Homo sapiens annexin A1 (ANXA1), mRNA.
| RefSeq Version | NM_000700.1, 4502100 |
| Length | 1399 bp |
| Structure | linear |
| Update Date | 24-APR-2011 |
| Organism | Homo sapiens (human) |
| Definition | Homo sapiens annexin A1 (ANXA1), mRNA. |
| Product | annexin A1 |
| Comment | Summary: Annexin I belongs to a family of Ca(2+)-dependent phospholipid binding proteins which have a molecular weight of approximately 35,000 to 40,000 and are preferentially located on the cytosolic face of the plasma membrane. Annexin I protein has an apparent relative molecular mass of 40 kDa, with phospholipase A2 inhibitory activity. Since phospholipase A2 is required for the biosynthesis of the potent mediators of inflammation, prostaglandins and leukotrienes, annexin I may have potential anti-inflammatory activity. [provided by RefSeq]. |
| RefSeq | NP_000691.1 |
| CDS | 75..1115 | Exon (1) | 1..60 | Exon (2) | 1..60 | Exon (3) | 61..140 | Exon (4) | 141..249 | Exon (5) | 250..344 | Exon (6) | 345..458 | Exon (7) | 459..549 | Exon (8) | 550..629 | Exon (9) | 630..686 | Exon (10) | 687..780 | Exon (11) | 781..876 | Exon (12) | 877..935 | Exon (13) | 936..1058 | Exon (14) | 1059..1399 |
| Translation | MAMVSEFLKQAWFIENEEQEYVQTVKSSKGGPGSAVSPYPTFNPSSDVAALHKAIMVKGV
DEATIIDILTKRNNAQRQQIKAAYLQETGKPLDETLKKALTGHLEEVVLALLKTPAQFDA
DELRAAMKGLGTDEDTLIEILASRTNKEIRDINRVYREELKRDLAKDITSDTSGDFRNAL
LSLAKGDRSEDFGVNEDLADSDARALYEAGERRKGTDVNVFNTILTTRSYPQLRRVFQKY
TKYSKHDMNKVLDLELKGDIEKCLTAIVKCATSKPAFFAEKLHQAMKGVGTRHKALIRIM
VSRSEIDMNDIKAFYQKMYGISLCQAILDETKGDYEKILVALCGGN
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| Position | Chain | Variation | Link |
| 58 | + | a, g | dbSNP:3739956 |
| 129 | + | c, t | dbSNP:11557056 |
| 140 | + | , largedeletion | dbSNP:71738797 |
| 179 | + | g, t | dbSNP:35304764 |
| 201 | + | a, g | dbSNP:11557052 |
| 217 | + | c, t | dbSNP:11557058 |
| 260 | + | a, g | dbSNP:11557057 |
| 288 | + | c, t | dbSNP:76459132 |
| 311 | + | c, g | dbSNP:116080195 |
| 401 | + | a, g | dbSNP:1050305 |
| 478 | + | a, g | dbSNP:111698970 |
| 924 | + | a, c | dbSNP:76606281 |
| 1106 | + | a, c | dbSNP:111929339 |
| 1181 | + | c, t | dbSNP:11557051 |
| 1197 | + | c, t | dbSNP:9561 |
| 1297 | + | a, t | dbSNP:78557029 |
| Title | Annexin A1 expression in atherosclerotic carotid plaques and its relationship with plaque characteristics . |
| Author | Cheuk,B.L. and Cheng,S.W. |
| Journal | Eur J Vasc Endovasc Surg 41 (3), 364-371 (2011) |
| Title | Annexin-1 signals mitogen-stimulated breast tumor cell proliferation by activation of the formyl peptide receptors (FPRs) 1 and 2 . |
| Author | Khau,T., Langenbach,S.Y., Schuliga,M., Harris,T., Johnstone,C.N., Anderson,R.L. and Stewart,A.G. |
| Journal | FASEB J. 25 (2), 483-496 (2011) |
| Title | Down-regulation of annexin A1 and A2 protein expression in intestinal-type sinonasal adenocarcinomas . |
| Author | Rodrigo,J.P., Garcia-Pedrero,J.M., Llorente,J.L., Fresno,M.F., Allonca,E., Suarez,C. and Hermsen,M. |
| Journal | Hum. Pathol. 42 (1), 88-94 (2011) |
| Title | Annexin A1: a central player in the anti-inflammatory and neuroprotective role of microglia . |
| Author | McArthur,S., Cristante,E., Paterno,M., Christian,H., Roncaroli,F., Gillies,G.E. and Solito,E. |
| Journal | J. Immunol. 185 (10), 6317-6328 (2010) |
| Title | Increased expression of annexin A1 is correlated with K-ras mutation in colorectal cancer . |
| Author | Su,N., Xu,X.Y., Chen,H., Gao,W.C., Ruan,C.P., Wang,Q. and Sun,Y.P. |
| Journal | Tohoku J. Exp. Med. 222 (4), 243-250 (2010) |
| Title | Treatment of Haemophilus aphrophilus endocarditis with ciprofloxacin . |
| Author | Dawson,S.J. and White,L.A. |
| Journal | J. Infect. 24 (3), 317-320 (1992) |
| Title | Isolation of a cDNA that encodes a novel granulocyte N-formyl peptide receptor . |
| Author | Ye,R.D., Cavanagh,S.L., Quehenberger,O., Prossnitz,E.R. and Cochrane,C.G. |
| Journal | Biochem. Biophys. Res. Commun. 184 (2), 582-589 (1992) |
| Title | Correlation of gene and protein structure of rat and human lipocortin I . |
| Author | Kovacic,R.T., Tizard,R., Cate,R.L., Frey,A.Z. and Wallner,B.P. |
| Journal | Biochemistry 30 (37), 9015-9021 (1991) |
| Title | Calcium-induced intracellular cross-linking of lipocortin I by tissue transglutaminase in A431 cells. Augmentation by membrane phospholipids . |
| Author | Ando,Y., Imamura,S., Owada,M.K. and Kannagi,R. |
| Journal | J. Biol. Chem. 266 (2), 1101-1108 (1991) |
| Title | Characterization of Ca2(+)-dependent phospholipid binding, vesicle aggregation and membrane fusion by annexins . |
| Author | Blackwood,R.A. and Ernst,J.D. |
| Journal | Biochem. J. 266 (1), 195-200 (1990) |
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