
Journal Cell. Signal. 25 (10), 1962-1969 (2013)
Title Identification of Annexin A1 interacting proteins in chronic myeloid leukemia KCL22 cells .
Author Colavita I, Esposito N, Quintarelli C, Nigro E, Pane F, Ruoppolo M and Salvatore F.
Journal Proteomics 13 (16), 2414-2418 (2013)
Title Annexin A1: A new immunohistological marker of cholangiocarcinoma .
Author Hongsrichan N, Rucksaken R, Chamgramol Y, Pinlaor P, Techasen A, Yongvanit P, Khuntikeo N, Pairojkul C and Pinlaor S.
Journal World J. Gastroenterol. 19 (16), 2456-2465 (2013)
Title Low Annexin A1 expression predicts benefit from induction chemotherapy in oral cancer patients with moderate or poor pathologic differentiation grade .
Author Zhu DW, Liu Y, Yang X, Yang CZ, Ma J, Yang X, Qiao JK, Wang LZ, Li J, Zhang CP, Zhang ZY and Zhong LP.
Journal BMC Cancer 13, 301 (2013)
Title Treatment of Haemophilus aphrophilus endocarditis with ciprofloxacin .
Author Dawson SJ and White LA.
Journal J. Infect. 24 (3), 317-320 (1992)
Title Isolation of a cDNA that encodes a novel granulocyte N-formyl peptide receptor .
Author Ye RD, Cavanagh SL, Quehenberger O, Prossnitz ER and Cochrane CG.
Journal Biochem. Biophys. Res. Commun. 184 (2), 582-589 (1992)
Title Correlation of gene and protein structure of rat and human lipocortin I .
Author Kovacic RT, Tizard R, Cate RL, Frey AZ and Wallner BP.
Journal Biochemistry 30 (37), 9015-9021 (1991)
Title Calcium-induced intracellular cross-linking of lipocortin I by tissue transglutaminase in A431 cells. Augmentation by membrane phospholipids .
Author Ando Y, Imamura S, Owada MK and Kannagi R.
Journal J. Biol. Chem. 266 (2), 1101-1108 (1991)
Title Characterization of Ca2(+)-dependent phospholipid binding, vesicle aggregation and membrane fusion by annexins .
Author Blackwood RA and Ernst JD.
Journal Biochem. J. 266 (1), 195-200 (1990)

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