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Homo sapiens ribosomal protein S10 (RPS10), transcript variant 2, mRNA.


RefSeq Accession Definition Services Price Order
NM_001014 Homo sapiens ribosomal protein S10 (RPS10), transcript variant 2, mRNA. ORF Sequence $159.00
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Antibody Services
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RefSeq Version NM_001014.4, 322303055
Length 660 bp
Structure linear
Update Date 17-APR-2013
Organism Homo sapiens (human)
Definition Homo sapiens ribosomal protein S10 (RPS10), transcript variant 2, mRNA.
Product 40S ribosomal protein S10
Comment

Summary: Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 40S subunit. The protein belongs to the S10E family of ribosomal proteins. It is located in the cytoplasm. Variable expression of this gene in colorectal cancers compared to adjacent normal tissues has been observed, although no correlation between the level of expression and the severity of the disease has been found. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. Alternate splicing results in multiple transcript variants that encode the same protein. Naturally occurring read-through transcription occurs between this locus and the neighboring locus NUDT3 (nudix (nucleoside diphosphate linked moiety X)-type motif 3).[provided by RefSeq, Feb 2011].


Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same protein.

RefSeq NP_001005.1
CDS 95..592
Misc Feature(1)101..397
Misc Feature(2)101..397
Misc Feature(3)128..130
Misc Feature(4)128..130
Misc Feature(5)128..130
Misc Feature(6)530..532
Misc Feature(7)566..568
Misc Feature(8)572..574
Exon (1)1..94
Gene:RPS10
Gene Synonym:DBA9; S10
Exon (2)95..244
Gene:RPS10
Gene Synonym:DBA9; S10
Exon (3)245..416
Gene:RPS10
Gene Synonym:DBA9; S10
Exon (4)417..494
Gene:RPS10
Gene Synonym:DBA9; S10
Exon (5)495..550
Gene:RPS10
Gene Synonym:DBA9; S10
Exon (6)551..644
Gene:RPS10
Gene Synonym:DBA9; S10
Translation MLMPKKNRIAIYELLFKEGVMVAKKDVHMPKHPELADKNVPNLHVMKAMQSLKSRGYVKE QFAWRHFYWYLTNEGIQYLRDYLHLPPEIVPATLRRSRPETGRPRPKGLEGERPARLTRG EADRDTYRRSAVPPGADKKAEAGAGSATEFQFRGGFGRGRGQPPQ
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Position Chain Variation Link
complement(37)-dbSNP:
complement(37)-g, adbSNP:78454682
complement(38)-t, gdbSNP:186368512
complement(52)-c, adbSNP:111597547
complement(54)-g, adbSNP:144750085
complement(58)-g, adbSNP:9469779
complement(66)-g, adbSNP:140822093
complement(74)-g, cdbSNP:181470609
97+dbSNP:
97+a, gdbSNP:267607021
complement(100)-t, cdbSNP:146246722
complement(120)-g, adbSNP:141000590
complement(165)-t, cdbSNP:201147592
complement(194)-t, cdbSNP:148020948
complement(197)-g, adbSNP:143557454
complement(229)-g, adbSNP:148901210
complement(271)-dbSNP:
complement(271)-g, cdbSNP:200140933
complement(325)-t, cdbSNP:147863199
complement(385)-g, adbSNP:145746888
431+dbSNP:
431+c, tdbSNP:267607022
complement(439)-t, cdbSNP:141996004
complement(451)-t, cdbSNP:200850769
complement(502)-dbSNP:
complement(502)-g, adbSNP:147566753
complement(526)-c, adbSNP:199758134
complement(538)-g, adbSNP:149897629
complement(573)-dbSNP:
