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Blast Method:


Homo sapiens dopamine receptor D2 (DRD2), transcript variant 1, mRNA.

Clone ID Definition Vector Stock Status Price *Turnaround time Select
OHu23461 Homo sapiens dopamine receptor D2 (DRD2), transcript variant 1, mRNA. pcDNA3.1+-DYK In-stock Starting from $99 5-7
OHu23461C Homo sapiens dopamine receptor D2 (DRD2), transcript variant 1, mRNA. Your vector of choice In-stock Starting from $99 5-7
OHu23461M Mutant Clone for Homo sapiens dopamine receptor D2 (DRD2), transcript variant 1, mRNA. pcDNA3.1+-DYK In-stock Starting from $149 Additional 5 days
OHu23461CM Mutant Clone for Homo sapiens dopamine receptor D2 (DRD2), transcript variant 1, mRNA. Your vector of choice In-stock Starting from $149 Additional 5 days

*Business Day

Sequence Information ORF Nucleotide Sequence
Protein sequence
Vector pcDNA3.1+-DYK or customized vector
Clone information Clone Map
Tag on pcDNA3.1+-DYK N terminal DYKDDDDK tags
ORF Insert Method CloneEZ® Seamless cloning technology
RefSeq Version NM_000795.3, 181336946
Length 1332 bp
Structure linear
Update Date 11-MAY-2014
Organism Homo sapiens (human)
Definition Homo sapiens dopamine receptor D2 (DRD2), transcript variant 1, mRNA.
Product D(2) dopamine receptor isoform long

Summary: This gene encodes the D2 subtype of the dopamine receptor. This G-protein coupled receptor inhibits adenylyl cyclase activity. A missense mutation in this gene causes myoclonus dystonia; other mutations have been associated with schizophrenia. Alternative splicing of this gene results in two transcript variants encoding different isoforms. A third variant has been described, but it has not been determined whether this form is normal or due to aberrant splicing. [provided by RefSeq, Jul 2008].

Transcript Variant: This variant (1) encodes the longer isoform (long).

