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Blast Method:


Homo sapiens gamma-aminobutyric acid (GABA) A receptor, beta 1 (GABRB1), mRNA.

Clone ID Definition Vector Stock Status Price *Turnaround time Select
OHu17601 Homo sapiens gamma-aminobutyric acid (GABA) A receptor, beta 1 (GABRB1), mRNA. pcDNA3.1+-DYK On-demand $379.00 7-9
OHu17601C Homo sapiens gamma-aminobutyric acid (GABA) A receptor, beta 1 (GABRB1), mRNA. Your vector of choice On-demand $429.00 7-9
OHu17601M Mutant Clone for Homo sapiens gamma-aminobutyric acid (GABA) A receptor, beta 1 (GABRB1), mRNA. pcDNA3.1+-DYK On-demand Starting from $149 Additional 5 days
OHu17601CM Mutant Clone for Homo sapiens gamma-aminobutyric acid (GABA) A receptor, beta 1 (GABRB1), mRNA. Your vector of choice On-demand Starting from $149 Additional 5 days

*Business Day

Sequence Information ORF Nucleotide Sequence
Protein sequence
Vector pcDNA3.1+-DYK or customized vector
Clone information Clone Map
Tag on pcDNA3.1+-DYK N terminal DYKDDDDK tags
ORF Insert Method CloneEZ® Seamless cloning technology
RefSeq Version NM_000812.3, 194097326
Length 1425 bp
Structure linear
Update Date 27-APR-2014
Organism Homo sapiens (human)
Definition Homo sapiens gamma-aminobutyric acid (GABA) A receptor, beta 1 (GABRB1), mRNA.
Product gamma-aminobutyric acid receptor subunit beta-1 precursor

Summary: The gamma-aminobutyric acid (GABA) A receptor is a multisubunit chloride channel that mediates the fastest inhibitory synaptic transmission in the central nervous system. This gene encodes GABA A receptor, beta 1 subunit. It is mapped to chromosome 4p12 in a cluster comprised of genes encoding alpha 4, alpha 2 and gamma 1 subunits of the GABA A receptor. Alteration of this gene is implicated in the pathogenetics of schizophrenia. [provided by RefSeq, Jul 2008].

