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Homo sapiens retinoic acid receptor, alpha (RARA), transcript variant 2, mRNA.

Clone ID Definition Vector Stock Status Price *Turnaround time Order
OHu21799 Homo sapiens retinoic acid receptor, alpha (RARA), transcript variant 2, mRNA. pcDNA3.1+-DYK In-stock $99.00 TBD
OHu21799C Homo sapiens retinoic acid receptor, alpha (RARA), transcript variant 2, mRNA. Customized vector In-stock $149.00 TBD

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Sequence Information ORF Nucleotide Sequence
Protein sequence
Vector pcDNA3.1+-DYK or customized vector
Clone information Clone Map
Tag on pcDNA3.1+-DYK N terminal DYKDDDK tags
ORF Insert Method CloneEZ® Seamless cloning technology
RefSeq Version NM_001024809.3, 300388162
Length 1374 bp
Update Date 05-MAY-2014
Organism Homo sapiens (human)
Definition Homo sapiens retinoic acid receptor, alpha (RARA), transcript variant 2, mRNA.
Product retinoic acid receptor alpha isoform 2

Summary: This gene represents a nuclear retinoic acid receptor. The encoded protein, retinoic acid receptor alpha, regulates transcription in a ligand-dependent manner. This gene has been implicated in regulation of development, differentiation, apoptosis, granulopoeisis, and transcription of clock genes. Translocations between this locus and several other loci have been associated with acute promyelocytic leukemia. Alternatively spliced transcript variants have been found for this locus.[provided by RefSeq, Sep 2010].

Transcript Variant: This variant (2) reflects the use of an alternate promoter and has a distinct 5' exon, compared to transcript variant 1. Translation is predicted to initiate from this alternate exon, and the resulting protein (isoform 2) has a shorter and a distinct N-terminus compared to isoform 1.