RefSeq NP_000786.1
CDS 236..1567
Misc Feature(1)200..202
Misc Feature(2)347..415
Misc Feature(3)347..415
Misc Feature(4)380..>934
Misc Feature(5)404..1513
Misc Feature(6)446..514
Misc Feature(7)order(554..556,779..781)
Misc Feature(8)560..625
Misc Feature(9)689..751
Misc Feature(10)800..874
Misc Feature(11)803..826
Misc Feature(12)815..817
Misc Feature(13)824..826
Misc Feature(14)866..1354
Misc Feature(15)1355..1420
Misc Feature(16)1391..1417
Misc Feature(17)1463..1528
Exon (1)1..204
Gene Synonym:D2DR; D2R
Exon (2)205..520
Gene Synonym:D2DR; D2R
Exon (3)521..630
Gene Synonym:D2DR; D2R
Exon (4)631..767
Gene Synonym:D2DR; D2R
Exon (5)768..958
Gene Synonym:D2DR; D2R
Exon (6)959..1045
Gene Synonym:D2DR; D2R
Exon (7)1046..1373
Gene Synonym:D2DR; D2R
Exon (8)1374..2699
Gene Synonym:D2DR; D2R
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Position Chain Variation Link
complement(15)-c, adbSNP:12281924
complement(184)-g, cdbSNP:7116768
complement(232)-g, adbSNP:200715742
complement(293)-g, adbSNP:149874318
complement(294)-t, cdbSNP:199932425
295+a, gdbSNP:4986923
complement(304)-g, adbSNP:200831689
complement(313)-g, adbSNP:200272626
complement(314)-t, cdbSNP:201424743
complement(318)-t, cdbSNP:200802757
complement(321)-g, adbSNP:368119402
complement(322)-t, cdbSNP:199524272
complement(330)-g, cdbSNP:201238984
367+c, tdbSNP:4986918
complement(370)-g, adbSNP:201795635
complement(371)-t, cdbSNP:374010633
complement(372)-g, adbSNP:201061220
379+c, tdbSNP:75275037
complement(380)-t, cdbSNP:139923738
388+a, cdbSNP:80030508
complement(391)-g, adbSNP:201114741
complement(392)-t, cdbSNP:200010436
complement(400)-t, cdbSNP:376236416
complement(418)-t, g, adbSNP:201945675
complement(426)-g, adbSNP:201137518
complement(434)-t, adbSNP:201057025
complement(463)-g, adbSNP:200084134
complement(466)-t, cdbSNP:202172997
complement(484)-g, adbSNP:201736234
complement(485)-t, cdbSNP:199961459
complement(530)-t, cdbSNP:199765712
complement(565)-g, adbSNP:201130366
complement(577)-g, adbSNP:200402411
complement(592)-t, cdbSNP:141811103
complement(594)-g, c, adbSNP:201724929
complement(595)-t, cdbSNP:199754592
complement(613)-c, adbSNP:148478679
complement(617)-t, cdbSNP:372879445
complement(636)-g, adbSNP:370100350
complement(653)-t, cdbSNP:377059381
complement(658)-g, adbSNP:1800499
complement(661)-t, cdbSNP:71653612
complement(667)-t, cdbSNP:201471837
complement(669)-t, cdbSNP:200486137
complement(684)-t, cdbSNP:199517364
complement(688)-t, g, cdbSNP:199549160
complement(694)-g, adbSNP:202047707
695+a, gdbSNP:104894220
complement(707)-t, cdbSNP:139000780
complement(728)-t, cdbSNP:199577077
complement(751)-g, adbSNP:147347002
complement(769)-g, adbSNP:143890565
complement(775)-g, adbSNP:200496289
complement(814)-g, adbSNP:202200970
complement(823)-g, adbSNP:373761235
complement(833)-t, c, adbSNP:138509142
complement(853)-c, adbSNP:147086003
complement(891)-t, cdbSNP:200148328
complement(898)-t, cdbSNP:140638952
complement(909)-g, adbSNP:151320768
complement(914)-g, cdbSNP:201881891
complement(915)-t, cdbSNP:371023969
complement(924)-t, cdbSNP:200419139
complement(925)-t, adbSNP:199961951
complement(942)-c, adbSNP:376532450
complement(946)-t, cdbSNP:201628301
complement(952)-t, cdbSNP:201004067
976+c, g, tdbSNP:80350280
complement(977)-t, cdbSNP:201628227
complement(1001)-t, cdbSNP:148827819
complement(1007)-t, gdbSNP:201649606
complement(1026)-g, cdbSNP:200966282
complement(1041)-t, cdbSNP:146652676
complement(1056)-t, cdbSNP:200184730
1067+a, gdbSNP:75673283
complement(1087)-t, cdbSNP:4986921
complement(1095)-g, adbSNP:370606616
complement(1104)-g, cdbSNP:201131985
1105+a, c, gdbSNP:74548208
complement(1106)-t, cdbSNP:370321461
complement(1119)-t, adbSNP:199926793
complement(1123)-g, adbSNP:201676705
complement(1157)-g, adbSNP:200829286
complement(1159)-g, adbSNP:146497846
complement(1160)-t, cdbSNP:149926361
complement(1163)-t, cdbSNP:1800496
complement(1164)-g, adbSNP:373984882
complement(1165)-t, cdbSNP:201422791
complement(1167)-g, cdbSNP:1801028
