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Homo sapiens ribosomal protein S6 (RPS6), mRNA.
| RefSeq Version | NM_001010.2, 17158043 |
| Length | 829 bp |
| Structure | linear |
| Update Date | 07-APR-2011 |
| Organism | Homo sapiens (human) |
| Definition | Homo sapiens ribosomal protein S6 (RPS6), mRNA. |
| Product | 40S ribosomal protein S6 |
| Comment | Summary: Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a cytoplasmic ribosomal protein that is a component of the 40S subunit. The protein belongs to the S6E family of ribosomal proteins. It is the major substrate of protein kinases in the ribosome, with subsets of five C-terminal serine residues phosphorylated by different protein kinases. Phosphorylation is induced by a wide range of stimuli, including growth factors, tumor-promoting agents, and mitogens. Dephosphorylation occurs at growth arrest. The protein may contribute to the control of cell growth and proliferation through the selective translation of particular classes of mRNA. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq]. |
| RefSeq | NP_001001.2 |
| CDS | 43..792 | Exon (1) | 1..48 | Exon (2) | 1..48 | Exon (3) | 49..180 | Exon (4) | 181..391 | Exon (5) | 392..538 | Exon (6) | 539..696 | Exon (7) | 697..829 |
| Translation | MKLNISFPATGCQKLIEVDDERKLRTFYEKRMATEVAADALGEEWKGYVVRISGGNDKQG
FPMKQGVLTHGRVRLLLSKGHSCYRPRRTGERKRKSVRGCIVDANLSVLNLVIVKKGEKD
IPGLTDTTVPRRLGPKRASRIRKLFNLSKEDDVRQYVVRKPLNKEGKKPRTKAPKIQRLV
TPRVLQHKRRRIALKKQRTKKNKEEAAEYAKLLAKRMKEAKEKRQEQIAKRRRLSSLRAS
TSKSESSQK
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| Position | Chain | Variation | Link |
| 4 | + | c, t | dbSNP:17523533 |
| complement(31) | - | t, c | dbSNP:41270111 |
| 60 | + | c, t | dbSNP:11541616 |
| complement(62) | - | g, a | dbSNP:74591565 |
| 75 | + | c, t | dbSNP:1804396 |
| 87 | + | c, t | dbSNP:11541625 |
| 93 | + | a, g | dbSNP:11541620 |
| 219 | + | a, g | dbSNP:11541627 |
| 227 | + | c, t | dbSNP:11541614 |
| 263 | + | a, g | dbSNP:61743827 |
| 264 | + | c, t | dbSNP:1804397 |
| 294 | + | c, t | dbSNP:11541624 |
| 344 | + | g, t | dbSNP:11541615 |
| complement(384) | - | , t | dbSNP:34590252 |
| 430 | + | c, t | dbSNP:11541618 |
| complement(557) | - | t, c | dbSNP:17851023 |
| 657 | + | a, g | dbSNP:11541619 |
| 676..677 | + | c, t | dbSNP:11541622 |
| 683 | + | c, g | dbSNP:11541621 |
| 698 | + | a, g | dbSNP:3209388 |
| complement(704) | - | t, c | dbSNP:17852447 |
| 714 | + | a, c | dbSNP:3209385 |
| 718 | + | a, g | dbSNP:3206714 |
| 741 | + | a, g | dbSNP:3209386 |
| complement(755) | - | t, c | dbSNP:11541612 |
| 767 | + | c, t | dbSNP:1143622 |
| complement(825) | - | g, c | dbSNP:67906804 |
| complement(828) | - | c, a | dbSNP:67710536 |
| Title | The degree of p70 S6k and S6 phosphorylation in human skeletal muscle in response to resistance exercise depends on the training volume . |
| Author | Terzis,G., Spengos,K., Mascher,H., Georgiadis,G., Manta,P. and Blomstrand,E. |
| Journal | Eur. J. Appl. Physiol. 110 (4), 835-843 (2010) |
| Title | mTOR signaling is activated by FLT3 kinase and promotes survival of FLT3-mutated acute myeloid leukemia cells . |
| Author | Chen,W., Drakos,E., Grammatikakis,I., Schlette,E.J., Li,J., Leventaki,V., Staikou-Drakopoulou,E., Patsouris,E., Panayiotidis,P., Medeiros,L.J. and Rassidakis,G.Z. |
| Journal | Mol. Cancer 9, 292 (2010) |
| Title | Nucleophosmin serves as a rate-limiting nuclear export chaperone for the Mammalian ribosome . |
| Author | Maggi,L.B. Jr., Kuchenruether,M., Dadey,D.Y., Schwope,R.M., Grisendi,S., Townsend,R.R., Pandolfi,P.P. and Weber,J.D. |
| Journal | Mol. Cell. Biol. 28 (23), 7050-7065 (2008) |
| Title | Immunohistochemical identification of messenger RNA-related proteins in basophilic inclusions of adult-onset atypical motor neuron disease . |
| Author | Fujita,K., Ito,H., Nakano,S., Kinoshita,Y., Wate,R. and Kusaka,H. |
| Journal | Acta Neuropathol. 116 (4), 439-445 (2008) |
| Title | The role of human ribosomal proteins in the maturation of rRNA and ribosome production . |
| Author | Robledo,S., Idol,R.A., Crimmins,D.L., Ladenson,J.H., Mason,P.J. and Bessler,M. |
| Journal | RNA 14 (9), 1918-1929 (2008) |
| Title | The human ribosomal protein S6 gene: isolation, primary structure and location in chromosome 9 . |
| Author | Pata,I., Hoth,S., Kruppa,J. and Metspalu,A. |
| Journal | Gene 121 (2), 387-392 (1992) |
| Title | The organization of the intron-containing human S6 ribosomal protein (rpS6) gene and determination of its location at chromosome 9p21 . |
| Author | Antoine,M. and Fried,M. |
| Journal | Hum. Mol. Genet. 1 (8), 565-570 (1992) |
| Title | Antigenic reactivity of ribosomal protein S6 and the calcium-binding ATPase inhibitor protein of mammalian mitochondria . |
| Author | Penner,C.G., Murphy,L.C., Huzel,N.J. and Yamada,E.W. |
| Journal | Mol. Cell. Biochem. 108 (1), 57-66 (1991) |
| Title | Ribosomal protein genes are overexpressed in colorectal cancer: isolation of a cDNA clone encoding the human S3 ribosomal protein . |
| Author | Pogue-Geile,K., Geiser,J.R., Shu,M., Miller,C., Wool,I.G., Meisler,A.I. and Pipas,J.M. |
| Journal | Mol. Cell. Biol. 11 (8), 3842-3849 (1991) |
| Title | Identification and characterization of ribosomal proteins phosphorylated in vaccinia-virus-infected HeLa cells . |
| Author | Kaerlein,M. and Horak,I. |
| Journal | Eur. J. Biochem. 90 (3), 463-469 (1978) |
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