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Blast Method:


Homo sapiens LIM homeobox 8 (LHX8), transcript variant 1, mRNA.

Clone ID Definition Vector Stock Status Price *Turnaround time Order
OHu08288 Homo sapiens LIM homeobox 8 (LHX8), transcript variant 1, mRNA. pcDNA3.1+-DYK In-stock $99.00 5-7
OHu08288C Homo sapiens LIM homeobox 8 (LHX8), transcript variant 1, mRNA. Customized vector In-stock $149.00 5-7

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Mutation services

Sequence Information ORF Nucleotide Sequence
Protein sequence
Vector pcDNA3.1+-DYK or customized vector
Clone information Clone Map
Tag on pcDNA3.1+-DYK N terminal DYKDDDK tags
ORF Insert Method CloneEZ® Seamless cloning technology
RefSeq Version NM_001001933.1, 50083286
Length 1071 bp
Update Date 27-FEB-2014
Organism Homo sapiens (human)
Definition Homo sapiens LIM homeobox 8 (LHX8), transcript variant 1, mRNA.
Product LIM/homeobox protein Lhx8 isoform 1

Summary: The protein encoded by this gene is a member of the LIM homeobox family of proteins, which are involved in patterning and differentiation of various tissue types. These proteins contain two tandemly repeated cysteine-rich double-zinc finger motifs known as LIM domains, in addition to a DNA-binding homeodomain. This family member is a transcription factor that plays a role in tooth morphogenesis. It is also involved in oogenesis and in neuronal differentiation. This gene is a candidate gene for cleft palate, and it is also associated with odontoma formation. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jan 2012].

Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).