1174+c, tdbSNP:6275
complement(1174)-g, adbSNP:386602147
complement(1186)-g, adbSNP:369170961
complement(1192)-t, cdbSNP:6277
complement(1201)-g, adbSNP:143935143
complement(1214)-g, adbSNP:71653614
complement(1227)-g, adbSNP:202088196
complement(1228)-g, adbSNP:375783558
1245+c, tdbSNP:78973299
complement(1254)-g, adbSNP:372849659
complement(1255)-g, cdbSNP:201256011
complement(1274)-g, adbSNP:200340299
complement(1275)-g, adbSNP:144999500
complement(1278)-t, cdbSNP:143779712
1286+a, gdbSNP:1110977
complement(1294)-g, cdbSNP:199840213
complement(1297)-g, adbSNP:149410294
complement(1305)-g, adbSNP:202098964
complement(1313)-g, adbSNP:201230093
complement(1314)-t, cdbSNP:138873192
complement(1322)-t, gdbSNP:201735014
complement(1361)-t, cdbSNP:200890663
complement(1375)-g, adbSNP:201123323
complement(1376)-t, cdbSNP:200352240
complement(1381)-g, adbSNP:199514519
complement(1411)-t, cdbSNP:201537500
complement(1447)-t, cdbSNP:200532405
complement(1453)-g, cdbSNP:377018461
complement(1471)-g, adbSNP:71653615
1492+c, tdbSNP:79932566
complement(1495)-g, adbSNP:200440686
complement(1498)-t, cdbSNP:202151925
complement(1513)-g, adbSNP:201093886
complement(1527)-g, adbSNP:376186482
1540+a, gdbSNP:77930100
complement(1559)-g, adbSNP:201801648
complement(1563)-c, adbSNP:140938110
complement(1572)-t, cdbSNP:201275953
1574+c, g, tdbSNP:79266662
complement(1582)-g, adbSNP:201621795
complement(1583)-t, cdbSNP:199523375
complement(1587)-t, cdbSNP:199542111
1604+a, cdbSNP:9282673
complement(1607)-g, adbSNP:376825868
complement(1613)-g, adbSNP:200858680
complement(1619)-g, adbSNP:6276
complement(1636)-t, g, adbSNP:201475538
complement(1637)-t, cdbSNP:200559334
complement(1640)-g, cdbSNP:199729096
complement(1641)-g, adbSNP:201423084
complement(1642)-t, cdbSNP:200266844
1658+a, gdbSNP:9282672
complement(1663)-t, cdbSNP:201535094
complement(1667)-t, c, adbSNP:145419243
complement(1673)-g, adbSNP:202032930
complement(1677)-g, adbSNP:201110531
complement(1684)-t, cdbSNP:200147005
complement(1697)-g, cdbSNP:201877566
complement(1703)-t, cdbSNP:200902658
complement(1710)-g, adbSNP:199960714
complement(1716)-t, gdbSNP:201395618
complement(1728)-g, adbSNP:200907369
complement(1729)-t, cdbSNP:200094288
complement(1732)-g, adbSNP:201700158
complement(1738)-g, adbSNP:200800208
complement(1750)-t, cdbSNP:199530432
complement(1752)-t, cdbSNP:201483491
complement(1799)-t, adbSNP:200698836
complement(1822)-t, gdbSNP:199666125
complement(1887)-g, adbSNP:201468109
complement(1893)-t, cdbSNP:200553439
complement(1896)-c, adbSNP:202216753
complement(1902)-c, adbSNP:201476947
complement(1905)-c, adbSNP:200255258
complement(1910)-t, gdbSNP:111514221
complement(1912)-g, adbSNP:200963966
1943+c, gdbSNP:6279
complement(1945)-g, adbSNP:202029659
complement(1969)-t, g, adbSNP:201101625
complement(1970)-t, cdbSNP:199842575
complement(1983)-t, cdbSNP:202048283
complement(1987)-t, gdbSNP:200744960
complement(1995)-t, gdbSNP:199924485
complement(2012)-t, cdbSNP:201675047
complement(2064)-t, gdbSNP:200824645
complement(2082)-t, adbSNP:199733203
2088+a, g, tdbSNP:6274
complement(2096)-g, cdbSNP:1130354
complement(2127)-g, adbSNP:200800026
complement(2131)-g, adbSNP:199516692
complement(2132)-t, cdbSNP:190267578
complement(2135)-t, gdbSNP:200282737
complement(2139)-t, cdbSNP:199695073
complement(2144)-c, adbSNP:201058855
complement(2157)-g, adbSNP:113184960
complement(2161)-c, adbSNP:202236974
complement(2168)-g, adbSNP:184532204
complement(2169)-t, g, cdbSNP:200380382
complement(2184)-g, adbSNP:201931076
complement(2187)-c, adbSNP:201229921
complement(2189)-g, adbSNP:200074947
complement(2197)-g, adbSNP:201729901
complement(2211)-t, cdbSNP:200889099
complement(2252)-g, cdbSNP:199837640
complement(2253)-g, cdbSNP:202046871
complement(2259)-g, adbSNP:200736433
complement(2270)-t, adbSNP:199574690
complement(2271)-g, adbSNP:201648344
complement(2283)-g, cdbSNP:200708514
complement(2288)-g, adbSNP:199758344
2292+g, tdbSNP:6278
complement(2292)-c, adbSNP:386602160
complement(2304)-g, adbSNP:141843081