RefSeq NP_001019980.1
CDS 687..2060
Misc Feature(1)630..632
Misc Feature(2)915..1169
Misc Feature(3)915..1169
Misc Feature(4)order(933..935,942..944,984..986,993..995,1041..1043,
Misc Feature(5)order(963..971,987..992,996..998,1002..1004,1008..1013,
Misc Feature(6)order(1074..1076,1083..1094)
Misc Feature(7)1227..1919
Misc Feature(8)order(1353..1355,1362..1367,1374..1376,1467..1469,
Misc Feature(9)order(1389..1391,1401..1403,1431..1433,1440..1445,
Misc Feature(10)order(1614..1616,1680..1685,1716..1718,1725..1730,
Exon (1)1..849
Gene Synonym:NR1B1; RAR
Exon (2)850..998
Gene Synonym:NR1B1; RAR
Exon (3)999..1140
Gene Synonym:NR1B1; RAR
Exon (4)1141..1301
Gene Synonym:NR1B1; RAR
Exon (5)1302..1478
Gene Synonym:NR1B1; RAR
Exon (6)1479..1683
Gene Synonym:NR1B1; RAR
Exon (7)1684..1842
Gene Synonym:NR1B1; RAR
Exon (8)1843..3477
Gene Synonym:NR1B1; RAR
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Position Chain Variation Link
13+c, tdbSNP:376171160
359+a, gdbSNP:112359597
372+c, tdbSNP:367986970
458+a, cdbSNP:181948756
705+g, tdbSNP:149514124
721+c, tdbSNP:374297174
799+c, gdbSNP:370534498
813+c, tdbSNP:202229958
818+c, gdbSNP:185276091
902+a, gdbSNP:2229771
980+c, tdbSNP:148477186
1048+a, gdbSNP:367912717
1169+a, gdbSNP:142718201
1188+c, gdbSNP:369501728
1207+c, tdbSNP:375401606
1213+c, tdbSNP:367821941
1214+a, gdbSNP:376136601
1217+a, gdbSNP:200393055
complement(1228)-g, adbSNP:79997555
1231+c, tdbSNP:112626578
1253+c, gdbSNP:113014668
1344+c, tdbSNP:201919660
1397+c, tdbSNP:150816475
1412+c, tdbSNP:139260459
1413+a, gdbSNP:373673287
1414+a, gdbSNP:200827868
1424+c, gdbSNP:369508611
1430+a, cdbSNP:199944788
1436+c, tdbSNP:144249834
1475+c, tdbSNP:41283421
1475+c, tdbSNP:386489390
1508+c, tdbSNP:77633370
1526+c, gdbSNP:377203949
1532+a, gdbSNP:370610393
1577+c, tdbSNP:35163502
1584+c, gdbSNP:374550237
1607+c, tdbSNP:200326853
1616+a, gdbSNP:368477125
1624+c, gdbSNP:145829003
1626+c, tdbSNP:371856851
1640+g, tdbSNP:148999974
1649+a, gdbSNP:373590342
1658+c, tdbSNP:143827534
1661+c, tdbSNP:147971091
1700+a, gdbSNP:140714166
1706+a, c, gdbSNP:74349261
1710+a, cdbSNP:138717943
1745+a, gdbSNP:201508544
1757+c, tdbSNP:142769381
1830+a, gdbSNP:376831612
1850+a, gdbSNP:146977371
1862+a, gdbSNP:374319630
1955+g, tdbSNP:376329242
2062+c, tdbSNP:2229773
2100+c, tdbSNP:143781383
2151+c, gdbSNP:2229772
2176+g, tdbSNP:11544351
2213+c, tdbSNP:139482076
2215+a, gdbSNP:190879195
2224+a, gdbSNP:183204850
2286+a, cdbSNP:375417623
2344+c, tdbSNP:149687193
2405+a, gdbSNP:115635151
2418+a, cdbSNP:117770216
2468+c, gdbSNP:367819767
2480+g, tdbSNP:370334154
2497+c, gdbSNP:200674161
2501+g, tdbSNP:375909325
2502+a, tdbSNP:368586881
2530+a, cdbSNP:371896486
2605+a, tdbSNP:185566558
2753+c, gdbSNP:375581332
2839+c, gdbSNP:190326404
3163+c, tdbSNP:115248059
3166+a, gdbSNP:74396306
3167+c, tdbSNP:182891484
3168+a, gdbSNP:376581605
3179+a, cdbSNP:368001358
3241+, cdbSNP:71355453
3406+a, gdbSNP:140111856
Gene SymbolRARA
Gene SynonymNR1B1; RAR
Locus Map17q21
Title A TDG/CBP/RARalpha ternary complex mediates the retinoic acid-dependent expression of DNA methylation-sensitive genes .
Author Leger H, Smet-Nocca C, Attmane-Elakeb A, Morley-Fletcher S, Benecke
Journal Genomics Proteomics Bioinformatics 12 (1), 8-18 (2014)
Title A novel RARalpha/CAR-mediated mechanism for regulation of human organic solute transporter-beta gene expression .
Author Xu S, Sun AQ and Suchy FJ.
Journal Am. J. Physiol. Gastrointest. Liver Physiol. 306 (2), G154-G162 (2014)
Title The PRKAR1A gene is fused to RARA in a new variant acute promyelocytic leukemia .
Author Catalano A, Dawson MA, Somana K, Opat S, Schwarer A, Campbell LJ and Iland H.
Journal Blood 110 (12), 4073-4076 (2007)
Title Fusion of retinoic acid receptor alpha to NuMA, the nuclear mitotic apparatus protein, by a variant translocation in acute promyelocytic leukaemia .
Author Wells RA, Catzavelos C and Kamel-Reid S.
Journal Nat. Genet. 17 (1), 109-113 (1997)
Title PLZF-RAR alpha fusion proteins generated from the variant t(11;17)(q23;q21) translocation in acute promyelocytic leukemia inhibit ligand-dependent transactivation of wild-type retinoic acid receptors .
Author Chen Z, Guidez F, Rousselot P, Agadir A, Chen SJ, Wang ZY, Degos L, Zelent A, Waxman S and Chomienne C.
Journal Proc. Natl. Acad. Sci. U.S.A. 91 (3), 1178-1182 (1994)
Title A transferable silencing domain is present in the thyroid hormone receptor, in the v-erbA oncogene product and in the retinoic acid receptor .
Author Baniahmad A, Kohne AC and Renkawitz R.
Journal EMBO J. 11 (3), 1015-1023 (1992)
Title Structure, localization and transcriptional properties of two classes of retinoic acid receptor alpha fusion proteins in acute promyelocytic leukemia (APL): structural similarities with a new family of oncoproteins .
Author Kastner P, Perez A, Lutz Y, Rochette-Egly C, Gaub MP, Durand B, Lanotte M, Berger R and Chambon P.
Journal EMBO J. 11 (2), 629-642 (1992)
Title Retinoid X receptor interacts with nuclear receptors in retinoic acid, thyroid hormone and vitamin D3 signalling .
Author Kliewer SA, Umesono K, Mangelsdorf DJ and Evans RM.
Journal Nature 355 (6359), 446-449 (1992)
Title The PML-RAR alpha fusion mRNA generated by the t(15;17) translocation in acute promyelocytic leukemia encodes a functionally altered RAR .
Author de The H, Lavau C, Marchio A, Chomienne C, Degos L and Dejean A.
Journal Cell 66 (4), 675-684 (1991)
Title Characterization of a functional promoter for the human retinoic acid receptor-alpha (hRAR-alpha) .
Author Brand NJ, Petkovich M and Chambon P.
Journal Nucleic Acids Res. 18 (23), 6799-6806 (1990)

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