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Homo sapiens erythropoietin (EPO), mRNA.

RefSeq Accession Definition Service Stock Status Price *Turnaround time Order
NM_000799 Homo sapiens erythropoietin (EPO), mRNA. GenEZ ORF Cloning In-stock $308.00 $259.00 10

*Business Day

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RefSeq Version NM_000799.2, 62240996
Length 1340 bp
Structure linear
Update Date 21-APR-2013
Organism Homo sapiens (human)
Definition Homo sapiens erythropoietin (EPO), mRNA.
Product erythropoietin precursor

Summary: This gene is a member of the EPO/TPO family and encodes a secreted, glycosylated cytokine composed of four alpha helical bundles. The protein is found in the plasma and regulates red cell production by promoting erythroid differentiation and initiating hemoglobin synthesis. This protein also has neuroprotective activity against a variety of potential brain injuries and antiapoptotic functions in several tissue types. [provided by RefSeq, Jul 2008].

RefSeq NP_000790.2
CDS 182..763
Misc Feature(1)116..118
Misc Feature(2)278..760
Misc Feature(3)order(281..283,743..745)
Misc Feature(4)332..334
Misc Feature(5)order(347..349,359..361)
Misc Feature(6)374..376
Misc Feature(7)509..511
Misc Feature(8)638..640
Exon (1)1..194
Gene Synonym:EP; MVCD2
Exon (2)195..340
Gene Synonym:EP; MVCD2
Exon (3)341..427
Gene Synonym:EP; MVCD2
Exon (4)428..607
Gene Synonym:EP; MVCD2
Exon (5)608..1330
Gene Synonym:EP; MVCD2
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Position Chain Variation Link
127..128+, adbSNP:34144627
142+c, tdbSNP:141701177
218+c, tdbSNP:77762674
235+a, gdbSNP:73409072
289+c, tdbSNP:140045752
293+a, gdbSNP:200020971
328+c, gdbSNP:149877548
342+c, tdbSNP:201069425
352+c, tdbSNP:61735970
389+a, gdbSNP:62483572
409..410+, tdbSNP:34937405
418+a, gdbSNP:57694744
431+a, gdbSNP:137953994
442+c, tdbSNP:140683829
452..453+, gdbSNP:71517124
522+c, tdbSNP:11976235
570+a, gdbSNP:200241729
599+c, gdbSNP:1126887
602+c, gdbSNP:138922875
611+a, gdbSNP:201051019
621+c, gdbSNP:149431976
634+a, gdbSNP:78925197
668+c, gdbSNP:201326665
677+c, tdbSNP:73409075
733+a, cdbSNP:144031260
793+a, gdbSNP:189775061
809+c, tdbSNP:200436414
826+c, tdbSNP:202242218
856+g, tdbSNP:141911577
869+c, tdbSNP:192883541
906+a, gdbSNP:150610526
942+a, gdbSNP:184441242
1030+c, gdbSNP:78182250
1098+c, tdbSNP:77450727
1114+g, tdbSNP:188830852
1145+g, tdbSNP:564449
1225+a, gdbSNP:114461287
Gene SymbolEPO
Gene SynonymEP; MVCD2
Locus Map7q22
All Transcripts
RefSeq Accession Definition Stock Status Price Turnaround time Business Day Select
NM_000799 Homo sapiens erythropoietin (EPO), mRNA. In-stock $308.00 $259.00 10
Title Administration of recombinant erythropoietin alone does not improve the phenotype in iron refractory iron deficiency anemia patients .
Author Lehmberg,K., Grosse,R., Muckenthaler,M.U., Altamura,S., Nielsen,P., Schmid,H., Graubner,U., Oyen,F., Zeller,W., Schneppenheim,R. and Janka,G.E.
Journal Ann. Hematol. 92 (3), 387-394 (2013)
Title Endoplasmic reticulum stress signal impairs erythropoietin production: a role for ATF4 .
Author Chiang,C.K., Nangaku,M., Tanaka,T., Iwawaki,T. and Inagi,R.
Journal Am. J. Physiol., Cell Physiol. 304 (4), C342-C353 (2013)
Title Detection of neutralizing antibodies to erythropoietin by inhibition of rHuEPO-stimulated EGR1 gene expression in the UT-7/EPO cell line .
Author Ferguson,J., Bird,C., Wadhwa,M. and Burns,C.
Journal J. Immunol. Methods 387 (1-2), 191-198 (2013)
Title [Early erythropoietin deficiency in diabetic kidney lesion] .
Author Shestakova,M.V., Martynov,C.A., Kutyrina,I.M., Il'in,A.V., Arbuzova,M.I. and Dedov,I.I.
Journal Ter. Arkh. 84 (10), 9-13 (2012)
Title The erythropoietin/erythropoietin receptor signaling pathway promotes growth and invasion abilities in human renal carcinoma cells .
Author Wu,P., Zhang,N., Wang,X., Zhang,C., Li,T., Ning,X. and Gong,K.
Journal PLoS ONE 7 (9), E45122 (2012)
Title Structures and functional roles of the sugar chains of human erythropoietins .
Author Takeuchi,M. and Kobata,A.
Journal Glycobiology 1 (4), 337-346 (1991)
Title Regulation of the erythropoietin gene: evidence that the oxygen sensor is a heme protein .
Author Goldberg,M.A., Dunning,S.P. and Bunn,H.F.
Journal Science 242 (4884), 1412-1415 (1988)
Title Site-specific glycosylation of human recombinant erythropoietin: analysis of glycopeptides or peptides at each glycosylation site by fast atom bombardment mass spectrometry .
Author Sasaki,H., Ochi,N., Dell,A. and Fukuda,M.
Journal Biochemistry 27 (23), 8618-8626 (1988)
Title Comparative study of the asparagine-linked sugar chains of human erythropoietins purified from urine and the culture medium of recombinant Chinese hamster ovary cells .
Author Takeuchi,M., Takasaki,S., Miyazaki,H., Kato,T., Hoshi,S., Kochibe,N. and Kobata,A.
Journal J. Biol. Chem. 263 (8), 3657-3663 (1988)
Title Regional assignment of the erythropoietin gene to human chromosome region 7pter----q22 .
Author Watkins,P.C., Eddy,R., Hoffman,N., Stanislovitis,P., Beck,A.K., Galli,J., Vellucci,V., Gusella,J.F. and Shows,T.B.
Journal Cytogenet. Cell Genet. 42 (4), 214-218 (1986)

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