Homo sapiens ribosomal protein S10 (RPS10), transcript variant 2, mRNA.
| RefSeq Version | NM_001014.4, 322303055 |
| Length | 660 bp |
| Structure | linear |
| Update Date | 30-APR-2011 |
| Organism | Homo sapiens (human) |
| Definition | Homo sapiens ribosomal protein S10 (RPS10), transcript variant 2, mRNA. |
| Product | 40S ribosomal protein S10 |
| Comment | Summary: Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 40S subunit. The protein belongs to the S10E family of ribosomal proteins. It is located in the cytoplasm. Variable expression of this gene in colorectal cancers compared to adjacent normal tissues has been observed, although no correlation between the level of expression and the severity of the disease has been found. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. Alternate splicing results in multiple transcript variants that encode the same protein. Naturally occurring read-through transcription occurs between this locus and the neighboring locus NUDT3 (nudix (nucleoside diphosphate linked moiety X)-type motif 3). Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same protein. |
| RefSeq | NP_001005.1 |
| CDS | 95..592 | Exon (1) | 1..94 | Exon (2) | 1..94 | Exon (3) | 95..244 | Exon (4) | 245..416 | Exon (5) | 417..494 | Exon (6) | 495..550 | Exon (7) | 551..644 |
| Translation | MLMPKKNRIAIYELLFKEGVMVAKKDVHMPKHPELADKNVPNLHVMKAMQSLKSRGYVKE
QFAWRHFYWYLTNEGIQYLRDYLHLPPEIVPATLRRSRPETGRPRPKGLEGERPARLTRG
EADRDTYRRSAVPPGADKKAEAGAGSATEFQFRGGFGRGRGQPPQ
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| Position | Chain | Variation | Link |
| Gene Symbol | RPS10 |
| Gene Synonym | DBA9; MGC88819; S10 |
| Chromosome | 6 |
| Locus Map | 6p21.31 |
| All Transcripts | NM_001014 , NM_001203245 , NM_001204091 |
| Title | Methylation of ribosomal protein S10 by protein-arginine methyltransferase 5 regulates ribosome biogenesis . |
| Author | Ren,J., Wang,Y., Liang,Y., Zhang,Y., Bao,S. and Xu,Z. |
| Journal | J. Biol. Chem. 285 (17), 12695-12705 (2010) |
| Title | Ribosomal protein genes RPS10 and RPS26 are commonly mutated in Diamond-Blackfan anemia . |
| Author | Doherty,L., Sheen,M.R., Vlachos,A., Choesmel,V., O'Donohue,M.F., Clinton,C., Schneider,H.E., Sieff,C.A., Newburger,P.E., Ball,S.E., Niewiadomska,E., Matysiak,M., Glader,B., Arceci,R.J., Farrar,J.E., Atsidaftos,E., Lipton,J.M., Gleizes,P.E. and Gazda,H.T. |
| Journal | Am. J. Hum. Genet. 86 (2), 222-228 (2010) |
| Title | Mass spectrometric analysis of the human 40S ribosomal subunit: native and HCV IRES-bound complexes . |
| Author | Yu,Y., Ji,H., Doudna,J.A. and Leary,J.A. |
| Journal | Protein Sci. 14 (6), 1438-1446 (2005) |
| Title | Expression and purification of human ribosomal proteins S3, S5, S10, S19, and S26 . |
| Author | Malygin,A., Baranovskaya,O., Ivanov,A. and Karpova,G. |
| Journal | Protein Expr. Purif. 28 (1), 57-62 (2003) |
| Title | Differential expression of genes coding for ribosomal proteins in different human tissues . |
| Author | Bortoluzzi,S., d'Alessi,F., Romualdi,C. and Danieli,G.A. |
| Journal | Bioinformatics 17 (12), 1152-1157 (2001) |
| Title | Proteins S7, S10, S16 and S19 of the human 40S ribosomal subunit are most resistant to dissociation by salt . |
| Author | Malygin,A.A., Shaulo,D.D. and Karpova,G.G. |
| Journal | Biochim. Biophys. Acta 1494 (3), 213-216 (2000) |
| Title | Pituitary tumor-transforming gene protein associates with ribosomal protein S10 and a novel human homologue of DnaJ in testicular cells . |
| Author | Pei,L. |
| Journal | J. Biol. Chem. 274 (5), 3151-3158 (1999) |
| Title | A map of 75 human ribosomal protein genes . |
| Author | Kenmochi,N., Kawaguchi,T., Rozen,S., Davis,E., Goodman,N., Hudson,T.J., Tanaka,T. and Page,D.C. |
| Journal | Genome Res. 8 (5), 509-523 (1998) |
| Title | Characterization of the human small-ribosomal-subunit proteins by N-terminal and internal sequencing, and mass spectrometry . |
| Author | Vladimirov,S.N., Ivanov,A.V., Karpova,G.G., Musolyamov,A.K., Egorov,T.A., Thiede,B., Wittmann-Liebold,B. and Otto,A. |
| Journal | Eur. J. Biochem. 239 (1), 144-149 (1996) |
| Title | Cloning, sequencing and expression of the L5, L21, L27a, L28, S5, S9, S10 and S29 human ribosomal protein mRNAs . |
| Author | Frigerio,J.M., Dagorn,J.C. and Iovanna,J.L. |
| Journal | Biochim. Biophys. Acta 1262 (1), 64-68 (1995) |
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