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Sequence in raw or FASTA format:


Blast Method:


Homo sapiens CDGSH iron sulfur domain 2 (CISD2), mRNA.

Clone ID Definition Vector Stock Status Price *Turnaround time Order
OHu23185 Homo sapiens CDGSH iron sulfur domain 2 (CISD2), mRNA. pcDNA3.1+-DYK In-stock $99.00 5-7
OHu23185C Homo sapiens CDGSH iron sulfur domain 2 (CISD2), mRNA. Customized vector In-stock $149.00 5-7

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Sequence Information ORF Nucleotide Sequence
Protein sequence
Vector pcDNA3.1+-DYK or customized vector
Clone information Clone Map
Tag on pcDNA3.1+-DYK N terminal DYKDDDK tags
ORF Insert Method CloneEZ® Seamless cloning technology
RefSeq Version NM_001008388.4, 300116254
Length 408 bp
Structure linear
Update Date 10-MAY-2014
Organism Homo sapiens (human)
Definition Homo sapiens CDGSH iron sulfur domain 2 (CISD2), mRNA.
Product CDGSH iron-sulfur domain-containing protein 2

Summary: The protein encoded by this gene is a zinc finger protein that localizes to the endoplasmic reticulum. The encoded protein binds an iron/sulfur cluster and may be involved in calcium homeostasis. Defects in this gene are a cause of Wolfram syndrome 2. [provided by RefSeq, Mar 2011].

Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments.

