Homo sapiens nuclear receptor subfamily 1, group I, member 3 (NR1I3), transcript variant 2, mRNA.
|RefSeq Version||NM_001077480.2, 319039299|
|Organism||Homo sapiens (human)|
|Definition||Homo sapiens nuclear receptor subfamily 1, group I, member 3 (NR1I3), transcript variant 2, mRNA.|
|Product||nuclear receptor subfamily 1 group I member 3 isoform 2|
Summary: This gene encodes a member of the nuclear receptor superfamily, and is a key regulator of xenobiotic and endobiotic metabolism. The protein binds to DNA as a monomer or a heterodimer with the retinoid X receptor and regulates the transcription of target genes involved in drug metabolism and bilirubin clearance, such as cytochrome P450 family members. Unlike most nuclear receptors, this transcriptional regulator is constitutively active in the absence of ligand but is regulated by both agonists and inverse agonists. Ligand binding results in translocation of this protein to the nucleus, where it activates or represses target gene transcription. These ligands include bilirubin, a variety of foreign compounds, steroid hormones, and prescription drugs. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq].
Transcript Variant: This variant (2) uses an alternate splice site in the 3' coding region, compared to variant 1. The resulting protein (isoform 2) is shorter than isoform 1.
|CDS||204..1262||Exon (1)||1..170||Exon (2)||1..170||Exon (3)||171..310||Exon (4)||311..441||Exon (5)||442..611||Exon (6)||612..751||Exon (7)||752..897||Exon (8)||898..1026||Exon (9)||1027..1132||Exon (10)||1133..1393|
Order your protein of interest with our Guaranteed or It's Free Service now! For details, please click here.
|Gene Synonym||CAR; CAR1; MB67; MGC150433; MGC97144; MGC97209|
|All Transcripts||NM_001077480 , NM_001077481 , NM_001077482 , NM_001077478 , NM_001077469 , NM_005122 , NM_001077471 , NM_001077472 , NM_001077473 , NM_001077474 , NM_001077475 , NM_001077476 , NM_001077477 , NM_001077479 , NM_001077470|
Our customer service representatives are available 24 hours a day, Monday through Friday; please contact us anytime for assistance.