complement(2305)-t, cdbSNP:199512742
complement(2329)-g, adbSNP:115186256
complement(2344)-t, cdbSNP:200494127
complement(2365)-g, cdbSNP:74786742
complement(2402)-t, cdbSNP:200898113
complement(2404)-g, adbSNP:200439184
complement(2442)-t, adbSNP:202150911
complement(2445)-g, adbSNP:201091901
complement(2454)-t, adbSNP:61905361
complement(2455)-g, adbSNP:199985520
complement(2458)-c, adbSNP:201625222
complement(2469)-c, adbSNP:192448487
2493+a, g, tdbSNP:6273
complement(2516)-g, adbSNP:200080912
complement(2534)-g, adbSNP:201464003
complement(2536)-t, cdbSNP:200557458
complement(2637)-g, adbSNP:199536089
complement(2648)-t, cdbSNP:201583983
complement(2658)-t, g, cdbSNP:200733424
complement(2669)-c, adbSNP:199660782
complement(2674)-t, cdbSNP:114851076
complement(2696)-t, cdbSNP:200982455
Gene SymbolDRD2
Gene SynonymD2DR; D2R
Locus Map11q23
All Transcripts
RefSeq Accession Definition Stock Status Price Turnaround time Business Day Select
NM_000795 Homo sapiens dopamine receptor D2 (DRD2), transcript variant 1, mRNA. In-stock Starting from $99 5-7
NM_000795 Homo sapiens dopamine receptor D2 (DRD2), transcript variant 1, mRNA. In-stock Starting from $99 5-7
NM_000795 Homo sapiens dopamine receptor D2 (DRD2), transcript variant 1, mRNA. In-stock Starting from $99 5-7
NM_000795 Homo sapiens dopamine receptor D2 (DRD2), transcript variant 1, mRNA. In-stock Starting from $99 5-7
Title Single-nucleotide polymorphisms of the dopamine D2 receptor increase inflammation and fibrosis in human renal proximal tubule cells .
Author Jiang X, Konkalmatt P, Yang Y, Gildea J, Jones JE, Cuevas S, Felder RA, Jose PA and Armando I.
Journal Hypertension 63 (3), E74-E80 (2014)
Title Combined insular and striatal dopamine dysfunction are associated with executive deficits in Parkinson's disease with mild cognitive impairment .
Author Christopher L, Marras C, Duff-Canning S, Koshimori Y, Chen R, Boileau I, Segura B, Monchi O, Lang AE, Rusjan P, Houle S and Strafella AP.
Journal Brain 137 (PT 2), 565-575 (2014)
Title Initial responses to the first dose of nicotine in novel smokers: the role of exposure to environmental smoking and genetic predisposition .
Author Schuck K, Otten R, Engels RC and Kleinjan M.
Journal Psychol Health 29 (6), 698-716 (2014)
Title The effect of selected polymorphisms of the dopamine receptor gene DRD2 and the ANKK-1 on the preference of concentrations of sucrose solutions in men with alcohol dependence .
Author Jablonski M, Jasiewicz A, Kucharska-Mazur J, Samochowiec J, Bienkowski P, Mierzejewski P and Samochowiec A.
Journal Psychiatr Danub 25 (4), 371-378 (2013)
Title Functional connectivity in healthy subjects is nonlinearly modulated by the COMT and DRD2 polymorphisms in a functional system-dependent manner .
Author Tian T, Qin W, Liu B, Jiang T and Yu C.
Journal J. Neurosci. 33 (44), 17519-17526 (2013)
Title Myoclonus-Dystonia .
Author Raymond,D. and Ozelius,L.
Journal (in) Pagon RA, Adam MP, Ardinger HH, Bird TD, Dolan CR, Fong CT, Smith RJH and Stephens K (Eds.); GENEREVIEWS(R); (1993)
Title Structure and linkage of the D2 dopamine receptor and neural cell adhesion molecule genes on human chromosome 11q23 .
Author Eubanks JH, Djabali M, Selleri L, Grandy DK, Civelli O, McElligott
Journal Genomics 14 (4), 1010-1018 (1992)
Title Differential sensitivity of the short and long human dopamine D2 receptor subtypes to protein kinase C .
Author Liu YF, Civelli O, Grandy DK and Albert PR.
Journal J. Neurochem. 59 (6), 2311-2317 (1992)
Title Structure and expression of human and rat D2 dopamine receptor genes .
Author Araki K, Kuwano R, Morii K, Hayashi S, Minoshima S, Shimizu N, Katagiri T, Usui H, Kumanishi T and Takahashi Y.
Journal Neurochem. Int. 21 (1), 91-98 (1992)
Title D2 dopamine receptors in the human retina: cloning of cDNA and localization of mRNA .
Author Dearry A, Falardeau P, Shores C and Caron MG.
Journal Cell. Mol. Neurobiol. 11 (5), 437-453 (1991)

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