complement(573)-t, cdbSNP:139095177
complement(615)-g, adbSNP:200869507
complement(634)-t, cdbSNP:112078820
complement(635)-t, cdbSNP:200231286
Gene SymbolRPS10
Gene SynonymDBA9; S10
Chromosome6
Locus Map6p21.31
All Transcripts
RefSeq Accession Definition Sequence Price Select
NM_001014 Homo sapiens ribosomal protein S10 (RPS10), transcript variant 2, mRNA. Full Length $191.40
ORF Sequence $159.00
NM_001203245 Homo sapiens ribosomal protein S10 (RPS10), transcript variant 1, mRNA. Full Length $235.77
ORF Sequence $159.00
NM_001204091 Homo sapiens ribosomal protein S10 (RPS10), transcript variant 3, mRNA. Full Length $193.14
ORF Sequence $159.00
Title A novel mutation of ribosomal protein S10 gene in a Japanese patient with diamond-Blackfan anemia .
Author Yazaki,M., Kamei,M., Ito,Y., Konno,Y., Wang,R., Toki,T. and Ito,E.
Journal J. Pediatr. Hematol. Oncol. 34 (4), 293-295 (2012)
Title The HIV-1 Nef protein interacts with two components of the 40S small ribosomal subunit, the RPS10 protein and the 18S rRNA .
Author Abbas,W., Dichamp,I. and Herbein,G.
Journal Virol. J. 9, 103 (2012)
Title Methylation of ribosomal protein S10 by protein-arginine methyltransferase 5 regulates ribosome biogenesis .
Author Ren,J., Wang,Y., Liang,Y., Zhang,Y., Bao,S. and Xu,Z.
Journal J. Biol. Chem. 285 (17), 12695-12705 (2010)
Title Ribosomal protein genes RPS10 and RPS26 are commonly mutated in Diamond-Blackfan anemia .
Author Doherty,L., Sheen,M.R., Vlachos,A., Choesmel,V., O'Donohue,M.F., Clinton,C., Schneider,H.E., Sieff,C.A., Newburger,P.E., Ball,S.E., Niewiadomska,E., Matysiak,M., Glader,B., Arceci,R.J., Farrar,J.E., Atsidaftos,E., Lipton,J.M., Gleizes,P.E. and Gazda,H.T.
Journal Am. J. Hum. Genet. 86 (2), 222-228 (2010)
Title Differential expression of genes coding for ribosomal proteins in different human tissues .
Author Bortoluzzi,S., d'Alessi,F., Romualdi,C. and Danieli,G.A.
Journal Bioinformatics 17 (12), 1152-1157 (2001)
Title Proteins S7, S10, S16 and S19 of the human 40S ribosomal subunit are most resistant to dissociation by salt .
Author Malygin,A.A., Shaulo,D.D. and Karpova,G.G.
Journal Biochim. Biophys. Acta 1494 (3), 213-216 (2000)
Title Pituitary tumor-transforming gene protein associates with ribosomal protein S10 and a novel human homologue of DnaJ in testicular cells .
Author Pei,L.
Journal J. Biol. Chem. 274 (5), 3151-3158 (1999)
Title A map of 75 human ribosomal protein genes .
Author Kenmochi,N., Kawaguchi,T., Rozen,S., Davis,E., Goodman,N., Hudson,T.J., Tanaka,T. and Page,D.C.
Journal Genome Res. 8 (5), 509-523 (1998)
Title Characterization of the human small-ribosomal-subunit proteins by N-terminal and internal sequencing, and mass spectrometry .
Author Vladimirov,S.N., Ivanov,A.V., Karpova,G.G., Musolyamov,A.K., Egorov,T.A., Thiede,B., Wittmann-Liebold,B. and Otto,A.
Journal Eur. J. Biochem. 239 (1), 144-149 (1996)
Title Cloning, sequencing and expression of the L5, L21, L27a, L28, S5, S9, S10 and S29 human ribosomal protein mRNAs .
Author Frigerio,J.M., Dagorn,J.C. and Iovanna,J.L.
Journal Biochim. Biophys. Acta 1262 (1), 64-68 (1995)

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