Homo sapiens ribosomal protein S13 (RPS13), mRNA.
| RefSeq Version | NM_001017.2, 14591910 |
| Length | 529 bp |
| Structure | linear |
| Update Date | 07-APR-2011 |
| Organism | Homo sapiens (human) |
| Definition | Homo sapiens ribosomal protein S13 (RPS13), mRNA. |
| Product | 40S ribosomal protein S13 |
| Comment | Summary: Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 40S subunit. The protein belongs to the S15P family of ribosomal proteins. It is located in the cytoplasm. The protein has been shown to bind to the 5.8S rRNA in rat. The gene product of the E. coli ortholog (ribosomal protein S15) functions at early steps in ribosome assembly. This gene is co-transcribed with two U14 small nucleolar RNA genes, which are located in its third and fifth introns. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq]. |
| RefSeq | NP_001008.1 |
| CDS | 33..488 | Exon (1) | 1..55 | Exon (2) | 1..55 | Exon (3) | 56..104 | Exon (4) | 105..183 | Exon (5) | 184..353 | Exon (6) | 354..454 | Exon (7) | 455..529 |
| Translation | MGRMHAPGKGLSQSALPYRRSVPTWLKLTSDDVKEQIYKLAKKGLTPSQIGVILRDSHGV
AQVRFVTGNKILRILKSKGLAPDLPEDLYHLIKKAVAVRKHLERNRKDKDAKFRLILIES
RIHRLARYYKTKRVLPPNWKYESSTASALVA
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| Position | Chain | Variation | Link |
| complement(8) | - | g, a | dbSNP:78520678 |
| 86 | + | c, t | dbSNP:11550522 |
| complement(89) | - | t, c | dbSNP:113610512 |
| 215 | + | a, t | dbSNP:1804352 |
| 261 | + | c, t | dbSNP:1804353 |
| 277 | + | a, c | dbSNP:11550520 |
| 285 | + | c, t | dbSNP:11550523 |
| complement(290..291) | - | , t | dbSNP:36097163 |
| 323 | + | c, t | dbSNP:11050 |
| 331 | + | a, c | dbSNP:1804354 |
| 352 | + | a, g | dbSNP:1136720 |
| 354 | + | a, g | dbSNP:1804355 |
| 359 | + | a, g | dbSNP:1804348 |
| 374 | + | c, t | dbSNP:11550521 |
| 383 | + | a, g | dbSNP:1059640 |
| 384..385 | + | a, g | dbSNP:11550525 |
| 384 | + | a, g | dbSNP:3200417 |
| 400 | + | a, c | dbSNP:11550526 |
| 458 | + | a, g | dbSNP:1804350 |
| Title | Human ribosomal protein S13 regulates expression of its own gene at the splicing step by a feedback mechanism . |
| Author | Malygin,A.A., Parakhnevitch,N.M., Ivanov,A.V., Eperon,I.C. and Karpova,G.G. |
| Journal | Nucleic Acids Res. 35 (19), 6414-6423 (2007) |
| Title | Global, in vivo, and site-specific phosphorylation dynamics in signaling networks . |
| Author | Olsen,J.V., Blagoev,B., Gnad,F., Macek,B., Kumar,C., Mortensen,P. and Mann,M. |
| Journal | Cell 127 (3), 635-648 (2006) |
| Title | Mass spectrometric analysis of the human 40S ribosomal subunit: native and HCV IRES-bound complexes . |
| Author | Yu,Y., Ji,H., Doudna,J.A. and Leary,J.A. |
| Journal | Protein Sci. 14 (6), 1438-1446 (2005) |
| Title | Human ribosomal protein S13: cloning, expression, refolding, and structural stability . |
| Author | Malygin,A., Parakhnevitch,N. and Karpova,G. |
| Journal | Biochim. Biophys. Acta 1747 (1), 93-97 (2005) |
| Title | Immunoaffinity profiling of tyrosine phosphorylation in cancer cells . |
| Author | Rush,J., Moritz,A., Lee,K.A., Guo,A., Goss,V.L., Spek,E.J., Zhang,H., Zha,X.M., Polakiewicz,R.D. and Comb,M.J. |
| Journal | Nat. Biotechnol. 23 (1), 94-101 (2005) |
| Title | U14 snoRNAs are encoded in introns of human ribosomal protein S13 gene . |
| Author | Kenmochi,N., Higa,S., Yoshihama,M. and Tanaka,T. |
| Journal | Biochem. Biophys. Res. Commun. 228 (2), 371-374 (1996) |
| Title | Characterization of the human small-ribosomal-subunit proteins by N-terminal and internal sequencing, and mass spectrometry . |
| Author | Vladimirov,S.N., Ivanov,A.V., Karpova,G.G., Musolyamov,A.K., Egorov,T.A., Thiede,B., Wittmann-Liebold,B. and Otto,A. |
| Journal | Eur. J. Biochem. 239 (1), 144-149 (1996) |
| Title | Structure and evolution of mammalian ribosomal proteins . |
| Author | Wool,I.G., Chan,Y.L. and Gluck,A. |
| Journal | Biochem. Cell Biol. 73 (11-12), 933-947 (1995) |
| Title | Cloning and analysis of the human S13 ribosomal protein cDNA . |
| Author | Chadeneau,C., LeMoullac,B. and Denis,M.G. |
| Journal | Nucleic Acids Res. 21 (12), 2945 (1993) |
| Title | The primary structure of rat ribosomal protein S13 . |
| Author | Suzuki,K., Olvera,J. and Wool,I.G. |
| Journal | Biochem. Biophys. Res. Commun. 171 (2), 519-524 (1990) |
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