RefSeq NP_000803.2
CDS 375..1799
Misc Feature(1)360..362
Misc Feature(2)399..1790
Misc Feature(3)495..1103
Misc Feature(4)1110..1175
Misc Feature(5)1122..1781
Misc Feature(6)1185..1253
Misc Feature(7)1287..1355
Misc Feature(8)1728..1793
Exon (1)1..454
Gene Synonym:GABRB1
Exon (2)455..546
Gene Synonym:GABRB1
Exon (3)547..614
Gene Synonym:GABRB1
Exon (4)615..835
Gene Synonym:GABRB1
Exon (5)836..918
Gene Synonym:GABRB1
Exon (6)919..1056
Gene Synonym:GABRB1
Exon (7)1057..1209
Gene Synonym:GABRB1
Exon (8)1210..1454
Gene Synonym:GABRB1
Exon (9)1455..2226
Gene Synonym:GABRB1
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Position Chain Variation Link
29..30+, adbSNP:140732048
115+c, tdbSNP:142473173
268+c, tdbSNP:80151988
286+g, tdbSNP:151300023
complement(292)-t, gdbSNP:140573802
349+a, gdbSNP:371385364
351+c, tdbSNP:376259497
356+a, cdbSNP:368003363
408+c, tdbSNP:199819422
445+g, tdbSNP:372535761
460+a, gdbSNP:148675961
537+a, gdbSNP:142160221
593+c, tdbSNP:151171426
611+c, tdbSNP:372567401
629+c, tdbSNP:75042373
650+a, gdbSNP:79354288
674+c, tdbSNP:146577991
696+c, tdbSNP:76009420
703+a, gdbSNP:370609274
782+a, gdbSNP:145050185
788+c, tdbSNP:147553239
790+a, gdbSNP:200428754
827+c, tdbSNP:374630182
854+a, tdbSNP:367612329
882+c, tdbSNP:4482737
890+a, gdbSNP:3822111
911+a, cdbSNP:6284
960+a, gdbSNP:377538048
992+a, c, tdbSNP:6286
1002+c, tdbSNP:77043713
1046+a, gdbSNP:75190241
1061+a, gdbSNP:138912086
1094+g, tdbSNP:79937555
1139+a, gdbSNP:376932728
1140+c, tdbSNP:375744464
1148+a, tdbSNP:74488269
1172+a, gdbSNP:267600169
1184+c, tdbSNP:188599287
1220+a, gdbSNP:6289
1253+c, tdbSNP:80178222
1255+, gdbSNP:35402897
1349+c, tdbSNP:6290
1361+c, tdbSNP:115114447
1375+a, gdbSNP:142758601
1407+a, gdbSNP:150598937
1446+a, gdbSNP:377260679
1461+a, gdbSNP:375590397
1466+c, tdbSNP:112966893
1476+a, cdbSNP:75836800
1489+c, tdbSNP:79581540
1497+c, tdbSNP:369644137
1502+a, tdbSNP:200146996
1524+c, tdbSNP:76224883
1548+a, gdbSNP:77881121
1555+a, tdbSNP:149298100
1561+c, tdbSNP:377492047
1572+g, tdbSNP:144532495
1610+a, gdbSNP:187519096
1615+a, gdbSNP:148433093
1617+g, tdbSNP:373654564
1622+c, tdbSNP:78444131
1623+a, gdbSNP:370421589
1633+c, gdbSNP:200129765
1637+c, gdbSNP:41311286
1651+a, gdbSNP:147587936
1656+c, tdbSNP:78133797
1660+a, tdbSNP:17852014
1661+a, cdbSNP:140338802
1673+a, cdbSNP:116969944
1695+c, tdbSNP:76685630
1703+a, gdbSNP:6288
1712+a, gdbSNP:79262532
1723+a, gdbSNP:74608570
1747+c, tdbSNP:75612351
1760..1761+, gdbSNP:34208698
1781+g, tdbSNP:78815529
1819+a, gdbSNP:373376360
1843+a, tdbSNP:376352619
1985+, adbSNP:111359296
2003+c, gdbSNP:192098838
2069+a, gdbSNP:10028945
2099..2100+, tdbSNP:3832300
2123+a, cdbSNP:372181109
2177+c, tdbSNP:147193608
2210+, adbSNP:59682924
2226+a, cdbSNP:11731834
Gene SymbolGABRB1
Gene SynonymGABRB1
Locus Map4p12
All Transcripts
RefSeq Accession Definition Stock Status Price Turnaround time Business Day Select
NM_000812 Homo sapiens gamma-aminobutyric acid (GABA) A receptor, beta 1 (GABRB1), mRNA. On-demand $379.00 7-9
Title Protein interaction network of alternatively spliced isoforms from brain links genetic risk factors for autism .
Author Corominas R, Yang X, Lin GN, Kang S, Shen Y, Ghamsari L, Broly M, Rodriguez M, Tam S, Trigg SA, Fan C, Yi S, Tasan M, Lemmens I, Kuang X, Zhao N, Malhotra D, Michaelson JJ, Vacic V, Calderwood MA, Roth FP, Tavernier J, Horvath S, Salehi-Ashtiani K, Korkin D, Sebat J, Hill DE, Hao T, Vidal M and Iakoucheva LM.
Journal Nat Commun 5, 3650 (2014)
Title The effect of folic acid on GABA(A)-B 1 receptor subunit .
Author Vasquez K, Kuizon S, Junaid M and Idrissi AE.
Journal Adv. Exp. Med. Biol. 775, 101-109 (2013)
Title Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population .
Author Comuzzie AG, Cole SA, Laston SL, Voruganti VS, Haack K, Gibbs RA and Butte NF.
Journal PLoS ONE 7 (12), E51954 (2012)
Title [The expression of GABA(A) receptor alpha1 and GABA(B) receptor 1 in medulla oblongata solitary nucleus and ambiguous nucleus in the cases of tramadol intoxication] .
Author Zhang S, Guan DW, Wang L, Wang HX, Zhang GH, Zhao R and Fan YY.
Journal Fa Yi Xue Za Zhi 27 (6), 401-404 (2011)
Title New insight into the central benzodiazepine receptor-ligand interactions: design, synthesis, biological evaluation, and molecular modeling of 3-substituted 6-phenyl-4H-imidazo[1,5-a][1,4]benzodiazepines and related compounds .
Author Anzini M, Valenti S, Braile C, Cappelli A, Vomero S, Alcaro S, Ortuso F, Marinelli L, Limongelli V, Novellino E, Betti L, Giannaccini G, Lucacchini A, Daniele S, Martini C, Ghelardini C, Di Cesare Mannelli L, Giorgi G, Mascia MP and Biggio G.
Journal J. Med. Chem. 54 (16), 5694-5711 (2011)
Title Functional modulation of GABAA receptors by cAMP-dependent protein phosphorylation .
Author Moss SJ, Smart TG, Blackstone CD and Huganir RL.
Journal Science 257 (5070), 661-665 (1992)
Title Identification of the cAMP-dependent protein kinase and protein kinase C phosphorylation sites within the major intracellular domains of the beta 1, gamma 2S, and gamma 2L subunits of the gamma-aminobutyric acid type A receptor .
Author Moss SJ, Doherty CA and Huganir RL.
Journal J. Biol. Chem. 267 (20), 14470-14476 (1992)
Title Genetic mapping of the beta 1 GABA receptor gene to human chromosome 4, using a tetranucleotide repeat polymorphism .
Author Dean M, Lucas-Derse S, Bolos A, O'Brien SJ, Kirkness EF, Fraser CM and Goldman D.
Journal Am. J. Hum. Genet. 49 (3), 621-626 (1991)
Title Isolation, characterization, and localization of human genomic DNA encoding the beta 1 subunit of the GABAA receptor (GABRB1) .
Author Kirkness EF, Kusiak JW, Fleming JT, Menninger J, Gocayne JD, Ward
Journal Genomics 10 (4), 985-995 (1991)
Title Differential expression of gamma-aminobutyric acidA receptor subunits .
Author Garrett KM, Saito N, Duman RS, Abel MS, Ashton RA, Fujimori S, Beer B, Tallman JF, Vitek MP and Blume AJ.
Journal Mol. Pharmacol. 37 (5), 652-657 (1990)

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