RefSeq NP_001008389.1
CDS 108..515
Misc Feature(1)114..305
Misc Feature(2)114..305
Misc Feature(3)219..287
Misc Feature(4)348..464
Exon (1)1..210
Gene Synonym:ERIS; Miner1; NAF-1; WFS2; ZCD2
Exon (2)211..425
Gene Synonym:ERIS; Miner1; NAF-1; WFS2; ZCD2
Exon (3)426..5892
Gene Synonym:ERIS; Miner1; NAF-1; WFS2; ZCD2
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Position Chain Variation Link
52+g, tdbSNP:223332
67+a, gdbSNP:34403962
103+c, tdbSNP:374131019
119+a, gdbSNP:145312923
155+a, gdbSNP:374512796
159+c, tdbSNP:142339135
216+c, gdbSNP:63749888
226+a, gdbSNP:146299528
251+c, tdbSNP:371712100
279+a, cdbSNP:374058087
289+c, tdbSNP:142253163
290+a, gdbSNP:199702688
302+a, gdbSNP:375816656
347+a, gdbSNP:375529885
363+a, gdbSNP:370219158
401+c, tdbSNP:151223492
443+c, tdbSNP:199992363
447+c, tdbSNP:201294540
500+a, gdbSNP:3974627
523..524+, ttatadbSNP:3974628
746+a, tdbSNP:113520032
790+c, tdbSNP:7439174
843+a, gdbSNP:3974630
913+c, gdbSNP:4583764
938+g, tdbSNP:4597834
970+a, gdbSNP:181140079
984+c, tdbSNP:200929867
987..991+, acagadbSNP:200907667
992+g, tdbSNP:202177149
995+a, cdbSNP:200335385
1022+g, tdbSNP:4404547
1117+g, tdbSNP:111285950
1140..1141+, tgdbSNP:35045951
1145+g, tdbSNP:201534173
1151..1152+, gtdbSNP:140674520
1161+a, gdbSNP:371588195
1168..1169+, gt, gtgtdbSNP:201652008
1245+g, tdbSNP:79809177
1251..1252+, cdbSNP:35331282
1252..1253+, cdbSNP:368791098
1299+a, gdbSNP:184219643
1322+c, tdbSNP:115292237
1385+c, tdbSNP:188111609
1534+g, tdbSNP:200660717
1566+c, tdbSNP:112196870
1573+g, tdbSNP:7254
1743+a, tdbSNP:112503466
1745+c, gdbSNP:374112419
1808+a, gdbSNP:367544831
1842+a, cdbSNP:223311
1869+c, tdbSNP:188244827
1882+c, gdbSNP:145075446
1982+a, gdbSNP:200694706
2010+c, gdbSNP:181085468
2012+a, gdbSNP:368582286
2059..2062+, cagadbSNP:372068088
2102+a, gdbSNP:372309407
2104+a, cdbSNP:375157177
2130+a, cdbSNP:147549214
2269+a, tdbSNP:141865431
2278..2279+, attdbSNP:369653476
2324+c, tdbSNP:369656042
2328..2330+, cttdbSNP:148078599
2345+a, gdbSNP:62327287
2359+a, tdbSNP:62327288
2373..2374+, tgttdbSNP:373563874
2381+a, gdbSNP:112418987
2390+c, gdbSNP:111303980
2421+g, tdbSNP:79727311
2428+a, gdbSNP:77526189
2581+c, tdbSNP:374896684
2617+c, tdbSNP:187157550
2699+a, gdbSNP:374662941
2718+, tdbSNP:34550207
2719..2720+, tdbSNP:138483883
2722..2723+, tdbSNP:199992730
2722+, tdbSNP:397994774
2992+a, gdbSNP:74632941
3075..3076+, attdbSNP:35840247
3076..3077+, attdbSNP:373404676
3077..3078+g, tdbSNP:199490840
3077..3078+, tatdbSNP:70937578
3192+g, tdbSNP:113787390
3305+a, cdbSNP:223310
3312+a, gdbSNP:113008381
3336+a, gdbSNP:190765542
3539..3542+, tactdbSNP:142131629
3547+a, cdbSNP:181627301
3629+a, gdbSNP:223309
3659+g, tdbSNP:374612556
3673+c, gdbSNP:185744666
3783+c, tdbSNP:113360567
3907+a, tdbSNP:190561512
3909+a, gdbSNP:370868415
3926..3927+, aaaaaaaaaaaadbSNP:199492699
4024+g, tdbSNP:112056340
4176+c, gdbSNP:373666209
4273+g, tdbSNP:116373301
4273+g, tdbSNP:386452699
4319+a, cdbSNP:386508451
4396+c, gdbSNP:113836479
4396+c, gdbSNP:386452188
4427+a, gdbSNP:223308
4474+a, gdbSNP:72935554
4601+c, tdbSNP:7660301
4612+a, cdbSNP:7682231
4613+, adbSNP:36086281
4736+c, gdbSNP:146833214
4825+a, cdbSNP:114168354
4895+a, cdbSNP:182392254
4924+a, gdbSNP:72935555
4954+c, tdbSNP:185479449
5049+g, tdbSNP:6822658
5086+c, tdbSNP:374553853
5119+a, gdbSNP:190764358
5180+a, gdbSNP:367736367
5246+c, tdbSNP:10452178
5402+c, gdbSNP:36038242
5404..5405+, cdbSNP:35599629
5424+c, gdbSNP:182994503
5445+a, tdbSNP:188693384
5447+a, tdbSNP:193226502
5500+c, tdbSNP:183447777
5522+c, tdbSNP:6823625
5662+c, tdbSNP:6846762
5746+a, cdbSNP:199627415
5809+c, tdbSNP:4699032
Gene SymbolCISD2
Gene SynonymERIS; Miner1; NAF-1; WFS2; ZCD2
Locus Map4q24
Title Genome-wide association study on dimethylarginines reveals novel AGXT2 variants associated with heart rate variability but not with overall mortality .
Author Seppala I, Kleber ME, Lyytikainen LP, Hernesniemi JA, Makela KM, Oksala N, Laaksonen R, Pilz S, Tomaschitz A, Silbernagel G, Boehm BO, Grammer TB, Koskinen T, Juonala M, Hutri-Kahonen N, Alfthan G, Viikari JS, Kahonen M, Raitakari OT, Marz W, Meinitzer A and Lehtimaki T.
Journal Eur. Heart J. 35 (8), 524-531 (2014)
Title NAF-1 and mitoNEET are central to human breast cancer proliferation by maintaining mitochondrial homeostasis and promoting tumor growth .
Author Sohn YS, Tamir S, Song L, Michaeli D, Matouk I, Conlan AR, Harir Y, Holt SH, Shulaev V, Paddock ML, Hochberg A, Cabanchick IZ, Onuchic JN, Jennings PA, Nechushtai R and Mittler R.
Journal Proc. Natl. Acad. Sci. U.S.A. 110 (36), 14676-14681 (2013)
Title A role for the CISD2 gene in lifespan control and human disease .
Author Chen YF, Wu CY, Kirby R, Kao CH and Tsai TF.
Journal Ann. N. Y. Acad. Sci. 1201, 58-64 (2010)
Title Crystal structure of Miner1: The redox-active 2Fe-2S protein causative in Wolfram Syndrome 2 .
Author Conlan AR, Axelrod HL, Cohen AE, Abresch EC, Zuris J, Yee D, Nechushtai R, Jennings PA and Paddock ML.
Journal J. Mol. Biol. 392 (1), 143-153 (2009)
Title A homozygous mutation in a novel zinc-finger protein, ERIS, is responsible for Wolfram syndrome 2 .
Author Amr S, Heisey C, Zhang M, Xia XJ, Shows KH, Ajlouni K, Pandya A, Satin LS, El-Shanti H and Shiang R.
Journal Am. J. Hum. Genet. 81 (4), 673-683 (2007)
Title MitoNEET is an iron-containing outer mitochondrial membrane protein that regulates oxidative capacity .
Author Wiley SE, Murphy AN, Ross SA, van der Geer P and Dixon JE.
Journal Proc. Natl. Acad. Sci. U.S.A. 104 (13), 5318-5323 (2007)
Title Wolfram syndrome: phenotype and novel mutation in two Taiwanese siblings .
Author Shu SG, Tsai CR and Chi CS.
Journal J. Formos. Med. Assoc. 102 (11), 808-811 (2003)
Title Bleeding tendency in Wolfram syndrome: a newly identified feature with phenotype genotype correlation .
Author al-Sheyyab M, Jarrah N, Younis E, Shennak MM, Hadidi A, Awidi A, el-Shanti H and Ajlouni K.
Journal Eur. J. Pediatr. 160 (4), 243-246 (2001)
Title Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing .
Author Simpson JC, Wellenreuther R, Poustka A, Pepperkok R and Wiemann S.
Journal EMBO Rep. 1 (3), 287-292 (2000)
Title Homozygosity mapping identifies an additional locus for Wolfram syndrome on chromosome 4q .
Author El-Shanti H, Lidral AC, Jarrah N, Druhan L and Ajlouni K.
Journal Am. J. Hum. Genet. 66 (4), 1229-1236 (2000)

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