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Homo sapiens ribosomal protein S10 (RPS10), transcript variant 2, mRNA.

Clone ID Definition Vector Stock Status Price *Turnaround time Order
OHu20633 Homo sapiens ribosomal protein S10 (RPS10), transcript variant 2, mRNA. pcDNA3.1+-DYK In-stock $99.00 5-7
OHu20633C Homo sapiens ribosomal protein S10 (RPS10), transcript variant 2, mRNA. Customized vector In-stock $149.00 5-7

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Mutation services

Sequence Information ORF Nucleotide Sequence
Protein sequence
Vector pcDNA3.1+-DYK or customized vector
Clone information Clone Map
Tag on pcDNA3.1+-DYK N terminal DYKDDDK tags
ORF Insert Method CloneEZ® Seamless cloning technology
RefSeq Version NM_001014.4, 322303055
Length 498 bp
Update Date 05-MAY-2014
Organism Homo sapiens (human)
Definition Homo sapiens ribosomal protein S10 (RPS10), transcript variant 2, mRNA.
Product 40S ribosomal protein S10

Summary: Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 40S subunit. The protein belongs to the S10E family of ribosomal proteins. It is located in the cytoplasm. Variable expression of this gene in colorectal cancers compared to adjacent normal tissues has been observed, although no correlation between the level of expression and the severity of the disease has been found. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. Alternate splicing results in multiple transcript variants that encode the same protein. Naturally occurring read-through transcription occurs between this locus and the neighboring locus NUDT3 (nudix (nucleoside diphosphate linked moiety X)-type motif 3).[provided by RefSeq, Feb 2011].

Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same protein.

RefSeq NP_001005.1
CDS 95..592
Misc Feature(1)101..397
Misc Feature(2)101..397
Misc Feature(3)128..130
Misc Feature(4)128..130
Misc Feature(5)530..532
Misc Feature(6)566..568
Misc Feature(7)572..574
Exon (1)1..94
Gene Synonym:DBA9; S10
Exon (2)95..244
Gene Synonym:DBA9; S10
Exon (3)245..416
Gene Synonym:DBA9; S10
Exon (4)417..494
Gene Synonym:DBA9; S10
Exon (5)495..550
Gene Synonym:DBA9; S10
Exon (6)551..644
Gene Synonym:DBA9; S10
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Position Chain Variation Link
complement(37)-g, adbSNP:78454682
complement(38)-t, gdbSNP:186368512
complement(52)-c, adbSNP:111597547
complement(54)-g, adbSNP:144750085
complement(58)-g, adbSNP:9469779
complement(63)-, gdbSNP:373736898
complement(66)-g, adbSNP:140822093
complement(74)-g, cdbSNP:181470609
complement(92)-g, cdbSNP:369407350
97+a, gdbSNP:267607021
complement(100)-t, cdbSNP:146246722
complement(165)-t, cdbSNP:201147592
complement(197)-g, adbSNP:143557454
complement(205)-g, cdbSNP:374314919
complement(229)-g, adbSNP:148901210
complement(271)-g, cdbSNP:200140933
complement(298)-g, adbSNP:368563040
complement(325)-t, cdbSNP:147863199
complement(368)-c, adbSNP:369059115
complement(385)-g, adbSNP:145746888
complement(397)-g, adbSNP:375962616
431+c, tdbSNP:267607022
complement(439)-t, cdbSNP:141996004
complement(445)-g, adbSNP:376353902
complement(451)-t, cdbSNP:200850769
complement(502)-g, adbSNP:147566753
complement(526)-c, adbSNP:199758134
complement(531)-g, adbSNP:368791535
complement(538)-g, adbSNP:149897629
complement(573)-t, cdbSNP:139095177
complement(615)-g, adbSNP:200869507
complement(628)-g, cdbSNP:370136285
complement(634)-t, cdbSNP:112078820
complement(635)-t, cdbSNP:200231286
Gene SymbolRPS10
Gene SynonymDBA9; S10
Locus Map6p21.31
Title A novel mutation of ribosomal protein S10 gene in a Japanese patient with diamond-Blackfan anemia .
Author Yazaki M, Kamei M, Ito Y, Konno Y, Wang R, Toki T and Ito E.
Journal J. Pediatr. Hematol. Oncol. 34 (4), 293-295 (2012)
Title The HIV-1 Nef protein interacts with two components of the 40S small ribosomal subunit, the RPS10 protein and the 18S rRNA .
Author Abbas W, Dichamp I and Herbein G.
Journal Virol. J. 9, 103 (2012)
Title Methylation of ribosomal protein S10 by protein-arginine methyltransferase 5 regulates ribosome biogenesis .
Author Ren J, Wang Y, Liang Y, Zhang Y, Bao S and Xu Z.
Journal J. Biol. Chem. 285 (17), 12695-12705 (2010)
Title Ribosomal protein genes RPS10 and RPS26 are commonly mutated in Diamond-Blackfan anemia .
Author Doherty L, Sheen MR, Vlachos A, Choesmel V, O'Donohue MF, Clinton C, Schneider HE, Sieff CA, Newburger PE, Ball SE, Niewiadomska E, Matysiak M, Glader B, Arceci RJ, Farrar JE, Atsidaftos E, Lipton JM, Gleizes PE and Gazda HT.
Journal Am. J. Hum. Genet. 86 (2), 222-228 (2010)
Title Proteins S7, S10, S16 and S19 of the human 40S ribosomal subunit are most resistant to dissociation by salt .
Author Malygin AA, Shaulo DD and Karpova GG.
Journal Biochim. Biophys. Acta 1494 (3), 213-216 (2000)
Title Pituitary tumor-transforming gene protein associates with ribosomal protein S10 and a novel human homologue of DnaJ in testicular cells .
Author Pei L.
Journal J. Biol. Chem. 274 (5), 3151-3158 (1999)
Title A map of 75 human ribosomal protein genes .
Author Kenmochi N, Kawaguchi T, Rozen S, Davis E, Goodman N, Hudson TJ, Tanaka T and Page DC.
Journal Genome Res. 8 (5), 509-523 (1998)
Title Characterization of the human small-ribosomal-subunit proteins by N-terminal and internal sequencing, and mass spectrometry .
Author Vladimirov SN, Ivanov AV, Karpova GG, Musolyamov AK, Egorov TA, Thiede B, Wittmann-Liebold B and Otto A.
Journal Eur. J. Biochem. 239 (1), 144-149 (1996)
Title Cloning, sequencing and expression of the L5, L21, L27a, L28, S5, S9, S10 and S29 human ribosomal protein mRNAs .
Author Frigerio JM, Dagorn JC and Iovanna JL.
Journal Biochim. Biophys. Acta 1262 (1), 64-68 (1995)
Title Diamond-Blackfan Anemia .
Author Clinton,C. and Gazda,H.T.
Journal (in) Pagon RA, Adam MP, Ardinger HH, Bird TD, Dolan CR, Fong CT, Smith RJH and Stephens K (Eds.); GENEREVIEWS(R); (1993)

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