RefSeq NP_001001933.1
CDS 665..1735
Misc Feature(1)656..658
Misc Feature(2)884..1051
Misc Feature(3)884..1051
Misc Feature(4)order(887..889,896..898,950..952,959..961,968..970,
Misc Feature(5)1070..1234
Misc Feature(6)order(1070..1072,1079..1081,1136..1138,1145..1147,
Misc Feature(7)1340..1513
Misc Feature(8)order(1340..1354,1358..1360,1409..1411,1427..1429,
Misc Feature(9)order(1346..1348,1355..1357,1475..1477,1484..1489,
Exon (1)1..175
Gene Synonym:LHX7
Exon (2)176..682
Gene Synonym:LHX7
Exon (3)683..769
Gene Synonym:LHX7
Exon (4)770..931
Gene Synonym:LHX7
Exon (5)932..1053
Gene Synonym:LHX7
Exon (6)1054..1274
Gene Synonym:LHX7
Exon (7)1275..1378
Gene Synonym:LHX7
Exon (8)1379..1474
Gene Synonym:LHX7
Exon (9)1475..1658
Gene Synonym:LHX7
Exon (10)1659..2373
Gene Synonym:LHX7
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Position Chain Variation Link
36+c, gdbSNP:41289228
71+a, tdbSNP:182226067
194+a, cdbSNP:142466848
223+a, cdbSNP:192939997
241+g, tdbSNP:41289230
433+c, tdbSNP:111227275
504+c, tdbSNP:375399829
595+a, gdbSNP:41289232
635+c, g, tdbSNP:200867886
646+c, tdbSNP:200115972
649+c, tdbSNP:191646269
653+c, gdbSNP:41289234
675+c, tdbSNP:202103118
695+a, cdbSNP:116590034
713+c, tdbSNP:376772505
744+g, tdbSNP:143612358
754+c, tdbSNP:140847718
765+a, gdbSNP:369761078
775+c, tdbSNP:369347146
786+c, tdbSNP:141641179
792+a, gdbSNP:373338242
811+c, tdbSNP:371247581
814+c, gdbSNP:145195318
817+c, tdbSNP:371111953
842+c, gdbSNP:376300206
907+a, gdbSNP:149422695
936+a, tdbSNP:373880349
1001+a, tdbSNP:199843823
1068+a, gdbSNP:367958622
1084+a, gdbSNP:148556375
1090+c, tdbSNP:376834338
1100+a, gdbSNP:371719492
1105+c, tdbSNP:12084309
1108+g, tdbSNP:374741343
1264+a, gdbSNP:372110957
1276+g, tdbSNP:376728766
1300+c, tdbSNP:147867930
1477+g, tdbSNP:79714503
1513+c, tdbSNP:941032
1521+c, gdbSNP:200810970
1559+a, cdbSNP:201945188
1564+c, tdbSNP:144728419
1567+c, gdbSNP:375095039
1591+a, tdbSNP:368509617
1609+c, tdbSNP:370428970
1610+a, gdbSNP:374046822
1627+a, gdbSNP:145367581
1638+c, tdbSNP:34889650
1706+a, gdbSNP:368782371
1714+a, cdbSNP:377005651
1769+a, tdbSNP:41306167
1784+c, tdbSNP:199821156
1786+a, gdbSNP:41301265
1833+a, gdbSNP:184821578
1930+g, tdbSNP:187614610
2008+c, tdbSNP:374351080
2045+a, tdbSNP:192190181
2099+a, gdbSNP:142785057
2152+c, tdbSNP:184182933
2213+a, gdbSNP:147403016
2299+a, gdbSNP:190197837
2311+a, gdbSNP:4949795
2352+c, tdbSNP:377666437
Gene SymbolLHX8
Gene SynonymLHX7
Locus Map1p31.1
Title Oogenesis: transcriptional regulators and mouse models .
Author Jagarlamudi K and Rajkovic A.
Journal Mol. Cell. Endocrinol. 356 (1-2), 31-39 (2012)
Title Evaluation of the LIM homeobox genes LHX6 and LHX8 as candidates for Tourette syndrome .
Author Paschou P, Stylianopoulou E, Karagiannidis I, Rizzo R, Tarnok Z, Wolanczyk T, Hebebrand J, Nothen MM, Lehmkuhl G, Farkas L, Nagy P, Szymanska U, Lykidis D, Androutsos C, Tsironi V, Koumoula A, Barta C, Klidonas S, Ypsilantis P, Simopoulos C, Skavdis G and Grigoriou M.
Journal Genes Brain Behav. 11 (4), 444-451 (2012)
Title Pharmacological modulation of the Hedgehog pathway differentially affects dorsal/ventral patterning in mouse and human embryonic stem cell models of telencephalic development .
Author Nat R, Salti A, Suciu L, Strom S and Dechant G.
Journal Stem Cells Dev. 21 (7), 1016-1046 (2012)
Title Variation in FGF1, FOXE1, and TIMP2 genes is associated with nonsyndromic cleft lip with or without cleft palate .
Author Nikopensius T, Kempa I, Ambrozaityte L, Jagomagi T, Saag M, Matuleviciene A, Utkus A, Krjutskov K, Tammekivi V, Piekuse L, Akota I, Barkane B, Krumina A, Klovins J, Lace B, Kucinskas V and Metspalu A.
Journal Birth Defects Res. Part A Clin. Mol. Teratol. 91 (4), 218-225 (2011)
Title Comparative study of LHX8 expression between odontoma and dental tissue-derived stem cells .
Author Kim JY, Jeon SH, Park JY, Suh JD and Choung PH.
Journal J. Oral Pathol. Med. 40 (3), 250-256 (2011)
Title Analysis of LHX8 mutation in premature ovarian failure .
Author Qin Y, Zhao H, Kovanci E, Simpson JL, Chen ZJ and Rajkovic A.
Journal Fertil. Steril. 89 (4), 1012-1014 (2008)
Title Candidate genes for premature ovarian failure .
Author Suzumori N, Pangas SA and Rajkovic A.
Journal Curr. Med. Chem. 14 (3), 353-357 (2007)
Title Oogenesis requires germ cell-specific transcriptional regulators Sohlh1 and Lhx8 .
Author Pangas SA, Choi Y, Ballow DJ, Zhao Y, Westphal H, Matzuk MM and Rajkovic A.
Journal Proc. Natl. Acad. Sci. U.S.A. 103 (21), 8090-8095 (2006)
Title Medical sequencing of candidate genes for nonsyndromic cleft lip and palate .
Author Vieira AR, Avila JR, Daack-Hirsch S, Dragan E, Felix TM, Rahimov F, Harrington J, Schultz RR, Watanabe Y, Johnson M, Fang J, O'Brien SE, Orioli IM, Castilla EE, Fitzpatrick DR, Jiang R, Marazita ML and Murray JC.
Journal PLoS Genet. 1 (6), E64 (2005)
Title Isolated cleft palate in mice with a targeted mutation of the LIM homeobox gene lhx8 .
Author Zhao Y, Guo YJ, Tomac AC, Taylor NR, Grinberg A, Lee EJ, Huang S and Westphal H.
Journal Proc. Natl. Acad. Sci. U.S.A. 96 (26), 15002-15006 (1999)

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